D Rades

Summary

Publications

  1. doi request reprint Do patients with very few brain metastases from breast cancer benefit from whole-brain radiotherapy in addition to radiosurgery?
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck, 23538, Germany
    Radiat Oncol 9:267. 2014
  2. doi request reprint A matched-pair analysis comparing 5x4 Gy and 10x3 Gy for metastatic spinal cord compression (MSCC) in patients with favorable survival prognoses
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Radiat Oncol 10:90. 2015
  3. ncbi request reprint A new tool to predict survival after radiosurgery alone for newly diagnosed cerebral metastases
    Dirk Rades
    Department of Radiation Oncology, Faculty of Medicine, University of Lubeck, Schleswig Holstein, Germany e mail
    Asian Pac J Cancer Prev 16:2967-70. 2015
  4. doi request reprint A new tool predicting survival after radiosurgery alone for one or two cerebral metastases from lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Lung 193:299-302. 2015
  5. doi request reprint Nuclear expression of p65 (RelA) in patients receiving post-operative radiotherapy for locally advanced squamous cell carcinoma of the head and neck
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    BMC Cancer 15:1107. 2015
  6. ncbi request reprint Metastatic spinal cord compression from pancreatic cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 34:3727-30. 2014
  7. pmc Radiosurgery alone versus radiosurgery plus whole-brain irradiation for very few cerebral metastases from lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    BMC Cancer 14:931. 2014
  8. ncbi request reprint Number of extraspinal organs with metastases: a prognostic factor of survival in patients with metastatic spinal cord compression (MSCC) from non-small cell lung cancer (NSCLC)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 34:2503-7. 2014
  9. ncbi request reprint Comparison of Two Dose Levels of Stereotactic Radiosurgery for 1-3 Brain Metastases from Non-small Cell Lung Cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 34:7309-13. 2014
  10. ncbi request reprint Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    J Clin Oncol 23:3366-75. 2005

Detail Information

Publications169 found, 100 shown here

  1. doi request reprint Do patients with very few brain metastases from breast cancer benefit from whole-brain radiotherapy in addition to radiosurgery?
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck, 23538, Germany
    Radiat Oncol 9:267. 2014
    ..This study investigated the role of whole-brain radiotherapy added to radiosurgery in breast cancer patients...
  2. doi request reprint A matched-pair analysis comparing 5x4 Gy and 10x3 Gy for metastatic spinal cord compression (MSCC) in patients with favorable survival prognoses
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Radiat Oncol 10:90. 2015
    ..Therefore, this matched-pair study following strict matching criteria was perfomed instead...
  3. ncbi request reprint A new tool to predict survival after radiosurgery alone for newly diagnosed cerebral metastases
    Dirk Rades
    Department of Radiation Oncology, Faculty of Medicine, University of Lubeck, Schleswig Holstein, Germany e mail
    Asian Pac J Cancer Prev 16:2967-70. 2015
    ..As cause of death in group B was mostly new cerebral metastases, additional WBI appears even more important for this group. ..
  4. doi request reprint A new tool predicting survival after radiosurgery alone for one or two cerebral metastases from lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Lung 193:299-302. 2015
    ..001). This new tool enables physicians to estimate the survival of lung cancer patients with few cerebral metastases which should impact individualized treatment choices. ..
  5. doi request reprint Nuclear expression of p65 (RelA) in patients receiving post-operative radiotherapy for locally advanced squamous cell carcinoma of the head and neck
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    BMC Cancer 15:1107. 2015
    ..This study investigated the prognostic role of nuclear expression of p65 in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN) receiving post-operative radio(chemo)therapy...
  6. ncbi request reprint Metastatic spinal cord compression from pancreatic cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 34:3727-30. 2014
    ..Pancreatic cancer is an extremely rare entity in patients with metastatic epidural spinal cord compression (MESCC). This study aimed to identify prognostic factors for functional outcome and survival following irradiation...
  7. pmc Radiosurgery alone versus radiosurgery plus whole-brain irradiation for very few cerebral metastases from lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    BMC Cancer 14:931. 2014
    ..Since primary tumors disseminating to the brain show different behavior, this question should be answered separately for each tumor type. This study compared both treatments in patients with 1-3 cerebral metastases from lung cancer...
