D Rades

Summary

Publications

  1. ncbi request reprint Value of postoperative stereotactic radiosurgery and conventional radiotherapy for incompletely resected typical neurocytomas
    Dirk Rades
    Department of Radiation Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Cancer 106:1140-3. 2006
  2. ncbi request reprint A survival score for patients with metastatic spinal cord compression from prostate cancer
    D Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Strahlenther Onkol 188:802-6. 2012
  3. ncbi request reprint Comparison of short-course versus long-course whole-brain radiotherapy in the treatment of brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Strahlenther Onkol 184:30-5. 2008
  4. ncbi request reprint Two radiation regimens and prognostic factors for brain metastases in nonsmall cell lung cancer patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 110:1077-82. 2007
  5. ncbi request reprint A new prognostic factor for the survival of patients with renal cell carcinoma developing metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Lubeck, University of Lubeck, 23538, Ratzeburger Allee 160, Lubeck, Germany
    Strahlenther Onkol 190:667-70. 2014
  6. ncbi request reprint Hypofractionated whole-brain radiotherapy for multiple brain metastases from transitional cell carcinoma of the bladder
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Int J Radiat Oncol Biol Phys 78:404-8. 2010
  7. ncbi request reprint [The value of radiotherapy in treatment of meningeal melanocytoma]
    Dirk Rades
    Abteilung für Strahlentherapie und spezielle Onkologie, Medizinische Hochschule Hannover
    Strahlenther Onkol 178:336-42. 2002
  8. ncbi request reprint Resection plus whole-brain irradiation versus resection plus whole-brain irradiation plus boost for the treatment of single brain metastasis
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Strahlenther Onkol 188:143-7. 2012
  9. doi request reprint Prognostic factors for local control and survival in patients with spinal cord compression from myeloma
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:628-31. 2012
  10. doi request reprint A simple survival score for patients with brain metastases from breast cancer
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Strahlenther Onkol 189:664-7. 2013

Detail Information

Publications149 found, 100 shown here

  1. ncbi request reprint Value of postoperative stereotactic radiosurgery and conventional radiotherapy for incompletely resected typical neurocytomas
    Dirk Rades
    Department of Radiation Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Cancer 106:1140-3. 2006
    ..The current study investigated whether the outcome after incomplete resection can be improved by postoperative stereotactic radiosurgery (SRS) or by conventional radiotherapy...
  2. ncbi request reprint A survival score for patients with metastatic spinal cord compression from prostate cancer
    D Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Strahlenther Onkol 188:802-6. 2012
    ..This study aimed to develop and validate a survival scoring system for patients with metastatic spinal cord compression (MSCC) from prostate cancer...
  3. ncbi request reprint Comparison of short-course versus long-course whole-brain radiotherapy in the treatment of brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Strahlenther Onkol 184:30-5. 2008
    ..This study compares 20 Gy in five fractions (treatment time: 1 week) to longer programs, with higher doses including 30 Gy in ten fractions (2 weeks) and 40 Gy in 20 fractions (4 weeks)...
  4. ncbi request reprint Two radiation regimens and prognostic factors for brain metastases in nonsmall cell lung cancer patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 110:1077-82. 2007
    ..A short course of WBRT would be preferable to longer regimens if it could provide similar survival. This retrospective study of NSCLC patients compared longer treatment programs with short-course WBRT with 5 x 4 Gy given during 5 days...
  5. ncbi request reprint A new prognostic factor for the survival of patients with renal cell carcinoma developing metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Lubeck, University of Lubeck, 23538, Ratzeburger Allee 160, Lubeck, Germany
    Strahlenther Onkol 190:667-70. 2014
    ..This study aimed to identify a potential association of the number of involved extraspinal organs with the survival of patients with metastatic spinal cord compression (MSCC) from renal cell carcinoma...
  6. ncbi request reprint Hypofractionated whole-brain radiotherapy for multiple brain metastases from transitional cell carcinoma of the bladder
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Int J Radiat Oncol Biol Phys 78:404-8. 2010
    ..Because its radiosensitivity is relatively low, metastases from bladder cancer may be treated better with hypofractionated radiotherapy. This study compared short-course hypofractionated WBRT (5 × 4 Gy/1 week) to longer-course WBRT...
  7. ncbi request reprint [The value of radiotherapy in treatment of meningeal melanocytoma]
    Dirk Rades
    Abteilung für Strahlentherapie und spezielle Onkologie, Medizinische Hochschule Hannover
    Strahlenther Onkol 178:336-42. 2002
    ..Meningeal melanocytoma is described as rare benign lesion with a high risk of recurrence. There are no well-substantiated treatment recommendations in the literature. Only case reports have been published by now...
