D Rades

Summary

Publications

  1. ncbi request reprint A new score predicting survival prognosis after whole-brain radiotherapy alone for brain metastases in elderly patients
    Jasmin N Evers
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 34:2455-8. 2014
  2. ncbi request reprint Fibroblast growth factor 2 is of prognostic value for patients with locally advanced squamous cell carcinoma of the head and neck
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 190:68-74. 2014
  3. doi request reprint A new survival score for patients with brain metastases from non-small cell lung cancer
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Strahlenther Onkol 189:777-81. 2013
  4. ncbi request reprint Survival in patients with metastatic spinal cord compression from prostate cancer is associated with the number of extra-spinal organs involved
    Axel Weber
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 33:4505-7. 2013
  5. doi request reprint The first survival score for patients with brain metastases from small cell lung cancer (SCLC)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany Electronic address
    Clin Neurol Neurosurg 115:2029-32. 2013
  6. doi request reprint A validated survival score for breast cancer patients with metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 189:41-6. 2013
  7. ncbi request reprint Prognostic factors for survival and intracerebral control after irradiation for brain metastases from gynecological cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Gynecol Oncol 114:506-8. 2009
  8. ncbi request reprint Prognostic value of haemoglobin levels during concurrent radio-chemotherapy in the treatment of oesophageal cancer
    D Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Germany
    Clin Oncol (R Coll Radiol) 18:139-44. 2006
  9. ncbi request reprint Do bladder cancer patients with metastatic spinal cord compression benefit from radiotherapy alone?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Urology 69:1081-5. 2007
  10. doi request reprint Whole brain radiotherapy plus stereotactic radiosurgery (WBRT+SRS) versus surgery plus whole brain radiotherapy (OP+WBRT) for 1-3 brain metastases: results of a matched pair analysis
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Eur J Cancer 45:400-4. 2009

Detail Information

Publications134 found, 100 shown here

  1. ncbi request reprint A new score predicting survival prognosis after whole-brain radiotherapy alone for brain metastases in elderly patients
    Jasmin N Evers
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 34:2455-8. 2014
    ..Elderly patients represent an important subgroup of patients with brain metastases. A survival score has been developed specifically for these patients...
  2. ncbi request reprint Fibroblast growth factor 2 is of prognostic value for patients with locally advanced squamous cell carcinoma of the head and neck
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 190:68-74. 2014
    ..Patients with locally advanced SCCHN have a poor prognosis. This study investigated the prognostic value of the tumor cell expression of the fibroblast growth factor 2 (FGF-2) in patients treated with surgery followed by radiotherapy...
  3. doi request reprint A new survival score for patients with brain metastases from non-small cell lung cancer
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Strahlenther Onkol 189:777-81. 2013
    ..Non-small cell lung cancer (NSCLC) is the most common primary tumor in patients developing brain metastasis. This study was performed to develop and validate a survival score particularly for this group of patients...
  4. ncbi request reprint Survival in patients with metastatic spinal cord compression from prostate cancer is associated with the number of extra-spinal organs involved
    Axel Weber
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 33:4505-7. 2013
    ..To investigate the predictive value of the number of extra-spinal organs involved by metastases for survival in metastatic spinal cord compression (MSCC) from prostate cancer...
  5. doi request reprint The first survival score for patients with brain metastases from small cell lung cancer (SCLC)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany Electronic address
    Clin Neurol Neurosurg 115:2029-32. 2013
    ..Primary tumors have different biological behavior justifying separate scoring systems for different tumors. In this study, a survival score was developed for patients with brain metastasis from SCLC...
  6. doi request reprint A validated survival score for breast cancer patients with metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 189:41-6. 2013
    ..To create a validated scoring system predicting survival of breast cancer patients with metastatic spinal cord compression (MSCC)...
  7. ncbi request reprint Prognostic factors for survival and intracerebral control after irradiation for brain metastases from gynecological cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Gynecol Oncol 114:506-8. 2009
    ..Most of these patients receive whole-brain radiotherapy (WBRT) alone. Prognostic factors predicting the outcomes of these patients may guide the physician to select the appropriate treatment regimen for the individual patient...
  8. ncbi request reprint Prognostic value of haemoglobin levels during concurrent radio-chemotherapy in the treatment of oesophageal cancer
    D Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Germany
    Clin Oncol (R Coll Radiol) 18:139-44. 2006
    ..To evaluate the prognostic value of haemoglobin levels during radio-chemotherapy for overall survival, metastases-free survival (MFS) and locoregional control in patients with locally advanced oesophageal cancer...
