Li Xin Qiu

Summary

Publications

  1. pmc Association of LEP G2548A and LEPR Q223R polymorphisms with cancer susceptibility: evidence from a meta-analysis
    Jing He
    Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    PLoS ONE 8:e75135. 2013
  2. pmc Association between the ERCC5 Asp1104His polymorphism and cancer risk: a meta-analysis
    Mei ling Zhu
    Department of Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
    PLoS ONE 7:e36293. 2012
  3. doi request reprint The association between common genetic variant of microRNA-146a and cancer susceptibility
    Li Xin Qiu
    Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
    Cytokine 56:695-8. 2011
  4. doi request reprint miR-196a2 C allele is a low-penetrant risk factor for cancer development
    Li Xin Qiu
    Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
    Cytokine 56:589-92. 2011
  5. doi request reprint Current evidences on vascular endothelial growth factor polymorphisms and breast cancer susceptibility
    Li Xin Qiu
    Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
    Mol Biol Rep 38:4491-4. 2011
  6. doi request reprint Lack of association between methylenetetrahydrofolate reductase gene A1298C polymorphism and breast cancer susceptibility
    Li Xin Qiu
    Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
    Mol Biol Rep 38:2295-9. 2011
  7. doi request reprint The p21 Ser31Arg polymorphism and breast cancer risk: a meta-analysis involving 51,236 subjects
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 124:475-9. 2010
  8. doi request reprint Predictive value of thymidylate synthase expression in advanced colorectal cancer patients receiving fluoropyrimidine-based chemotherapy: evidence from 24 studies
    Li Xin Qiu
    Cancer Center, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing, China
    Int J Cancer 123:2384-9. 2008
  9. doi request reprint XPD Lys751Gln polymorphism and breast cancer susceptibility: a meta-analysis involving 28,709 subjects
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 124:229-35. 2010
  10. doi request reprint TGFB1 L10P polymorphism is associated with breast cancer susceptibility: evidence from a meta-analysis involving 47,817 subjects
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 123:563-7. 2010

Detail Information

Publications39

  1. pmc Association of LEP G2548A and LEPR Q223R polymorphisms with cancer susceptibility: evidence from a meta-analysis
    Jing He
    Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    PLoS ONE 8:e75135. 2013
    ..Therefore, we performed a meta-analysis to comprehensively evaluate such associations...
  2. pmc Association between the ERCC5 Asp1104His polymorphism and cancer risk: a meta-analysis
    Mei ling Zhu
    Department of Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
    PLoS ONE 7:e36293. 2012
    ..However, a series of epidemiological studies on the association between the ERCC5 Asp1104His polymorphism (rs17655, G>C) and cancer susceptibility generated conflicting results...
  3. doi request reprint The association between common genetic variant of microRNA-146a and cancer susceptibility
    Li Xin Qiu
    Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
    Cytokine 56:695-8. 2011
    ..Despite some limitations, this meta-analysis suggests that the miR-146a G allele is a low-penetrant risk factor for papillary thyroid carcinoma development...
  4. doi request reprint miR-196a2 C allele is a low-penetrant risk factor for cancer development
    Li Xin Qiu
    Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
    Cytokine 56:589-92. 2011
    ..TT: OR=1.19, 95% CI=1.06-1.35; dominant model: OR=1.13, 95% CI=1.01-1.25). Despite some limitations, this meta-analysis suggests that the miR-196a2 C allele is a low-penetrant risk factor for cancer development...
  5. doi request reprint Current evidences on vascular endothelial growth factor polymorphisms and breast cancer susceptibility
    Li Xin Qiu
    Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
    Mol Biol Rep 38:4491-4. 2011
    ..However, large sample and representative population-based studies with homogeneous breast cancer patients and well matched controls are warranted to confirm this finding...
  6. doi request reprint Lack of association between methylenetetrahydrofolate reductase gene A1298C polymorphism and breast cancer susceptibility
    Li Xin Qiu
    Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
    Mol Biol Rep 38:2295-9. 2011
    ..However, large sample and representative population-based studies with homogeneous breast cancer patients and well matched controls are warranted to confirm this finding...