  8. ncbi request reprint Resection plus whole-brain irradiation versus resection plus whole-brain irradiation plus boost for the treatment of single brain metastasis
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Strahlenther Onkol 188:143-7. 2012
    ..The optimal treatment for patients with a single brain metastasis is controversial. This study investigated the value of a radiation boost given in addition to neurosurgerical resection and whole-brain irradiation (WBI)...
  9. doi request reprint Prognostic factors for local control and survival in patients with spinal cord compression from myeloma
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:628-31. 2012
    ..This retrospective study aimed to identify prognostic factors for local control and survival in 214 patients irradiated for spinal cord compression (SCC) from myeloma...
  10. doi request reprint A simple survival score for patients with brain metastases from breast cancer
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Strahlenther Onkol 189:664-7. 2013
    ..This study aimed to create and validate a survival score for patients with brain metastasis from breast cancer, which is the second most common primary tumor in these patients...
  11. ncbi request reprint Impact of zoledronic acid on control of metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Strahlenther Onkol 188:910-6. 2012
    ..In contrast to other studies, this matched-pair analysis focused solely on the impact of zoledronic acid on metastatic spinal cord compression (MSCC)...
  12. doi request reprint Scoring systems to estimate intracerebral control and survival rates of patients irradiated for brain metastases
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 80:1122-7. 2011
    ..To create and validate scoring systems for intracerebral control (IC) and overall survival (OS) of patients irradiated for brain metastases...
  13. ncbi request reprint Number of involved extracranial organs predicts survival in patients with brain metastasis from small cell lung cancer
    Lavinia Gerdan
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 33:3887-9. 2013
    ..To investigate the prognostic role of the number of involved extracranial organs in patients with brain metastasis from small-cell lung cancer (SCLC)...
  14. doi request reprint Brain metastasis. Prognostic value of the number of involved extracranial organs
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 189:996-1000. 2013
    ..This study was performed to evaluate the prognostic role for survival of the number and the type of involved extracranial organs in patients with brain metastasis...
  15. ncbi request reprint Predicting the presence of extracranial metastases in patients with brain metastases upon first diagnosis of cancer
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 190:405-7. 2014
    ..This study aimed to determine factors allowing the prediction of extracranial metastases in patients presenting with brain metastases at the first diagnosis of cancer...
  16. ncbi request reprint Escalation of radiation dose beyond 30 Gy in 10 fractions for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 67:525-31. 2007
    ..In many centers worldwide, radiotherapy for metastatic spinal cord compression (MSCC) is performed with 30 Gy in 10 fractions. This study investigated the potential benefit of dose escalation...
  17. doi request reprint Surgery followed by radiotherapy versus radiotherapy alone for metastatic spinal cord compression from unfavorable tumors
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 81:e861-8. 2011
    ..It is thought that patients with MSCC from relatively radioresistant tumors or tumors associated with poor functional outcome after radiotherapy alone may benefit from surgery. This study focuses on these tumors...
  18. ncbi request reprint Re-irradiation of spinal cord compression due to metastasis in elderly patients
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 34:2555-8. 2014
    ..The present study investigated efficacy and toxicity of re-irradiation for an in-field recurrence of spinal cord compression due to metastasis (SCCM) in elderly patients...
  19. ncbi request reprint Dose escalation beyond 30 grays in 10 fractions for patients with multiple brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 110:1345-50. 2007
    ..The current study investigated the potential benefit of dose escalation beyond 30 Gy...
  20. ncbi request reprint Radiotherapy of metastatic spinal cord compression in very elderly patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 67:256-63. 2007
    ..This study investigated the results of radiotherapy (RT) for metastatic spinal cord compression (MSCC) in the very elderly, because few data are available for these patients...
  21. ncbi request reprint Biologic Factors Associated with Tumor Oxygenation Are Prognostic in Patients with Stage III Esophageal Cancer: Long-term Results
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 34:4351-5. 2014
    ..Long-term results of a study investigating potential prognostic factors for treatment outcomes in patients with stage III esophageal cancer are presented...
  22. ncbi request reprint Prognostic significance of the time of developing motor deficits before radiation therapy in metastatic spinal cord compression: one-year results of a prospective trial
    D Rades
    Department of Radiation Oncology, Hannover Medical University, Hannover, Germany
    Int J Radiat Oncol Biol Phys 48:1403-8. 2000
    ..To investigate prospectively the prognostic value of the time of developing motor deficits before radiation therapy (RT) for post-treatment functional outcome in metastatic spinal cord compression...