  9. ncbi request reprint Do bladder cancer patients with metastatic spinal cord compression benefit from radiotherapy alone?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Urology 69:1081-5. 2007
    ..To investigate the role of radiotherapy (RT) alone in metastatic spinal cord compression (MSCC) patients with bladder cancer...
  10. doi request reprint Whole brain radiotherapy plus stereotactic radiosurgery (WBRT+SRS) versus surgery plus whole brain radiotherapy (OP+WBRT) for 1-3 brain metastases: results of a matched pair analysis
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Eur J Cancer 45:400-4. 2009
    ..002) and longer interval (p=0.004); WBRT+SRS achieved borderline significance (p=0.052). Improved LC was associated with longer interval (p=0.017); WBRT+SRS showed a trend (p=0.09). WBRT+SRS appears at least as effective as OP+WBRT...
  11. doi request reprint Comparison of different treatment approaches for one to two brain metastases in elderly patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Strahlenther Onkol 184:565-71. 2008
    ..It compares whole-brain radiotherapy (WBRT), stereotactic radiosurgery (SRS), resection plus WBRT (OP + WBRT), and resection plus WBRT plus boost (OP + WBRT + boost) in elderly patients...
  12. ncbi request reprint [The value of positron emission tomography (PET) in the treatment of patients with cancer of unknown primary (CUP)]
    D Rades
    Abteilung für Strahlentherapie und spezielle Onkologie, Medizinische Hochschule Hannover
    Strahlenther Onkol 177:525-9. 2001
    ..In the study presented here the value of PET for detection of the primary tumor and a possible dissemination has been investigated and related to therapeutic regimens...
  13. ncbi request reprint Outcome after radiotherapy alone for metastatic spinal cord compression in patients with oligometastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    J Clin Oncol 25:50-6. 2007
    ..To investigate outcome and prognosis of metastatic spinal cord compression (MSCC) patients with oligometastatic disease treated with radiotherapy alone...
  14. ncbi request reprint Validation and simplification of a score predicting survival in patients irradiated for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Cancer 116:3670-3. 2010
    ..Based on an analysis of 1852 retrospectively evaluated patients with metastatic spinal cord compression (MSCC), a scoring system was developed to predict survival. This study was performed to validate the scoring system in a new data set...
  15. ncbi request reprint The first score predicting overall survival in patients with metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 112:157-61. 2008
    ..The current study was performed to create a scoring system to estimate the survival of patients with metastatic spinal cord compression (MSCC)...
  16. ncbi request reprint Whole-brain radiotherapy versus stereotactic radiosurgery for patients in recursive partitioning analysis classes 1 and 2 with 1 to 3 brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Germany
    Cancer 110:2285-92. 2007
    ..The authors investigated whether stereotactic radiosurgery (SRS) alone improved outcomes for patients in recursive partitioning analysis (RPA) Classes 1 and 2 who had 1 to 3 brain metastases compared with whole-brain radiotherapy (WBRT)...
  17. ncbi request reprint Prognostic factors in the nonsurgical treatment of esophageal carcinoma with radiotherapy or radiochemotherapy: the importance of pretreatment hemoglobin levels
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cancer 103:1740-6. 2005
    ..The current study was performed to evaluate prognostic factors for overall survival (OS), distant metastasis (DM), and local failure (LF) in patients with Stage II/III esophageal carcinoma...
  18. ncbi request reprint Locally advanced stage IV squamous cell carcinoma of the head and neck: impact of pre-radiotherapy hemoglobin level and interruptions during radiotherapy
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 70:1108-14. 2008
    ....
  19. doi request reprint Validation of a score predicting post-treatment ambulatory status after radiotherapy for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 79:1503-6. 2011
    ..A score predicting post-radiotherapy (RT) ambulatory status was developed based on 2,096 retrospectively evaluated metastatic spinal cord compression (MSCC) patients. This study aimed to validate the score in a prospective series...
  20. ncbi request reprint Effectiveness and toxicity of single-fraction radiotherapy with 1 x 8 Gy for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, D 20246 Hamburg, Germany
    Radiother Oncol 75:70-3. 2005
    ..Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory...
  21. ncbi request reprint Role of radiotherapy in the treatment of motor dysfunction due to metastatic spinal cord compression: comparison of three different fractionation schedules
    Dirk Rades
    Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    Int J Radiat Oncol Biol Phys 54:1160-4. 2002
    ..Several reports have compared different fractionation schedules for pain relief. To our knowledge, this retrospective analysis is the first to compare three different schedules for functional outcome...
