Simon W Rabkin

Summary

Publications

  1. doi Myocardial perfusion pressure in patients with hypertension and coronary artery disease: implications for DBP targets in hypertension management
    Simon W Rabkin
    Department of Medicine Cardiology, University of British Columbia, Vancouver, British Columbia, Canada
    J Hypertens 31:975-82. 2013
  2. pmc The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2--therapy
    Nadia A Khan
    Division of General Internal Medicine, University of British Columbia, Vancouver, Canada
    Can J Cardiol 25:287-98. 2009
  3. ncbi The action of nitric oxide to enhance cell survival in chick cardiomyocytes is mediated through a cGMP and ERK1/2 pathway while p38 mitogen-activated protein kinase-dependent pathways do not alter cell death
    Simon W Rabkin
    University of British Columbia, Level 9, 2775 Laurel Street, Vancouver, BC, Canada V5Z 1M9
    Exp Physiol 93:834-42. 2008
  4. doi The metalloporphyrin FeTPPS but not by cyclosporin A antagonizes the interaction of peroxynitrate and hydrogen peroxide on cardiomyocyte cell death
    Shaun S Klassen
    University of British Columbia, Vancouver, BC, V5Z 1M9, Canada
    Naunyn Schmiedebergs Arch Pharmacol 379:149-61. 2009
  5. doi Interaction of the HMG-CoA reductase inhibitor lovastatin and nitric oxide in cardiomyocyte cell death
    Simon W Rabkin
    University of British Columbia, Vancouver, BC, Canada
    Pharmacology 82:74-82. 2008
  6. ncbi P38 MAP kinase in valve interstitial cells is activated by angiotensin II or nitric oxide/peroxynitrite, but reduced by Toll-like receptor-2 stimulation
    Simon W Rabkin
    Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, B C, Canada
    J Heart Valve Dis 18:653-61. 2009
  7. pmc The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy
    Nadia A Khan
    Division of General Internal Medicine, University of British Columbia, Vancouver, Canada
    Can J Cardiol 24:465-75. 2008
  8. pmc The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy
    Nadia A Khan
    Division of General Internal Medicine, University of British Columbia, Vancouver, British Columbia
    Can J Cardiol 23:539-50. 2007
  9. doi p38 mitogen-activated protein kinase (MAPK) is activated by noradrenaline and serves a cardioprotective role, whereas adrenaline induces p38 MAPK dephosphorylation
    Michael Yc Tsang
    University of British Columbia, Department of Medicine Cardiology, Vancouver, British Columbia, Canada
    Clin Exp Pharmacol Physiol 36:e12-9. 2009
  10. doi Palmitate-induced NO production has a dual action to reduce cell death through NO and accentuate cell death through peroxynitrite formation
    Simon W Rabkin
    University of British Columbia, 9th Floor, 2775 Laurel Street, Vancouver, BC, Canada V5Z 1M9
    Prostaglandins Leukot Essent Fatty Acids 78:147-55. 2008

