D Rades

Summary

Publications

  1. Hansen H, Janssen S, Thieme C, Perlov A, Schild S, Rades D. Potential Impact of the Interval Between Imaging and Whole-brain Radiotherapy in Patients With Relatively Favorable Survival Prognoses. Anticancer Res. 2019;39:1343-1346 pubmed publisher
    ..Depending on the need for symptom relief, WBRT may be postponed for very important reasons such as obtaining a multidisciplinary tumor board decision or definitive histology. ..
  2. request reprint
    Rades D, Veninga T, Janssen S, Schild S. Outcomes After Whole-brain Radiotherapy for Brain Metastases with 5×4 Gy: Importance of Overall Treatment Time. Anticancer Res. 2016;36:4941-5 pubmed
    ..81). On multivariate analysis, survival was positively associated with better ECOG-PS (p<0.001) and absence of extracerebral lesions (p=0.004). Prolongation of OTT to 7 days had no impact on outcomes after WBRT with 5×4 Gy. ..
  3. Rades D, Bartscht T, Idel C, Schild S, Hakim S. Hyperfractionated or Accelerated Hyperfractionated Re-irradiation with ?42 Gy in Combination with Paclitaxel for Secondary/Recurrent Head-and-Neck Cancer. Anticancer Res. 2018;38:3653-3656 pubmed publisher
    ..Re-irradiation with 42.0-44.4 Gy given twice daily plus paclitaxel was well tolerated and achieved a favorable response. The results need to be confirmed in a prospective trial. ..
  4. Treder M, Vogelsang R, Janssen S, Schild S, Holländer N, Rades D. Potential Prognostic Factors of Downstaging Following Preoperative Chemoradiation for High Rectal Cancer. In Vivo. 2018;32:1481-1484 pubmed publisher
    ..The majority of patients with UICC-stage III tumors were downstaged and appear to benefit from preoperative chemoradiation. In general, the potential value of preoperative treatment for high rectal cancers needs further investigation. ..
  5. Rades D, Sondermann L, Motisi L, Janssen S, Cacicedo J, Schild S. Prognostic Factors and a Survival Score in Patients Irradiated for Metastatic Epidural Spinal Cord Compression from Urothelial Carcinoma Cancer of the Bladder. Anticancer Res. 2018;38:6841-6846 pubmed publisher
    ..5 months, respectively. Prognostic factors were identified and a new survival score was created that will help physicians aiming to personalize treatment for patients with MESCC from urothelial carcinoma of the bladder. ..
  6. Rades D, Vogelsang R, Treder M, Janssen S, Schild S, Holländer N, et al. A Matched-Pair Study Comparing Surgery Plus Neoadjuvant Radio-Chemotherapy and Surgery Alone for High Rectal Cancers. Anticancer Res. 2018;38:6877-6880 pubmed publisher
    ..Given the limitations of this study, the results showed that neoadjuvant radiochemotherapy may improve OS in patients with stage II/III high rectal cancers. However, these results need to be verified in a prospective randomized trial. ..
  7. Rades D, Veninga T, Hornung D, Wittkugel O, Schild S, Gliemroth J. Single brain metastasis: whole-brain irradiation plus either radiosurgery or neurosurgical resection. Cancer. 2012;118:1138-44 pubmed publisher
    ..Because WBI + RS is less invasive than NR + WBI, it appears to be preferable for many patients with a single brain metastasis. These results should be confirmed in a randomized trial. ..
  8. Rades D, Douglas S, Veninga T, Schild S. A validated survival score for patients with metastatic spinal cord compression from non-small cell lung cancer. BMC Cancer. 2012;12:302 pubmed publisher
    ..The scoring system can help when selecting the individual treatment for patients with MSCC from NSCLC. A prospective confirmatory study is warranted. ..
  9. Rades D, Panzner A, Janssen S, Dunst J, Veninga T, Holländer N, et al. Outcomes After Radiotherapy Alone for Metastatic Spinal Cord Compression in Patients with Oligo-metastatic Breast Cancer. Anticancer Res. 2018;38:6897-6903 pubmed publisher
    ..001) and ECOG-PS 1-2 (p=0.002) were associated with survival. Significant prognostic factors were identified for patients with MSCC from oligo-metastatic breast cancer. Higher radiation doses improved local control. ..

More Information

Publications154 found, 100 shown here

  1. Rades D, Conde Moreno A, Cacicedo J, Veninga T, Segedin B, Stanič K, et al. A scoring system to predict local progression-free survival in patients irradiated with 20 Gy in 5 fractions for malignant spinal cord compression. Radiat Oncol. 2018;13:257 pubmed publisher
    ..Many group B and most group C patients achieved long-time LPFS and appeared sufficiently treated with 20 Gy in 5 fractions. However, based on previous data, long-term survivors may benefit from longer-course RT. ..
  2. request reprint
    Janssen S, Bajrovic A, Schild S, Rades D. A Scoring Instrument to Predict the Survival Prognoses of Patients with Metastatic Epidural Spinal Cord Compression from Gynecological Malignancies. Anticancer Res. 2016;36:5469-5472 pubmed
    ..001). An instrument was developed for estimating the lifespan of patients with MESCC from gynecological malignancies. This instrument can support physicians when picking an individual treatment. ..
  3. request reprint
    Rades D, Conde Moreno A, Garcia R, Veninga T, Schild S. A Tool to Estimate Survival of Elderly Patients Presenting with Metastatic Epidural Spinal Cord Compression (MESCC) from Cancer of Unknown Primary. Anticancer Res. 2015;35:6219-22 pubmed
    ..001). This specific tool assists the physician to estimate survival and select for the most suitable radiotherapy program in elderly CUP patients with MESCC. ..