  23. ncbi request reprint Therapeutic options for meningeal melanocytoma. Case report
    D Rades
    Department of Radiation Oncology, Hannover Medical College, Germany
    J Neurosurg 95:225-31. 2001
    ..050) and for incomplete resection combined with radiotherapy after 2 years (p = 0.034). Complete tumor resection should be considered the best therapeutic option, followed by incomplete resection combined with postoperative radiotherapy...
  24. ncbi request reprint Localised disease in cancer of unknown primary (CUP): the value of positron emission tomography (PET) for individual therapeutic management
    D Rades
    Department of Radiation Oncology, Hannover Medical College, Germany
    Ann Oncol 12:1605-9. 2001
    ..After conservative diagnostic procedures including MRI, the primary is detected in less than 25%. The diagnostic value of PET and its influence on therapeutic strategies was evaluated...
  25. ncbi request reprint A new score predicting survival prognosis after whole-brain radiotherapy alone for brain metastases in elderly patients
    Jasmin N Evers
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 34:2455-8. 2014
    ..Elderly patients represent an important subgroup of patients with brain metastases. A survival score has been developed specifically for these patients...
  26. ncbi request reprint Fibroblast growth factor 2 is of prognostic value for patients with locally advanced squamous cell carcinoma of the head and neck
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 190:68-74. 2014
    ..Patients with locally advanced SCCHN have a poor prognosis. This study investigated the prognostic value of the tumor cell expression of the fibroblast growth factor 2 (FGF-2) in patients treated with surgery followed by radiotherapy...
  27. ncbi request reprint Survival in patients with metastatic spinal cord compression from prostate cancer is associated with the number of extra-spinal organs involved
    Axel Weber
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 33:4505-7. 2013
    ..To investigate the predictive value of the number of extra-spinal organs involved by metastases for survival in metastatic spinal cord compression (MSCC) from prostate cancer...
  28. doi request reprint The first survival score for patients with brain metastases from small cell lung cancer (SCLC)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany Electronic address
    Clin Neurol Neurosurg 115:2029-32. 2013
    ..Primary tumors have different biological behavior justifying separate scoring systems for different tumors. In this study, a survival score was developed for patients with brain metastasis from SCLC...
  29. doi request reprint A new survival score for patients with brain metastases from non-small cell lung cancer
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Strahlenther Onkol 189:777-81. 2013
    ..Non-small cell lung cancer (NSCLC) is the most common primary tumor in patients developing brain metastasis. This study was performed to develop and validate a survival score particularly for this group of patients...
  30. doi request reprint Comparison of different treatment approaches for one to two brain metastases in elderly patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Strahlenther Onkol 184:565-71. 2008
    ..It compares whole-brain radiotherapy (WBRT), stereotactic radiosurgery (SRS), resection plus WBRT (OP + WBRT), and resection plus WBRT plus boost (OP + WBRT + boost) in elderly patients...
  31. ncbi request reprint Do bladder cancer patients with metastatic spinal cord compression benefit from radiotherapy alone?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Urology 69:1081-5. 2007
    ..To investigate the role of radiotherapy (RT) alone in metastatic spinal cord compression (MSCC) patients with bladder cancer...
  32. ncbi request reprint [The value of positron emission tomography (PET) in the treatment of patients with cancer of unknown primary (CUP)]
    D Rades
    Abteilung für Strahlentherapie und spezielle Onkologie, Medizinische Hochschule Hannover
    Strahlenther Onkol 177:525-9. 2001
    ..In the study presented here the value of PET for detection of the primary tumor and a possible dissemination has been investigated and related to therapeutic regimens...
  33. doi request reprint A validated survival score for breast cancer patients with metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 189:41-6. 2013
    ..To create a validated scoring system predicting survival of breast cancer patients with metastatic spinal cord compression (MSCC)...
  34. ncbi request reprint Prognostic value of haemoglobin levels during concurrent radio-chemotherapy in the treatment of oesophageal cancer
    D Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Germany
    Clin Oncol (R Coll Radiol) 18:139-44. 2006
    ..To evaluate the prognostic value of haemoglobin levels during radio-chemotherapy for overall survival, metastases-free survival (MFS) and locoregional control in patients with locally advanced oesophageal cancer...
  35. ncbi request reprint Prognostic factors for survival and intracerebral control after irradiation for brain metastases from gynecological cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Gynecol Oncol 114:506-8. 2009
    ..Most of these patients receive whole-brain radiotherapy (WBRT) alone. Prognostic factors predicting the outcomes of these patients may guide the physician to select the appropriate treatment regimen for the individual patient...
