Gabriel A Rabinovich

Summary

Publications

  1. pmc Mast cells rescue implantation defects caused by c-kit deficiency
    K Woidacki
    Experimental Obstetrics and Gynecology, Medical Faculty, Otto von Guericke University, Magdeburg, Germany
    Cell Death Dis 4:e462. 2013
  2. pmc Glycobiology of immune responses
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Ciudad de Buenos Aires, Argentina
    Ann N Y Acad Sci 1253:1-15. 2012
  3. doi request reprint Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, C1428 Buenos Aires, Argentina
    Immunity 36:322-35. 2012
  4. pmc "Time sweet time": circadian characterization of galectin-1 null mice
    Leandro P Casiraghi
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Argentina
    J Circadian Rhythms 8:4. 2010
  5. ncbi request reprint Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors
    Diego O Croci
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, 1428 Buenos Aires, Argentina
    Cell 156:744-58. 2014
  6. pmc Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma
    Diego O Croci
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, 1428 Buenos Aires, Argentina
    J Exp Med 209:1985-2000. 2012
  7. doi request reprint Nuclear factor (NF)-κB controls expression of the immunoregulatory glycan-binding protein galectin-1
    Marta A Toscano
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Tecnológicas CONICET, Buenos Aires, Argentina
    Mol Immunol 48:1940-9. 2011
  8. doi request reprint Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: mechanisms and biomedical applications
    Ivan D Mascanfroni
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, C1428 Ciudad de Buenos Aires, Argentina
    Int Immunopharmacol 11:833-41. 2011
  9. doi request reprint Targeting galectin-1 overcomes breast cancer-associated immunosuppression and prevents metastatic disease
    Tomás Dalotto-Moreno
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Buenos Aires, Argentina
    Cancer Res 73:1107-17. 2013
  10. doi request reprint Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments
    Rocío Soldati
    Laboratory of Pediatric Immunotherapy, Department of Pediatrics, Medical Faculty, Otto von Guericke University of Magdeburg, Germany
    Int J Cancer 131:1131-41. 2012

Collaborators

  • Norberto W Zwirner
  • Eduardo Osinaga
  • M Maurer
  • A Schumacher
  • Carlos Bais
  • Nikolay E Nifantiev
  • S Fest
  • A C Zenclussen
  • Ingrid S Cogno
  • Yvette van Kooyk
  • Stefano Iacobelli
  • Licia Totani
  • Osvaldo L Podhajcer
  • Adriana Albini
  • Diego O Croci
  • Mariana Salatino
  • Juan M Ilarregui
  • Juan P Cerliani
  • Marta A Toscano
  • Ivan D Mascanfroni
  • Santiago P Méndez-Huergo
  • Santiago Di Lella
  • Tomás Dalotto-Moreno
  • Sebastián Dergan-Dylon
  • Carolina I Domaica
  • Jing Ouyang
  • Enrique A Mesri
  • Margaret A Shipp
  • K Woidacki
  • Julio J Caramelo
  • Rocío Soldati
  • Victoria Sundblad
  • Maria V Espelt
  • Dario A Estrin
  • Mercedes B Fuertes
  • Leandro P Casiraghi
  • German A Bianco
  • Mauricio F Farez
  • Karina Mariño
  • Jorge Correale
  • Melissa R Junttila
  • Sebastián M Maller
  • Juan J Garcia-Vallejo
  • Verónica C Martinez-Allo
  • A Teles
  • Juan C Stupirski
  • F Jensen
  • Daniel Mazal
  • M Popovic
  • N Linzke
  • F Poirier
  • M Metz
  • Holger N Lode
  • Natalia Rubinstein
  • Lucas E Cavallin
  • Gerhard Jorch
  • María C Croci
  • Howard J Leung
  • Elisa Berger
  • Connie M Arthur
  • Marina E Preobrazhenskaya
  • Carlos M Guardia
  • Marina C Muñoz
  • Galina E Morozevich
  • Albana Cumashi
  • María L Bacigalupo
  • María T Elola
  • Maeve Kelly
  • Fernando P Dominici
  • Alexey A Grachev
  • Albert E Berman
  • Cosmo Rossi
  • Monica A Costas
  • Craig J Sanderson
  • Natalia A Ushakova
  • Malena Manzi
  • Sean R Stowell
  • Antonio Piccoli
  • Patrizia Di Gregorio
  • Maria I Bilan
  • Leonardo Campagna
  • Richard D Cummings
  • Gerardo R Vasta
  • Juan P Fededa
  • Anatolii I Usov
  • María F Troncoso
  • Luciana L Molinero
  • Nicola Tinari
  • Nadezhda E Ustyuzhanina
  • Ignacio M Nojek

