Niko Radulovic

Summary

Publications

  1. ncbi request reprint Synthesis, characterization, and antimicrobial evaluation of a small library of ferrocene-containing acetoacetates and phenyl analogs: the discovery of a potent anticandidal agent
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000, Nis, Serbia
    Mol Divers 18:497-510. 2014
  2. ncbi request reprint Further antibacterial Geranium macrorrhizum L. metabolites and synthesis of epoxygermacrones
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, RS 18000 Niš phone 381 628049210 fax 381 18533014
    Chem Biodivers 11:542-50. 2014
  3. ncbi request reprint Cytotoxic effect of Reseda lutea L.: A case of forgotten remedy
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, RS 18000 Nis, Serbia Electronic address
    J Ethnopharmacol 153:125-32. 2014
  4. doi request reprint Chemical composition of the tuber essential oil from Helianthus tuberosus L. (Asteraceae)
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia, phone 381 628049210 fax 381 18533014
    Chem Biodivers 11:427-37. 2014
  5. doi request reprint Effects of methyl and isopropyl N-methylanthranilates from Choisya ternata Kunth (Rutaceae) on experimental anxiety and depression in mice
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Phytother Res 27:1334-8. 2013
  6. ncbi request reprint The last decade of antinociceptive alkaloids: structure, synthesis, mechanism of action and prospect
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Curr Top Med Chem 13:2134-70. 2013
  7. ncbi request reprint Toxic essential oils. Part III: identification and biological activity of new allylmethoxyphenyl esters from a Chamomile species (Anthemis segetalis Ten.)
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia Electronic address
    Food Chem Toxicol 62:554-65. 2013
  8. ncbi request reprint Chemistry of spices: bornyl 4-methoxybenzoate from Ferula ovina (Boiss.) Boiss. (Apiaceae) induces hyperalgesia in mice
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, RS 18000 Nis, Serbia
    Food Funct 4:1751-8. 2013
  9. doi request reprint Methyl and isopropyl N-methylanthranilates attenuate diclofenac- and ethanol-induced gastric lesions in rats
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia Electronic address
    Life Sci 93:840-6. 2013
  10. ncbi request reprint Volatiles of Geranium purpureum Vill. and Geranium phaeum L.: chemotaxonomy of balkan Geranium and Erodium species (Geraniaceae)
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia phone 381 628049210 fax 381 18533014
    Chem Biodivers 10:2042-52. 2013

Collaborators

  • Polina D Blagojević
  • Jelena Lazarevic
  • Danielle Skropeta
  • Zorica Stojanović-Radić
  • Vidoslav Dekić
  • Radosav Palic
  • Ivan Damljanović
  • Ljiljana Comić
  • Tatjana Mihajilov-Krstev
  • Jelena Rajković
  • Rastko Vukićević
  • Biljana Dekić
  • Ernst Ellmerer
  • Rastko D Vukićević
  • Milan D Joksović
  • Mirjana Vukićević
  • Zoran Ratković

