Zheng Hong Qin

Summary

Publications

  1. ncbi request reprint Animal models of Huntington's disease: implications in uncovering pathogenic mechanisms and developing therapies
    Lin Hui Wang
    Department of Physiology, Soochow University School of Medicine, Suzhou 215123, China
    Acta Pharmacol Sin 27:1287-302. 2006
  2. ncbi request reprint Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription
    Kimberly B Kegel
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 277:7466-76. 2002
  3. ncbi request reprint Autophagy regulates the processing of amino terminal huntingtin fragments
    Zheng Hong Qin
    Laboratory of Cellular Neurobiology, Masschusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    Hum Mol Genet 12:3231-44. 2003
  4. pmc Antinociceptive and anti-inflammatory effects of orally administrated denatured naja naja atra venom on murine rheumatoid arthritis models
    Kou Zhu Zhu
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Sciences, 199 Ren Ai Road, Suzhou 215123, China Department of Pharmacy, Wuxi People s Hospital Affiliated to Nanjing Medical University, Wuxi 214073, China
    Evid Based Complement Alternat Med 2013:616241. 2013
  5. pmc DRAM1 regulates autophagy flux through lysosomes
    Xing Ding Zhang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China
    PLoS ONE 8:e63245. 2013
  6. pmc Poloxamer 188 protects neurons against ischemia/reperfusion injury through preserving integrity of cell membranes and blood brain barrier
    Jin Hua Gu
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China
    PLoS ONE 8:e61641. 2013
  7. pmc The prosurvival role of autophagy in Resveratrol-induced cytotoxicity in human U251 glioma cells
    Jun Li
    Department of Pharmacology, Soochow University School of Medicine, Suzhou, PR China
    BMC Cancer 9:215. 2009
  8. ncbi request reprint Huntingtin processing in pathogenesis of Huntington disease
    Zheng Hong Qin
    Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, China
    Acta Pharmacol Sin 25:1243-9. 2004
  9. ncbi request reprint A short-chain alpha-neurotoxin from Naja naja atra produces potent cholinergic-dependent analgesia
    Hui Ling Zhang
    Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, China ReceptoPharm, Plantation, Florida, USA E mail
    Neurosci Bull 22:103-9. 2006
  10. ncbi request reprint Mitochondrial dysfunction and Huntington disease
    Wei Yan Zhang
    SooChow University School of Life Sciences Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China E mail
    Neurosci Bull 22:129-36. 2006

Collaborators

Detail Information

Publications93

  1. ncbi request reprint Animal models of Huntington's disease: implications in uncovering pathogenic mechanisms and developing therapies
    Lin Hui Wang
    Department of Physiology, Soochow University School of Medicine, Suzhou 215123, China
    Acta Pharmacol Sin 27:1287-302. 2006
    ..In this review we discussed usefulness and limitations of various animal and cellular models of HD in uncovering molecular mechanisms of pathogenesis and developing novel therapies for HD...
  2. ncbi request reprint Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription
    Kimberly B Kegel
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 277:7466-76. 2002
    ..Proteolysis of mutant huntingtin may alter nuclear functions by disrupting protein complexes and inappropriately repressing transcription in HD...
  3. ncbi request reprint Autophagy regulates the processing of amino terminal huntingtin fragments
    Zheng Hong Qin
    Laboratory of Cellular Neurobiology, Masschusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    Hum Mol Genet 12:3231-44. 2003
    ..These results suggest that autophagy plays a critical role in the degradation of N-terminal htt. Altered processing of mutant htt by autophagy and cathepsin D may contribute to HD pathogenesis...
  4. pmc Antinociceptive and anti-inflammatory effects of orally administrated denatured naja naja atra venom on murine rheumatoid arthritis models
    Kou Zhu Zhu
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Sciences, 199 Ren Ai Road, Suzhou 215123, China Department of Pharmacy, Wuxi People s Hospital Affiliated to Nanjing Medical University, Wuxi 214073, China
    Evid Based Complement Alternat Med 2013:616241. 2013
    ....
  5. pmc DRAM1 regulates autophagy flux through lysosomes
    Xing Ding Zhang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China
    PLoS ONE 8:e63245. 2013
    ..DRAM1 affects autophagy through argument of lysosomal acidification, fusion of lysosomes with autophagosomes and clearance of autophagosomes...