  22. pmc Prognostic factors for different outcomes in patients with metastatic spinal cord compression from cancer of unknown primary
    Sarah Douglas
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    BMC Cancer 12:261. 2012
    ..This retrospective study was performed to identify prognostic factors for functional outcome, local control of MSCC, and survival in 175 of such patients treated with radiotherapy alone...
  23. doi request reprint A new survival score for patients with brain metastases who received whole-brain radiotherapy (WBRT) alone
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Radiother Oncol 108:123-7. 2013
    ..Survival scores for patients with brain metastasis exist. However, the treatment regimens used to create these scores were heterogeneous. This study aimed to develop and validate a survival score in homogeneously treated patients...
  24. doi request reprint A validated scoring system to identify long-term survivors after radiotherapy for metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Strahlenther Onkol 189:462-6. 2013
    ..This study aimed to develop and validate a scoring system to identify long-term survivors after conventional radiotherapy (RT) for metastatic spinal cord compression (MSCC)...
  25. doi request reprint Prognostic factors and a survival score for patients with metastatic spinal cord compression from colorectal cancer
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:1114-8. 2012
    ..This study aimed to identify independent prognostic factors and to create a survival score for patients with metastatic spinal cord compression (MSCC) from colorectal cancer (CRC)...
  26. doi request reprint A score to identify patients with metastatic spinal cord compression who may be candidates for best supportive care
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, D 23538 Lubeck, Germany
    Cancer 119:897-903. 2013
    ..The objective of the current study was to develop a scoring system that identifies those patients with metastatic spinal cord compression who may be candidates for best supportive care or single-fraction radiotherapy...
  27. pmc A new score predicting the survival of patients with spinal cord compression from myeloma
    Sarah Douglas
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    BMC Cancer 12:425. 2012
    ..This study was performed to create and validate a scoring system for the survival of patients with malignant spinal cord compression (SCC) from myeloma...
  28. pmc A validated survival score for patients with metastatic spinal cord compression from non-small cell lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    BMC Cancer 12:302. 2012
    ..This multicenter study aimed to create and validate a scoring system for survival of patients with metastatic spinal cord compression (MSCC) from non-small cell lung cancer (NSCLC)...
  29. doi request reprint Dose-escalation of whole-brain radiotherapy for brain metastasis in patients with a favorable survival prognosis
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Cancer 118:3852-9. 2012
    ..The most common WBRT schedule is 30 grays (Gy) in 10 fractions. In this retrospective study, the authors investigated whether these patients benefit from a dose escalation beyond 30 Gy...
  30. doi request reprint Metastatic spinal cord compression in non-small cell lung cancer patients. Prognostic factors in a series of 356 patients
    D Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Strahlenther Onkol 188:472-6. 2012
    ..This study was performed to identify prognostic factors for functional outcome and survival in these patients after radiotherapy (RT) alone...
  31. doi request reprint Do elderly patients benefit from surgery in addition to radiotherapy for treatment of metastatic spinal cord compression?
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:424-30. 2012
    ....
  32. doi request reprint Single brain metastasis: radiosurgery alone compared with radiosurgery plus up-front whole-brain radiotherapy
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Cancer 118:2980-5. 2012
    ..It was demonstrated that whole-brain radiotherapy (WBRT) in addition to RS improves local control of 1-3 brain metastases. Little information is available regarding WBRT in addition to RS for a single lesion...
  33. doi request reprint Single brain metastasis: resection followed by whole-brain irradiation and a boost to the metastatic site compared to whole-brain irradiation plus radiosurgery
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Clin Neurol Neurosurg 114:326-30. 2012
    ..This matched-pair analysis compared whole-brain irradiation plus radiosurgery (WBI+RS) to neurosurgical resection followed by whole-brain irradiation and a boost to the metastatic site (NR+WBI+B)...
  34. doi request reprint Prognostic factors in a series of 504 breast cancer patients with metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:340-5. 2012
    ..This study was performed to identify new significant prognostic factors in breast cancer patients irradiated for metastatic spinal cord compression (MSCC)...
  35. doi request reprint Cisplatin superior to carboplatin in adjuvant radiochemotherapy for locally advanced cancers of the oropharynx and oral cavity
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:42-8. 2012
    ..This retrospective study compared radiochemotherapy with either cisplatin or carboplatin in patients with locally advanced SCC of the oropharynx and oral cavity...