Detail Information

Publications34

  1. ncbi request reprint Synthesis, characterization, and antimicrobial evaluation of a small library of ferrocene-containing acetoacetates and phenyl analogs: the discovery of a potent anticandidal agent
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000, Nis, Serbia
    Mol Divers 18:497-510. 2014
    ....
  2. ncbi request reprint Further antibacterial Geranium macrorrhizum L. metabolites and synthesis of epoxygermacrones
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, RS 18000 Niš phone 381 628049210 fax 381 18533014
    Chem Biodivers 11:542-50. 2014
    ..043 and 0.855 μmol/ml for 1,10- and 4,5-epoxygermacrone, resp.). The discovery and observed activity of the two epoxides fills the gap in our knowledge of the active principles in this highly renowned ethnomedicinal plant species. ..
  3. ncbi request reprint Cytotoxic effect of Reseda lutea L.: A case of forgotten remedy
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, RS 18000 Nis, Serbia Electronic address
    J Ethnopharmacol 153:125-32. 2014
    ..However, to date no in vivo or in vitro evidence exists in support of the alleged tumor healing properties of R. lutea...
  4. doi request reprint Chemical composition of the tuber essential oil from Helianthus tuberosus L. (Asteraceae)
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia, phone 381 628049210 fax 381 18533014
    Chem Biodivers 11:427-37. 2014
    ..0-0.4%), desmethoxyencecalin (7; traces - 0.2%), desmethylencecalin (8; 0.0-0.4%), and an isomer of desmethylencecalin (0.0%-traces). The essential oils isolated from the tuber and the aerial parts share the common major component 1. ..
  5. doi request reprint Effects of methyl and isopropyl N-methylanthranilates from Choisya ternata Kunth (Rutaceae) on experimental anxiety and depression in mice
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Phytother Res 27:1334-8. 2013
    ..The anthranilates administered on their own did not induce sleep in mice but significantly prolonged the diazepam-induced sleep, in a dose-dependent way, suggesting an interaction with the gamma-aminobutyric acid receptor complex...
  6. ncbi request reprint The last decade of antinociceptive alkaloids: structure, synthesis, mechanism of action and prospect
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Curr Top Med Chem 13:2134-70. 2013
    ..e. could they be used as potential leads for new antinociceptive drugs)?..
  7. ncbi request reprint Toxic essential oils. Part III: identification and biological activity of new allylmethoxyphenyl esters from a Chamomile species (Anthemis segetalis Ten.)
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia Electronic address
    Food Chem Toxicol 62:554-65. 2013
    ....
  8. ncbi request reprint Chemistry of spices: bornyl 4-methoxybenzoate from Ferula ovina (Boiss.) Boiss. (Apiaceae) induces hyperalgesia in mice
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, RS 18000 Nis, Serbia
    Food Funct 4:1751-8. 2013
    ..Ferula ovina (Boiss.) Boiss. is a traditional Iranian flavoring agent used as an ingredient of spices and condiments...
  9. doi request reprint Methyl and isopropyl N-methylanthranilates attenuate diclofenac- and ethanol-induced gastric lesions in rats
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia Electronic address
    Life Sci 93:840-6. 2013
    ....
  10. ncbi request reprint Volatiles of Geranium purpureum Vill. and Geranium phaeum L.: chemotaxonomy of balkan Geranium and Erodium species (Geraniaceae)
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia phone 381 628049210 fax 381 18533014
    Chem Biodivers 10:2042-52. 2013
    ..The results put forward pro arguments for the oil-yield-oil-composition correlation hypothesis. ..
  11. doi request reprint A 'low-level' chemotaxonomic analysis of the plant family Apiaceae: the case of Scandix balansae Reut. ex Boiss. (tribe Scandiceae)
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Chem Biodivers 10:1202-19. 2013
    ..MVA demonstrated that the evolution of the volatiles' metabolism of Scandiceae taxa was neither genera-specific nor follows their morphological evolution. ..
  12. doi request reprint Average mass scan of the total ion chromatograms: a new gas chromatography-mass spectrometry derived variable for fast and reliable multivariate statistical treatment of essential oil compositional data
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    J Chromatogr A 1301:190-9. 2013
    ..The AMS approach gives comparable or even better results than the traditional method - it reflected the natural relationships between observations within both studied groups of oils. ..