  36. doi request reprint Whole brain radiotherapy plus stereotactic radiosurgery (WBRT+SRS) versus surgery plus whole brain radiotherapy (OP+WBRT) for 1-3 brain metastases: results of a matched pair analysis
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Eur J Cancer 45:400-4. 2009
    ..002) and longer interval (p=0.004); WBRT+SRS achieved borderline significance (p=0.052). Improved LC was associated with longer interval (p=0.017); WBRT+SRS showed a trend (p=0.09). WBRT+SRS appears at least as effective as OP+WBRT...
  37. ncbi request reprint Validation and simplification of a score predicting survival in patients irradiated for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Cancer 116:3670-3. 2010
    ..Based on an analysis of 1852 retrospectively evaluated patients with metastatic spinal cord compression (MSCC), a scoring system was developed to predict survival. This study was performed to validate the scoring system in a new data set...
  38. ncbi request reprint Outcome after radiotherapy alone for metastatic spinal cord compression in patients with oligometastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    J Clin Oncol 25:50-6. 2007
    ..To investigate outcome and prognosis of metastatic spinal cord compression (MSCC) patients with oligometastatic disease treated with radiotherapy alone...
  39. ncbi request reprint Prognostic factors in the nonsurgical treatment of esophageal carcinoma with radiotherapy or radiochemotherapy: the importance of pretreatment hemoglobin levels
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cancer 103:1740-6. 2005
    ..The current study was performed to evaluate prognostic factors for overall survival (OS), distant metastasis (DM), and local failure (LF) in patients with Stage II/III esophageal carcinoma...
  40. ncbi request reprint The first score predicting overall survival in patients with metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 112:157-61. 2008
    ..The current study was performed to create a scoring system to estimate the survival of patients with metastatic spinal cord compression (MSCC)...
  41. ncbi request reprint Effectiveness and toxicity of single-fraction radiotherapy with 1 x 8 Gy for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, D 20246 Hamburg, Germany
    Radiother Oncol 75:70-3. 2005
    ..Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory...
  42. ncbi request reprint Whole-brain radiotherapy versus stereotactic radiosurgery for patients in recursive partitioning analysis classes 1 and 2 with 1 to 3 brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Germany
    Cancer 110:2285-92. 2007
    ..The authors investigated whether stereotactic radiosurgery (SRS) alone improved outcomes for patients in recursive partitioning analysis (RPA) Classes 1 and 2 who had 1 to 3 brain metastases compared with whole-brain radiotherapy (WBRT)...
  43. ncbi request reprint Role of radiotherapy in the treatment of motor dysfunction due to metastatic spinal cord compression: comparison of three different fractionation schedules
    Dirk Rades
    Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    Int J Radiat Oncol Biol Phys 54:1160-4. 2002
    ..Several reports have compared different fractionation schedules for pain relief. To our knowledge, this retrospective analysis is the first to compare three different schedules for functional outcome...
  44. ncbi request reprint Locally advanced stage IV squamous cell carcinoma of the head and neck: impact of pre-radiotherapy hemoglobin level and interruptions during radiotherapy
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 70:1108-14. 2008
    ....
  45. doi request reprint Validation of a score predicting post-treatment ambulatory status after radiotherapy for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 79:1503-6. 2011
    ..A score predicting post-radiotherapy (RT) ambulatory status was developed based on 2,096 retrospectively evaluated metastatic spinal cord compression (MSCC) patients. This study aimed to validate the score in a prospective series...
  46. pmc Prognostic factors for different outcomes in patients with metastatic spinal cord compression from cancer of unknown primary
    Sarah Douglas
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    BMC Cancer 12:261. 2012
    ..This retrospective study was performed to identify prognostic factors for functional outcome, local control of MSCC, and survival in 175 of such patients treated with radiotherapy alone...
  47. ncbi request reprint A new survival score for patients with brain metastases who received whole-brain radiotherapy (WBRT) alone
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Radiother Oncol 108:123-7. 2013
    ..Survival scores for patients with brain metastasis exist. However, the treatment regimens used to create these scores were heterogeneous. This study aimed to develop and validate a survival score in homogeneously treated patients...
  48. doi request reprint A validated scoring system to identify long-term survivors after radiotherapy for metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Strahlenther Onkol 189:462-6. 2013
    ..This study aimed to develop and validate a scoring system to identify long-term survivors after conventional radiotherapy (RT) for metastatic spinal cord compression (MSCC)...