Collaborators

Detail Information

Publications27

  1. doi Myocardial perfusion pressure in patients with hypertension and coronary artery disease: implications for DBP targets in hypertension management
    Simon W Rabkin
    Department of Medicine Cardiology, University of British Columbia, Vancouver, British Columbia, Canada
    J Hypertens 31:975-82. 2013
    ..Focusing only on one determinant of coronary blood flow (CBF) - myocardial perfusion pressure (MPP) - coronary BP in patients with hypertension was used to estimate the impact of setting BP targets...
  2. pmc The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2--therapy
    Nadia A Khan
    Division of General Internal Medicine, University of British Columbia, Vancouver, Canada
    Can J Cardiol 25:287-98. 2009
    ..To update the evidence-based recommendations for the prevention and management of hypertension in adults for 2009...
  3. ncbi The action of nitric oxide to enhance cell survival in chick cardiomyocytes is mediated through a cGMP and ERK1/2 pathway while p38 mitogen-activated protein kinase-dependent pathways do not alter cell death
    Simon W Rabkin
    University of British Columbia, Level 9, 2775 Laurel Street, Vancouver, BC, Canada V5Z 1M9
    Exp Physiol 93:834-42. 2008
    ..Not all cGMP targets affect NO-induced cell death, since the PKG pathway does not enhance or suppress NO-induced cardiomyocyte cell death. Enhancement of the ERK1/2 responses to NO may permit the beneficial effects of NO to predominate...
  4. doi The metalloporphyrin FeTPPS but not by cyclosporin A antagonizes the interaction of peroxynitrate and hydrogen peroxide on cardiomyocyte cell death
    Shaun S Klassen
    University of British Columbia, Vancouver, BC, V5Z 1M9, Canada
    Naunyn Schmiedebergs Arch Pharmacol 379:149-61. 2009
    ..The ability of FeTPPS to reduce reactive nitrogen-induced cell death, and protein nitration suggests that FeTPPS is a useful agent to maintain cell viability and is better than cyclosporin in this situation...
  5. doi Interaction of the HMG-CoA reductase inhibitor lovastatin and nitric oxide in cardiomyocyte cell death
    Simon W Rabkin
    University of British Columbia, Vancouver, BC, Canada
    Pharmacology 82:74-82. 2008
    ..The objective of this study was to examine the interaction ofa 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (statin) with a nitric oxide (NO) donor from the perspective of the impact on cardiomyocyte cell viability...
  6. ncbi P38 MAP kinase in valve interstitial cells is activated by angiotensin II or nitric oxide/peroxynitrite, but reduced by Toll-like receptor-2 stimulation
    Simon W Rabkin
    Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, B C, Canada
    J Heart Valve Dis 18:653-61. 2009
    ..A variety of proinflammatory factors utilize Toll-like receptors, and these may also play a role in the development of aortic valve disease...
  7. pmc The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy
    Nadia A Khan
    Division of General Internal Medicine, University of British Columbia, Vancouver, Canada
    Can J Cardiol 24:465-75. 2008
    ..To update the evidence-based recommendations for the prevention and management of hypertension in adults...
  8. pmc The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy
    Nadia A Khan
    Division of General Internal Medicine, University of British Columbia, Vancouver, British Columbia
    Can J Cardiol 23:539-50. 2007
    ..To provide updated, evidence-based recommendations for the prevention and management of hypertension in adults...
  9. doi p38 mitogen-activated protein kinase (MAPK) is activated by noradrenaline and serves a cardioprotective role, whereas adrenaline induces p38 MAPK dephosphorylation
    Michael Yc Tsang
    University of British Columbia, Department of Medicine Cardiology, Vancouver, British Columbia, Canada
    Clin Exp Pharmacol Physiol 36:e12-9. 2009
    ..In contrast, beta-adrenoceptor stimulation produces dephosphorylation of p38 MAPK...
  10. doi Palmitate-induced NO production has a dual action to reduce cell death through NO and accentuate cell death through peroxynitrite formation
    Simon W Rabkin
    University of British Columbia, 9th Floor, 2775 Laurel Street, Vancouver, BC, Canada V5Z 1M9
    Prostaglandins Leukot Essent Fatty Acids 78:147-55. 2008
    ..The protective effect of NO is operative through stimulation of NOS2 but not NOS3. The actions of NO on palmitate-induced cell death are independent of mitochondrial cell death pathways...
  11. doi Inflammatory biomarkers CRP, MCP-1, serum amyloid alpha and interleukin-18 in patients with HTN and dyslipidemia: impact of diabetes mellitus on metabolic syndrome and the effect of statin therapy
    Simon W Rabkin
    University of British Columbia, Vancouver, British Columbia, Canada
    Hypertens Res 36:550-8. 2013
    ..In addition, there are different responses to statins depending on the nature of the inflammatory marker...
  12. ncbi Renal denervation therapy for the treatment of resistant hypertension: a position statement by the Canadian Hypertension Education Program
    Nadia A Khan
    Division of General Internal Medicine, University of British Columbia, Vancouver, British Columbia, Canada Electronic address
    Can J Cardiol 30:16-21. 2014
