GREGORY QUIRK

Summary

Publications

  1. ncbi request reprint The role of ventromedial prefrontal cortex in the recovery of extinguished fear
    G J Quirk
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732, USA
    J Neurosci 20:6225-31. 2000
  2. pmc Neural mechanisms of extinction learning and retrieval
    Gregory J Quirk
    Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan, Puerto Rico
    Neuropsychopharmacology 33:56-72. 2008
  3. pmc Erasing fear memories with extinction training
    Gregory J Quirk
    Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan 00936 5067, Puerto Rico
    J Neurosci 30:14993-7. 2010
  4. ncbi request reprint Prefrontal mechanisms in extinction of conditioned fear
    Gregory J Quirk
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico
    Biol Psychiatry 60:337-43. 2006
  5. ncbi request reprint Stuck in time without a nucleus: theoretical comment on Sangha et Al. (2005)
    Gregory J Quirk
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico
    Behav Neurosci 119:1155-7. 2005
  6. ncbi request reprint Inhibition of the amygdala: key to pathological states?
    Gregory J Quirk
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico, 00732 7004
    Ann N Y Acad Sci 985:263-72. 2003
  7. pmc Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery
    Gregory J Quirk
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732, USA
    Learn Mem 9:402-7. 2002
  8. pmc Sustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure
    Anthony Burgos-Robles
    Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan, Puerto Rico 00936 5067, USA
    J Neurosci 29:8474-82. 2009
  9. ncbi request reprint Neurons in medial prefrontal cortex signal memory for fear extinction
    Mohammed R Milad
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732, USA
    Nature 420:70-4. 2002
  10. ncbi request reprint Delayed recall of fear extinction in rats with lesions of ventral medial prefrontal cortex
    Kelimer Lebrón
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732, USA
    Learn Mem 11:544-8. 2004