  49. doi request reprint A score to identify patients with metastatic spinal cord compression who may be candidates for best supportive care
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, D 23538 Lubeck, Germany
    Cancer 119:897-903. 2013
    ..The objective of the current study was to develop a scoring system that identifies those patients with metastatic spinal cord compression who may be candidates for best supportive care or single-fraction radiotherapy...
  50. doi request reprint Prognostic factors and a survival score for patients with metastatic spinal cord compression from colorectal cancer
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:1114-8. 2012
    ..This study aimed to identify independent prognostic factors and to create a survival score for patients with metastatic spinal cord compression (MSCC) from colorectal cancer (CRC)...
  51. pmc A new score predicting the survival of patients with spinal cord compression from myeloma
    Sarah Douglas
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    BMC Cancer 12:425. 2012
    ..This study was performed to create and validate a scoring system for the survival of patients with malignant spinal cord compression (SCC) from myeloma...
  52. pmc A validated survival score for patients with metastatic spinal cord compression from non-small cell lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    BMC Cancer 12:302. 2012
    ..This multicenter study aimed to create and validate a scoring system for survival of patients with metastatic spinal cord compression (MSCC) from non-small cell lung cancer (NSCLC)...
  53. doi request reprint Dose-escalation of whole-brain radiotherapy for brain metastasis in patients with a favorable survival prognosis
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Cancer 118:3852-9. 2012
    ..The most common WBRT schedule is 30 grays (Gy) in 10 fractions. In this retrospective study, the authors investigated whether these patients benefit from a dose escalation beyond 30 Gy...
  54. doi request reprint Metastatic spinal cord compression in non-small cell lung cancer patients. Prognostic factors in a series of 356 patients
    D Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Strahlenther Onkol 188:472-6. 2012
    ..This study was performed to identify prognostic factors for functional outcome and survival in these patients after radiotherapy (RT) alone...
  55. doi request reprint Do elderly patients benefit from surgery in addition to radiotherapy for treatment of metastatic spinal cord compression?
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:424-30. 2012
    ....
  56. doi request reprint Single brain metastasis: radiosurgery alone compared with radiosurgery plus up-front whole-brain radiotherapy
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Cancer 118:2980-5. 2012
    ..It was demonstrated that whole-brain radiotherapy (WBRT) in addition to RS improves local control of 1-3 brain metastases. Little information is available regarding WBRT in addition to RS for a single lesion...
  57. doi request reprint Single brain metastasis: resection followed by whole-brain irradiation and a boost to the metastatic site compared to whole-brain irradiation plus radiosurgery
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Clin Neurol Neurosurg 114:326-30. 2012
    ..This matched-pair analysis compared whole-brain irradiation plus radiosurgery (WBI+RS) to neurosurgical resection followed by whole-brain irradiation and a boost to the metastatic site (NR+WBI+B)...
  58. doi request reprint Prognostic factors in a series of 504 breast cancer patients with metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:340-5. 2012
    ..This study was performed to identify new significant prognostic factors in breast cancer patients irradiated for metastatic spinal cord compression (MSCC)...
  59. doi request reprint Cisplatin superior to carboplatin in adjuvant radiochemotherapy for locally advanced cancers of the oropharynx and oral cavity
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:42-8. 2012
    ..This retrospective study compared radiochemotherapy with either cisplatin or carboplatin in patients with locally advanced SCC of the oropharynx and oral cavity...
  60. doi request reprint Single brain metastasis: whole-brain irradiation plus either radiosurgery or neurosurgical resection
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Cancer 118:1138-44. 2012
    ..The current study was conducted to compare neurosurgical resection (NR) followed by whole-brain irradiation (WBI) (NR + WBI) with WBI followed by radiosurgery (WBI + RS) in patients with a single brain metastasis...
  61. doi request reprint Dose escalation of radiotherapy for metastatic spinal cord compression (MSCC) in patients with relatively favorable survival prognosis
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Strahlenther Onkol 187:729-35. 2011
    ..The most frequently used schedule world wide is 30 Gy/10 fractions. This study investigated whether patients with favorable survival prognoses benefit from a dose escalation beyond 30 Gy...
  62. pmc Prognostic factors for outcomes after whole-brain irradiation of brain metastases from relatively radioresistant tumors: a retrospective analysis
    Thekla Meyners
    Department of Radiation Oncology, University of Lubeck, Germany
    BMC Cancer 10:582. 2010
    ..Additionally, a potential benefit from escalating the radiation dose was investigated...