  36. doi request reprint Single brain metastasis: whole-brain irradiation plus either radiosurgery or neurosurgical resection
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Cancer 118:1138-44. 2012
    ..The current study was conducted to compare neurosurgical resection (NR) followed by whole-brain irradiation (WBI) (NR + WBI) with WBI followed by radiosurgery (WBI + RS) in patients with a single brain metastasis...
  37. doi request reprint Dose escalation of radiotherapy for metastatic spinal cord compression (MSCC) in patients with relatively favorable survival prognosis
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Strahlenther Onkol 187:729-35. 2011
    ..The most frequently used schedule world wide is 30 Gy/10 fractions. This study investigated whether patients with favorable survival prognoses benefit from a dose escalation beyond 30 Gy...
  38. pmc Prognostic factors for outcomes after whole-brain irradiation of brain metastases from relatively radioresistant tumors: a retrospective analysis
    Thekla Meyners
    Department of Radiation Oncology, University of Lubeck, Germany
    BMC Cancer 10:582. 2010
    ..Additionally, a potential benefit from escalating the radiation dose was investigated...
  39. ncbi request reprint Effect of smoking during radiotherapy, respiratory insufficiency, and hemoglobin levels on outcome in patients irradiated for non-small-cell lung cancer
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 71:1134-42. 2008
    ....
  40. ncbi request reprint Prognostic factors affecting locally recurrent rectal cancer and clinical significance of hemoglobin
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 70:1087-93. 2008
    ..To investigate potential prognostic factors, including hemoglobin levels before and during radiotherapy, for associations with survival and local control in patients with unirradiated locally recurrent rectal cancer...
  41. ncbi request reprint Evaluation of 2 whole-brain radiotherapy schedules and prognostic factors for brain metastases in breast cancer patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 110:2587-92. 2007
    ..This retrospective study compared survival and local control within the brain resulting from short-course WBRT with longer programs in 207 breast cancer patients...
  42. doi request reprint A new scoring system to predicting the survival of patients treated with whole-brain radiotherapy for brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Strahlenther Onkol 184:251-5. 2008
    ..To create a scoring system to estimate survival of patients who received whole-brain radiotherapy (WBRT) for brain metastases...
  43. doi request reprint Comparison of radiochemotherapy alone to surgery plus radio(chemo)therapy for non-metastatic stage III/IV squamous cell carcinoma of the head and neck: A matched-pair analysis
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Strahlenther Onkol 187:541-7. 2011
    ..This study compared the outcomes of radiochemotherapy alone to surgery followed by radio(chemo)therapy (radiotherapy plus/minus concurrent chemotherapy)...
  44. ncbi request reprint Matched pair analysis comparing surgery followed by radiotherapy and radiotherapy alone for metastatic spinal cord compression
    Dirk Rades
    University of Lubeck, Lubeck, Germany
    J Clin Oncol 28:3597-604. 2010
    ..That study was limited to highly selected patients. Additional studies comparing surgery plus radiotherapy to radiotherapy could better clarify the role of surgery...
  45. doi request reprint Prognostic impact of erythropoietin expression and erythropoietin receptor expression on locoregional control and survival of patients irradiated for stage II/III non-small-cell lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Int J Radiat Oncol Biol Phys 80:499-505. 2011
    ..This study investigates the prognostic value of erythropoietin (EPO) and EPO receptor (EPO-R) expression of tumor cells for locoregional control and survival in non-small-cell lung cancer (NSCLC) patients...
  46. doi request reprint Prognostic factors (including HPV status) for irradiation of locally advanced squamous cell carcinoma of the head and neck (SCCHN)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Strahlenther Onkol 187:626-32. 2011
    ..This study investigated potential prognostic factors, including HPV status, for locoregional control (LRC), metastases-free survival (MFS), and survival (OS)...
  47. ncbi request reprint The impact of tumor expression of erythropoietin receptors and erythropoietin on clinical outcome of esophageal cancer patients treated with chemoradiation
    Dirk Rades
    Department of Radiation Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 71:152-9. 2008
    ..To investigate the impact of tumor erythropoietin receptors (Epo-R) and erythropoietin (Epo) expression in 64 patients with Stage III esophageal cancer receiving or not receiving erythropoietin during chemoradiation...
  48. doi request reprint Surgical resection followed by whole brain radiotherapy versus whole brain radiotherapy alone for single brain metastasis
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 70:1319-24. 2008
    ..To compare the outcome of surgical resection followed by whole brain radiotherapy (WBRT) with WBRT alone in patients treated for single brain metastasis...