  8. ncbi request reprint Number of extraspinal organs with metastases: a prognostic factor of survival in patients with metastatic spinal cord compression (MSCC) from non-small cell lung cancer (NSCLC)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 34:2503-7. 2014
    ..In patients irradiated for MSCC from NSCLC, the number of extraspinal organs involved by metastases was investigated for associations with survival...
  9. ncbi request reprint Comparison of Two Dose Levels of Stereotactic Radiosurgery for 1-3 Brain Metastases from Non-small Cell Lung Cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 34:7309-13. 2014
    ..Two dose groups of patients treated with stereotactic radiosurgery (SRS) alone for 1-3 brain metastases from non-small cell lung cancer (NSCLC) were compared for outcomes...
  10. ncbi request reprint Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    J Clin Oncol 23:3366-75. 2005
    ..To study five radiotherapy (RT) schedules and potential prognostic factors for functional outcome in metastatic spinal cord compression (MSCC)...
  11. doi request reprint Impact of the HPV-positivity definition on the prognostic value of HPV status in patients with locally advanced squamous cell carcinoma of the head and neck
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 189:856-60. 2013
    ..A modified definition of HPV positivity was used in the current study compared to the authors' previous study...
  12. doi request reprint Stereotactic radiosurgery for newly diagnosed brain metastases: comparison of three dose levels
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 190:786-91. 2014
    ..Three doses were compared for local control of irradiated metastases, freedom from new brain metastases, and survival in patients receiving stereotactic radiosurgery (SRS) alone for one to three newly diagnosed brain metastases...
  13. doi request reprint Metastatic spinal cord compression: a validated survival score for elderly patients
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 190:919-24. 2014
    ..This study aimed to develop a validated survival score for elderly patients with metastatic spinal cord compression (MSCC)...
  14. doi request reprint Prognostic role of the number of involved extraspinal organs in patients with metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany Electronic address
    Clin Neurol Neurosurg 118:12-5. 2014
    ..This study was investigated the prognostic role of the number of involved extraspinal organs in the survival of patients with metastatic spinal cord compression (MSCC)...
  15. ncbi request reprint Predicting survival of patients with metastatic epidural spinal cord compression from cancer of the head-and-neck
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 35:385-8. 2015
    ..To develop an instrument for estimating survival after irradiation for metastatic epidural spinal cord compression (MESCC) from head and neck cancer...
  16. ncbi request reprint Radiosurgery alone for 1-3 newly-diagnosed brain metastases from melanoma: impact of dose on treatment outcomes
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 34:5079-82. 2014
    ..To compare different doses of stereotactic radiosurgery (SRS) for 1-3 newly-diagnosed cerebral metastases from melanoma...
  17. doi request reprint Do patients with a limited number of brain metastases need whole-brain radiotherapy in addition to radiosurgery?
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Strahlenther Onkol 188:702-6. 2012
    ..In patients with a good performance status, radiosurgery also resulted in better survival. However, the question is whether the results of radiosurgery alone can be further improved with additional WBRT...
  18. ncbi request reprint Predicting overall survival in patients with brain metastases from esophageal cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 34:6763-5. 2014
    ..To identify survival predictors and develop a survival score for patients with brain metastases from esophageal cancer...
  19. doi request reprint Evaluation of prognostic factors and two radiation techniques in patients treated with surgery followed by radio(chemo)therapy or definitive radio(chemo)therapy for locally advanced head-and-neck cancer
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Strahlenther Onkol 184:198-205. 2008
    ..Comparative studies regarding outcome and toxicity are lacking. This study compared both techniques for overall survival (OS), metastases-free survival (MFS), loco-regional control (LC), and toxicity in stage III/IV head-and-neck cancer...
  20. ncbi request reprint Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 35:333-6. 2015
    ..To determine the optimal dose of radiosurgery-alone for patients with 1-3 cerebral metastases from breast cancer...
  21. ncbi request reprint Impact of VEGF and VEGF receptor 1 (FLT1) expression on the prognosis of stage III esophageal cancer patients after radiochemotherapy
    Dirk Rades
    Department of Radiation Oncology, University Medical Center Hamburg Eppendorf, Germany
    Strahlenther Onkol 184:416-20. 2008
    ..The prognostic value of VEGF receptor 1 (FLT1) is unclear. This retrospective study investigated the impact of tumor expression of VEGF and FLT1 on outcome in 68 stage III esophageal cancer patients...
  22. doi request reprint Dose escalation of whole-brain radiotherapy for brain metastases from melanoma
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 77:537-41. 2010
    ..Hypofractionation regimens failed to improve the outcome of these patients. This study investigates a potential benefit from escalation of the WBRT dose beyond the "standard" regimen 30 Gy in 10 fractions (10x3 Gy)...