Detail Information

Publications35

  1. ncbi request reprint The role of ventromedial prefrontal cortex in the recovery of extinguished fear
    G J Quirk
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732, USA
    J Neurosci 20:6225-31. 2000
    ..These data suggest a role of the vmPFC in consolidation of extinction learning or the recall of contexts in which extinction took place...
  2. pmc Neural mechanisms of extinction learning and retrieval
    Gregory J Quirk
    Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan, Puerto Rico
    Neuropsychopharmacology 33:56-72. 2008
    ..Pharmacological methods to facilitate consolidation and retrieval of extinction, for both aversive and appetitive conditioning, are setting the stage for novel treatments for anxiety disorders and addictions...
  3. pmc Erasing fear memories with extinction training
    Gregory J Quirk
    Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan 00936 5067, Puerto Rico
    J Neurosci 30:14993-7. 2010
    ..The use of modified extinction protocols to eliminate fear memories complements existing pharmacological strategies for strengthening extinction...
  4. ncbi request reprint Prefrontal mechanisms in extinction of conditioned fear
    Gregory J Quirk
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico
    Biol Psychiatry 60:337-43. 2006
    ..Strategies for augmenting prefrontal function for clinical benefit are discussed...
  5. ncbi request reprint Stuck in time without a nucleus: theoretical comment on Sangha et Al. (2005)
    Gregory J Quirk
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico
    Behav Neurosci 119:1155-7. 2005
    ..Furthermore, memory for conditioning and extinction can coexist in the same neuron...
  6. ncbi request reprint Inhibition of the amygdala: key to pathological states?
    Gregory J Quirk
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico, 00732 7004
    Ann N Y Acad Sci 985:263-72. 2003
    ..Novel neuropeptides, which can either excite or inhibit specific components of anxiety responses, offer promise in this regard...
  7. pmc Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery
    Gregory J Quirk
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732, USA
    Learn Mem 9:402-7. 2002
    ..These data support the idea that conditioning and extinction of fear are learned by independent systems, each able to retain a long-term memory...
  8. pmc Sustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure
    Anthony Burgos-Robles
    Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan, Puerto Rico 00936 5067, USA
    J Neurosci 29:8474-82. 2009
    ....
  9. ncbi request reprint Neurons in medial prefrontal cortex signal memory for fear extinction
    Mohammed R Milad
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732, USA
    Nature 420:70-4. 2002
    ..We suggest that consolidation of extinction learning potentiates infralimbic activity, which inhibits fear during subsequent encounters with fear stimuli...
  10. ncbi request reprint Delayed recall of fear extinction in rats with lesions of ventral medial prefrontal cortex
    Kelimer Lebrón
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732, USA
    Learn Mem 11:544-8. 2004
    ..We suggest that the vmPFC accelerates extinction by permitting access to recently learned extinction trials, thereby maximizing behavioral flexibility...
  11. pmc Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction
    Jose Rodriguez-Romaguera
    Department of Psychology Undergraduate Program, University of Puerto Rico, San Juan, Puerto Rico
    Biol Psychiatry 65:887-92. 2009
    ..With an auditory fear conditioning task in rats, we assessed the effects of systemic propranolol on the expression and extinction of two measures of conditioned fear: freezing and suppression of bar-pressing...
  12. ncbi request reprint Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons
    Gregory J Quirk
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732, USA
    J Neurosci 23:8800-7. 2003
    ..Thus, our findings support the idea that mPFC gates impulse transmission from the BLA to Ce, perhaps through GABAergic intercalated cells, thereby gating the expression of conditioned fear...
  13. doi request reprint Noradrenergic signaling in infralimbic cortex increases cell excitability and strengthens memory for fear extinction
    Devin Mueller
    Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan, Puerto Rico
    J Neurosci 28:369-75. 2008
    ..Thus, emotional arousal evoked by conditioned fear paradoxically promotes the subsequent extinction of that fear, thereby ensuring behavioral flexibility...
  14. ncbi request reprint Fear extinction in rats: implications for human brain imaging and anxiety disorders
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Bldg 149 13th St, Charlestown, 02129, USA
    Biol Psychol 73:61-71. 2006
    ....
  15. pmc Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear
    Ivan Vidal-Gonzalez
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732
    Learn Mem 13:728-33. 2006
    ..We suggest that PL excites amygdala output and IL inhibits amygdala output, providing a mechanism for bidirectional modulation of fear expression...
  16. ncbi request reprint Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex
    Anthony Burgos-Robles
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732
    Neuron 53:871-80. 2007
    ..We suggest that NMDAR-dependent bursting in the infralimbic vmPFC initiates calcium-dependent molecular cascades that stabilize extinction memory, thereby allowing for successful recall of extinction...
  17. doi request reprint Fear conditioning and extinction differentially modify the intrinsic excitability of infralimbic neurons
    Edwin Santini
    Department of Pharmacology and Physiology, Ponce School of Medicine, Ponce, Puerto Rico
    J Neurosci 28:4028-36. 2008
    ..Inappropriate modulation of these intrinsic mechanisms may underlie anxiety disorders, characterized by exaggerated fear and deficient extinction...
  18. doi request reprint Extinction circuits for fear and addiction overlap in prefrontal cortex
    Jamie Peters
    Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan, Puerto Rico 00936
    Learn Mem 16:279-88. 2009
    ..Given that the mPFC represents a common node in the extinction circuit for these behaviors, treatments that target this region may help alleviate symptoms of both anxiety and addictive disorders by enhancing extinction memory...
  19. ncbi request reprint Extinction: new excitement for an old phenomenon
    Gregory J Quirk
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732
    Biol Psychiatry 60:317-8. 2006
  20. pmc Translating findings from basic fear research to clinical psychiatry in Puerto Rico
    Gregory J Quirk
    Department of Psychiatry, School of Medicine, University of Puerto Rico, San Juan
    P R Health Sci J 26:321-8. 2007
    ..We also analyze the available literature on the epidemiology of anxiety disorders and the existing evidence-based treatments for these conditions...
  21. pmc Prefrontal control of fear: more than just extinction
    Francisco Sotres-Bayon
    Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan, Puerto Rico
    Curr Opin Neurobiol 20:231-5. 2010
    ..We suggest that dual control of the amygdala by separate prefrontal modules increases the flexibility of an organism's response to danger cues...
  22. ncbi request reprint Recalling safety: cooperative functions of the ventromedial prefrontal cortex and the hippocampus in extinction
    Kevin A Corcoran
    Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan, PR, USA
    CNS Spectr 12:200-6. 2007
    ..Imaging studies of human fear conditioning and extinction lend credence to this extinction network. Understanding the neural circuitry underlying extinction recall will lead to more effective therapies for disorders of fear and anxiety...
  23. ncbi request reprint Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 62:446-54. 2007
    ..The aim of the present study is to investigate the mediating anatomy of extinction recall in healthy humans...
  24. ncbi request reprint Inactivation of the ventromedial prefrontal cortex reduces expression of conditioned fear and impairs subsequent recall of extinction
    Demetrio Sierra-Mercado
    Department of Physiology, Ponce School of Medicine, PO Box 7004, Ponce, Puerto Rico
    Eur J Neurosci 24:1751-8. 2006
    ..The vmPFC appears to be involved both in stimulating the expression of conditioned fear and in serving as a site of extinction-related plasticity that inhibits fear during recall of extinction...
  25. ncbi request reprint Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex
    Edwin Santini
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732
    J Neurosci 24:5704-10. 2004
    ..Understanding consolidation of fear extinction could lead to new treatments for anxiety disorders in which fear extinction is thought to be compromised...
  26. pmc Induction of fear extinction with hippocampal-infralimbic BDNF
    Jamie Peters
    Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan, PR 00936
    Science 328:1288-90. 2010
    ..Hence, boosting BDNF activity in hippocampal-infralimbic circuits may ameliorate disorders of learned fear...
  27. ncbi request reprint Prefrontal involvement in the regulation of emotion: convergence of rat and human studies
    Gregory J Quirk
    Department of Physiology, Ponce School of Medicine, P O Box 7004, Ponce, Puerto Rico 00732
    Curr Opin Neurobiol 16:723-7. 2006
    ..The overlap in circuitry is consistent with a common mechanism, and points toward future experiments designed to bridge human and rodent models of emotion regulation...
  28. ncbi request reprint Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears
    Kevin A Corcoran
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico
    J Neurosci 27:840-4. 2007
    ..We suggest that PL integrates information from auditory and contextual inputs and regulates expression of fear memories via projections to the basal nucleus of the amygdala...
  29. ncbi request reprint Learning not to fear, faster
    Gregory J Quirk
    Department of Physiology, Ponce School of Medicine, Ponce, Puerto Rico 00732
    Learn Mem 11:125-6. 2004
  30. ncbi request reprint A role for the human dorsal anterior cingulate cortex in fear expression
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 62:1191-4. 2007
    ..This study examined the role of dACC during fear conditioning in healthy humans with magnetic resonance imaging (MRI)...
  31. doi request reprint Signaling aversive events in the midbrain: worse than expected
    Gregory J Quirk
    Departments of Psychiatry and Anatomy and Neurobiology, University of Puerto Rico School of Medicine, San Juan, PR 00936
    Neuron 61:655-6. 2009
    ..In this issue of Neuron, Jhou and colleagues identify a region in the midbrain tegmentum that signals aversive events and inhibits midbrain dopamine neurons...
  32. ncbi request reprint Lesions of the basal amygdala block expression of conditioned fear but not extinction
    David Anglada-Figueroa
    Department of Physiology, Ponce School of Medicine, Ponce, 00732, Puerto Rico
    J Neurosci 25:9680-5. 2005
    ..The pattern of lesion deficits we observed (after but not before training) might be explained by homeostatic mechanisms that balance plasticity over multiple inputs, regulating the influence of the BA and LA onto Ce output neurons...
  33. ncbi request reprint Keeping the memories flowing
    Gregory J Quirk
    Nat Neurosci 9:1199-200. 2006
  34. ncbi request reprint Neuronal signalling of fear memory
    Stephen Maren
    Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Rev Neurosci 5:844-52. 2004
    ..Understanding the signalling of aversive memory by amygdala neurons opens new avenues for research into the neural systems that support fear behaviour...
  35. ncbi request reprint New vistas on amygdala networks in conditioned fear
    DENIS PARE
    Center for Molecular and Behavioral Neuroscience, Rutgers State University, 197 University Ave, Newark, NJ 07102, USA
    J Neurophysiol 92:1-9. 2004
    ..Thus plasticity in both LA and CE would be necessary for acquisition of conditioned fear. This revised model also accounts for inhibition of conditioned fear after extinction...