    ..Until more data are available, renal sympathetic denervation should be considered as a treatment option of last resort for patients with resistant hypertension who have exhausted all other available medical management options...
  13. ncbi Sodium nitroprusside activates p38 mitogen activated protein kinase through a cGMP/PKG independent mechanism
    Simon W Rabkin
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Life Sci 81:640-6. 2007
    ....
  14. doi Jumonji is a potential regulatory factor mediating nitric oxide-induced modulation of cardiac hypertrophy
    Simon W Rabkin
    Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Cardiovasc Med (Hagerstown) 10:206-11. 2009
    ..It regulates the expression of several genes, in particular genes involved in cardiac cell growth in the embryonic heart. The function of jmj in the mature or developed heart, however, is unclear...
  15. ncbi The role of p53 in nitric oxide-induced cardiomyocyte cell death
    Shaun S Klassen
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    DNA Cell Biol 26:465-75. 2007
    ..NO-induced cell death, however, operates through p53-independent pathways, including a mitochondrial apoptotic pathway...
  16. doi Metalloporphyrins as a therapeutic drug class against peroxynitrite in cardiovascular diseases involving ischemic reperfusion injury
    Simon W Rabkin
    Cardiovascular Medicine, University of British Columbia, Vancouver, B C, Canada
    Eur J Pharmacol 586:1-8. 2008
    ..The data suggest that modification of peroxynitrite-induced cardiovascular injury is an intriguing and useful treatment approach...
  17. doi Stearic acid-induced cardiac lipotoxicity is independent of cellular lipid and is mitigated by the fatty acids oleic and capric acid but not by the PPAR agonist troglitazone
    Simon W Rabkin
    University of British Columbia, 9th Floor, 2775 Laurel Street, Vancouver, BC V5Z1M9, Canada
    Exp Physiol 94:877-87. 2009
    ..Troglitazone has potential cardiotoxicity at high doses but, at lower concentrations, does not prevent cardiac lipotoxicity, which can be completely prevented by low concentrations of oleic acid...
  18. doi Nitric oxide and peroxynitrite induce gene expression of interleukin receptors increasing IL-21, IL-7, IL-1 and oncostatin M in cardiomyocytes
    Simon W Rabkin
    University of British Columbia, Vancouver, B C Canada
    Life Sci 86:45-51. 2010
    ..The objective of this investigation was to determine whether nitric oxide (NO) and peroxynitrite alter the gene expression of interleukin receptors (IL-R) in cardiomyocytes...
  19. ncbi Reduction of protein synthesis and statin-induced cardiomyocyte cell death
    Simon W Rabkin
    University of British Columbia, Level 9, 2775 Laurel St, Vancouver, BC, Canada V5Z 1M9
    Cardiovasc Toxicol 7:1-9. 2007
    ..These data suggest that statin-induced inhibition of protein synthesis is an underlying mechanism for statin-induced cell death...
  20. pmc Achieving cholesterol targets by individualizing starting doses of statin according to baseline low-density lipoprotein cholesterol and coronary artery disease risk category: the CANadians Achieve Cholesterol Targets Fast with Atorvastatin Stratified Titr
    Ehud Ur
    University of British Columbia, Vancouver, BC, Canada
    Can J Cardiol 26:80-6. 2010
    ..Despite an increasing body of evidence on the benefit of lowering elevated levels of low-density lipoprotein cholesterol (LDL-C), there is still considerable concern that patients are not achieving target LDL-C levels...
  21. ncbi Aortic valve sclerosis is associated with an echocardiographically determined thinner aortic wall
    Simon W Rabkin
    Department of Medicine Cardiology, University of British Columbia, Vancouver, BC, Canada
    J Heart Valve Dis 15:158-64. 2006
    ....
  22. pmc The 2006 Canadian Hypertension Education Program recommendations for the management of hypertension: Part II - Therapy
    N A Khan
    Division of General Internal Medicine, University of British Columbia, Vancouver, BC, Canada
    Can J Cardiol 22:583-93. 2006
    ..To provide updated, evidence-based recommendations for the management of hypertension in adults...
  23. ncbi Nitric oxide-induced cell death in the heart: the role of autophagy
    Simon W Rabkin
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Autophagy 3:347-9. 2007
    ....
  24. ncbi Endogenous kappa opioids mediate the action of brain angiotensin II to increase blood pressure
    Simon W Rabkin
    University of British Columbia, 9th Floor 2775 Laurel St, Vancouver, BC, Canada V5Z 1M9
    Neuropeptides 41:411-9. 2007
    ....
  25. ncbi The role of interleukin 18 in the pathogenesis of hypertension-induced vascular disease
    Simon W Rabkin
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Nat Clin Pract Cardiovasc Med 6:192-9. 2009
    ..This Review examines the data on IL-18 and hypertensive vascular disease, and explores the potential cellular and molecular mechanisms that might connect hypertension to vascular disease...
  26. ncbi The association of hypertension and aortic valve sclerosis
    Simon W Rabkin
    Department of Medicine Cardiology, University of British Columbia, Vancouver, Canada
    Blood Press 14:264-72. 2005
    ..The objective of this study is to critically review the data on the association of blood pressure and hypertension with AVS...