  4. Huttenlocher S, Dziggel L, Hornung D, Blanck O, Schild S, Rades D. A new prognostic instrument to predict the probability of developing new cerebral metastases after radiosurgery alone. Radiat Oncol. 2014;9:215 pubmed publisher
    ..Patients of groups I and II appear good candidates for additional WBI in addition to radiosurgery, whereas patients of group III may not require WBI in addition to radiosurgery. ..
  5. Janssen S, Kaesmann L, Rudat V, Rades D. A scoring system for predicting the survival prognosis of patients receiving stereotactic body radiation therapy (SBRT) for 1-3 lung metastases. Lung. 2016;194:631-5 pubmed publisher
    ..This score allowed us to estimate the survival prognosis of these patients and can aid physicians when aiming to choose the optimal SBRT dose for individual patients. ..
  6. request reprint
    Kilic E, Schild S, Thorns C, Bajrovic A, Rades D. Prognostic role of vascular endothelial growth factor and its receptor-1 in patients with esophageal cancer. Anticancer Res. 2014;34:5221-6 pubmed
    ..VEGF showed a trend towards worse LRC and survival, VEGFR-1 towards worse survival. Outcomes were associated with hemoglobin, performance status and tumor stage. ..
  7. Rades D, Douglas S, Schild S. A validated survival score for breast cancer patients with metastatic spinal cord compression. Strahlenther Onkol. 2013;189:41-6 pubmed publisher
    ..Therefore, this score was reproducible and can help when selecting the appropriate radiotherapy regimen for each patient taking into account her survival prognosis. ..
  8. request reprint
    Rades D, Dziggel L, Hakim S, Rudat V, Janssen S, Trang N, et al. Predicting Survival After Irradiation for Brain Metastases from Head and Neck Cancer. In Vivo. 2015;29:525-8 pubmed
    ..Six-month survival rates for these groups were 0%, 50% and 100%, respectively. This new instrument guides physicians in choosing optimal irradiation programs for patients with cerebral metastases from head-and-neck cancer. ..
  9. request reprint
    Rades D, Dziggel L, Janssen S, Khoa M, Duong V, Khiem V, et al. Predictive Factors for Local Control and Survival in Patients with Cancer of Unknown Primary (CUP) Irradiated for Cerebral Metastases. Anticancer Res. 2018;38:2415-2418 pubmed
    ..001) were significant. Significant predictors of local control and survival were identified that contribute to treatment personalization and design of prospective trials in patients with cerebral metastases from CUP. ..
  10. request reprint
    Huttenlocher S, Sehmisch L, Schild S, Blank O, Hornung D, Rades D. Identifying melanoma patients with 1-3 brain metastases who may benefit from whole-brain irradiation in addition to radiosurgery. Anticancer Res. 2014;34:5589-92 pubmed
    ..Freedom from new cerebral lesion rates were 28%, 60% and 92% (p<0.001). Group A and B patients should be considered for additional whole-brain radiotherapy (WBRT). ..
  11. request reprint
    Rades D, Huttenlocher S, Gebauer N, Hornung D, Trang N, Khoa M, et al. Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma. Anticancer Res. 2015;35:3571-4 pubmed
    ..001) and absence of extracranial metastatic disease (p=0.006). In patients treated with SRS alone, local control of cerebral metastases from RCC was better after 20 Gy than after 16-18 Gy. ..
  12. Treder M, Janssen S, Holländer N, Schild S, Rades D. Role of Neoadjuvant Radio-chemotherapy for the Treatment of High Rectal Cancer. Anticancer Res. 2018;38:5371-5377 pubmed publisher
    ..Neoadjuvant radio-chemotherapy for high rectal cancer was well tolerated and led to promising results. Comparative studies are required to investigate whether it is superior to postoperative chemotherapy alone. ..
  13. request reprint
    Rades D, Conde Moreno A, Cacicedo J, Segedin B, Veninga T, Schild S. Metastatic Spinal Cord Compression: A Survival Score Particularly Developed for Elderly Prostate Cancer Patients. Anticancer Res. 2015;35:6189-92 pubmed
    ..001). The present study identified four groups with different survival probabilities that require treatment strategies with different priorities ranging from symptom control to prolongation of life. ..
  14. request reprint
    Rades D, Schild S, Tatagiba M, Molina H, Alberti W. Therapy of meningeal melanocytomas. Cancer. 2004;100:2442-7 pubmed
    ..1). CTR was found to be significantly superior to ITR with regard to both local control and survival. Outcome was significantly improved by RT after ITR. Doses of 45-55 Gy appeared to be more beneficial than doses of < or = 40 Gy. ..
  15. Rades D, Nadrowitz R, Buchmann I, Hunold P, Noack F, Schild S, et al. Radiolabeled cetuximab plus whole-brain irradiation (WBI) for the treatment of brain metastases from non-small cell lung cancer (NSCLC). Strahlenther Onkol. 2010;186:458-62 pubmed publisher
    ..The reference lesion measured 31 x 22 x 21 mm at 4 months. Enhancement of contrast medium was less pronounced. This is the first demonstration of cetuximab crossing the BBB and accumulating in brain metastasis. ..
  16. Rades D, Dziggel L, Manig L, Janssen S, Khoa M, Duong V, et al. Predicting Survival After Whole-brain Irradiation for Cerebral Metastases in Patients with Cancer of the Bladder. In Vivo. 2018;32:633-636 pubmed
    ..Based on two clinical parameters, a tool was developed that may help estimate the lifespan of patients irradiated for cerebral metastases from bladder cancer. ..