  13. doi request reprint Toxic essential oils. Part II: chemical, toxicological, pharmacological and microbiological profiles of Artemisia annua L. volatiles
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Food Chem Toxicol 58:37-49. 2013
    ..annua botanical drugs are not limited only to their antimalarial properties. Taking into account its relatively low toxicity, the usage of A. annua volatiles (at least of the herein studied population) does not represent a health risk. ..
  14. doi request reprint Essential oils from the roots of Echinops bannaticus Rochel ex Schrad. and Echinops sphaerocephalus L. (Asteraceae): chemotaxonomic and biosynthetic aspects
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, RS 18000 Nis
    Chem Biodivers 10:658-76. 2013
    ....
  15. ncbi request reprint Antimicrobial plant metabolites: structural diversity and mechanism of action
    N S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Curr Med Chem 20:932-52. 2013
    ..Moreover, possible ways of overcoming some of PSMs molecular limitations in respect to their usage as potential antibiotics were also discussed (e.g. derivatization that would enable fine tuning of certain molecular characteristics)...
  16. ncbi request reprint Exploitation of the antioxidant potential of Geranium macrorrhizum (Geraniaceae): hepatoprotective and antimicrobial activities
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Nat Prod Commun 7:1609-14. 2012
    ..Besides the known astringent effect, one can expect that the observed antimicrobial activity against several human pathogens contributes to the wound healing properties of this plant...
  17. doi request reprint Chemical composition of Hypericum rumeliacum Boiss. essential oil. A new chemotype of this pharmacologically valuable species?
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, RS 18000 Niš Serbia
    Chem Biodivers 9:2324-41. 2012
    ..rumeliacum chemotypes. However, they have implied that the volatile profile of this plant species is determined by the stage of its phenological development...
  18. doi request reprint Toxic essential oils: anxiolytic, antinociceptive and antimicrobial properties of the yarrow Achillea umbellata Sibth. et Sm. (Asteraceae) volatiles
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Food Chem Toxicol 50:2016-26. 2012
    ..According to the results obtained, fragranol may be considered as the main active principle responsible for the observed activity/toxicity...
  19. doi request reprint Volatile secondary metabolites of Micromeria dalmatica Benth. (Lamiaceae): biosynthetical and chemotaxonomical aspects
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Nis
    Chem Biodivers 9:1303-19. 2012
    ..dalmatica samples, implied the occurrence of at least two different chemotypes of the mentioned species...
  20. ncbi request reprint A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): identification, synthesis and antinociceptive activity
    Niko Radulovic
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Food Chem Toxicol 50:274-9. 2012
    ..Conmaculatin's strong peripheral and central antinociceptive activity in mice was observed in a narrow dose range (10-20mg/kg). It was found to be lethal in doses higher than 20mg/kg...
  21. doi request reprint The most frequently encountered volatile contaminants of essential oils and plant extracts introduced during the isolation procedure: fast and easy profiling
    Niko S Radulović
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000, Nis, Serbia
    Phytochem Anal 23:131-42. 2012
    ..Unfortunately, contaminants of synthetic/artificial origin are sometimes identified as major constituents of essential oils or plant extracts and considered to be biologically active native plant metabolites...
  22. ncbi request reprint Chemotaxonomy of Serbian Teucrium species inferred from essential oil chemical composition: the case of Teucrium scordium L. ssp. scordioides
    Niko Radulovic
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Chem Biodivers 9:106-22. 2012
    ..The chemistry of the volatiles of eight Teucrium taxa from Serbia and Montenegro were compared using multivariate statistical analysis, and this provided chemotaxonomically important conclusions...
  23. doi request reprint Commercial Carlinae radix herbal drug: botanical identity, chemical composition and antimicrobial properties
    Zorica Stojanović-Radić
    Department of Biology and Ecology, Faculty of Science and Mathematics, University of Nis, Nis, Serbia
    Pharm Biol 50:933-40. 2012
    ..There still seems to be no detailed studies correlating the chemical composition of this drug and its ethnopharmacological uses...
  24. ncbi request reprint Chemical composition of the essential oils of serbian wild-growing Artemisia absinthium and Artemisia vulgaris