  23. pmc A new prognostic instrument to predict the probability of developing new cerebral metastases after radiosurgery alone
    Stefan Huttenlocher
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck 23538, Germany
    Radiat Oncol 9:215. 2014
    ..This study aimed to create an instrument that estimates the probability of developing new cerebral metastases after radiosurgery to facilitate the decision regarding additional WBI...
  24. pmc A validated score estimating ambulatory status following radiotherapy of elderly patients for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    BMC Cancer 14:589. 2014
    ..This study was performed to develop a validated score predicting ambulatory status after radiotherapy (RT) alone for metastatic spinal cord compression (MSCC) in elderly patients...
  25. ncbi request reprint Value of postoperative stereotactic radiosurgery and conventional radiotherapy for incompletely resected typical neurocytomas
    Dirk Rades
    Department of Radiation Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Cancer 106:1140-3. 2006
    ..The current study investigated whether the outcome after incomplete resection can be improved by postoperative stereotactic radiosurgery (SRS) or by conventional radiotherapy...
  26. doi request reprint Hypofractionated whole-brain radiotherapy for multiple brain metastases from transitional cell carcinoma of the bladder
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Int J Radiat Oncol Biol Phys 78:404-8. 2010
    ..Because its radiosensitivity is relatively low, metastases from bladder cancer may be treated better with hypofractionated radiotherapy. This study compared short-course hypofractionated WBRT (5 × 4 Gy/1 week) to longer-course WBRT...
  27. ncbi request reprint A survival score for patients with metastatic spinal cord compression from prostate cancer
    D Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Strahlenther Onkol 188:802-6. 2012
    ..This study aimed to develop and validate a survival scoring system for patients with metastatic spinal cord compression (MSCC) from prostate cancer...
  28. doi request reprint A new prognostic factor for the survival of patients with renal cell carcinoma developing metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Lubeck, University of Lubeck, 23538, Ratzeburger Allee 160, Lubeck, Germany
    Strahlenther Onkol 190:667-70. 2014
    ..This study aimed to identify a potential association of the number of involved extraspinal organs with the survival of patients with metastatic spinal cord compression (MSCC) from renal cell carcinoma...
  29. doi request reprint Comparison of short-course versus long-course whole-brain radiotherapy in the treatment of brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Strahlenther Onkol 184:30-5. 2008
    ..This study compares 20 Gy in five fractions (treatment time: 1 week) to longer programs, with higher doses including 30 Gy in ten fractions (2 weeks) and 40 Gy in 20 fractions (4 weeks)...
  30. ncbi request reprint Two radiation regimens and prognostic factors for brain metastases in nonsmall cell lung cancer patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 110:1077-82. 2007
    ..A short course of WBRT would be preferable to longer regimens if it could provide similar survival. This retrospective study of NSCLC patients compared longer treatment programs with short-course WBRT with 5 x 4 Gy given during 5 days...
  31. ncbi request reprint [The value of radiotherapy in treatment of meningeal melanocytoma]
    Dirk Rades
    Abteilung für Strahlentherapie und spezielle Onkologie, Medizinische Hochschule Hannover
    Strahlenther Onkol 178:336-42. 2002
    ..Meningeal melanocytoma is described as rare benign lesion with a high risk of recurrence. There are no well-substantiated treatment recommendations in the literature. Only case reports have been published by now...
  32. doi request reprint Surgery followed by radiotherapy versus radiotherapy alone for metastatic spinal cord compression from unfavorable tumors
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 81:e861-8. 2011
    ..It is thought that patients with MSCC from relatively radioresistant tumors or tumors associated with poor functional outcome after radiotherapy alone may benefit from surgery. This study focuses on these tumors...
  33. doi request reprint Scoring systems to estimate intracerebral control and survival rates of patients irradiated for brain metastases
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 80:1122-7. 2011
    ..To create and validate scoring systems for intracerebral control (IC) and overall survival (OS) of patients irradiated for brain metastases...
  34. ncbi request reprint Impact of zoledronic acid on control of metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Strahlenther Onkol 188:910-6. 2012
    ..In contrast to other studies, this matched-pair analysis focused solely on the impact of zoledronic acid on metastatic spinal cord compression (MSCC)...