  17. request reprint
    Rades D, Tatagiba M, Brandis A, Dubben H, Karstens J. [The value of radiotherapy in treatment of meningeal melanocytoma]. Strahlenther Onkol. 2002;178:336-42 pubmed
    ..However, for multiple cranial or spinal lesions total cranial irradiation or craniospinal irradiation is indicated. ..
  18. Rades D, Rudat V, Veninga T, Stalpers L, Hoskin P, Schild S. Prognostic factors for functional outcome and survival after reirradiation for in-field recurrences of metastatic spinal cord compression. Cancer. 2008;113:1090-6 pubmed publisher
    ..Motor function after Re-RT was associated with the effect of first irradiation, performance status, time to development of motor deficits, and visceral metastases, whereas the Re-RT schedule had no significant impact. ..
  19. Rades D, Huttenlocher S, Dziggel L, Khoa M, VAN Thai P, Hornung D, et al. A new tool predicting survival after radiosurgery alone for one or two cerebral metastases from lung cancer. Lung. 2015;193:299-302 pubmed publisher
    ..001). This new tool enables physicians to estimate the survival of lung cancer patients with few cerebral metastases which should impact individualized treatment choices. ..
  20. Rades D, Blanck O, Khoa M, VAN Thai P, Hung N, Dziggel L, et al. Validation of a Survival Score for Patients Receiving Radiosurgery or Fractionated Stereotactic Radiotherapy for 1 to 3 Brain Metastases. In Vivo. 2018;32:381-384 pubmed
    ..060). In the 16-17 points group, 1-year survival rates were 75% versus 77% (p=0.79). In the more favorable group, the scoring-system was very reproducible. In the less favorable group, the difference was larger, but also not signficant. ..
  21. request reprint
    Rades D, Dziggel L, Blanck O, Gebauer N, Bartscht T, Schild S. A Score to Identify Patients with Brain Metastases from Colorectal Cancer Who May Benefit from Whole-brain Radiotherapy in Addition to Stereotactic Radiosurgery/Radiotherapy. Anticancer Res. 2018;38:3111-3114 pubmed
    ..027). This study identified three risk groups regarding new brain metastases after stereotactic irradiation. Patients with 2 points could benefit from additional whole-brain radiotherapy. ..
  22. Rades D, Staackmann C, Janssen S. Predicting the Ambulatory Status of Patients Irradiated for Metastatic Spinal Cord Compression (MSCC) from Head-and-neck Cancer. Anticancer Res. 2018;38:4833-4837 pubmed publisher
    ..Three groups were designed (7-12, 15-20 and 22-27 points) with post-treatment ambulatory rates of 11%, 62% and 96% (p<0.001). This scoring system helps predict ambulatory status after radiotherapy for MSCC from head-and-neck cancer. ..
  23. Rades D, Schild S. Do patients with a limited number of brain metastases need whole-brain radiotherapy in addition to radiosurgery?. Strahlenther Onkol. 2012;188:702-6 pubmed publisher
    ..Further randomized studies including adequate assessment of neurocognitive function and a follow-up period of at least 2 years are needed to help customize the treatment for individual patients. ..
  24. request reprint
    Manig L, Käsmann L, Janssen S, Schild S, Rades D. Simplified Comorbidity Score and Eastern Cooperative Oncology Group Performance Score Predicts Survival in Patients Receiving Organ-preserving Treatment for Bladder Cancer. Anticancer Res. 2017;37:2693-2696 pubmed
    ..16) and AAC (p=0.49), a significant association with survival was not observed. SCS and ECOG-PS were significantly associated with survival in patients irradiated for bladder cancer and can help estimate the prognoses of these patients. ..
  25. Rades D, Manig L, Janssen S, Schild S. Factors Impacting the Overall Survival of Patients Irradiated for Invasive Carcinoma of the Urinary Bladder. In Vivo. 2017;31:741-744 pubmed
    ..033) and KPS (RR=3.45; p=0.018) remained significant. This study identified independent predictors of survival in patients irradiated for carcinoma of the urinary bladder and contributes to creation of personalised treatment programs. ..
  26. request reprint
    Rades D, Dziggel L, Blanck O, Gebauer N, Bartscht T, Schild S. Predicting the Risk of Developing New Cerebral Lesions After Stereotactic Radiosurgery or Fractionated Stereotactic Radiotherapy for Brain Metastases from Renal Cell Carcinoma. Anticancer Res. 2018;38:2973-2976 pubmed
    ..002). Two groups were identified with different risks of new brain metastases after SRS or FSRT alone. High-risk patients may benefit from additional whole-brain irradiation. ..
  27. request reprint
    Bolm L, Janssen S, Käsmann L, Wellner U, Bartscht T, Schild S, et al. Predicting Survival After Irradiation of Metastases from Pancreatic Cancer. Anticancer Res. 2015;35:4105-8 pubmed
    ..41; p=0.005) achieved significance. The present study identified four independent predictors of survival in patients with pancreatic cancer irradiated for metastasis and thus contributes to treatment optimization. ..
  28. request reprint
    Janssen S, Bolm L, Käsmann L, Bartscht T, Rades D. Palliative Radiation Therapy for Spinal Cord Compression from Metastatic Soft Tissue Sarcoma. In Vivo. 2016;30:529-31 pubmed
    ..Radiotherapy alone resulted in high rates of pain relief in patients with SCC from metastatic soft tissue sarcoma. The effect on motor function was less favorable. Upfront neurosurgery is required for improvement of motor deficits. ..
  29. request reprint
    Rades D, Dziggel L, Bartscht T, Gliemroth J. Predicting overall survival in patients with brain metastases from esophageal cancer. Anticancer Res. 2014;34:6763-5 pubmed
    ..001). This new score facilitates the selection of individual therapies for patients with brain metastases from esophageal cancer. ..
