Sudeep S Gill

..Antipsychotic drugs are widely used to manage behavioral and psychological symptoms in dementia despite concerns about their safety...

..To compare the incidence of admissions to hospital for stroke among older adults with dementia receiving atypical or typical antipsychotics...

..We present a new example of the prescribing cascade involving cholinesterase inhibitors and anticholinergic drugs used to manage urinary incontinence...

..Cholinesterase inhibitors (ChEIs) are a mainstay treatment for individuals with dementia. ChEIs may worsen airflow obstruction because of their pro-cholinergic properties...

..To evaluate the representation of frail older adults in randomized controlled trials (RCTs), and to assess consequences of under representation by analyzing drug discontinuation rates...

..Donepezil is metabolized by the cytochrome P450 isozyme 3A4 (CYP3A4). Clarithromycin is a potent inhibitor of CYP3A4, and patients taking both of these drugs may be at increased risk of cardiac adverse events...

..To determine whether current antipsychotic use among older persons without diabetes is associated with a higher risk of hospital visits for hyperglycemia, as previous studies in this population have yielded conflicting results...

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..These drugs can provoke symptomatic bradycardia and syncope, which may lead to permanent pacemaker insertion. Drug-induced syncope may also precipitate fall-related injuries, including hip fracture...

..We evaluated the effects of ChEIs on the postoperative outcomes of older adults who underwent hip fracture surgery...

..Determining the extent to which variations in antipsychotic use are a symptom of facility-level quality problems as compared with a drug safety issue is important for selecting the correct interventions to effect change...

..The use of antipsychotic medications is associated with an increased risk of death in older adults with dementia. The risk of death in patients with preexisting parkinsonism who receive antipsychotic drugs is not known...

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..These drugs enhance the effects of acetylcholine, and reports suggest they may precipitate bradycardia in some patients. We aimed to examine the association between use of cholinesterase inhibitors and hospitalization for bradycardia...

..However, the generally modest efficacy and risks of adverse events highlight the need for the development of safe and effective pharmacological and non-pharmacological interventions for this population...

..To estimate the rate of new chronic benzodiazepine use after hospitalization in older adults not previously prescribed with benzodiazepines...

..Evidence suggests that there is an association between antipsychotic drugs and new-onset diabetes, but little is known about the risk of hyperglycemia among persons with preexisting diabetes...

..We quantified the scope of this practice by exploring variation in the use of nine or more drug therapies across LTC homes...

..The systemic anticholinergic effects of IAC therapy have not been extensively studied. This study sought to determine the risk of acute urinary retention (AUR) in seniors with COPD using IACs...

..To assess whether stroke rates among patients with retinal disease were influenced by the rapid and sequential uptakes of bevacizumab and ranibizumab for age-related macular degeneration (AMD)...

..Little is known of the prevalence of dementia and cognitive impairment among older adults with hip fractures...

..Clinical pharmacist services, which are mandated in the nursing home setting, may be responsible for these differences in Ontario, Canada...

..No studies have documented whether use of tamsulosin or other alpha-blocker drug therapies affect the risk of serious postoperative adverse events...

..For-profit nursing homes appear to provide lower quality of care in many important areas of process and outcome...

..To review the role of oral atypical antipsychotic drugs in the management of the behavioural and psychological symptoms of dementia (BPSD)...

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..To assess the risk of systemic adverse events associated with intravitreal injections of vascular endothelial growth factor inhibiting drugs...

..Agitation and psychosis are common among older adults with dementia and are challenging to manage. At the present time, little is known about the efficacy and safety of antidepressant medications when used to treat these symptoms...

..Neuroleptic malignant syndrome (NMS) is a potentially fatal adverse event associated with the use of antipsychotics...

..The purpose of this study was to systematically evaluate the evidence for the efficacy and safety of antipsychotics in treating delirium...

..Pressure ulcers are common in a variety of patient settings and are associated with adverse health outcomes and high treatment costs...

..To determine the efficacy and tolerability of citalopram when compared to other antidepressants for late-life depression (LLD)...

..Other approaches have been taken by the United Kingdom and Denmark. A solution is necessary, as the relationship between authorship and accountability must be maintained...

..In conclusion, there is little evidence to support the addition of PET to the routine clinical evaluation of patients with suspected or established dementia. Suggestions for future research in this area are offered...

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..To study the relationship between initiating therapy with an antipsychotic medication and a subsequent new diagnosis of a drug-induced movement disorder other than parkinsonism in older adults with dementia...

..CONCLUSIONS: Postacute residents with an uncertain prognosis are an important target population for intensive RT...

..We assessed the impact of these warnings on prescription rates of antipsychotic drugs in this patient population...