  63. ncbi request reprint Treatment of painful bone metastases
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nat Rev Clin Oncol 7:220-9. 2010
    ..Thus, long-course multi-fraction radiotherapy should be reserved for patients with a relatively favorable survival prognosis...
  64. doi request reprint The prognostic impact of tumor cell expression of estrogen receptor-α, progesterone receptor, and androgen receptor in patients irradiated for nonsmall cell lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Cancer 118:157-63. 2012
    ....
  65. doi request reprint Final results of a prospective study comparing the local control of short-course and long-course radiotherapy for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Int J Radiat Oncol Biol Phys 79:524-30. 2011
    ..This is the first prospective study that has compared local control of different radiotherapy schedules for MSCC...
  66. ncbi request reprint Prognostic impact of VEGF and VEGF receptor 1 (FLT1) expression in patients irradiated for stage II/III non-small cell lung cancer (NSCLC)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Strahlenther Onkol 186:307-14. 2010
    ..This study investigated the impact of tumor expression of VEGF and FLT1 on outcomes in 61 patients irradiated for stage II/III non-small cell lung cancer (NSCLC)...
  67. doi request reprint Comparison of stereotactic radiosurgery (SRS) alone and whole brain radiotherapy (WBRT) plus a stereotactic boost (WBRT+SRS) for one to three brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Germany
    Strahlenther Onkol 184:655-62. 2008
    ..The best available treatment of patients with one to three brain metastases is still unclear. This study compared the results of stereotactic radiosurgery (SRS) alone and whole brain radiotherapy (WBRT) plus SRS (WBRT+SRS)...
  68. ncbi request reprint The role of postoperative radiotherapy for the treatment of gangliogliomas
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Cancer 116:432-42. 2010
    ..The optimal treatment regimen is unclear. In this study, the authors compared 4 therapies for local control (LC) and overall survival (OS) in patients with ganglioglioma...
  69. ncbi request reprint Acute toxicity of three versus two courses of cisplatin for radiochemotherapy of locally advanced squamous cell carcinoma of the head and neck (SCCHN): a matched pair analysis
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Oral Oncol 46:549-52. 2010
    ..001). At least one grade >or= 3 toxicity occurred in 90% of group A and 20% of group B patients, respectively (p=0.005). Two courses of fractionated cisplatin appeared much better tolerated than three courses of fractionated cisplatin...
  70. ncbi request reprint Treatment of atypical neurocytomas
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cancer 100:814-7. 2004
    ..The objective of this analysis was to define the optimal treatment for patients with these atypical tumors...
  71. doi request reprint Comparison of radiochemotherapy alone to surgery plus radio(chemo)therapy for non-metastatic stage III/IV squamous cell carcinoma of the head and neck: A matched-pair analysis
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Strahlenther Onkol 187:541-7. 2011
    ..This study compared the outcomes of radiochemotherapy alone to surgery followed by radio(chemo)therapy (radiotherapy plus/minus concurrent chemotherapy)...
  72. doi request reprint Prognostic factors (including HPV status) for irradiation of locally advanced squamous cell carcinoma of the head and neck (SCCHN)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Strahlenther Onkol 187:626-32. 2011
    ..This study investigated potential prognostic factors, including HPV status, for locoregional control (LRC), metastases-free survival (MFS), and survival (OS)...
  73. doi request reprint Fibroblast growth factor 2--a predictor of outcome for patients irradiated for stage II-III non-small-cell lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 82:442-7. 2012
    ..The present study investigated the effect of tumor cell expression of FGF-2 on the outcome of 60 patients irradiated for Stage II-III NSCLC...
  74. doi request reprint The role of radiotherapy for metastatic epidural spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nat Rev Clin Oncol 7:590-8. 2010
    ..Larger prospective trials are required to better define the appropriate treatment for the individual patient...
  75. ncbi request reprint Radiolabeled cetuximab plus whole-brain irradiation (WBI) for the treatment of brain metastases from non-small cell lung cancer (NSCLC)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Strahlenther Onkol 186:458-62. 2010
    ..Radiolabeling of cetuximab was performed to investigate whether this antibody crosses the BBB...
  76. doi request reprint Prognostic impact of erythropoietin expression and erythropoietin receptor expression on locoregional control and survival of patients irradiated for stage II/III non-small-cell lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Int J Radiat Oncol Biol Phys 80:499-505. 2011
    ..This study investigates the prognostic value of erythropoietin (EPO) and EPO receptor (EPO-R) expression of tumor cells for locoregional control and survival in non-small-cell lung cancer (NSCLC) patients...