  30. request reprint
    Rades D, Dahlke M, Gebauer N, Bartscht T, Hornung D, Trang N, et al. A New Predictive Tool for Optimization of the Treatment of Brain Metastases from Colorectal Cancer After Stereotactic Radiosurgery. Anticancer Res. 2015;35:5515-8 pubmed
    ..Six- and 12-month survival rates were 20% vs. 78% and 0% vs. 44% (p=0.002), respectively. This tool helps optimize the treatment of patients after stereotactic radiosurgery for brain metastases from colorectal cancer. ..
  31. Janssen S, Hansen H, Schild S, Rades D. An Instrument for Estimating the 6-Month Survival Probability After Whole-brain Irradiation Alone for Cerebral Metastases from Gynecological Cancer. Anticancer Res. 2018;38:3753-3756 pubmed publisher
    ..004). An instrument was designed to predict the 6-month survival of patients receiving WBI for cerebral metastases from gynecological cancer and facilitate personalized care. ..
  32. Rades D, Seibold N, Hoffmann A, Gebhard M, Noack F, Thorns C, et al. Impact of the HPV-positivity definition on the prognostic value of HPV status in patients with locally advanced squamous cell carcinoma of the head and neck. Strahlenther Onkol. 2013;189:856-60 pubmed publisher
  33. Rades D, Huttenlocher S, Hornung D, Blanck O, Schild S. Radiosurgery alone versus radiosurgery plus whole-brain irradiation for very few cerebral metastases from lung cancer. BMC Cancer. 2014;14:931 pubmed publisher
    ..001). Addition of whole-brain irradiation to radiosurgery significantly improved distant brain control in patients with few cerebral metastases from lung cancer. This improvement did not translate into better overall survival. ..
  34. request reprint
    Rades D, Huttenlocher S, Dahlke M, Hornung D, Blanck O, VAN Thai P, et al. Comparison of two dose levels of stereotactic radiosurgery for 1-3 brain metastases from non-small cell lung cancer. Anticancer Res. 2014;34:7309-13 pubmed
    ..030). SRS dose was not associated with freedom from new brain metastases (p=0.24) or survival (p=0.37). SRS with 20 Gy resulted in better control of the irradiated metastases than 15-18 Gy did. ..
  35. request reprint
    Rades D, Conde Moreno A, Cacicedo J, Segedin B, Stanič K, Metz M, et al. Comparison of Two Radiotherapy Regimens for Metastatic Spinal Cord Compression: Subgroup Analyses from a Randomized Trial. Anticancer Res. 2018;38:1009-1015 pubmed
    ..85), improvement 39% vs. 45%, ambulatory status 84% vs. 82% (p=0.90), 6-month LPFS 79% vs. 92% (p=0.17) and 6-months OS 65% vs. 58% (p=0.65). 5×4Gy was not significantly inferior to 10x3Gy in both subgroups. ..
  36. Rades D, Strojan P, Seidl D, Janssen S, Bajrovic A, Kazic N, et al. Radiochemotherapy for locally advanced squamous cell carcinoma of the head and neck: Higher-dose cisplatin every 3 weeks versus cisplatin/5-fluorouracil every 4 weeks. J Craniomaxillofac Surg. 2016;44:1436-40 pubmed publisher
    ..Otherwise, adverse events were not significantly different. Thus, both radiochemotherapy regimens appeared similarly effective for LASCCHN. Patients receiving 100 mg/m(2) of cisplatin require close monitoring of their renal function. ..
  37. Rades D, Conde A, Garcia R, Cacicedo J, Segedin B, Perpar A, et al. A new instrument for estimation of survival in elderly patients irradiated for metastatic spinal cord compression from breast cancer. Radiat Oncol. 2015;10:173 pubmed publisher
    ..001). This new instrument contributes to personalized treatment in elderly patients with MSCC from breast cancer by predicting an individual patient's survival prognosis. ..
  38. request reprint
    Rades D, Conde Moreno A, Cacicedo J, Szegedin B, Schild S. Estimating the Survival of Elderly Patients with Renal Cell Carcinoma Presenting with Malignant Spinal Cord Compression. Anticancer Res. 2016;36:409-13 pubmed
    ..Six-month survival rates were 8%, 30%, 69% and 100%, respectively (p<0.001). This tool improves estimation of survival and personalized treatment options in elderly patients with MSCC from renal cell carcinoma. ..
  39. Staackmann C, Janssen S, Schild S, Rades D. A Tool to Predict the Probability of Intracerebral Recurrence or New Cerebral Metastases After Whole-brain Irradiation in Patients with Head-and-Neck Cancer. Anticancer Res. 2018;38:4199-4202 pubmed publisher
    ..003), respectively, for these groups. A new tool was created to predict intracerebral control following WBI and should contribute to personalization of treatment for patients with cerebral metastases of head-and-neck cancer. ..
  40. Rades D, Kaesmann L, Janssen S, Schild S. A New Score for Estimating Survival After Definitive Radiochemotherapy of Limited Disease Small Cell Lung Cancers. Lung. 2016;194:625-9 pubmed publisher
    ..When using this instrument, the limitations if this study must be taken into account. ..
  41. Rades D, Dziggel L, Schild S. A Specific Survival Score for Patients Receiving Local Therapy for Single Brain Metastasis from a Gynecological Malignancy. In Vivo. 2018;32:825-828 pubmed publisher
    ..020). This specific score can be used to estimate OS in patients receiving local therapies for single brain metastasis from gynecological malignancies and personalize their care. ..