  6. pmc Poloxamer 188 protects neurons against ischemia/reperfusion injury through preserving integrity of cell membranes and blood brain barrier
    Jin Hua Gu
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China
    PLoS ONE 8:e61641. 2013
    ..Therefore, the present study concludes that P188 can protect against cerebral ischemia/reperfusion injury, and the protection involves multi-mechanisms in addition to the membrane resealing...
  7. pmc The prosurvival role of autophagy in Resveratrol-induced cytotoxicity in human U251 glioma cells
    Jun Li
    Department of Pharmacology, Soochow University School of Medicine, Suzhou, PR China
    BMC Cancer 9:215. 2009
    ..Previous study reported that resveratrol has anti-tumor activity. In this study, we investigated the involvement of autophagy in the resveratrol-induced apoptotic death of human U251 glioma cells...
  8. ncbi request reprint Huntingtin processing in pathogenesis of Huntington disease
    Zheng Hong Qin
    Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, China
    Acta Pharmacol Sin 25:1243-9. 2004
    ..This review focused on the role of proteases in huntingtin cleavage and degradation and the contribution of altered processing of mutant huntingtin to HD pathogenesis...
  9. ncbi request reprint A short-chain alpha-neurotoxin from Naja naja atra produces potent cholinergic-dependent analgesia
    Hui Ling Zhang
    Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, China ReceptoPharm, Plantation, Florida, USA E mail
    Neurosci Bull 22:103-9. 2006
    ..The central cholinergic system but not opioid system appears to be involved in the antinociceptive action of CT...
  10. ncbi request reprint Mitochondrial dysfunction and Huntington disease
    Wei Yan Zhang
    SooChow University School of Life Sciences Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China E mail
    Neurosci Bull 22:129-36. 2006
    ..The gene coding Huntingtin has been identified, but the pathogenic mechanisms of the disease are still not fully understood. This paper reviews the involvement of mitochondrial dysfunction in pathogenesis of HD...
  11. ncbi request reprint Analgesic effects of receptin, a chemically modified cobratoxin from Thailand cobra venom
    Hui Ling Zhang
    Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China ReceptoPharm Inc, Florida 33324, USA E mail
    Neurosci Bull 22:267-73. 2006
    ..The central cholinergic system and opioid peptidergic system appear not to be involved in the antinociceptive action of REC...
  12. ncbi request reprint Regulatory genes controlling neural stem cells differentiation into neurons
    Li Zhang
    Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China E mail
    Neurosci Bull 22:294-300. 2006
    ..In this paper, we summarized the recent findings on the gene regulation of NSCs differentiation into neuronal cells...
  13. ncbi request reprint Inflammatory mechanism in ischemic neuronal injury
    Ya Dan Wen
    Department of Pharmacology, Soochow University, School of Medicine, Suzhou 215123, China E mail
    Neurosci Bull 22:171-82. 2006
    ..While many studies have tested these hypotheses, the significance of inflammation in stroke models is inconclusive. This review summarizes data regarding roles of cell adhesion molecules, astrocytes, microglia and leukocytes in stroke...
  14. ncbi request reprint Dual roles of NF-kappaB in cell survival and implications of NF-kappaB inhibitors in neuroprotective therapy
    Zheng Hong Qin
    Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China
    Acta Pharmacol Sin 28:1859-72. 2007
    ..This paper will also focus on the effects of various NF-kappaB inhibitors on neuroprotection in certain pathological conditions to speculate if NF-kappaB is a potential target for neuroprotective therapy...
  15. ncbi request reprint Development of novel therapies for Huntington's disease: hope and challenge
    Zheng Hong Qin
    Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, China
    Acta Pharmacol Sin 26:129-42. 2005
    ..There is a large body of encouraging news on novel therapeutic developments. The present paper reviews drugs used for symptomatic treatment of HD and experimental therapies targeting HD molecular pathology...
  16. ncbi request reprint Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction
    Zheng Hong Qin
    Laboratory of Cellular Neurobiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 24:269-81. 2004
    ..Results suggest that accumulation of a nonfibrillar form of mutant htt in the cytoplasm contributes to neuronal dysfunction by sequestering proteins involved in vesicle trafficking...