  77. doi request reprint Comparison of four cisplatin-based radiochemotherapy regimens for nonmetastatic stage III/IV squamous cell carcinoma of the head and neck
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 80:1037-44. 2011
    ..To compare the outcomes of four cisplatin-based radiochemotherapy regimens in 311 patients with Stage III/IV squamous cell carcinoma of the head and neck...
  78. ncbi request reprint Matched pair analysis comparing surgery followed by radiotherapy and radiotherapy alone for metastatic spinal cord compression
    Dirk Rades
    University of Lubeck, Lubeck, Germany
    J Clin Oncol 28:3597-604. 2010
    ..That study was limited to highly selected patients. Additional studies comparing surgery plus radiotherapy to radiotherapy could better clarify the role of surgery...
  79. doi request reprint Shorter-course whole-brain radiotherapy for brain metastases in elderly patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 81:e469-73. 2011
    ..Regarding the extraordinarily poor survival prognosis of elderly patients with multiple brain metastases, a shorter WBRT regimen would be preferable. This study compared 10 × 3 Gy with 5 × 4 Gy in elderly patients (≥65 years)...
  80. doi request reprint Dose escalation for metastatic spinal cord compression in patients with relatively radioresistant tumors
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Int J Radiat Oncol Biol Phys 80:1492-7. 2011
    ..However, the results of the "standard" regimen 30 Gy/10 fractions need to be improved with respect to functional outcome. This study investigated whether a dose escalation beyond 30 Gy can improve treatment outcomes...
  81. ncbi request reprint Do patients receiving whole-brain radiotherapy for brain metastases from renal cell carcinoma benefit from escalation of the radiation dose?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 78:398-403. 2010
    ..The standard WBRT regimen, 30 Gy/10 fractions (10 × 3 Gy), has resulted in poor survival (OS). This study investigates whether escalation of the WBRT dose improves treatment outcomes...
  82. ncbi request reprint Dose-response relationship for fractionated irradiation in the treatment of spinal meningeal melanocytomas: a review of the literature
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Neurooncol 77:311-4. 2006
    ..The recurrence rates after CTR would mandate the use of post-operative radiotherapy in all spinal meningeal melanocytoma cases. Our results should be confirmed in a larger series of patients when available...
  83. ncbi request reprint [Effectiveness and toxicity of reirradiation (Re-RT) for metastatic spinal cord compression (MSCC)]
    Dirk Rades
    Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Universitatsklinikum, Hamburg Eppendorf
    Strahlenther Onkol 181:595-600. 2005
    ..Many radiation oncologists are concerned about spinal Re-RT, because it may result in a high cumulative EQD2. This study investigates effectiveness and feasibility of Re-RT for in-field recurrence of MSCC...
  84. ncbi request reprint Evaluation of functional outcome and local control after radiotherapy for metastatic spinal cord compression in patients with prostate cancer
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Urol 175:552-6. 2006
    ..This study investigates prognostic factors and radiation schedules for functional outcome and local control of MSCC after radiotherapy in patients with prostate cancer...
  85. ncbi request reprint Short-course radiotherapy is not optimal for spinal cord compression due to myeloma
    Dirk Rades
    Department of Radiation Oncology, University Hospital, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 64:1452-7. 2006
    ..To investigate the suitability of short-course radiotherapy (RT) for spinal cord compression (SCC) in myeloma patients...
  86. ncbi request reprint Short-course radiotherapy (RT) for metastatic spinal cord compression (MSCC) due to renal cell carcinoma: results of a retrospective multi-center study
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Eur Urol 49:846-52; discussion 852. 2006
    ..Our study compares short-course (1 x 8 Gy, 5 x 4 Gy) and long-course RT (10 x 3 Gy, 15 x 2.5 Gy, 20 x 2 Gy) for functional outcome in MSCC patients with renal cell carcinoma...
  87. ncbi request reprint Treatment recommendations for the various subgroups of neurocytomas
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Neurooncol 77:305-9. 2006
    ..In children, <or=50 Gy and >50 Gy were comparable.CTR does not require post-operative RT. Following ITR, RT improves outcome. Of 50-54 Gy appear sufficient for typical lesions, 50 Gy for children. Atypical lesions require 56-60 Gy...
  88. ncbi request reprint Defining the appropriate radiotherapy regimen for metastatic spinal cord compression in non-small cell lung cancer patients
    Dirk Rades
    Department of Radiation Oncology, University Medical Center Hamburg Eppendorf, University Hospital Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Eur J Cancer 42:1052-6. 2006
    ..94). Short-course and long-course RT appear similarly effective for MSCC in NSCLC patients. As 1 x 8 Gy and 5 x 4 Gy showed comparable results, 1 x 8 Gy can be considered appropriate...