  42. Rades D, Schild S, Abrahm J. Treatment of painful bone metastases. Nat Rev Clin Oncol. 2010;7:220-9 pubmed publisher
    ..Thus, long-course multi-fraction radiotherapy should be reserved for patients with a relatively favorable survival prognosis. ..
  43. request reprint
    Rades D, Sehmisch L, Huttenlocher S, Blank O, Hornung D, Terheyden P, et al. Radiosurgery alone for 1-3 newly-diagnosed brain metastases from melanoma: impact of dose on treatment outcomes. Anticancer Res. 2014;34:5079-82 pubmed
    ..006) and KPS 90-100 (p=0.046). SRS doses of 21-22.5 Gy resulted in better local control than 20 Gy. Freedom from new brain metastases and survival were not significantly different. ..
  44. request reprint
    Rades D, Schild S, Fehlauer F. Prognostic value of the MIB-1 labeling index for central neurocytomas. Neurology. 2004;62:987-9 pubmed
    ..The data suggested an MIB-1 index score of >3% to be associated with a worse prognosis for local control (p < 0.0001) and survival (p = 0.0004). ..
  45. Rades D, Panzner A, Rudat V, Karstens J, Schild S. Dose escalation of radiotherapy for metastatic spinal cord compression (MSCC) in patients with relatively favorable survival prognosis. Strahlenther Onkol. 2011;187:729-35 pubmed publisher
    ..98). Escalation of the radiation dose beyond 30 Gy resulted in significantly better local control, progression-free survival, and overall survival in patients with favorable survival prognoses. ..
  46. Rades D, Douglas S, Huttenlocher S, Veninga T, Bajrovic A, Rudat V, et al. Prognostic factors and a survival score for patients with metastatic spinal cord compression from colorectal cancer. Strahlenther Onkol. 2012;188:1114-8 pubmed publisher
    ..001). This study identified several independent prognostic factors for treatment outcomes in patients irradiated for MSCC from CRC. The survival prognosis of these patients can be estimated with a new score. ..
  47. request reprint
    Rades D, Sehmisch L, Bajrovic A, Janssen S, Schild S. Comparison of 20×2 Gy and 12×3 Gy for Whole-brain Irradiation of Multiple Brain Metastases from Malignant Melanoma. In Vivo. 2016;30:917-919 pubmed
    ..50% and 25% after 12×3 Gy (p=0.75). The less time-consuming regimen 12x3 Gy appeared not inferior to 20×2 Gy and a reasonable treatment option, particularly for patients with a limited life expectancy. ..
  48. request reprint
    Rades D, Fehlauer F, Veninga T, Stalpers L, Basic H, Hoskin P, et al. Functional outcome and survival after radiotherapy of metastatic spinal cord compression in patients with cancer of unknown primary. Int J Radiat Oncol Biol Phys. 2007;67:532-7 pubmed
    ..Short-course RT appears preferable, at least for patients with a poor predicted survival, as it is more patient convenient and more cost-effective. ..
  49. Rades D, Douglas S, Veninga T, Stalpers L, Bajrovic A, Rudat V, et al. Prognostic factors in a series of 504 breast cancer patients with metastatic spinal cord compression. Strahlenther Onkol. 2012;188:340-5 pubmed publisher
    ..001). Several new independent prognostic factors were identified for treatment outcomes. These prognostic factors should be considered in future trials and may be used to develop prognostic scores for breast cancer patients with MSCC. ..
  50. Kaesmann L, Janssen S, Schild S, Rades D. Value of Comorbidity Scales for Predicting Survival After Radiochemotherapy of Small Cell Lung Cancer. Lung. 2016;194:295-8 pubmed publisher
    ..Thus, particularly the MRC Breathlessness Scale can contribute to personalization of the treatment of SCLC. ..
  51. request reprint
    Rades D, Dziggel L, Janssen S, Blanck O, Hornung D, Schild S. A Survival Score for Patients Receiving Stereotactic Radiosurgery Alone for Brain Metastases from Breast Cancer. Anticancer Res. 2016;36:1073-6 pubmed
    ..One-year survival rates were 48%, 71% and 100%, respectively (p<0.001). This score contributes to appropriate selection of personalized treatment in patients with breast cancer with few cerebral metastases. ..
  52. request reprint
    Seidl D, Janssen S, Strojan P, Hakim S, Wollenberg B, Schild S, et al. Importance of Chemotherapy and Radiation Dose After Microscopically Incomplete Resection of Stage III/IV Head and Neck Cancer. Anticancer Res. 2016;36:2487-91 pubmed
    ..021). Concurrent chemotherapy and a radiation dose of 66 Gy resulted in better outcomes. Cisplatin and cisplatin/5-FU were similarly effective. Radiation doses >66 Gy appear not to be necessary. ..
  53. request reprint
    Rades D, Conde Moreno A, Cacicedo J, Segedin B, Rudat V, Schild S. Radiation Therapy Alone Provides Excellent Outcomes for Spinal Cord Compression from Vertebral Lymphoma. Anticancer Res. 2016;36:3081-3 pubmed
    ..Freedom from in-field recurrence was 100% at 6 and 12 months. Survival rates at 6 and 12 months were 79% and 75%. RT alone resulted in excellent outcomes for SCC from lymphoma. These patients may not require surgery. ..
  54. Rades D, Veninga T, Bajrovic A, Karstens J, Schild S. A validated scoring system to identify long-term survivors after radiotherapy for metastatic spinal cord compression. Strahlenther Onkol. 2013;189:462-6 pubmed publisher
    ..This new scoring system enabled identification of long-term survivors after RT for MSCC with very high specificity and positive predictive value. The score proved to be valid and reproducible. ..