  17. ncbi request reprint p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum
    Xing Ding Zhang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Autophagy 5:339-50. 2009
    ..These results suggest that p53 plays roles in signaling both autophagy and apoptosis. Autophagy, at least partially, contributes to neurodegeneration induced by mitochondria dysfunction...
  18. ncbi request reprint Down-regulation of Bcl-2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum
    Xing Ding Zhang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    J Neurosci Res 87:3600-10. 2009
    ..Bcl-2 thus plays important roles in mitochondria dysfunction-induced apoptotic death of stritatal neurons by modulating both autophagic and apoptotic processes...
  19. ncbi request reprint Contributions of autophagic and apoptotic mechanisms to CrTX-induced death of K562 cells
    Ci hui Yan
    Department of Pharmacology, Soochow University School of Medicine, Suzhou Institute of Chinese Materia Medica, 708 Ren Min Road, Suzhou 215007, People s Republic of China
    Toxicon 47:521-30. 2006
    ..These results suggest that an apoptotic mechanism contributes to the Crotoxin-induced death of K562 cells, while the activation of autophagy delays neurotoxin-induced apoptosis...
  20. doi request reprint Therapeutic effect of SN50, an inhibitor of nuclear factor-κB, in treatment of TBI in mice
    Yu Xia Sun
    Department of Forensic Medicine, Soochow University, 199 Ren Ai Road, Suzhou Dushuhu High Educational Town, Suzhou 215123, People s Republic of China
    Neurol Sci 34:345-55. 2013
    ..The results imply that through NF-κB/TNF-α/cathepsin networks SN50 may contribute to TBI-induced extrinsic and intrinsic apoptosis, and inflammatory pathways, which partly determined the fate of injured cells in our TBI model...
  21. ncbi request reprint Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways
    Ya Dan Wen
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Autophagy 4:762-9. 2008
    ..These results demonstrate that ischemic insult activates autophagy and an autophagic mechanism may contribute to ischemic neuronal injury. Thus, autophagy may be a potential target for developing a novel therapy for stroke...
  22. ncbi request reprint NF-kappaB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53
    Zhong qin Liang
    Department of Pharmacology, Soochow University School of Medicine, Suzhou Singapore Industrial Park, Suzhou 215123, China
    Brain Res 1145:190-203. 2007
    ..These results suggest that NF-kappaB activation contributes, at least in part, to oxidative stress-induced degeneration of dopaminergic neurons through a NF-kappaB-dependent p53-signaling pathway...
  23. ncbi request reprint Susceptibility of striatal neurons to excitotoxic injury correlates with basal levels of Bcl-2 and the induction of P53 and c-Myc immunoreactivity
    Zhong qin Liang
    Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, P R China
    Neurobiol Dis 20:562-73. 2005
    ..The selective vulnerability of striatal medium spiny neurons to degeneration in a rodent model of Huntington's disease appears to correlate with their low levels of Bcl-2-i and high levels of induced p53-i and c-Myc-i...
  24. ncbi request reprint Huntingtin associates with acidic phospholipids at the plasma membrane
    Kimberly B Kegel
    Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:36464-73. 2005
    ..Our data support a new model in which huntingtin directly binds membranes through electrostatic interactions with acidic phospholipids...
  25. ncbi request reprint Inhibitory effect of crotoxin on the pain-evoked discharge of neurons in thalamic parafascicular nucleus in rats
    Qi Zhu
    Department of Neurobiology, School of Medicine, Soochow University, Ren Ai Road, Dushu Lake Campus, Suzhou Industrial Park, Suzhou 215123, PR China
    Toxicon 51:102-11. 2008
    ..The results suggested that Cro has an analgesic effect, which is mediated, at least partially, by the central serotonergic system...
  26. pmc Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity
    Xueyi Li
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Mol Cell Biol 29:6106-16. 2009
    ..We propose a novel mechanism for cellular dysfunction by the HD mutation arising from the inhibition of Rab11 activity and a deficit in vesicle formation at recycling endosomes...
  27. ncbi request reprint Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning
    Rui Sheng
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Autophagy 8:310-25. 2012
    ..These results demonstrated that pre-activation of autophagy by ischemic preconditioning can boost endogenous defense mechanisms to upregulate molecular chaperones, and hence reduce excessive ER stress during fatal ischemia...
