L Quarles

Summary

Publications

  1. pmc Calcium regulates FGF-23 expression in bone
    Valentin David
    MD, Coleman College of Medicine Building, Suite B226, University of Tennessee Health Science Center, 956 Court Avenue, Memphis Tennessee 38163
    Endocrinology 154:4469-82. 2013
  2. pmc Reducing cardiovascular mortality in chronic kidney disease: something borrowed, something new
    L Darryl Quarles
    University of Tennessee Health Science Center, 956 Court Ave, Suite B226, Memphis, Tennessee, USA
    J Clin Invest 123:542-3. 2013
  3. doi A systems biology preview of the relationships between mineral and metabolic complications in chronic kidney disease
    L Darryl Quarles
    Department of Medicine and Division of Nephrology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Semin Nephrol 33:130-42. 2013
  4. pmc Role of FGF23 in vitamin D and phosphate metabolism: implications in chronic kidney disease
    L Darryl Quarles
    Department of Medicine and Division of Nephrology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Exp Cell Res 318:1040-8. 2012
  5. doi Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism
    L Darryl Quarles
    Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, 19 South Manassas Street, Memphis, TN 38163, USA
    Nat Rev Endocrinol 8:276-86. 2012
  6. pmc Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype
    Hua Li
    University of Tennessee Health Science Center, 956 Court Ave, Memphis, TN 38163, USA
    Am J Physiol Endocrinol Metab 300:E508-17. 2011
  7. pmc Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice
    Zhousheng Xiao
    Department of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38165, USA
    FASEB J 25:2418-32. 2011

Research Grants

Collaborators

  • Xiaobin Han
  • Valentin David
  • Aline Martin
  • Zhousheng Xiao
  • Hua Li
  • Bing Dai
  • Jinsong Huang
  • Mark Johnson
  • DANIEL NICOLELLA
  • Lynda Bonewald
  • Ni Qiu
  • Mark Dallas
  • Li Cao

Detail Information

Publications7

  1. pmc Calcium regulates FGF-23 expression in bone
    Valentin David
    MD, Coleman College of Medicine Building, Suite B226, University of Tennessee Health Science Center, 956 Court Avenue, Memphis Tennessee 38163
    Endocrinology 154:4469-82. 2013
    ..The effects of chronic low calcium to prevent 1,25(OH)2D and PTH stimulation of FGF-23 in these mutant mouse models suggest that suppression of FGF-23 plays an important physiological adaptive response to hypocalcemia. ..
  2. pmc Reducing cardiovascular mortality in chronic kidney disease: something borrowed, something new
    L Darryl Quarles
    University of Tennessee Health Science Center, 956 Court Ave, Suite B226, Memphis, Tennessee, USA
    J Clin Invest 123:542-3. 2013
    ..Medications included chlorthalidone, amlodipine, carvedilol, cholecalciferol, erythropoietin, and a phosphate binder. What additional therapy should be initiated to reduce vascular calcifications and cardiovascular mortality?..
  3. doi A systems biology preview of the relationships between mineral and metabolic complications in chronic kidney disease
    L Darryl Quarles
    Department of Medicine and Division of Nephrology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Semin Nephrol 33:130-42. 2013
    ..The complex interconnections between the various endocrine networks in chronic kidney disease may account for the difficulty in treating the uremic state...
  4. pmc Role of FGF23 in vitamin D and phosphate metabolism: implications in chronic kidney disease
    L Darryl Quarles
    Department of Medicine and Division of Nephrology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Exp Cell Res 318:1040-8. 2012
    ..Finally, increments in FGF23 are associated with increased cardiovascular mortality in CKD. Whether these effects represent direct effects of FGF23 or represent a marker of other abnormalities in CKD remains to be determined...
  5. doi Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism
    L Darryl Quarles
    Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, 19 South Manassas Street, Memphis, TN 38163, USA
    Nat Rev Endocrinol 8:276-86. 2012
    ....
  6. pmc Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype
    Hua Li
    University of Tennessee Health Science Center, 956 Court Ave, Memphis, TN 38163, USA
    Am J Physiol Endocrinol Metab 300:E508-17. 2011
    ..These studies suggest that FGFR1, FGFR3, and FGFR4 act in concert to mediate FGF23 effects on the kidney and that loss of FGFR function leads to feedback stimulation of Fgf23 expression in bone...
  7. pmc Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice
    Zhousheng Xiao
    Department of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38165, USA
    FASEB J 25:2418-32. 2011
    ..These data indicate that polycystin-1 is essential for the anabolic response to skeletal loading in osteoblasts/osteocytes...

Research Grants40

  1. Extrarenal Functions of Polycystin-1
    L Darryl Quarles; Fiscal Year: 2010
    ..In addition, a greater knowledge of polycystins and primary cilia functions in a different cellular context could translate into a broader understanding of their functions in the kidney. ..
  2. EXTRACELLULAR CALCIUM-SENSING RECEPTORS IN OSTEOBLASTS
    L Quarles; Fiscal Year: 2007
    ..Successful completion of this project is certain to yield important new knowledge regarding the function of GPRC6A. ..
  3. DIFFERENTIAL FUNCTION AND REGULATION OF RUNX2 ISOFORMS
    L Quarles; Fiscal Year: 2007
    ..These studies will define the unique functions of the N-terminal domains, and determine if translational regulation contributes to the tissue-specific expression of Runx2-I and Runx2-II isoforms. ..
  4. Pathogenesis of XLH/Hyp: Role of Phex MEPE and FGF23
    L Quarles; Fiscal Year: 2007
    ..abstract_text> ..
  5. PHARMACOLOGICALLY INDUCED NEO-OSTEOGENESIS
    L Quarles; Fiscal Year: 2005
    ....
  6. PEX FUNCTION IN OSTEOBLASTS
    L Quarles; Fiscal Year: 2003
    ..The study of Pex may yield an entirely new view of mineral metabolism. ..
  7. PHARMACOLOGICALLY INDUCED NEO-OSTEOGENESIS
    L Quarles; Fiscal Year: 1993
    ..Information obtained from these studies will likely lead to a better understanding of a novel agent(s) with osteogenic potential and may be useful in designing effective therapy for currently refractory osteopenic disorders...
  8. PHARMACOLOGICALLY INDUCED NEO-OSTEOGENESIS
    L Quarles; Fiscal Year: 2000
    ..It is hoped that such kn owledge will permit a better understanding of physiologic and pharmacologic control of de novo bone formation by cations that may lead to new therapies for osteopenic disorders. ..
  9. GENETICS OF FAMILIAL FOCAL SEGMENTAL GLOMERULOSCLEROSIS
    L Quarles; Fiscal Year: 2002
    ..Knowledge derived from FFSGS will also allow a better understanding of pathogenesis of non-hereditary forms FSGS and may provide insights regarding management of the more common sporadic forms of this disorder. ..
  10. EXTRACELLULAR CALCIUM-SENSING RECEPTORS IN OSTEOBLASTS
    L Darryl Quarles; Fiscal Year: 2009
    ..Successful completion of this project is certain to yield important new knowledge regarding the function of GPRC6A. ..