  55. request reprint
    Rades D, Schild S, Karstens J, Hakim S. Predicting survival of patients with metastatic epidural spinal cord compression from cancer of the head-and-neck. Anticancer Res. 2015;35:385-8 pubmed
    ..Six-month survival rates were 0%, 27%, 71% and 100% (p<0.001). With this new instrument, one can estimate 6-month survival probabilities of patients with MESCC from head-and-neck cancer. ..
  56. Rades D, Huttenlocher S, Veninga T, Bajrovic A, Bremer M, Rudat V, et al. A matched-pair analysis comparing 5x4 Gy and 10x3 Gy for metastatic spinal cord compression (MSCC) in patients with favorable survival prognoses. Radiat Oncol. 2015;10:90 pubmed publisher
    ..64). In patients irradiated for MSCC who had favorable survival prognoses, post-RT motor function, LC and OS were not significantly different after 5x4 Gy and after 10x3 Gy. ..
  57. Rades D, Huttenlocher S, Dunst J, Bajrovic A, Karstens J, Rudat V, et al. Matched pair analysis comparing surgery followed by radiotherapy and radiotherapy alone for metastatic spinal cord compression. J Clin Oncol. 2010;28:3597-604 pubmed publisher
    ..In this study, the outcomes of the end points evaluated after radiotherapy alone appeared similar to those of surgery plus radiotherapy. A new randomized trial comparing both treatments is justified. ..
  58. request reprint
    Janssen S, Dahlke M, Trang N, Khoa M, Rades D. Estimation of the Six-month Survival Probability After Radiosurgery for Brain Metastases from Kidney Cancer. Anticancer Res. 2015;35:4215-7 pubmed
    ..Six-month overall survival rates were 13%, 79% and 100%, respectively (p=0.004). This new score facilitates personalized treatment decisions for patients with kidney cancer with very few brain metastases. ..
  59. request reprint
    Rades D, Dziggel L, Veninga T, Bajrovic A, Schild S. Overall Survival After Whole-Brain Radiation Therapy for Intracerebral Metastases from Testicular Cancer. Anticancer Res. 2016;36:4817-9 pubmed
    ..100% at 6 months and 0% vs. 100% at 12 months (p=0.006), respectively. A simple instrument enabling physicians to judge the overall survival of patients with intracerebral metastasis from testicular cancer is provided. ..
  60. request reprint
    Rades D, Manig L, Janssen S, Schild S. Concurrent Chemotherapy Improves the Overall Survival of Patients Irradiated for Locally Recurrent Bladder Cancer. Anticancer Res. 2017;37:1485-1488 pubmed
    ..076). Addition of concurrent chemotherapy to radiotherapy for locally recurrent bladder cancer resulted in improved overall survival. Concurrent radiochemotherapy should be considered when this is clinically reasonable for such patients. ..
  61. request reprint
    Dziggel L, Gebauer N, Bartscht T, Schild S, Rades D. Performance Status and Number of Metastatic Extra-cerebral Sites Predict Survival After Radiotherapy of Brain Metastases from Thyroid Cancer. Anticancer Res. 2018;38:2391-2394 pubmed
    ..KPS and number of involved extra-cranial metastatic sites were associated with survival and may be helpful for individualizing therapy in patients with brain metastases from thyroid cancer. ..
  62. Heisterkamp C, Haatanen T, Schild S, Rades D. Dose escalation in patients receiving whole-brain radiotherapy for brain metastases from colorectal cancer. Strahlenther Onkol. 2010;186:70-75 pubmed publisher
    ..06). These data suggest that patients with brain metastases from colorectal cancer treated with WBRT alone appeared to benefit from escalation of the radiation dose beyond 10 x 3 Gy in terms of improved OS and LC. ..
  63. request reprint
    Rades D, Huttenlocher S, Rudat V, Hornung D, Blanck O, Phuong P, et al. Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses. Anticancer Res. 2015;35:333-6 pubmed
    ..10). Radiosurgery with 20 Gy resulted in significantly better local control and led to a trend towards improved overall survival compared to treatment with 16-18.5 Gy. ..
  64. Rades D, Huttenlocher S, Bartscht T, Schild S. Predicting the survival probability of gastric cancer patients developing metastatic epidural spinal cord compression (MESCC). Gastric Cancer. 2015;18:881-4 pubmed publisher
    ..Six-month survival rates were 0, 20 and 100 % (p < 0.001). This tool for patients with MESCC from gastric cancer estimates survival probabilities, which is important for tailoring treatment to patients' needs. ..
  65. Rades D, Huttenlocher S, Å egedin B, Perpar A, Conde A, Garcia R, et al. Single-Fraction Versus 5-Fraction Radiation Therapy for Metastatic Epidural Spinal Cord Compression in Patients With Limited Survival Prognoses: Results of a Matched-Pair Analysis. Int J Radiat Oncol Biol Phys. 2015;93:368-72 pubmed publisher
    ..Thus, 8 Gy × 1 fraction may be a reasonable option for patients with survival prognosis of a few months. ..
  66. request reprint
    Rades D, Dahlke M, Janssen S, Gebauer N, Bartscht T. Radiation Therapy for Metastatic Spinal Cord Compression in Patients with Hepatocellular Carcinoma. In Vivo. 2015;29:749-52 pubmed
    ..08). Many patients with MSCC from HCC have a short survival, which can be predicted with a new tool. Radiation therapy can stop progression of motor dysfunction. ..
  67. request reprint
    Rades D, Schild S, Bajrovic A, Janssen S, Bartscht T. Personalized Radiotherapeutic Approaches for Elderly Patients with Epidural Cord Compression from Gastric Cancer. In Vivo. 2016;30:69-72 pubmed
    ..Three-month survival rates for these groups were 0%, 50%, 75% and 100%, respectively (p<0.001). This score is of great assistance when assigning the appropriate RT approach to an elderly patient with ECC from gastric cancer. ..