  89. ncbi request reprint Prognostic factors predicting functional outcomes, recurrence-free survival, and overall survival after radiotherapy for metastatic spinal cord compression in breast cancer patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 64:182-8. 2006
    ..To identify significant prognostic factors after irradiation of metastatic spinal cord compression (MSCC) in 335 breast cancer patients...
  90. ncbi request reprint Is 50 Gy sufficient to achieve long-term local control after incomplete resection of typical neurocytomas?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Strahlenther Onkol 182:415-8. 2006
    ..Typical neurocytomas are associated with better outcome. This study investigates whether a decrease in radiation dose from 54 Gy to 50 Gy for incompletely resected typical neurocytomas would jeopardize the outcome...
  91. ncbi request reprint Prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Germany
    J Clin Oncol 24:3388-93. 2006
    ..To evaluate potential prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression (MSCC)...
  92. ncbi request reprint Prognostic factors in head-and-neck cancer patients treated with surgery followed by intensity-modulated radiotherapy (IMRT), 3D-conformal radiotherapy, or conventional radiotherapy
    Dirk Rades
    Department of Radiation Oncology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Oral Oncol 43:535-43. 2007
    ..The three radiation techniques provided similar disease control. IMRT was effective in significantly reducing xerostomia...
  93. ncbi request reprint Functional outcome and survival after radiotherapy of metastatic spinal cord compression in patients with cancer of unknown primary
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 67:532-7. 2007
    ..Patients with cancer of unknown primary (CUP) account for about 10% of patients with metastatic spinal cord compression (MSCC). This study aims to define the appropriate radiation regimen for these patients...
  94. ncbi request reprint Spinal reirradiation after short-course RT for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 63:872-5. 2005
    ..To investigate the feasibility and effectiveness of reirradiation (re-RT) for in-field recurrence of metastatic spinal cord compression after primary RT with 1 x 8 Gy or 5 x 4 Gy...
  95. ncbi request reprint Comparison of 1 x 8 Gy and 10 x 3 Gy for functional outcome in patients with metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 62:514-8. 2005
    ..This study investigates a reduction of the overall treatment time to only one day by comparing 1 x 8 Gy to the multi-fractionated 10 x 3 Gy for functional outcome...
  96. ncbi request reprint Epoetin-alpha during radiotherapy for stage III esophageal carcinoma
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cancer 103:2274-9. 2005
    ....
  97. ncbi request reprint Final results of a prospective study of the prognostic value of the time to develop motor deficits before irradiation in metastatic spinal cord compression
    Dirk Rades
    Department ofRadiation Oncology, Hannover Medical University, Hannover, Germany
    Int J Radiat Oncol Biol Phys 53:975-9. 2002
    ..Because only the type of primary tumor and pretreatment ambulatory status are known as prognostic factors for functional outcome, we investigated the prognostic value of the time of motor deficit development before radiotherapy (RT)...
  98. ncbi request reprint A comparison of two different radiation schedules for metastatic spinal cord compression considering a new prognostic factor
    Dirk Rades
    Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    Strahlenther Onkol 178:556-61. 2002
    ..This analysis compares the effect of two schedules on motor function considering three relevant prognostic factors (type of primary tumor, pre-treatment ambulatory status, time of developing motor deficits before radiotherapy)...
  99. ncbi request reprint Is there a dose-effect relationship for the treatment of symptomatic vertebral hemangioma?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Eppendorf, Hamburg, Germany
    Int J Radiat Oncol Biol Phys 55:178-81. 2003
    ..Symptomatic vertebral hemangiomas are rare vascular lesions. Radiotherapy is the most common treatment. Because of a lack of information in the literature, uncertainty exists about the total radiation dose to be applied...
  100. ncbi request reprint Defining the optimal dose of radiation after incomplete resection of central neurocytomas
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Germany
    Int J Radiat Oncol Biol Phys 55:373-7. 2003
    ..Central neurocytomas are uncommon benign central nervous system tumors. There is uncertainty regarding the most appropriate radiation dose after incomplete resection. This analysis was performed to determine the optimal dose...
  101. ncbi request reprint [Treatment for central neurocytoma: a meta-analysis based on the data of 358 patients]
    Dirk Rades
    Abteilung für Strahlentherapie und Radioonkologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Deutschland
    Strahlenther Onkol 179:213-8. 2003
    ....