  49. ncbi request reprint Prognostic factors for functional outcome and survival after reirradiation for in-field recurrences of metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 113:1090-6. 2008
    ..The purpose of the current study was to retrospectively investigate clinical outcome and potential prognostic factors after reirradiation (Re-RT) for in-field recurrence of metastatic spinal cord compression (MSCC)...
  50. ncbi request reprint A matched-pair analysis comparing whole-brain radiotherapy plus stereotactic radiosurgery versus surgery plus whole-brain radiotherapy and a boost to the metastatic site for one or two brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 73:1077-81. 2009
    ....
  51. doi request reprint Radiolabeled cetuximab plus whole-brain irradiation (WBI) for the treatment of brain metastases from non-small cell lung cancer (NSCLC)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Strahlenther Onkol 186:458-62. 2010
    ..Radiolabeling of cetuximab was performed to investigate whether this antibody crosses the BBB...
  52. doi request reprint Dose escalation for metastatic spinal cord compression in patients with relatively radioresistant tumors
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Int J Radiat Oncol Biol Phys 80:1492-7. 2011
    ..However, the results of the "standard" regimen 30 Gy/10 fractions need to be improved with respect to functional outcome. This study investigated whether a dose escalation beyond 30 Gy can improve treatment outcomes...
  53. doi request reprint The role of radiotherapy for metastatic epidural spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nat Rev Clin Oncol 7:590-8. 2010
    ..Larger prospective trials are required to better define the appropriate treatment for the individual patient...
  54. doi request reprint Do patients receiving whole-brain radiotherapy for brain metastases from renal cell carcinoma benefit from escalation of the radiation dose?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 78:398-403. 2010
    ..The standard WBRT regimen, 30 Gy/10 fractions (10 × 3 Gy), has resulted in poor survival (OS). This study investigates whether escalation of the WBRT dose improves treatment outcomes...
  55. doi request reprint Fibroblast growth factor 2--a predictor of outcome for patients irradiated for stage II-III non-small-cell lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 82:442-7. 2012
    ..The present study investigated the effect of tumor cell expression of FGF-2 on the outcome of 60 patients irradiated for Stage II-III NSCLC...
  56. doi request reprint Final results of a prospective study comparing the local control of short-course and long-course radiotherapy for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Int J Radiat Oncol Biol Phys 79:524-30. 2011
    ..This is the first prospective study that has compared local control of different radiotherapy schedules for MSCC...
  57. ncbi request reprint Prognostic impact of VEGF and VEGF receptor 1 (FLT1) expression in patients irradiated for stage II/III non-small cell lung cancer (NSCLC)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Strahlenther Onkol 186:307-14. 2010
    ..This study investigated the impact of tumor expression of VEGF and FLT1 on outcomes in 61 patients irradiated for stage II/III non-small cell lung cancer (NSCLC)...
  58. ncbi request reprint Acute toxicity of three versus two courses of cisplatin for radiochemotherapy of locally advanced squamous cell carcinoma of the head and neck (SCCHN): a matched pair analysis
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Oral Oncol 46:549-52. 2010
    ..001). At least one grade >or= 3 toxicity occurred in 90% of group A and 20% of group B patients, respectively (p=0.005). Two courses of fractionated cisplatin appeared much better tolerated than three courses of fractionated cisplatin...
  59. doi request reprint Treatment of painful bone metastases
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nat Rev Clin Oncol 7:220-9. 2010
    ..Thus, long-course multi-fraction radiotherapy should be reserved for patients with a relatively favorable survival prognosis...
  60. doi request reprint The role of postoperative radiotherapy for the treatment of gangliogliomas
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Cancer 116:432-42. 2010
    ..The optimal treatment regimen is unclear. In this study, the authors compared 4 therapies for local control (LC) and overall survival (OS) in patients with ganglioglioma...
  61. doi request reprint Shorter-course whole-brain radiotherapy for brain metastases in elderly patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 81:e469-73. 2011
    ..Regarding the extraordinarily poor survival prognosis of elderly patients with multiple brain metastases, a shorter WBRT regimen would be preferable. This study compared 10 × 3 Gy with 5 × 4 Gy in elderly patients (≥65 years)...
  62. doi request reprint Comparison of stereotactic radiosurgery (SRS) alone and whole brain radiotherapy (WBRT) plus a stereotactic boost (WBRT+SRS) for one to three brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Germany
    Strahlenther Onkol 184:655-62. 2008
    ..The best available treatment of patients with one to three brain metastases is still unclear. This study compared the results of stereotactic radiosurgery (SRS) alone and whole brain radiotherapy (WBRT) plus SRS (WBRT+SRS)...