  68. request reprint
    Rades D, Sehmisch L, Janssen S, Schild S. Prognostic Factors After Whole-brain Radiotherapy Alone for Brain Metastases from Malignant Melanoma. Anticancer Res. 2016;36:6637-6640 pubmed
    ..02-1.56; p=0.030) maintained significance regarding survival. The study identified predictors of survival for patients with melanoma receiving WBRT for brain metastases that can contribute to selection of individualized therapies. ..
  69. Rades D, Schiff D. Epidural and intramedullary spinal metastasis: clinical features and role of fractionated radiotherapy. Handb Clin Neurol. 2018;149:227-238 pubmed publisher
    ..Herein we review the clinical manifestations, pathophysiology, importance of early diagnosis and initiation of treatment, and role of fractionated radiotherapy of these disorders. ..
  70. request reprint
    Rades D, Huttenlocher S, Dziggel L, Blanck O, Hornung D, Mai K, et al. A new tool to predict survival after radiosurgery alone for newly diagnosed cerebral metastases. Asian Pac J Cancer Prev. 2015;16:2967-70 pubmed
    ..As cause of death in group B was mostly new cerebral metastases, additional WBI appears even more important for this group. ..
  71. Rades D, Conde Moreno A, Segedin B, Veninga T, Cacicedo J, Schild S. A Prognostic Instrument to Estimate the Survival of Elderly Patients Irradiated for Metastatic Epidural Spinal Cord Compression From Lung Cancer. Clin Lung Cancer. 2016;17:279-84 pubmed publisher
    ..This new instrument will enable physicians to predict the survival prognosis of elderly patients with lung cancer-related MESCC, facilitating individualized treatment care. ..
  72. Rades D, Huttenlocher S, Bajrovic A, Karstens J, Adamietz I, Kazic N, et al. Surgery followed by radiotherapy versus radiotherapy alone for metastatic spinal cord compression from unfavorable tumors. Int J Radiat Oncol Biol Phys. 2011;81:e861-8 pubmed publisher
    ..30); 45% and 18% of patients regained ambulatory status (p=0.29). Patients with MSCC from an unfavorable primary tumor appeared to benefit from DDSS but not LE when added to radiotherapy in terms of improved functional outcome. ..
  73. request reprint
    Dziggel L, Dahlke M, Janssen S, Hornung D, Blanck O, Khoa M, et al. Predicting the Risk of New Cerebral Lesions After Stereotactic Radiosurgery (SRS) for Brain Metastases from Breast Cancer. Anticancer Res. 2015;35:6793-7 pubmed
    ..Freedom from new cerebral metastases rates were 27% and 92%, respectively, at 15 months (p=0.003). This tool helps select breast cancer with few cerebral metastases receiving SRS who may benefit from additional whole-brain irradiation. ..
  74. request reprint
    Rades D, Conde Moreno A, Gebauer N, Bartscht T, Cacicedo J, Segedin B, et al. Immunoglobulin G (IgG) Subtype Is Associated with a Favorable Survival Prognosis in Patients Irradiated for Spinal Cord Compression from Myeloma. Anticancer Res. 2016;36:375-8 pubmed
    ..44; 95% confidence interval=1.56-3.85; p<0.001). This study identified myeloma subtype as being an independent prognostic factor of survival in patients with SCC from myeloma. ..
  75. request reprint
    Janssen S, Kaesmann L, Schild S, Rades D. Impact of the Radiation Dose and Completion of Palliative Radiotherapy on Survival in Patients Treated for Locally Advanced Lung Cancer. Anticancer Res. 2016;36:1825-8 pubmed
    ..Higher RT doses resulted in significantly better survival than lower doses. The favorable results were impaired when the planned treatment could not be completed. ..
  76. request reprint
    Seidl D, Janssen S, Strojan P, Bajrovic A, Schild S, Rades D. Prognostic Factors After Definitive Radio(Chemo)Therapy of Locally Advanced Head and Neck Cancer. Anticancer Res. 2016;36:2523-6 pubmed
    ..001) were predictors of improved OS. Predictors of LRC and OS were identified that can improve personalization of treatment. Since chemotherapy type was associated with OS, studies comparing different regimens are warranted. ..
  77. request reprint
    Sehmisch L, Schild S, Rades D. Development of a Survival Score for Patients with Cerebral Metastases from Melanoma. Anticancer Res. 2017;37:249-252 pubmed
    ..0001). A survival score was developed for patients assigned to WBI alone for cerebral metastases from melanoma. This new instrument may facilitate the decision for the appropriate WBI-program. ..
  78. request reprint
    Rades D, Seidl D, Janssen S, Hakim S, Wollenberg B, Bartscht T, et al. A New Scoring-system for Estimating Overall Survival After Radiotherapy of Recurrent Head and Neck Cancers. Anticancer Res. 2018;38:1611-1613 pubmed
    ..0001). This new scoring system includes three groups of patients with significantly different OS prognoses and can assist physicians when designing individualized therapy for locoregional recurrences of head and neck cancer. ..
  79. Rades D, Huttenlocher S, Hornung D, Blanck O, Schild S, Fischer D. Do patients with very few brain metastases from breast cancer benefit from whole-brain radiotherapy in addition to radiosurgery?. Radiat Oncol. 2014;9:267 pubmed publisher
    ..However, this advantage did not lead to significantly better survival. ..