Research Grants16

  1. Prefrontal-Amygdala Interactions in Fear Conditioning
    Gregory J Quirk; Fiscal Year: 2010
    ..This information could also lead to new ways to increase the effectiveness of extinction-based therapies for treatment of PTSD. ..
  2. Prefrontal-Amygdala Interactions in Fear Conditioning
    Gregory J Quirk; Fiscal Year: 2010
    ..This information could also lead to new ways to increase the effectiveness of extinction-based therapies for treatment of PTSD. ..
  3. Translational Studies of Prefrontal Control of Fear Extinction
    Gregory J Quirk; Fiscal Year: 2010
    ..If successful, this approach could lead to a screening tool for identifying persons at high risk for developing an anxiety disorder and could augment existing extinction-based therapies. ..
  4. Translational Studies of Prefrontal Control of Fear Extinction
    GREGORY QUIRK; Fiscal Year: 2009
    ..If successful, this approach could lead to a screening tool for identifying persons at high risk for developing an anxiety disorder and could augment existing extinction-based therapies. ..
  5. PREFRONTAL AMYGDALA INTERACTIONS IN FEAR CONDITIONING
    GREGORY QUIRK; Fiscal Year: 2007
    ..A detailed knowledge of the circuits and pharmacology of fear extinction could improve current exposure-based treatments for PTSD and phobias, which rely on extinction learning. ..
  6. Extinction: The Neural Mechanisms of Behavior Change
    GREGORY QUIRK; Fiscal Year: 2005
    ..Thus, the conference should have considerable scientific impact, as well as serving a capacity-building function in the region. ..