Jeongchan Ra

Summary

Affiliation: RNLBIO
Location: Seoul, Korea
Summary:
RNL BIO CO.,LTD., Chairman
Bethesda Hospital, Chairman
Seoul National University,Veterinary Medicine,Adjunct professor
Far East Broadcasting Co., Korea, Auditor
Ulaanbaatar University Foundation, Director
Academia Christiana of Korea, Director
Korea Bio Venture Associlation, Director
Korean Society for Zoonoses, Director
Korean Society of Veterinary Medicine, International Collaboration Committee
Grants:
LG research and developing grant (2000)
The venture business grand prize(2003)
Grand Prize at the 2007 Korea Technology Awards (2007)
Korea New Technology Product Frontier Awards (2009)
Jangyeongsil Korea Science and Technology Awards (2009)
Asia Emerging Company of the Year 2010 BioSpectrum Pacific Award (2010)
Korea Academia Christiana Awards (2011)

Publications

  1. ncbi Safety of intravenous infusion of human adipose tissue-derived mesenchymal stem cells in animals and humans
    Jeong Chan Ra
    Stem Cell Research Center, RNL BIO Co, Ltd, Seoul, Republic of Korea
    Stem Cells Dev 20:1297-308. 2011
  2. pmc Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells
    Jeong Chan Ra
    Stem Cell Research Center, RNL BIO, Seoul, 153 768, Republic of Korea
    J Transl Med 9:181. 2011
  3. ncbi Chemopreventive properties of the ethanol extract of chinese licorice (Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells
    Eun Hye Jo
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, San 56 1, Shillim Dong, Kwanak gu, Seoul 151 742, South Korea
    Cancer Lett 230:239-47. 2005
  4. doi Reversal of serologic, immunologic, and histologic dysfunction in mice with systemic lupus erythematosus by long-term serial adipose tissue-derived mesenchymal stem cell transplantation
    Eun Wha Choi
    Laboratory Animal Research Center, Samsung Biomedical Research Institute, Seoul, Republic of Korea
    Arthritis Rheum 64:243-53. 2012
  5. pmc In vitro migration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors
    Sun Jin Baek
    Stem Cell Research Center RNL BIO Co, Ltd Seoul, Korea
    Exp Mol Med 43:596-603. 2011
  6. doi Generation of transgenic dogs that conditionally express green fluorescent protein
    Min Jung Kim
    Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul, 151 744, Korea
    Genesis 49:472-8. 2011
  7. pmc Establishment of efficacy and safety assessment of human adipose tissue-derived mesenchymal stem cells (hATMSCs) in a nude rat femoral segmental defect model
    Hyung Jun Choi
    Graduate School of Immunology, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 26:482-91. 2011
  8. pmc Effects of expanded human adipose tissue-derived mesenchymal stem cells on the viability of cryopreserved fat grafts in the nude mouse
    Myung Soon Ko
    Stem Cell Research Center, RNL BIO Co, Ltd, Seoul 153 803, Republic of Korea
    Int J Med Sci 8:231-8. 2011
  9. doi Therapeutic lymphangiogenesis using stem cell and VEGF-C hydrogel
    Ji Hye Hwang
    Department of Physical and Rehabilitation Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea
    Biomaterials 32:4415-23. 2011
  10. doi Transplantation of CTLA4Ig gene-transduced adipose tissue-derived mesenchymal stem cells reduces inflammatory immune response and improves Th1/Th2 balance in experimental autoimmune thyroiditis
    Eun Wha Choi
    Laboratory Animal Research Center, Samsung Biomedical Research Institute, 50 Irwon dong, Gangnam Gu, Seoul 135 710, Republic of Korea
    J Gene Med 13:3-16. 2011