  80. request reprint
    Rades D, Dahlke M, Dziggel L, Janssen S, Bajrovic A, Trang N, et al. Defining the Optimal Dose of Stereotactic Radiosurgery for Treating Cerebral Metastases in Elderly Patients. Anticancer Res. 2015;35:5701-4 pubmed
    ..069). Overall survival rates at 12 months were 29% and 31%, respectively (p=0.67). SRS with 16-18 Gy was not significantly inferior to SRS with 20 Gy in elderly patients with few cerebral metastases. ..
  81. request reprint
    Rades D, Bolm L, Schild S, Bartscht T. Survival Following Palliative External-beam Radiotherapy of Locally Advanced and Metastatic Liver Cancer. Anticancer Res. 2017;37:203-206 pubmed
    ..68, p=0.056) showed a strong trend for association with survival. Predictors of survival were found that can facilitate choosing the optimal treatment for individual patients with liver cancer assigned to palliative EBRT. ..
  82. request reprint
    Käsmann L, Janssen S, Schild S, Rades D. Impact of the Radiation Dose on Survival after Radiochemotherapy for Small-cell Lung Cancer. Anticancer Res. 2016;36:1089-91 pubmed
    ..This study identified several independent predictors of survival after radiochemotherapy of small-cell lung cancer. A radiation dose of ≥56 Gy resulted in better survival than lower doses. ..
  83. request reprint
    Rades D, Bartscht T, Janssen S, Bajrovic A, Segedin B, Schild S. Forecasting Survival Probabilities After Radiotherapy of Metastatic Epidural Spinal Cord Compression from Colorectal Cancer in the Elderly. Anticancer Res. 2016;36:1829-33 pubmed
    ..001). By applying this tool, it is possible to forecast the survival of elderly patients experiencing MESCC from CRC, which is important for optimal treatment personalization. ..
  84. Rades D, Conde Moreno A, Cacicedo J, Veninga T, Gebauer N, Bartscht T, et al. A predictive tool particularly designed for elderly myeloma patients presenting with spinal cord compression. BMC Cancer. 2016;16:292 pubmed publisher
    ..It allows estimating the survival prognosis of this patient group and supports the treating physicians when looking for the optimal treatment approach for an individual patient. ..
  85. Rades D, Seidl D, Janssen S, Bajrovic A, Hakim S, Wollenberg B, et al. Chemoradiation of locally advanced squamous cell carcinoma of the head-and-neck (LASCCHN): Is 20mg/m(2) cisplatin on five days every four weeks an alternative to 100mg/m(2) cisplatin every three weeks?. Oral Oncol. 2016;59:67-72 pubmed publisher
    ..Given the limitations of a retrospective study, 20mg/m(2) cisplatin appeared preferable. The results should be confirmed in a randomized trial. ..
  86. Rades D, Seidl D, Janssen S, Strojan P, Karner K, Bajrovic A, et al. Comparing two lower-dose cisplatin programs for radio-chemotherapy of locally advanced head-and-neck cancers. Eur Arch Otorhinolaryngol. 2017;274:1021-1027 pubmed publisher
    ..Confirmation of these results in a randomized trial is warranted. ..
  87. Rades D, Janssen S, Dziggel L, Blanck O, Bajrovic A, Veninga T, et al. A matched-pair study comparing whole-brain irradiation alone to radiosurgery or fractionated stereotactic radiotherapy alone in patients irradiated for up to three brain metastases. BMC Cancer. 2017;17:30 pubmed publisher
    ..These results can be considered a revision of the findings from our retrospective previous study without matched-pair design, where RS alone resulted in significantly better IC than WBI alone on multivariate analysis. ..
  88. Käsmann L, Manig L, Janssen S, Rades D. Chemoradiation Including Paclitaxel for Locally Recurrent Muscle-invasive Bladder Cancer in Elderly Patients. In Vivo. 2017;31:239-241 pubmed
    ..Chemoradiation with a less intensive paclitaxel regimen resulted in excellent 5-year results and was very well tolerated. It may be a reasonable option for elderly patients who cannot tolerate more intensive approaches. ..
  89. Janssen S, Kaesmann L, Rudat V, Rades D. Stereotactic Body Radiotherapy (SBRT) with Lower Doses for Selected Patients with Stage I Non-small-cell Lung Cancer (NSCLC). Lung. 2016;194:291-4 pubmed publisher
    ..Thus, SBRT with BED <90 Gy resulted in excellent local control and appears to be a reasonable option for stage I NSCLC in elderly patients and those with a poor performance status. ..
  90. request reprint
    Bolm L, Janssen S, Bartscht T, Rades D. Radiotherapy Alone for Malignant Spinal Cord Compression in Young Men with Seminoma. Anticancer Res. 2016;36:2033-4 pubmed
    ..Radiotherapy alone resulted in excellent outcomes. If clear indications for neurosurgery are not given, radiotherapy alone can be considered the treatment of choice for patients with MSCC from seminoma. ..
  91. Rades D, Seidl D, Janssen S, Wollenberg B, Hakim S, Schild S. The effect of low hemoglobin levels on outcomes of radiotherapy following microscopically complete resection of locally advanced SCCHN: Implications for the future. J Craniomaxillofac Surg. 2016;44:1441-4 pubmed publisher
    ..Levels <12 g/dl were associated with worse outcomes than ≥12 g/dl. Tumor cell oxygenation and correction of anemia appear important also after R0-resection. ..
  92. request reprint
    Rades D, Manig L, Janssen S, Schild S. A Survival Score for Patients Assigned to Palliative Radiotherapy for Metastatic Bladder Cancer. Anticancer Res. 2017;37:1481-1484 pubmed
    ..002), respectively. A new survival score was developed. Patients with 6-8 points should receive less aggressive treatments for metastatic bladder cancer. Those with 10-12 points may receive more intensive approaches. ..