  7. doi request reprint The p21 Ser31Arg polymorphism and breast cancer risk: a meta-analysis involving 51,236 subjects
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 124:475-9. 2010
    ..However, large sample and representative population-based studies with homogeneous breast cancer patients and well-matched controls are warranted to confirm this finding...
  8. doi request reprint Predictive value of thymidylate synthase expression in advanced colorectal cancer patients receiving fluoropyrimidine-based chemotherapy: evidence from 24 studies
    Li Xin Qiu
    Cancer Center, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing, China
    Int J Cancer 123:2384-9. 2008
    ..Subgroup analyses indicated that the predictive value of TS expression evaluated in metastases was more prominent than that of primary lesions, and that TS expression tested by RTPCR was also of greater predictive value than by IHC...
  9. doi request reprint XPD Lys751Gln polymorphism and breast cancer susceptibility: a meta-analysis involving 28,709 subjects
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 124:229-35. 2010
    ..20; Gln/Gln vs. Lys/Lys: OR = 1.15, 95% CI = 1.01-1.31; dominant model: OR = 1.12, 95% CI = 1.03-1.23). In conclusion, this meta-analysis suggests that the XPD 751Gln allele is a low-penetrant risk factor for developing breast cancer...
  10. doi request reprint TGFB1 L10P polymorphism is associated with breast cancer susceptibility: evidence from a meta-analysis involving 47,817 subjects
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 123:563-7. 2010
    ..However, large sample and representative population-based studies with homogeneous breast cancer patients and well-matched controls are warranted to confirm this finding...
  11. ncbi request reprint Lack of association of CYP1A2-164 A/C polymorphism with breast cancer susceptibility: a meta-analysis involving 17,600 subjects
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 122:521-5. 2010
    ..In conclusion, upto date, there is still not enough evidence to indicate the association of CYP1A2-164 A/C polymorphism and breast cancer development...
  12. doi request reprint BRCA2 N372H polymorphism and breast cancer susceptibility: a meta-analysis involving 44,903 subjects
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 123:487-90. 2010
    ..However, large sample and representative population-based studies with homogeneous breast cancer patients and well matched controls are warranted to confirm this finding...
  13. doi request reprint Lack of association between MnSOD Val16Ala polymorphism and breast cancer risk: a meta-analysis involving 58,448 subjects
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 123:543-7. 2010
    ..However, large sample and representative population-based studies with homogeneous breast cancer patients and well-matched controls are warranted to confirm this finding...
  14. doi request reprint MTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls
    Jian Zhang
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 123:549-55. 2010
    ..CC: OR = 1.12, 95% CI = 1.02-1.23; dominant model: OR = 1.11, 95% CI = 1.01-1.22). In conclusion, this meta-analysis suggests that the MTHFR T allele is a low-penetrant risk factor for developing breast cancer...
  15. doi request reprint Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population
    Jing He
    Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    Mol Carcinog 52:E70-9. 2013
    ..These data support the hypothesis that functional polymorphisms of mTOR may contribute to gastric cancer risk. Clearly, our results require validation in larger studies with different ethnic populations...
  16. doi request reprint GSTM1 null allele is a risk factor for gastric cancer development in Asians
    Li Xin Qiu
    Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
    Cytokine 55:122-5. 2011
    ..11, 95% CI: 0.99-1.25). In summary, this meta-analysis result indicates that the GSTM1 null genotype is a low-penetrant risk factor for gastric cancer development in Asians...
  17. ncbi request reprint XRCC3 5'-UTR and IVS5-14 polymorphisms and breast cancer susceptibility: a meta-analysis
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 122:489-93. 2010
    ....
  18. doi request reprint Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations
    Jing He
    Department of Medical Oncology, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai 200032, China
    Hum Genet 131:1235-44. 2012
    ..001). These support the hypothesis that functional XPG variants may contribute to the risk of gastric cancer. Larger studies with different ethnic populations are warranted to validate our findings...