  35. ncbi request reprint Escalation of radiation dose beyond 30 Gy in 10 fractions for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 67:525-31. 2007
    ..In many centers worldwide, radiotherapy for metastatic spinal cord compression (MSCC) is performed with 30 Gy in 10 fractions. This study investigated the potential benefit of dose escalation...
  36. doi request reprint A simple survival score for patients with brain metastases from breast cancer
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Strahlenther Onkol 189:664-7. 2013
    ..This study aimed to create and validate a survival score for patients with brain metastasis from breast cancer, which is the second most common primary tumor in these patients...
  37. doi request reprint Resection plus whole-brain irradiation versus resection plus whole-brain irradiation plus boost for the treatment of single brain metastasis
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Strahlenther Onkol 188:143-7. 2012
    ..The optimal treatment for patients with a single brain metastasis is controversial. This study investigated the value of a radiation boost given in addition to neurosurgerical resection and whole-brain irradiation (WBI)...
  38. doi request reprint Predicting the presence of extracranial metastases in patients with brain metastases upon first diagnosis of cancer
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 190:405-7. 2014
    ..This study aimed to determine factors allowing the prediction of extracranial metastases in patients presenting with brain metastases at the first diagnosis of cancer...
  39. ncbi request reprint Number of involved extracranial organs predicts survival in patients with brain metastasis from small cell lung cancer
    Lavinia Gerdan
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 33:3887-9. 2013
    ..To investigate the prognostic role of the number of involved extracranial organs in patients with brain metastasis from small-cell lung cancer (SCLC)...
  40. ncbi request reprint Re-irradiation of spinal cord compression due to metastasis in elderly patients
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 34:2555-8. 2014
    ..The present study investigated efficacy and toxicity of re-irradiation for an in-field recurrence of spinal cord compression due to metastasis (SCCM) in elderly patients...
  41. doi request reprint Brain metastasis. Prognostic value of the number of involved extracranial organs
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 189:996-1000. 2013
    ..This study was performed to evaluate the prognostic role for survival of the number and the type of involved extracranial organs in patients with brain metastasis...
  42. doi request reprint Prognostic factors for local control and survival in patients with spinal cord compression from myeloma
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:628-31. 2012
    ..This retrospective study aimed to identify prognostic factors for local control and survival in 214 patients irradiated for spinal cord compression (SCC) from myeloma...
  43. ncbi request reprint Dose escalation beyond 30 grays in 10 fractions for patients with multiple brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 110:1345-50. 2007
    ..The current study investigated the potential benefit of dose escalation beyond 30 Gy...
  44. ncbi request reprint Biologic factors associated with tumor oxygenation are prognostic in patients with stage III esophageal cancer: long-term results
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 34:4351-5. 2014
    ..Long-term results of a study investigating potential prognostic factors for treatment outcomes in patients with stage III esophageal cancer are presented...
  45. ncbi request reprint Therapeutic options for meningeal melanocytoma. Case report
    D Rades
    Department of Radiation Oncology, Hannover Medical College, Germany
    J Neurosurg 95:225-31. 2001
    ..050) and for incomplete resection combined with radiotherapy after 2 years (p = 0.034). Complete tumor resection should be considered the best therapeutic option, followed by incomplete resection combined with postoperative radiotherapy...
  46. ncbi request reprint Localised disease in cancer of unknown primary (CUP): the value of positron emission tomography (PET) for individual therapeutic management
    D Rades
    Department of Radiation Oncology, Hannover Medical College, Germany
    Ann Oncol 12:1605-9. 2001
    ..After conservative diagnostic procedures including MRI, the primary is detected in less than 25%. The diagnostic value of PET and its influence on therapeutic strategies was evaluated...
  47. ncbi request reprint Prognostic significance of the time of developing motor deficits before radiation therapy in metastatic spinal cord compression: one-year results of a prospective trial
    D Rades
    Department of Radiation Oncology, Hannover Medical University, Hannover, Germany
    Int J Radiat Oncol Biol Phys 48:1403-8. 2000
    ..To investigate prospectively the prognostic value of the time of developing motor deficits before radiation therapy (RT) for post-treatment functional outcome in metastatic spinal cord compression...
  48. ncbi request reprint Radiotherapy of metastatic spinal cord compression in very elderly patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 67:256-63. 2007
    ..This study investigated the results of radiotherapy (RT) for metastatic spinal cord compression (MSCC) in the very elderly, because few data are available for these patients...