  28. ncbi request reprint Neuroprotective effects of prostaglandin A1 in animal models of focal ischemia
    Hui Ling Zhang
    Department of Pharmacology, Soochow University School of Medicine, 48 Ren Ming Road, Suzhou 215007, PR China
    Brain Res 1039:203-6. 2005
    ..01) when administered immediately following permanent ischemia in rats. PGA1 treatment also significantly ameliorated motor dysfunction after brain ischemia. These results suggest that PGA1 protects neurons from ischemic injury...
  29. ncbi request reprint Enhancement of neuroprotection and heat shock protein induction by combined prostaglandin A1 and lithium in rodent models of focal ischemia
    Xi hui Xu
    Department of Pharmacology, Soochow University School of Medicine, Suzhou Singopore Industrial Park, Suzhou, China
    Brain Res 1102:154-62. 2006
    ..These studies suggest that lithium can potentiate PGA(1)'s neuroprotective effects and thus may have potential clinical value for the treatment of stroke in combination with other neuroprotective agents...
  30. pmc Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons
    Yan Ru Wang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases SZS0703, Soochow University School of Pharmaceutical Science, Wen Jing Road, Suzhou, China
    PLoS ONE 8:e75702. 2013
    ..These results suggest that cathepsin L is involved in glutamate receptor-induced NF-κB activation. Cathepsin L inhibitors have neuroprotective effects by inhibiting glutamate receptor-induced IκB-α degradation and NF-κB activation. ..
  31. ncbi request reprint Nuclear factor-kappaB-dependent cyclin D1 induction and DNA replication associated with N-methyl-D-aspartate receptor-mediated apoptosis in rat striatum
    Zhong qin Liang
    Department of Pharmacology, Soochow University School of Medicine, Suzhou, China
    J Neurosci Res 85:1295-309. 2007
    ..Excitotoxin-induced neuronal apoptosis may thus result from, at least partially, a failed cell cycle attempt...
  32. pmc The role of chaperone-mediated autophagy in huntingtin degradation
    Lin Qi
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China
    PLoS ONE 7:e46834. 2012
    ..These studies suggest that Hsc70 and LAMP-2A through CMA play a role in the clearance of Htt and suggest a novel strategy to target the degradation of mutant Htt...
  33. pmc The pro-survival role of autophagy depends on Bcl-2 under nutrition stress conditions
    Hai dong Xu
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China
    PLoS ONE 8:e63232. 2013
    ..Thus Bcl-2 may be an important mechanism for balancing beneficial and detrimental impacts of autophagy on cell survival...
  34. ncbi request reprint Lysosomal enzyme cathepsin B is involved in kainic acid-induced excitotoxicity in rat striatum
    Yan Wang
    Department of Pharmacology, Soochow University School of Medicine, 708 Ren Min Road, Suzhou 215007, PR China
    Brain Res 1071:245-9. 2006
    ..Z-FA-FMK (10 microg) also significantly reduced the size of striatal lesions induced by KA (P < 0.01, n = 6). These results suggest that lysosomal enzyme cathepsin B plays an important role in excitotoxic neuronal injury...
  35. ncbi request reprint An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid
    Yan Wang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases SZS0703, Soochow University School of Medicine, Suzhou, China
    Autophagy 4:214-26. 2008
    ..These results suggest that over-stimulation of KA receptors can activate autophagy. The autophagic mechanism participates in programmed cell death through regulating the mitochondria-mediated apoptotic pathway...
  36. ncbi request reprint Neuroprotective effects of prostaglandin A(1) in rat models of permanent focal cerebral ischemia are associated with nuclear factor-kappaB inhibition and peroxisome proliferator-activated receptor-gamma up-regulation
    Hui Ling Zhang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    J Neurosci Res 86:1132-41. 2008
    ..These findings suggest that PGA(1)-mediated neuroprotective effect against ischemia appears to be associated with blocking NF-kappaB activation and likely with up-regulating PPAR-gamma expression...