  19. pmc Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population
    Jing He
    Cancer Research Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China
    PLoS ONE 7:e49308. 2012
    ..Inherited functional single nucleotide polymorphisms (SNPs) in DNA repair genes may alter DNA repair capacity and thus contribute to cancer risk...
  20. doi request reprint IGFBP3 A-202C polymorphism and breast cancer susceptibility: a meta-analysis involving 33,557 cases and 45,254 controls
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 122:867-71. 2010
    ..In conclusion, this meta-analysis suggests that the IGFBP3 C allele is a low-penetrant risk factor for developing breast cancer...
  21. doi request reprint The association between ERCC2 Asp312Asn polymorphism and breast cancer risk: a meta-analysis involving 22,766 subjects
    Lei Yao
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People s Republic of China
    Breast Cancer Res Treat 123:227-31. 2010
    ..82; 95% CI 0.68-0.99) in population-based studies. In conclusion, this meta-analysis provides an evidence that ERCC2 312Asn allele may have a protective effect for breast cancer development in Asians...
  22. doi request reprint Current evidence on the relationship between three polymorphisms in the FGFR2 gene and breast cancer risk: a meta-analysis
    Jian Zhang
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 124:419-24. 2010
    ..We recommend that these single nucleotide polymorphisms to be included in future association studies and functional assays...
  23. doi request reprint The association between HSD17B1 Ser312Gly polymorphism and breast cancer risk: a meta-analysis including 31,053 subjects
    Lei Yao
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People s Republic of China
    Breast Cancer Res Treat 123:577-80. 2010
    ..However, large sample and representative population-based studies with homogeneous breast cancer patients and well-matched controls are warranted to confirm this finding...
  24. ncbi request reprint Current evidence on the relationship between polymorphisms in the COX-2 gene and breast cancer risk: a meta-analysis
    Ke Da Yu
    Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People s Republic of China
    Breast Cancer Res Treat 122:251-7. 2010
    ..There is a need for further large studies into the role of these polymorphisms (especially rs5277) and other potentially functional polymorphisms/haplotypes in the COX-2 gene as breast cancer risk modifiers...
  25. doi request reprint TNF-308 gene polymorphism is associated with COPD risk among Asians: meta-analysis of data for 6,118 subjects
    Ping Zhan
    First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing University School of Medicine, 215 Guangzhou Road, Nanjing, 210029, China
    Mol Biol Rep 38:219-27. 2011
    ..This meta-analysis suggested that the TNF-308 A allele is a more significant risk factor for developing COPD among Asian populations, but not among Caucasians...
  26. doi request reprint TNF-308 gene polymorphism and tuberculosis susceptibility: a meta-analysis involving 18 studies
    Qin Wang
    Department of Respiratory Medicine, No 81 Hospital of PLA, Nanjing, China
    Mol Biol Rep 39:3393-400. 2012
    ..This meta-analysis indicated that the TNF-308 polymorphism was not associated with the risk of TB in the total population, however the significant risk for TNF-308 A allele was found among Asians not Caucasians...
  27. doi request reprint NAT2 polymorphisms combining with smoking associated with breast cancer susceptibility: a meta-analysis
    Jian Zhang
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 123:877-83. 2010
    ....
  28. pmc The E-cadherin (CDH1)--160 C/A polymorphism and prostate cancer risk: a meta-analysis
    Li Xin Qiu
    Cancer Center, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing, China
    Eur J Hum Genet 17:244-9. 2009
    ..32-1.09; P=0.090, P(heterogeneity)=0.070). Although some modest bias could not be eliminated, this meta-analysis suggests that the CDH1 -160A allele is a low-penetrant risk factor for developing PCA, especially in Europeans and Asians...
  29. doi request reprint FAS -1,377 G/A polymorphism is associated with cancer susceptibility: evidence from 10,564 cases and 12,075 controls
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Hum Genet 125:431-5. 2009
    ..29; 95% CI = 1.00-1.67; P (heterogeneity) = 0.41). In summary, this meta-analysis suggests that the FAS -1,377 G/A polymorphism is associated with cancer susceptibility...