  63. doi request reprint The prognostic impact of tumor cell expression of estrogen receptor-α, progesterone receptor, and androgen receptor in patients irradiated for nonsmall cell lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Cancer 118:157-63. 2012
    ....
  64. ncbi request reprint Defining the optimal dose of radiation after incomplete resection of central neurocytomas
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Germany
    Int J Radiat Oncol Biol Phys 55:373-7. 2003
    ..Central neurocytomas are uncommon benign central nervous system tumors. There is uncertainty regarding the most appropriate radiation dose after incomplete resection. This analysis was performed to determine the optimal dose...
  65. doi request reprint Comparison of four cisplatin-based radiochemotherapy regimens for nonmetastatic stage III/IV squamous cell carcinoma of the head and neck
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 80:1037-44. 2011
    ..To compare the outcomes of four cisplatin-based radiochemotherapy regimens in 311 patients with Stage III/IV squamous cell carcinoma of the head and neck...
  66. pmc Well-differentiated neurocytoma: what is the best available treatment?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Neuro Oncol 7:77-83. 2005
    ..A radiation dose of 54 Gy appeared sufficient. Application of postoperative radiotherapy should be decided individually, taking into account the risk of local failure, the need for another craniotomy, and potential radiation toxicity...
  67. ncbi request reprint Epoetin-alpha during radiotherapy for stage III esophageal carcinoma
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cancer 103:2274-9. 2005
    ....
  68. ncbi request reprint Spinal reirradiation after short-course RT for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 63:872-5. 2005
    ..To investigate the feasibility and effectiveness of reirradiation (re-RT) for in-field recurrence of metastatic spinal cord compression after primary RT with 1 x 8 Gy or 5 x 4 Gy...
  69. ncbi request reprint [Effectiveness and toxicity of reirradiation (Re-RT) for metastatic spinal cord compression (MSCC)]
    Dirk Rades
    Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Universitatsklinikum, Hamburg Eppendorf
    Strahlenther Onkol 181:595-600. 2005
    ..Many radiation oncologists are concerned about spinal Re-RT, because it may result in a high cumulative EQD2. This study investigates effectiveness and feasibility of Re-RT for in-field recurrence of MSCC...
  70. ncbi request reprint Prognostic factors predicting functional outcomes, recurrence-free survival, and overall survival after radiotherapy for metastatic spinal cord compression in breast cancer patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 64:182-8. 2006
    ..To identify significant prognostic factors after irradiation of metastatic spinal cord compression (MSCC) in 335 breast cancer patients...
  71. ncbi request reprint Comparison of 1 x 8 Gy and 10 x 3 Gy for functional outcome in patients with metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 62:514-8. 2005
    ..This study investigates a reduction of the overall treatment time to only one day by comparing 1 x 8 Gy to the multi-fractionated 10 x 3 Gy for functional outcome...
  72. ncbi request reprint Dose-response relationship for fractionated irradiation in the treatment of spinal meningeal melanocytomas: a review of the literature
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Neurooncol 77:311-4. 2006
    ..The recurrence rates after CTR would mandate the use of post-operative radiotherapy in all spinal meningeal melanocytoma cases. Our results should be confirmed in a larger series of patients when available...
  73. ncbi request reprint Evaluation of functional outcome and local control after radiotherapy for metastatic spinal cord compression in patients with prostate cancer
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Urol 175:552-6. 2006
    ..This study investigates prognostic factors and radiation schedules for functional outcome and local control of MSCC after radiotherapy in patients with prostate cancer...
  74. ncbi request reprint Defining the best available treatment for neurocytomas in children
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cancer 101:2629-32. 2004
    ..Since this entity was introduced in 1982, approximately 60 cases have been reported among patients age </= =18 years of age. The current analysis was performed to define the best available neurocytoma therapy in children...
  75. ncbi request reprint A prospective evaluation of two radiotherapy schedules with 10 versus 20 fractions for the treatment of metastatic spinal cord compression: final results of a multicenter study
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg, Hamburg, Germany
    Cancer 101:2687-92. 2004
    ..The current observational multicenter study, performed prospectively by the authors, evaluated two radiotherapy (RT) schedules and prognostic factors with respect to functional outcome..
  76. ncbi request reprint Therapy of meningeal melanocytomas
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cancer 100:2442-7. 2004
    ..In the current study, four therapies were compared with regard to local control and survival to identify which is best...
