Manchikatla Venkat Rajam
Mamta -, Reddy K, Rajam M. Targeting chitinase gene of Helicoverpa armigera by host-induced RNA interference confers insect resistance in tobacco and tomato. Plant Mol Biol. 2016;90:281-92 pubmed publisher
..armigera larvae after feeding on the leaves of RNAi lines. These results demonstrated the role of chitinase in insect development and potential of HI-RNAi for effective management of H. armigera. ..
Gupta E, Pachauri M, Ghosh P, Rajam M. Targeting polyamine biosynthetic pathway through RNAi causes the abrogation of MCF 7 breast cancer cell line. Tumour Biol. 2016;37:1159-71 pubmed publisher
..These results suggest that the targeting polyamine biosynthesis through RNAi approach could be a promising strategy for breast cancer therapy and might be extended for therapy of other cancers. ..
Yogindran S, Rajam M. Artificial miRNA-mediated silencing of ecdysone receptor (EcR) affects larval development and oogenesis in Helicoverpa armigera. Insect Biochem Mol Biol. 2016;77:21-30 pubmed publisher
..The method is cost effective and can be exploited as an efficient and alternative tool for insect pest management. ..
Choubey A, Rajam M. Transcriptome response and developmental implications of RNAi-mediated ODC knockdown in tobacco. Funct Integr Genomics. 2017;17:399-412 pubmed publisher
Pareek M, Rajam M. RNAi-mediated silencing of MAP kinase signalling genes (Fmk1, Hog1, and Pbs2) in Fusarium oxysporum reduces pathogenesis on tomato plants. Fungal Biol. 2017;121:775-784 pubmed publisher
..oxysporum and this could be extended for other fungal systems. The obtained knowledge can be easily translated for developing fungal resistant crops by RNAi. ..