  37. doi request reprint Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning
    Rui Sheng
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Autophagy 6:482-94. 2010
    ..These results demonstrate that autophagy activation during IPC offers a remarkable tolerance to a subsequent fatal ischemic insult, and IPC's neuroprotective effects can be mimicked by autophagy inducers...
  38. ncbi request reprint The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1
    Jun Chao Wu
    Department of Pharmacology, Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China
    Acta Pharmacol Sin 33:743-51. 2012
    ..Huntingtin protein (Htt) was a neuropathological hallmark in human Huntington's Disease. The study aimed to investigate whether the macroautophagy regulator, Beclin1, was involved in the degradation of Htt...
  39. ncbi request reprint Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia
    Ai Ping Qin
    Department of Pharmacology, Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Autophagy 6:738-53. 2010
    ..These results suggest that ischemia or hypoxia-induced autophagic/lysosomal pathway activation may at least partly contribute to ischemic injury of astrocytes...
  40. ncbi request reprint A long-form alpha-neurotoxin from cobra venom produces potent opioid-independent analgesia
    Zhi Xin Chen
    Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, China
    Acta Pharmacol Sin 27:402-8. 2006
    ....
  41. doi request reprint p38(MAPK)/p53-Mediated Bax induction contributes to neurons degeneration in rotenone-induced cellular and rat models of Parkinson's disease
    Feng Wu
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Sciences, Suzhou 215123, China
    Neurochem Int 63:133-40. 2013
    ..These results suggest that the p38(MAPK)/p53-dependent induction of Bax contributes to rotenone's neurotoxicity in PD models. ..
  42. ncbi request reprint Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine
    Xi Feng Fei
    Department of Pharmacology, Soochow University School of Medicine, Suzhou, China
    Brain Res 1264:85-97. 2009
    ..These findings suggest that olomoucine may exert neuroprotective effects through inhibiting cathepsin L nuclear translocation and activating autophagy...
  43. pmc Effects of LY294002 on the invasiveness of human gastric cancer in vivo in nude mice
    Chun gen Xing
    Department of General Surgery, The Second Affiliated Hospital, Soochow University, Suzhou 215006, Jiangsu Province, China
    World J Gastroenterol 15:5044-52. 2009
    ..To investigate the effects of class I phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 on the invasiveness and related mechanisms of implanted tumors of SGC7901 human gastric carcinoma cells in nude mice...
  44. doi request reprint Cathepsin B contributes to traumatic brain injury-induced cell death through a mitochondria-mediated apoptotic pathway
    Cheng Liang Luo
    Department of Forensic Medicine, Soochow University, Suzhou, China
    J Neurosci Res 88:2847-58. 2010
    ..The results imply that cathepsin B contributes to TBI-induced cell death through the present programmed cell necrosis and mitochondria-mediated apoptotic pathways...
  45. doi request reprint Inhibition of NF-κB activation is associated with anti-inflammatory and anti-apoptotic effects of Ginkgolide B in a mouse model of cerebral ischemia/reperfusion injury
    Jin Hua Gu
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou 215123, China
    Eur J Pharm Sci 47:652-60. 2012
    ..These results suggest that GB's neuroprotection is attributable to its anti-inflammatory and anti-apoptotic effect through inhibition of NF-κB...
  46. ncbi request reprint Quality control system of the endoplasmic reticulum and related diseases
    Jun Chao Wu
    Department of Pharmacology, School of Medicine, Soochow University, Suzhou 215123, China
    Acta Biochim Biophys Sin (Shanghai) 38:219-26. 2006
    ..A better understanding of molecular regulation in the QC system will uncover the molecular pathogenic mechanisms of many diseases caused by protein misfolding and help discover novel strategies for preventing or treating these diseases...
  47. ncbi request reprint Molecular mechanism and regulation of autophagy
    Ya Ping Yang
    Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, China
    Acta Pharmacol Sin 26:1421-34. 2005
    ..The molecular mechanisms and regulation of autophagy are discussed in this review...
  48. ncbi request reprint Involvement of cholinergic system in suppression of formalin-induced inflammatory pain by cobratoxin
    Gao Na Shi
    Department of Pharmacology, Soochow University School of Pharmacy, Suzhou, China
    Acta Pharmacol Sin 32:1233-8. 2011
    ..To investigate the analgesic effect of cobratoxin (CTX), a long-chain α-neurotoxin from Thailand cobra venom, in a rat model of formalin-induced inflammatory pain...