Detail Information

Publications26

  1. pmc Mast cells rescue implantation defects caused by c-kit deficiency
    K Woidacki
    Experimental Obstetrics and Gynecology, Medical Faculty, Otto von Guericke University, Magdeburg, Germany
    Cell Death Dis 4:e462. 2013
    ..Our data unveil unrecognized roles for MCs at the fetomaternal interface with critical implications in reproductive medicine...
  2. pmc Glycobiology of immune responses
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Ciudad de Buenos Aires, Argentina
    Ann N Y Acad Sci 1253:1-15. 2012
    ..Here, we attempt to summarize general concepts on glycans and glycan-binding proteins (mainly C-type lectins, siglecs, and galectins) and their contributions to the biology of immune responses in physiologic and pathologic settings...
  3. doi request reprint Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, C1428 Buenos Aires, Argentina
    Immunity 36:322-35. 2012
    ..We also discuss the mechanisms by which glycan-dependent regulatory programs integrate into canonical circuits that amplify or silence immune responses related to autoimmunity and neoplastic disease...
  4. pmc "Time sweet time": circadian characterization of galectin-1 null mice
    Leandro P Casiraghi
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Argentina
    J Circadian Rhythms 8:4. 2010
    ..To further analyze the role of endogenous galectin-1 in vivo, we aimed to characterize the circadian behavior of galectin-1 null (Lgals1-/-) mice...
  5. ncbi request reprint Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors
    Diego O Croci
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, 1428 Buenos Aires, Argentina
    Cell 156:744-58. 2014
    ..Thus, targeting glycosylation-dependent lectin-receptor interactions may increase the efficacy of anti-VEGF treatment. PAPERFLICK: ..
  6. pmc Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma
    Diego O Croci
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, 1428 Buenos Aires, Argentina
    J Exp Med 209:1985-2000. 2012
    ....
  7. doi request reprint Nuclear factor (NF)-κB controls expression of the immunoregulatory glycan-binding protein galectin-1
    Marta A Toscano
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Tecnológicas CONICET, Buenos Aires, Argentina
    Mol Immunol 48:1940-9. 2011
    ..The present study suggest a novel regulatory loop by which NF-κB induces expression of Gal-1, which in turn may lead to negative control of NF-κB signaling...
  8. doi request reprint Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: mechanisms and biomedical applications
    Ivan D Mascanfroni
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, C1428 Ciudad de Buenos Aires, Argentina
    Int Immunopharmacol 11:833-41. 2011
    ....
  9. doi request reprint Targeting galectin-1 overcomes breast cancer-associated immunosuppression and prevents metastatic disease
    Tomás Dalotto-Moreno
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Buenos Aires, Argentina
    Cancer Res 73:1107-17. 2013
    ..Taken together, our results offer a preclinical proof of concept that therapeutic targeting of Gal1 can overcome breast cancer-associated immunosuppression and can prevent metastatic disease...
  10. doi request reprint Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments
    Rocío Soldati
    Laboratory of Pediatric Immunotherapy, Department of Pediatrics, Medical Faculty, Otto von Guericke University of Magdeburg, Germany
    Int J Cancer 131:1131-41. 2012
    ..These results demonstrate a novel immunoinhibitory role of the Gal-1-glycan axis in NB, highlighting an alternative target for novel immunotherapeutic modalities...
  11. doi request reprint Fine-tuning antitumor responses through the control of galectin-glycan interactions: an overview
    Mariana Salatino
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Methods Mol Biol 677:355-74. 2011
    ..In this review, we will highlight recent findings on how galectin-glycan lattices control the dialogue between tumor and immune cells and how these interactions could be exploited for therapeutic purposes...
  12. doi request reprint Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
    Juan M Ilarregui
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Nat Immunol 10:981-91. 2009
    ..Our findings identify a tolerogenic circuit linking galectin-1 signaling, IL-27-producing DCs and IL-10-secreting T cells, which has broad therapeutic implications in immunopathology...
  13. doi request reprint Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, C1428, Ciudad de Buenos Aires, Argentina
    Nat Rev Immunol 9:338-52. 2009
    ....
  14. doi request reprint Conveying glycan information into T-cell homeostatic programs: a challenging role for galectin-1 in inflammatory and tumor microenvironments
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Ciudad de Buenos Aires, Argentina
    Immunol Rev 230:144-59. 2009
    ....
  15. doi request reprint Tolerogenic dendritic cells in the control of autoimmune neuroinflammation: an emerging role of protein-glycan interactions
    Juan M Ilarregui
    Laboratorio de Inmunopatología, Instituto de Biologia, Buenos Aires, Argentina
    Neuroimmunomodulation 17:157-60. 2010