  77. ncbi request reprint Final results of a prospective study of the prognostic value of the time to develop motor deficits before irradiation in metastatic spinal cord compression
    Dirk Rades
    Department ofRadiation Oncology, Hannover Medical University, Hannover, Germany
    Int J Radiat Oncol Biol Phys 53:975-9. 2002
    ..Because only the type of primary tumor and pretreatment ambulatory status are known as prognostic factors for functional outcome, we investigated the prognostic value of the time of motor deficit development before radiotherapy (RT)...
  78. ncbi request reprint A comparison of two different radiation schedules for metastatic spinal cord compression considering a new prognostic factor
    Dirk Rades
    Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    Strahlenther Onkol 178:556-61. 2002
    ..This analysis compares the effect of two schedules on motor function considering three relevant prognostic factors (type of primary tumor, pre-treatment ambulatory status, time of developing motor deficits before radiotherapy)...
  79. ncbi request reprint Treatment options for central neurocytoma
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Neurology 59:1268-70. 2002
    ..The data suggest that complete resection leads to significantly better local control and survival than incomplete resection. After incomplete resection, patients benefit from postoperative radiotherapy...
  80. ncbi request reprint Is there a dose-effect relationship for the treatment of symptomatic vertebral hemangioma?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 55:178-81. 2003
    ..Symptomatic vertebral hemangiomas are rare vascular lesions. Radiotherapy is the most common treatment. Because of a lack of information in the literature, uncertainty exists about the total radiation dose to be applied...
  81. ncbi request reprint [Treatment for central neurocytoma: a meta-analysis based on the data of 358 patients]
    Dirk Rades
    Abteilung für Strahlentherapie und Radioonkologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Deutschland
    Strahlenther Onkol 179:213-8. 2003
    ....
  82. ncbi request reprint Treatment of atypical neurocytomas
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cancer 100:814-7. 2004
    ..The objective of this analysis was to define the optimal treatment for patients with these atypical tumors...
  83. ncbi request reprint Treatment of solitary brain metastasis. Resection followed by whole brain radiation therapy (WBRT) and a radiation boost to the metastatic site
    Dirk Rades
    Department of Radiotherapy and Radiooncology, University Hospital Hamburg Eppendorf, Germany
    Strahlenther Onkol 180:144-7. 2004
    ..The optimum radiation schedule has yet to be defined. The authors' experience with a postoperative approach including WBRT and a radiation boost to the metastatic site is presented...
  84. ncbi request reprint Prognostic value of the MIB-1 labeling index for central neurocytomas
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Neurology 62:987-9. 2004
    ..The data suggested an MIB-1 index score of >3% to be associated with a worse prognosis for local control (p < 0.0001) and survival (p = 0.0004)...
  85. ncbi request reprint Short-course radiotherapy is not optimal for spinal cord compression due to myeloma
    Dirk Rades
    Department of Radiation Oncology, University Hospital, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 64:1452-7. 2006
    ..To investigate the suitability of short-course radiotherapy (RT) for spinal cord compression (SCC) in myeloma patients...
  86. ncbi request reprint Reduction of overall treatment time in patients irradiated for more than three brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 69:1509-13. 2007
    ..Regarding the poor survival of these patients, a shorter RT regimen would be preferable if it provides a similar outcome as that with 10 x 3 Gy. This study compared 20 Gy in five fractions (5 x 4 Gy) within 5 days to 10 x 3 Gy...
  87. ncbi request reprint Functional outcome and survival after radiotherapy of metastatic spinal cord compression in patients with cancer of unknown primary
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 67:532-7. 2007
    ..Patients with cancer of unknown primary (CUP) account for about 10% of patients with metastatic spinal cord compression (MSCC). This study aims to define the appropriate radiation regimen for these patients...
  88. ncbi request reprint Toxicity of two cisplatin-based radiochemotherapy regimens for the treatment of patients with stage III/IV head and neck cancer
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Head Neck 30:235-41. 2008
    ..This nonrandomized study compared 2 radiochemotherapy regimens for toxicity in 128 patients with stage III/IV head and neck cancer...
  89. ncbi request reprint A boost in addition to whole-brain radiotherapy improves patient outcome after resection of 1 or 2 brain metastases in recursive partitioning analysis class 1 and 2 patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Germany
    Cancer 110:1551-9. 2007
    ..The current study was conducted to compare 2 treatment regimens including surgical resection and whole-brain radiotherapy (WBRT) for patients with 1 to 2 brain metastases...