  49. pmc Blocking NF-κB nuclear translocation leads to p53-related autophagy activation and cell apoptosis
    Bao song Zhu
    Department of General Surgery, The Second Affiliated Hospital, Soochow University, Suzhou, Jiangsu Province, China
    World J Gastroenterol 17:478-87. 2011
    ..To investigate the anti-tumor effects of nuclear factor-κB (NF-κB) inhibitor SN50 and related mechanisms of SGC7901 human gastric carcinoma cells...
  50. doi request reprint Protective effect of Ginkgolids (A+B) is associated with inhibition of NIK/IKK/IkappaB/NF-kappaB signaling pathway in a rat model of permanent focal cerebral ischemia
    Xuan Wang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Brain Res 1234:8-15. 2008
    ..The present study evaluated the effects of GKAB on NIK/IKK/IkappaB/NF-kappaB signaling pathway in a rat model of permanent focal cerebral ischemia...
  51. doi request reprint Growth inhibitory effects and molecular mechanisms of crotoxin treatment in esophageal Eca-109 cells and transplanted tumors in nude mice
    Jing kang He
    Department of Cardiothoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China
    Acta Pharmacol Sin 34:295-300. 2013
    ..To investigate the antitumor actions of the Crotalus durissus neurotoxin (crotoxin) on human esophageal carcinoma (Eca-109) cells in vitro and transplanted esophageal Eca-109 tumors in nude mice...
  52. doi request reprint Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes
    Lei Lei Chen
    Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China
    Acta Pharmacol Sin 33:385-92. 2012
    ..To investigate the effects of rapamycin on glutamate uptake in cultured rat astrocytes expressing N-terminal 552 residues of mutant huntingtin (Htt-552)...
  53. doi request reprint Suppression of complete Freund's adjuvant-induced adjuvant arthritis by cobratoxin
    Yan Li Liu
    College of Pharmacy, Soochow University, Suzhou, China
    Acta Pharmacol Sin 30:219-27. 2009
    ..The present study evaluated the anti-inflammatory and anti-nociceptive effects of CTX on adjuvant arthritis (AA) in rats...
  54. doi request reprint Poloxamer-188 attenuates TBI-induced blood-brain barrier damage leading to decreased brain edema and reduced cellular death
    Hai Jun Bao
    Institute of Forensic Sciences, Soochow University, Suzhou 215123, Jiangsu, China
    Neurochem Res 37:2856-67. 2012
    ..Plasmalemma permeability may be a potential target for TBI treatment...
  55. doi request reprint The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning
    Bo Gao
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou 215123, China
    Acta Pharmacol Sin 34:657-66. 2013
    ..To investigate whether endoplasmic reticulum (ER) stress participates in the neuroprotective effects of ischemic preconditioning (IPC)-induced neuroprotection and autophagy activation in rat brains...
  56. doi request reprint Combined prostaglandin E1 and lithium exert potent neuroprotection in a rat model of cerebral ischemia
    Rui Sheng
    Department of Pharmacology, Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Acta Pharmacol Sin 32:303-10. 2011
    ..The effects of the mixture on protein expression of heat shock proteins (HSPs), p53, and Bcl-2 were also determined...
  57. ncbi request reprint Opiate and acetylcholine-independent analgesic actions of crotoxin isolated from crotalus durissus terrificus venom
    Hui Ling Zhang
    Department of Pharmacology, Soochow University School of Medicine, 48 Ren Ming Road, Suzhou 215007, PR China
    Toxicon 48:175-82. 2006
    ..These results suggest that Cro has analgesic effects mediated by an action on the central nervous system. The muscarinic and opioid receptors are not involved in the antinociceptive effects of Cro...
  58. ncbi request reprint Prostaglandin A1 inhibits increases in intracellular calcium concentration, TXA(2) production and platelet activation
    Yi Zhu
    Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China
    Acta Pharmacol Sin 27:549-54. 2006
    ..In our previous studies we found that cyclopentenane prostaglandin A1 (PGA1) had neuroprotective effects in a rodent ischemic model. In the present study we aimed to investigate the inhibitory effect of PGA1 on platelet function...