Collaborators

  • Young Ho Kim
  • Byeong Cheol Kang
  • Jeong Ah Kim
  • Byeong Chun Lee
  • Kyung Sun Kang
  • Okezie I Aruoma
  • Dae Yong Kim
  • Hwa Young Youn
  • Yan Ding
  • Eun Mi Choi
  • Nguyen Huu Tung
  • Sung Keun Kang
  • Hyun Ju Oh
  • So Gun Hong
  • Myung Soon Ko
  • Min Jung Kim
  • Goo Jang
  • Jung Eun Park
  • Eun Hye Jo
  • Il Seob Shin
  • Jung Youn Jo
  • Hyung Jun Choi
  • Ji Hye Hwang
  • Sun Jin Baek
  • Mo Sun Kwon
  • Dong Hwan Sohn
  • Teoan Kim
  • Hyuk Joon Kwon
  • Chemyong Ko
  • Bon Chul Koo
  • Jung Ran Park
  • Joon Suk Park
  • Yong Soon Lee
  • Jae Woong Hwang
  • Ji Young Lee
  • Ji Youl Jung
  • Jae Il Lee
  • Geon A Kim
  • Shuyu Piao
  • Tae Seung Lee
  • In Gul Kim
  • Jeong Hwan Che
  • Euna Kwon
  • Seong Ryul Cho
  • David S Lee
  • Ji Youl Lee
  • Yu Zhe Zhao
  • Sang Kyum Kim
  • Jung Taek Kang
  • Min Kyu Kim
  • Ok Jae Koo
  • Sun Jung Kim
  • Sung Ran Kim
  • Ji Won Jung
  • Se Ran Yang
  • Sung Dae Cho
  • Tae Yung Kim
  • Sung Hoon Kim