  49. ncbi request reprint A new score predicting survival prognosis after whole-brain radiotherapy alone for brain metastases in elderly patients
    Jasmin N Evers
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 34:2455-8. 2014
    ..Elderly patients represent an important subgroup of patients with brain metastases. A survival score has been developed specifically for these patients...
  50. doi request reprint Fibroblast growth factor 2 is of prognostic value for patients with locally advanced squamous cell carcinoma of the head and neck
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 190:68-74. 2014
    ..Patients with locally advanced SCCHN have a poor prognosis. This study investigated the prognostic value of the tumor cell expression of the fibroblast growth factor 2 (FGF-2) in patients treated with surgery followed by radiotherapy...
  51. doi request reprint The first survival score for patients with brain metastases from small cell lung cancer (SCLC)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany Electronic address
    Clin Neurol Neurosurg 115:2029-32. 2013
    ..Primary tumors have different biological behavior justifying separate scoring systems for different tumors. In this study, a survival score was developed for patients with brain metastasis from SCLC...
  52. doi request reprint A new survival score for patients with brain metastases from non-small cell lung cancer
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Strahlenther Onkol 189:777-81. 2013
    ..Non-small cell lung cancer (NSCLC) is the most common primary tumor in patients developing brain metastasis. This study was performed to develop and validate a survival score particularly for this group of patients...
  53. ncbi request reprint Survival in patients with metastatic spinal cord compression from prostate cancer is associated with the number of extra-spinal organs involved
    Axel Weber
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 33:4505-7. 2013
    ..To investigate the predictive value of the number of extra-spinal organs involved by metastases for survival in metastatic spinal cord compression (MSCC) from prostate cancer...
  54. doi request reprint A validated survival score for breast cancer patients with metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 189:41-6. 2013
    ..To create a validated scoring system predicting survival of breast cancer patients with metastatic spinal cord compression (MSCC)...
  55. doi request reprint Comparison of different treatment approaches for one to two brain metastases in elderly patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Strahlenther Onkol 184:565-71. 2008
    ..It compares whole-brain radiotherapy (WBRT), stereotactic radiosurgery (SRS), resection plus WBRT (OP + WBRT), and resection plus WBRT plus boost (OP + WBRT + boost) in elderly patients...
  56. doi request reprint Whole brain radiotherapy plus stereotactic radiosurgery (WBRT+SRS) versus surgery plus whole brain radiotherapy (OP+WBRT) for 1-3 brain metastases: results of a matched pair analysis
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Eur J Cancer 45:400-4. 2009
    ..002) and longer interval (p=0.004); WBRT+SRS achieved borderline significance (p=0.052). Improved LC was associated with longer interval (p=0.017); WBRT+SRS showed a trend (p=0.09). WBRT+SRS appears at least as effective as OP+WBRT...
  57. ncbi request reprint Prognostic value of haemoglobin levels during concurrent radio-chemotherapy in the treatment of oesophageal cancer
    D Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Germany
    Clin Oncol (R Coll Radiol) 18:139-44. 2006
    ..To evaluate the prognostic value of haemoglobin levels during radio-chemotherapy for overall survival, metastases-free survival (MFS) and locoregional control in patients with locally advanced oesophageal cancer...
  58. doi request reprint Prognostic factors for survival and intracerebral control after irradiation for brain metastases from gynecological cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Gynecol Oncol 114:506-8. 2009
    ..Most of these patients receive whole-brain radiotherapy (WBRT) alone. Prognostic factors predicting the outcomes of these patients may guide the physician to select the appropriate treatment regimen for the individual patient...
  59. ncbi request reprint [The value of positron emission tomography (PET) in the treatment of patients with cancer of unknown primary (CUP)]
    D Rades
    Abteilung für Strahlentherapie und spezielle Onkologie, Medizinische Hochschule Hannover
    Strahlenther Onkol 177:525-9. 2001
    ..In the study presented here the value of PET for detection of the primary tumor and a possible dissemination has been investigated and related to therapeutic regimens...
  60. ncbi request reprint Do bladder cancer patients with metastatic spinal cord compression benefit from radiotherapy alone?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Urology 69:1081-5. 2007
    ..To investigate the role of radiotherapy (RT) alone in metastatic spinal cord compression (MSCC) patients with bladder cancer...