  30. pmc Association between XPF polymorphisms and cancer risk: a meta-analysis
    Ting Yan Shi
    Cancer Research Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China
    PLoS ONE 7:e38606. 2012
    ..A series of epidemiological studies have examined associations between XPF polymorphisms and cancer risk, but the findings remain inconclusive...
  31. doi request reprint The CYP1B1 Leu432Val polymorphism contributes to lung cancer risk: evidence from 6501 subjects
    Bo Chen
    Department of Geriatrics, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China
    Lung Cancer 70:247-52. 2010
    ..175). However, we did not find any statistically significant association by subgroup analyses of pathological type. This meta-analysis suggests that the CYP1B1 Val allele is a low-penetrant risk factor for developing lung cancer...
  32. doi request reprint Predictive and prognostic value of KRAS mutations in metastatic colorectal cancer patients treated with cetuximab: a meta-analysis of 22 studies
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Eur J Cancer 46:2781-7. 2010
    ..Patients with tumours that harbour mutant-type KRAS are more likely to have a worse response, PFS, and OS when treated with cetuximab...
  33. doi request reprint Glutathione S-transferase M1 polymorphism and breast cancer susceptibility: a meta-analysis involving 46,281 subjects
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 121:703-8. 2010
    ..15, 95% CI = 1.04-1.28). In conclusion, this meta-analysis suggests that the GSTM1 null genotype is a low-penetrant risk factor for developing breast cancer...
  34. ncbi request reprint The association between XPD Asp312Asn polymorphism and lung cancer risk: a meta-analysis including 16,949 subjects
    Jian Zhang
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Med Oncol 28:655-60. 2011
    ..Asp/Asp: OR=1.315, 95% CI=1.110-1.558; recessive model: OR=1.290, 95% CI=1.099-1.513). In conclusion, this meta-analysis suggests that the XPD Asn allele is a low-penetrant risk factor for developing lung cancer...
  35. doi request reprint Glutathione S-transferase T1 polymorphism is associated with breast cancer susceptibility
    Xing xing Chen
    Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
    Cytokine 56:477-80. 2011
    ..However, large sample and representative population-based studies with homogeneous breast cancer patients and well matched controls are warranted to confirm this finding...
  36. doi request reprint Chlamydia pneumoniae infection and lung cancer risk: a meta-analysis
    Ping Zhan
    First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, China
    Eur J Cancer 47:742-7. 2011
    ..22; 95% CI, 1.06-1.41) and the IgA ≥ 64 cutoff group (OR, 2.35; 95% CI, 1.88-2.93). In conclusion, C. pneumoniae infection is associated with an increased risk for lung cancer, higher titre may be a better predictor of lung cancer risk...
  37. doi request reprint The association between TA-repeat polymorphism in the promoter region of UGT1A1 and breast cancer risk: a meta-analysis
    Lei Yao
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People s Republic of China
    Breast Cancer Res Treat 122:879-82. 2010
    ..88; 95% CI: 0.77-0.99; P = 0.425 for heterogeneity) in Caucasians, but no in other genetic models. In conclusion, this meta-analysis suggests that UGT1A1 A(TA)(7)TAA allele is a potential risk factor for breast cancer in Caucasians...
  38. ncbi request reprint MDM2 309 T/G polymorphism is associated with lung cancer risk among Asians
    Xian Hua Gui
    Department of Respiratory Medicine, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China
    Eur J Cancer 45:2023-6. 2009
    ..14). However, no significant associations were found in both Europeans and Africans for all genetic models. This meta-analysis suggests that the MDM2 309G allele is a low-penetrant risk factor for developing lung cancer in Asians...
  39. doi request reprint Prognostic value of vascular endothelial growth factor expression in patients with lung cancer: a systematic review with meta-analysis
    Ping Zhan
    Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
    J Thorac Oncol 4:1094-103. 2009
    ..However, the prognostic value of VEGF overexpression in patients with lung cancer remains controversial...