Detail Information

Publications19

  1. ncbi Safety of intravenous infusion of human adipose tissue-derived mesenchymal stem cells in animals and humans
    Jeong Chan Ra
    Stem Cell Research Center, RNL BIO Co, Ltd, Seoul, Republic of Korea
    Stem Cells Dev 20:1297-308. 2011
    ..None of the patients developed any serious adverse events related to hAdMSC transplantation during the 3-month follow-up. In conclusion, the systemic transplantation of hAdMSCs appears to be safe and does not induce tumor development...
  2. pmc Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells
    Jeong Chan Ra
    Stem Cell Research Center, RNL BIO, Seoul, 153 768, Republic of Korea
    J Transl Med 9:181. 2011
    ..Further clinical studies are needed that take into account the results obtained from case studies as those presented here...
  3. ncbi Chemopreventive properties of the ethanol extract of chinese licorice (Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells
    Eun Hye Jo
    Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, San 56 1, Shillim Dong, Kwanak gu, Seoul 151 742, South Korea
    Cancer Lett 230:239-47. 2005
    ..uralensis might be of importance in this debate...
  4. doi Reversal of serologic, immunologic, and histologic dysfunction in mice with systemic lupus erythematosus by long-term serial adipose tissue-derived mesenchymal stem cell transplantation
    Eun Wha Choi
    Laboratory Animal Research Center, Samsung Biomedical Research Institute, Seoul, Republic of Korea
    Arthritis Rheum 64:243-53. 2012
    ....
  5. pmc In vitro migration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors
    Sun Jin Baek
    Stem Cell Research Center RNL BIO Co, Ltd Seoul, Korea
    Exp Mol Med 43:596-603. 2011
    ..Prior in vitro modulation of the homing capacity of hAdMSCs could stimulate their movement into injured sites in vivo when administered intravenously, thereby improving their therapeutic potential...
  6. doi Generation of transgenic dogs that conditionally express green fluorescent protein
    Min Jung Kim
    Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul, 151 744, Korea
    Genesis 49:472-8. 2011
    ..This inducible dog model will be useful for a variety of medical research studies...
  7. pmc Establishment of efficacy and safety assessment of human adipose tissue-derived mesenchymal stem cells (hATMSCs) in a nude rat femoral segmental defect model
    Hyung Jun Choi
    Graduate School of Immunology, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 26:482-91. 2011
    ..In conclusion, hATMSCs loaded on HA/TCP enhance the repair of bone defects and was found to be safe under our preclinical efficacy/safety hybrid assessment system...
  8. pmc Effects of expanded human adipose tissue-derived mesenchymal stem cells on the viability of cryopreserved fat grafts in the nude mouse
    Myung Soon Ko
    Stem Cell Research Center, RNL BIO Co, Ltd, Seoul 153 803, Republic of Korea
    Int J Med Sci 8:231-8. 2011
    ..The hAdMSCs enhanced the survival and quality of transplanted cryopreserved fat tissues. Cultured and expanded hAdMSCs have reconstructive capacity in cryopreserved fat grafting by increasing the number of stem cells...
  9. doi Therapeutic lymphangiogenesis using stem cell and VEGF-C hydrogel
    Ji Hye Hwang
    Department of Physical and Rehabilitation Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea
    Biomaterials 32:4415-23. 2011
    ..Our results suggest that co-administration of hADSCs and VEGF-C hydrogel has a substantial positive effect on lymphangiogenesis...
  10. doi Transplantation of CTLA4Ig gene-transduced adipose tissue-derived mesenchymal stem cells reduces inflammatory immune response and improves Th1/Th2 balance in experimental autoimmune thyroiditis
    Eun Wha Choi
    Laboratory Animal Research Center, Samsung Biomedical Research Institute, 50 Irwon dong, Gangnam Gu, Seoul 135 710, Republic of Korea
    J Gene Med 13:3-16. 2011
    ..Autoimmune thyroiditis is one of common organ-specific autoimmune disease. The aim of this study was to observe the effect of adipose tissue derived mesenchymal stem cells (ATMSC) and CTLA4Ig gene-transduced ATMSC on autoimmune thyroiditis...
  11. doi Recloned dogs derived from adipose stem cells of a transgenic cloned beagle
    Hyun Ju Oh
    Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul, 151 742, Korea
    Theriogenology 75:1221-31. 2011
    ..In conclusion, the present study demonstrates that adipose stem cells can be a good nuclear donor source for dog cloning...
  12. doi A new diarylheptanoid from the bark of Alnus japonica
    Nguyen Huu Tung
    College of Pharmacy, Chungnam National University, Daejeon, South Korea
    J Asian Nat Prod Res 12:921-4. 2010
    ..Their structures were elucidated on the basis of extensive spectroscopic evidence. The new compound 1 showed significant hepatoprotective activity on the basis of t-butylhydroperoxide-induced hepatocyte injury in vitro assay...
  13. ncbi Phenolic compounds from Artemisia iwayomogi and their effects on osteoblastic MC3T3-E1 cells
    Yan Ding
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Korea
    Biol Pharm Bull 33:1448-53. 2010
    ..Compounds 3, 4, 7, and 9 showed potential in stimulating osteoblastic bone formation and may be useful for the prevention and/or treatment of osteoporosis...
  14. doi An anti-influenza component of the bark of Alnus japonica
    Nguyen Huu Tung
    College of Pharmacy, Chungnam National University, Daejeon, 305 764, Korea
    Arch Pharm Res 33:363-7. 2010
    ..Betulinic aldehyde (3) exhibited a particularly strong anti-influenza effect against KBNP-0028 relative to a positive control...
  15. doi Anti-influenza diarylheptanoids from the bark of Alnus japonica
    Nguyen Huu Tung
    College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea
    Bioorg Med Chem Lett 20:1000-3. 2010
    ....
  16. doi Antioxidative and hepatoprotective diarylheptanoids from the bark of Alnus japonica
    Nguyen Huu Tung
    College of Pharmacy, Chungnam National University, Daejeon, Korea
    Planta Med 76:626-9. 2010
    ..Mixtures 1, 2-6, 10, and 11 showed good antioxidative and hepatoprotective effects as compared with the positive controls...
  17. doi Generation of red fluorescent protein transgenic dogs
    So Gun Hong
    Seoul National University, Korea
    Genesis 47:314-22. 2009
    ..Using this approach, we produced the first generation of transgenic dogs with four female and two male expressing RFP...
  18. ncbi Reversal of the TPA-induced inhibition of gap junctional intercellular communication by Chaga mushroom (Inonotus obliquus) extracts: effects on MAP kinases
    Jung Ran Park
    Laboratory of Stem Cell and Tumor Biology, Department of Veterinary Public Health, College of Veterinary Medicine and BK 21 Program for Veterinary Science, Seoul National University, Sillim 9 Dong, Gwanak Gu, Seoul 151 742, South Korea
    Biofactors 27:147-55. 2006
    ..Thus Chaga mushroom may act as a natural anticancer product by preventing the inhibition of GJIC through the inactivation of ERK1/2 and p38 MAP kinase...
  19. pmc Journey of mesenchymal stem cells for homing: strategies to enhance efficacy and safety of stem cell therapy
    Sung Keun Kang
    Stem Cell Research Center, RNL BIO, Gasan Dong, Geumcheon gu, Seoul 153 768, Republic of Korea
    Stem Cells Int 2012:342968. 2012
    ..This may allow MSCs to quickly find and migrate to injured tissues, where they may best exert clinical benefits resulting from improved homing and the presence of increased numbers of MSCs...