  61. ncbi request reprint Prognostic factors in the nonsurgical treatment of esophageal carcinoma with radiotherapy or radiochemotherapy: the importance of pretreatment hemoglobin levels
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cancer 103:1740-6. 2005
    ..The current study was performed to evaluate prognostic factors for overall survival (OS), distant metastasis (DM), and local failure (LF) in patients with Stage II/III esophageal carcinoma...
  62. ncbi request reprint Role of radiotherapy in the treatment of motor dysfunction due to metastatic spinal cord compression: comparison of three different fractionation schedules
    Dirk Rades
    Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    Int J Radiat Oncol Biol Phys 54:1160-4. 2002
    ..Several reports have compared different fractionation schedules for pain relief. To our knowledge, this retrospective analysis is the first to compare three different schedules for functional outcome...
  63. ncbi request reprint The first score predicting overall survival in patients with metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 112:157-61. 2008
    ..The current study was performed to create a scoring system to estimate the survival of patients with metastatic spinal cord compression (MSCC)...
  64. ncbi request reprint Outcome after radiotherapy alone for metastatic spinal cord compression in patients with oligometastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    J Clin Oncol 25:50-6. 2007
    ..To investigate outcome and prognosis of metastatic spinal cord compression (MSCC) patients with oligometastatic disease treated with radiotherapy alone...
  65. ncbi request reprint Locally advanced stage IV squamous cell carcinoma of the head and neck: impact of pre-radiotherapy hemoglobin level and interruptions during radiotherapy
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 70:1108-14. 2008
    ....
  66. doi request reprint Validation and simplification of a score predicting survival in patients irradiated for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Cancer 116:3670-3. 2010
    ..Based on an analysis of 1852 retrospectively evaluated patients with metastatic spinal cord compression (MSCC), a scoring system was developed to predict survival. This study was performed to validate the scoring system in a new data set...
  67. doi request reprint Validation of a score predicting post-treatment ambulatory status after radiotherapy for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 79:1503-6. 2011
    ..A score predicting post-radiotherapy (RT) ambulatory status was developed based on 2,096 retrospectively evaluated metastatic spinal cord compression (MSCC) patients. This study aimed to validate the score in a prospective series...
  68. ncbi request reprint Whole-brain radiotherapy versus stereotactic radiosurgery for patients in recursive partitioning analysis classes 1 and 2 with 1 to 3 brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Germany
    Cancer 110:2285-92. 2007
    ..The authors investigated whether stereotactic radiosurgery (SRS) alone improved outcomes for patients in recursive partitioning analysis (RPA) Classes 1 and 2 who had 1 to 3 brain metastases compared with whole-brain radiotherapy (WBRT)...
  69. ncbi request reprint Effectiveness and toxicity of single-fraction radiotherapy with 1 x 8 Gy for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, D 20246 Hamburg, Germany
    Radiother Oncol 75:70-3. 2005
    ..Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory...
  70. pmc Prognostic factors for different outcomes in patients with metastatic spinal cord compression from cancer of unknown primary
    Sarah Douglas
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    BMC Cancer 12:261. 2012
    ..This retrospective study was performed to identify prognostic factors for functional outcome, local control of MSCC, and survival in 175 of such patients treated with radiotherapy alone...
  71. doi request reprint A new survival score for patients with brain metastases who received whole-brain radiotherapy (WBRT) alone
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Radiother Oncol 108:123-7. 2013
    ..Survival scores for patients with brain metastasis exist. However, the treatment regimens used to create these scores were heterogeneous. This study aimed to develop and validate a survival score in homogeneously treated patients...
  72. doi request reprint A validated scoring system to identify long-term survivors after radiotherapy for metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Strahlenther Onkol 189:462-6. 2013
    ..This study aimed to develop and validate a scoring system to identify long-term survivors after conventional radiotherapy (RT) for metastatic spinal cord compression (MSCC)...
  73. doi request reprint A score to identify patients with metastatic spinal cord compression who may be candidates for best supportive care
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, D 23538 Lubeck, Germany
    Cancer 119:897-903. 2013
    ..The objective of the current study was to develop a scoring system that identifies those patients with metastatic spinal cord compression who may be candidates for best supportive care or single-fraction radiotherapy...
  74. doi request reprint Prognostic factors and a survival score for patients with metastatic spinal cord compression from colorectal cancer
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:1114-8. 2012
    ..This study aimed to identify independent prognostic factors and to create a survival score for patients with metastatic spinal cord compression (MSCC) from colorectal cancer (CRC)...