    ..In addition, we will underscore recent findings on the emerging role of galectin-glycan interactions in the establishment of immunosuppressive networks during the resolution of chronic inflammation...
  16. pmc When galectins recognize glycans: from biochemistry to physiology and back again
    Santiago Di Lella
    Laboratorio de Inmunopatologı́a, Instituto de Biologı́a y Medicina Experimental, CONICET, Ciudad de Buenos Aires, Argentina
    Biochemistry 50:7842-57. 2011
    ..In this review, we aim to integrate structural, biochemical, and functional aspects of this bewildering and ancient family of glycan-binding proteins and discuss their implications in physiologic and pathologic settings...
  17. ncbi request reprint Overcoming the hurdles of tumor immunity by targeting regulatory pathways in innate and adaptive immune cells
    Norberto W Zwirner
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Buenos Aires, Argentina
    Curr Pharm Des 16:255-67. 2010
    ....
  18. pmc Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling
    Ivan D Mascanfroni
    Centro de Investigaciones en Bioquimica Clinica e Inmunologia, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, 5000 Cordoba, Argentina
    J Biol Chem 285:9569-82. 2010
    ..These results underscore a novel unrecognized target that regulates DC maturation and function with critical implications in immunopathology at the cross-roads of the immune-endocrine circuits...
  19. doi request reprint Expanding the universe of cytokines and pattern recognition receptors: galectins and glycans in innate immunity
    Juan P Cerliani
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, 1428 Buenos Aires, Argentina
    J Clin Immunol 31:10-21. 2011
    ..Challenges for the future will embrace the rational manipulation of galectin-glycan interactions to instruct and shape innate immunity during microbial infections, inflammation, and cancer...
  20. doi request reprint Novel roles of galectin-1 in hepatocellular carcinoma cell adhesion, polarization, and in vivo tumor growth
    Maria V Espelt
    Instituto de Quimica y Fisicoquimica Biologicas, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Hepatology 53:2097-106. 2011
    ..Finally, expression levels of this endogenous lectin correlated with HCC cell adhesion and polarization and up-regulation of Gal-1-favored growth of hepatocarcinoma in vivo...
  21. ncbi request reprint Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer
    Mariana Salatino
    Instituto de Biología y Medicina Experimental IBYME, Laboratorio de Inmunopatología, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Argentina
    Expert Opin Biol Ther 8:45-57. 2008
    ..Here the authors review the dual role of galectin-1 as a selective immunosuppressive agent in T helper (T(H))1 and T(H)17-mediated inflammatory/autoimmune disorders and a potential therapeutic target in cancer and metastasis...
  22. doi request reprint Linking the structure and thermal stability of beta-galactoside-binding protein galectin-1 to ligand binding and dimerization equilibria
    Santiago Di Lella
    Departamento de Quimica Inorganica, Analitica y Quimica Fisica INQUIMAE CONICET, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina
    Biochemistry 49:7652-8. 2010
    ....
  23. pmc Tumour-experienced T cells promote NK cell activity through trogocytosis of NKG2D and NKp46 ligands
    Carolina I Domaica
    Institute of Biology and Experimental Medicine IBYME, National Research Council CONICET, Ciudad de Buenos Aires, Argentina
    EMBO Rep 10:908-15. 2009
    ..Our findings identify a new, so far, unrecognized mechanism by which effector T cells support NK cell function through the capture of specific tumour ligands with profound implications at the crossroad of innate and adaptive immunity...
  24. pmc Fucans, but not fucomannoglucuronans, determine the biological activities of sulfated polysaccharides from Laminaria saccharina brown seaweed
    Diego O Croci
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas y Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina
    PLoS ONE 6:e17283. 2011
    ..Thus, sulfated fucans are mainly responsible for the anti-inflammatory, anticoagulant, antiangiogenic, and antitumor activities of sulfated polysaccharides from L. saccharina brown seaweed...
  25. ncbi request reprint Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation
    Santiago P Méndez-Huergo
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas IBYME CONICET, C1428 Buenos Aires, Argentina
    Cytokine Growth Factor Rev 25:247-55. 2014
    ..Understanding the regulatory circuits governed by lectin-glycan interactions and their association with disease-associated cytokine networks will contribute to develop novel therapeutic strategies in MS. ..
  26. doi request reprint Silencing survivin gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway
    Diego O Croci
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Buenos Aires, Argentina
    J Cell Biochem 105:381-90. 2008
    ..Thus, silencing survivin expression using siRNA strategies represents a suitable therapeutic approach to selectively modulate the survival and growth of human breast cancer cells...