    Polina Blagojević
    Department of Chemistry, Faculty of Science and Mathematics, Visegradska 33, 18000 Nis, Serbia and Montenegro
    J Agric Food Chem 54:4780-9. 2006
    ..The oils showed a broad spectrum of antimicrobial activity against the tested strains. Therefore, these oils can be used as flavor and fragrance ingredients...
  25. doi request reprint Composition of Achillea distans Willd. subsp. distans root essential oil
    Jelena Lazarevic
    Department of Pharmacy, Faculty of Medical Sciences, University of Nis, Bul, dr Zorana Dindica 81, 18000 Nis, Serbia
    Nat Prod Res 24:718-31. 2010
    ..This is the first report on A. distans subsp. distans root volatiles and on the occurrence of piperidides and piperideides as essential oil constituents...
  26. ncbi request reprint Volatile profiles of Artemisia alba from contrasting serpentine and calcareous habitats
    Niko Radulovic
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Nat Prod Commun 5:1117-22. 2010
    ..alba volatiles (genetically predetermined or environmental), especially in the case of populations grown on serpentine rock, characterized by a deficiency of water and indispensable mineral elements...
  27. ncbi request reprint Fatty acid derived compounds--the dominant volatile class of the essential oil poor Sonchus arvensis subsp. uliginosus (Bieb.) Nyman
    Niko Radulovic
    Department Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Nat Prod Commun 4:405-10. 2009
    ..1%) are generally characterized by the specific production of mono- and sesquiterpenoids, and/or phenylpropanoids...
  28. doi request reprint Synthesis and antimicrobial activity of some new pyrazole derivatives containing a ferrocene unit
    Ivan Damljanović
    University of Kragujevac, Faculty of Science, Department of Chemistry, R Domanovica 12, 34000 Kragujevac, Serbia
    Bioorg Med Chem Lett 19:1093-6. 2009
    ..They have shown a wide range of activities, from completely inactive to the highly active compounds...
  29. ncbi request reprint Composition of diethyl ether flower extracts of Lonicera fragrantissima Lindl. & Paxton (caprifoliaceae)
    Niko Radulovic
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia
    Nat Prod Commun 4:1581-4. 2009
    ..1 and 2.1%, respectively). To the best of our knowledge, this is the first report on the GC behavior of loganetin. It seems that this and the long-chain fatty acid hexyl esters could have chemotaxonomic significance at the generic level...
  30. doi request reprint Comparative study of the leaf volatiles of Arctostaphylos uva-ursi (L.) Spreng. and Vaccinium vitis-idaea L. (Ericaceae)
    Niko Radulovic
    Faculty of Science and Mathematics, University of Nis, Nis, Serbia
    Molecules 15:6168-85. 2010
    ..Results of the chemical and statistical analyses pointed to a strong relation between the genera Vaccinium and Arctostaphylos...
  31. doi request reprint Antimicrobial phenolic abietane diterpene from Lycopus europaeus L. (Lamiaceae)
    Niko Radulovic
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Nis, Serbia
    Bioorg Med Chem Lett 20:4988-91. 2010
    ..Euroabienol showed a broad spectrum of activity and probably is a first line defense plant metabolite against pathogen attack. This is the first report on the occurrence of abietanes in the genus Lycopus...
  32. doi request reprint Complete assignment of the 1H and 13C NMR spectra of antimicrobial 4-arylamino- 3-nitrocoumarin derivatives
    Vidoslav Dekić
    Department of Chemistry, Faculty of Science and Mathematics, University of Pristina, Lole Ribara 29, 38220 Kosovska Mitrovica, Serbia
    Magn Reson Chem 48:896-902. 2010
    ..This study provides the first complete and fully assigned NMR data for this important group of antimicrobial compounds and bridges the gap existing in the literature with regard to NMR structural data for 4-arylamino-3-nitrocoumarins...
  33. ncbi request reprint Essential oil of Nepeta x faassenii Bergmans ex Stearn (N. mussinii Spreng. x N. nepetella L.): a comparison study
    Niko Radulovic
    Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Serbia
    Nat Prod Commun 6:1015-22. 2011
    ..faassenii to N. mussinii, than to the other parent species, was observed...
  34. ncbi request reprint Composition and antimicrobial activity of Equisetum arvense L. essential oil
    Niko Radulovic
    University of Nis, Faculty of Sciences and Mathematics, Department of Chemistry, Visegradska 33, 18000 Nis, Serbia and Montenegro
    Phytother Res 20:85-8. 2006
    ..The 1:10 dilution of the essential oil of Equisetum arvense L. was shown to possess a broad spectrum of a very strong antimicrobial activity against all tested strains...