  75. pmc A new score predicting the survival of patients with spinal cord compression from myeloma
    Sarah Douglas
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    BMC Cancer 12:425. 2012
    ..This study was performed to create and validate a scoring system for the survival of patients with malignant spinal cord compression (SCC) from myeloma...
  76. pmc A validated survival score for patients with metastatic spinal cord compression from non-small cell lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    BMC Cancer 12:302. 2012
    ..This multicenter study aimed to create and validate a scoring system for survival of patients with metastatic spinal cord compression (MSCC) from non-small cell lung cancer (NSCLC)...
  77. doi request reprint Dose-escalation of whole-brain radiotherapy for brain metastasis in patients with a favorable survival prognosis
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Cancer 118:3852-9. 2012
    ..The most common WBRT schedule is 30 grays (Gy) in 10 fractions. In this retrospective study, the authors investigated whether these patients benefit from a dose escalation beyond 30 Gy...
  78. doi request reprint Metastatic spinal cord compression in non-small cell lung cancer patients. Prognostic factors in a series of 356 patients
    D Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Strahlenther Onkol 188:472-6. 2012
    ..This study was performed to identify prognostic factors for functional outcome and survival in these patients after radiotherapy (RT) alone...
  79. doi request reprint Do elderly patients benefit from surgery in addition to radiotherapy for treatment of metastatic spinal cord compression?
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:424-30. 2012
    ....
  80. doi request reprint Single brain metastasis: radiosurgery alone compared with radiosurgery plus up-front whole-brain radiotherapy
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Cancer 118:2980-5. 2012
    ..It was demonstrated that whole-brain radiotherapy (WBRT) in addition to RS improves local control of 1-3 brain metastases. Little information is available regarding WBRT in addition to RS for a single lesion...
  81. doi request reprint Single brain metastasis: resection followed by whole-brain irradiation and a boost to the metastatic site compared to whole-brain irradiation plus radiosurgery
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Clin Neurol Neurosurg 114:326-30. 2012
    ..This matched-pair analysis compared whole-brain irradiation plus radiosurgery (WBI+RS) to neurosurgical resection followed by whole-brain irradiation and a boost to the metastatic site (NR+WBI+B)...
  82. doi request reprint Prognostic factors in a series of 504 breast cancer patients with metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:340-5. 2012
    ..This study was performed to identify new significant prognostic factors in breast cancer patients irradiated for metastatic spinal cord compression (MSCC)...
  83. doi request reprint Cisplatin superior to carboplatin in adjuvant radiochemotherapy for locally advanced cancers of the oropharynx and oral cavity
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:42-8. 2012
    ..This retrospective study compared radiochemotherapy with either cisplatin or carboplatin in patients with locally advanced SCC of the oropharynx and oral cavity...
  84. doi request reprint Single brain metastasis: whole-brain irradiation plus either radiosurgery or neurosurgical resection
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Cancer 118:1138-44. 2012
    ..The current study was conducted to compare neurosurgical resection (NR) followed by whole-brain irradiation (WBI) (NR + WBI) with WBI followed by radiosurgery (WBI + RS) in patients with a single brain metastasis...
  85. doi request reprint Dose escalation of radiotherapy for metastatic spinal cord compression (MSCC) in patients with relatively favorable survival prognosis
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Strahlenther Onkol 187:729-35. 2011
    ..The most frequently used schedule world wide is 30 Gy/10 fractions. This study investigated whether patients with favorable survival prognoses benefit from a dose escalation beyond 30 Gy...
  86. pmc Prognostic factors for outcomes after whole-brain irradiation of brain metastases from relatively radioresistant tumors: a retrospective analysis
    Thekla Meyners
    Department of Radiation Oncology, University of Lubeck, Germany
    BMC Cancer 10:582. 2010
    ..Additionally, a potential benefit from escalating the radiation dose was investigated...
  87. doi request reprint Matched pair analysis comparing surgery followed by radiotherapy and radiotherapy alone for metastatic spinal cord compression
    Dirk Rades
    University of Lubeck, Lubeck, Germany
    J Clin Oncol 28:3597-604. 2010
    ..That study was limited to highly selected patients. Additional studies comparing surgery plus radiotherapy to radiotherapy could better clarify the role of surgery...
  88. ncbi request reprint Therapy of meningeal melanocytomas
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cancer 100:2442-7. 2004
    ..In the current study, four therapies were compared with regard to local control and survival to identify which is best...