  90. ncbi request reprint Is short-course radiotherapy with high doses per fraction the appropriate regimen for metastatic spinal cord compression in colorectal cancer patients?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Strahlenther Onkol 182:708-12. 2006
    ..5 Gy given in 3 weeks, 20 x 2 Gy given in 4 weeks) and whether higher doses per fraction (more cell kill) and shorter overall treatment time (less repopulation) can compensate for lower total doses...
  91. ncbi request reprint Experiences with a new high-dose-rate brachytherapy (HDR-BT) boost technique for T3b prostate cancer
    Dirk Rades
    Department of Radiation Oncology, University Medical Center Hamburg Eppendorf, Germany
    Strahlenther Onkol 183:398-402. 2007
    ..Experiences with a new high-dose-rate brachytherapy (HDR-BT) boost technique in 41 patients with stage T3b prostate cancer are presented...
  92. ncbi request reprint Radiotherapy is effective for metastatic spinal cord compression in patients with epithelial ovarian cancer
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Int J Gynecol Cancer 17:263-5. 2007
    ..A recurrence of MSCC did not occur. Radiotherapy alone is effective in improving or maintaining motor function in MSCC patients with ovarian cancer and should be administered if decompressive surgery is not indicated...
  93. ncbi request reprint High accuracy of virtual simulation with the laser system Dorado CT4
    Dirk Rades
    Department of Radiation Oncology, University Medical Center, Hamburg Eppendorf, Germany
    Strahlenther Onkol 183:89-93. 2007
    ..To evaluate the accuracy of virtual simulation, which is less time-consuming than physical simulation, with the new laser system Dorado CT4 in 96 prostate cancer patients...
  94. ncbi request reprint Stereotactic radiosurgery alone versus resection plus whole-brain radiotherapy for 1 or 2 brain metastases in recursive partitioning analysis class 1 and 2 patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Germany
    Cancer 109:2515-21. 2007
    ....
  95. ncbi request reprint Defining the appropriate radiotherapy regimen for metastatic spinal cord compression in non-small cell lung cancer patients
    Dirk Rades
    Department of Radiation Oncology, University Medical Center Hamburg Eppendorf, University Hospital Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Eur J Cancer 42:1052-6. 2006
    ..94). Short-course and long-course RT appear similarly effective for MSCC in NSCLC patients. As 1 x 8 Gy and 5 x 4 Gy showed comparable results, 1 x 8 Gy can be considered appropriate...
  96. ncbi request reprint Prognostic factors in head-and-neck cancer patients treated with surgery followed by intensity-modulated radiotherapy (IMRT), 3D-conformal radiotherapy, or conventional radiotherapy
    Dirk Rades
    Department of Radiation Oncology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Oral Oncol 43:535-43. 2007
    ..The three radiation techniques provided similar disease control. IMRT was effective in significantly reducing xerostomia...
  97. ncbi request reprint Prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Germany
    J Clin Oncol 24:3388-93. 2006
    ..To evaluate potential prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression (MSCC)...
  98. ncbi request reprint Short-course radiotherapy (RT) for metastatic spinal cord compression (MSCC) due to renal cell carcinoma: results of a retrospective multi-center study
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 49:846-52; discussion 852. 2006
    ..Our study compares short-course (1 x 8 Gy, 5 x 4 Gy) and long-course RT (10 x 3 Gy, 15 x 2.5 Gy, 20 x 2 Gy) for functional outcome in MSCC patients with renal cell carcinoma...
  99. ncbi request reprint Is 50 Gy sufficient to achieve long-term local control after incomplete resection of typical neurocytomas?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Strahlenther Onkol 182:415-8. 2006
    ..Typical neurocytomas are associated with better outcome. This study investigates whether a decrease in radiation dose from 54 Gy to 50 Gy for incompletely resected typical neurocytomas would jeopardize the outcome...
  100. ncbi request reprint Treatment recommendations for the various subgroups of neurocytomas
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Neurooncol 77:305-9. 2006
    ..In children, <or=50 Gy and >50 Gy were comparable.CTR does not require post-operative RT. Following ITR, RT improves outcome. Of 50-54 Gy appear sufficient for typical lesions, 50 Gy for children. Atypical lesions require 56-60 Gy...
  101. ncbi request reprint Time of developing motor deficits before radiotherapy as a new and relevant prognostic factor in metastatic spinal cord compression: final results of a retrospective analysis
    D Rades
    Department of Radiation Oncology, Hannover Medical University, Hannover, Germany
    Eur Neurol 45:266-9. 2001
    ..001). A slower development of motor deficits predicts a better functional outcome. Time of developing motor deficits before RT is a relevant prognostic factor in metastatic spinal cord compression...