  89. doi request reprint Dose escalation for metastatic spinal cord compression in patients with relatively radioresistant tumors
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Int J Radiat Oncol Biol Phys 80:1492-7. 2011
    ..However, the results of the "standard" regimen 30 Gy/10 fractions need to be improved with respect to functional outcome. This study investigated whether a dose escalation beyond 30 Gy can improve treatment outcomes...
  90. doi request reprint Comparison of four cisplatin-based radiochemotherapy regimens for nonmetastatic stage III/IV squamous cell carcinoma of the head and neck
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 80:1037-44. 2011
    ..To compare the outcomes of four cisplatin-based radiochemotherapy regimens in 311 patients with Stage III/IV squamous cell carcinoma of the head and neck...
  91. doi request reprint Radiolabeled cetuximab plus whole-brain irradiation (WBI) for the treatment of brain metastases from non-small cell lung cancer (NSCLC)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Strahlenther Onkol 186:458-62. 2010
    ..Radiolabeling of cetuximab was performed to investigate whether this antibody crosses the BBB...
  92. doi request reprint The role of radiotherapy for metastatic epidural spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nat Rev Clin Oncol 7:590-8. 2010
    ..Larger prospective trials are required to better define the appropriate treatment for the individual patient...
  93. doi request reprint Fibroblast growth factor 2--a predictor of outcome for patients irradiated for stage II-III non-small-cell lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 82:442-7. 2012
    ..The present study investigated the effect of tumor cell expression of FGF-2 on the outcome of 60 patients irradiated for Stage II-III NSCLC...
  94. doi request reprint Shorter-course whole-brain radiotherapy for brain metastases in elderly patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 81:e469-73. 2011
    ..Regarding the extraordinarily poor survival prognosis of elderly patients with multiple brain metastases, a shorter WBRT regimen would be preferable. This study compared 10 × 3 Gy with 5 × 4 Gy in elderly patients (≥65 years)...
  95. doi request reprint The prognostic impact of tumor cell expression of estrogen receptor-α, progesterone receptor, and androgen receptor in patients irradiated for nonsmall cell lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Cancer 118:157-63. 2012
    ....
  96. doi request reprint Comparison of radiochemotherapy alone to surgery plus radio(chemo)therapy for non-metastatic stage III/IV squamous cell carcinoma of the head and neck: A matched-pair analysis
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Strahlenther Onkol 187:541-7. 2011
    ..This study compared the outcomes of radiochemotherapy alone to surgery followed by radio(chemo)therapy (radiotherapy plus/minus concurrent chemotherapy)...
  97. doi request reprint Prognostic factors (including HPV status) for irradiation of locally advanced squamous cell carcinoma of the head and neck (SCCHN)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Strahlenther Onkol 187:626-32. 2011
    ..This study investigated potential prognostic factors, including HPV status, for locoregional control (LRC), metastases-free survival (MFS), and survival (OS)...
  98. doi request reprint Do patients receiving whole-brain radiotherapy for brain metastases from renal cell carcinoma benefit from escalation of the radiation dose?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 78:398-403. 2010
    ..The standard WBRT regimen, 30 Gy/10 fractions (10 × 3 Gy), has resulted in poor survival (OS). This study investigates whether escalation of the WBRT dose improves treatment outcomes...
  99. ncbi request reprint Treatment recommendations for the various subgroups of neurocytomas
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Neurooncol 77:305-9. 2006
    ..In children, <or=50 Gy and >50 Gy were comparable.CTR does not require post-operative RT. Following ITR, RT improves outcome. Of 50-54 Gy appear sufficient for typical lesions, 50 Gy for children. Atypical lesions require 56-60 Gy...
  100. ncbi request reprint [Effectiveness and toxicity of reirradiation (Re-RT) for metastatic spinal cord compression (MSCC)]
    Dirk Rades
    Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Universitatsklinikum, Hamburg Eppendorf
    Strahlenther Onkol 181:595-600. 2005
    ..Many radiation oncologists are concerned about spinal Re-RT, because it may result in a high cumulative EQD2. This study investigates effectiveness and feasibility of Re-RT for in-field recurrence of MSCC...
  101. ncbi request reprint Prognostic factors predicting functional outcomes, recurrence-free survival, and overall survival after radiotherapy for metastatic spinal cord compression in breast cancer patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 64:182-8. 2006
    ..To identify significant prognostic factors after irradiation of metastatic spinal cord compression (MSCC) in 335 breast cancer patients...