  59. ncbi request reprint Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia
    Xi hui Xu
    Laboratory of Aging and Nervous Disease, Soochow University School of Medicine, Suzhou, China
    Acta Pharmacol Sin 28:1097-104. 2007
    ....
  60. ncbi request reprint Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway
    Yan xia Yu
    Soochow Institute of Chinese Materia Medica, Suzhou, Suzhou, Jiangsu 215007, China
    Chin Med J (Engl) 123:1915-23. 2010
    ..The objective of this study was to investigate the inhibitory effect and mechanisms of UA on the human hepatoma cell line SMMC-7721...
  61. doi request reprint The role of post-translational modifications of huntingtin in the pathogenesis of Huntington's disease
    Yan Wang
    Department of Pharmacology, Laboratory of Aging and Nervous Diseases SZS0703, Soochow University School of Medicine, Suzhou 215123, China
    Neurosci Bull 26:153-62. 2010
    ..Therefore, identifying signaling pathways of Htt modification and evaluating the significance of Htt modifications would lead to a better understanding of the normal function of wild-type Htt and the pathogenic mechanisms of mutant Htt...
  62. doi request reprint Anti-tumor activity of CrTX in human lung adenocarcinoma cell line A549
    Bin Ye
    Dept of Cardiothoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China
    Acta Pharmacol Sin 32:1397-401. 2011
    ..To assess the cytotoxic effect of crotoxin (CrTX), a potent neurotoxin extracted from the venom of the pit viper Crotalus durissus terrificus, in human lung adenocarcinoma A549 cells and investigated the underlying mechanisms...
  63. doi request reprint Mechanisms of lysosomal proteases participating in cerebral ischemia-induced neuronal death
    Ai Ping Qin
    Department of Pharmacology, Laboratory of Aging and Nervous Disease, Soochow University School of Medicine, Suzhou 215123, China
    Neurosci Bull 24:117-23. 2008
    ..Moreover, the research related to the selective cathepsin inhibitors may provide a novel therapeutic target for treating stroke and promoting recovery...
  64. ncbi request reprint Autophagy is involved in cytotoxic effects of crotoxin in human breast cancer cell line MCF-7 cells
    Ci hui Yan
    Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China
    Acta Pharmacol Sin 28:540-8. 2007
    ..To investigate the role of crotoxin (CrTX)-induced autophagy in the death of MCF-7 cells, a caspase-3-deficient, human breast cancer cell line...
  65. ncbi request reprint Cobratoxin inhibits pain-evoked discharge of neurons in thalamic parafascicular nucleus in rats: involvement of cholinergic and serotonergic systems
    Bo Chao Cheng
    Department of Neurobiology and Medical Psychology, Medical College, Soochow University, Suzhou 215123, PR China
    Toxicon 54:224-32. 2009
    ....
  66. ncbi request reprint Bilobalide inhibits 6-OHDA-induced activation of NF-kappaB and loss of dopaminergic neurons in rat substantia nigra
    Ling Yun Li
    Department of Pharmacology, Soochow University School of Medicine, Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou 215123, China
    Acta Pharmacol Sin 29:539-47. 2008
    ..To investigate the effects of bilobalide on the activation of NF-kappaB, and apoptosis of dopaminergic neurons induced by 6-hydroxydopamine (6-OHDA)...
  67. doi request reprint Autophagic and apoptotic mechanisms of curcumin-induced death in K562 cells
    Yan li Jia
    Department of Pharmacology, Soochow University School of Medicine, Suzhou, China
    J Asian Nat Prod Res 11:918-28. 2009
    ..Overall, these results suggest that curcumin induces autophagic and apoptotic death of K562 cells. These findings suggest that both apoptotic and autophagic mechanisms contribute to the curcumin-induced K562 cell death...
  68. doi request reprint The roles of the proteasome pathway in signal transduction and neurodegenerative diseases
    Jiao Jiao Chen
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Neurosci Bull 24:183-94. 2008
    ..This paper reviews the biological functions of proteasome in signal transduction and its potential roles in neurodegenerative diseases...
  69. pmc Dysfunction of nucleus accumbens-1 activates cellular senescence and inhibits tumor cell proliferation and oncogenesis
    Yi Zhang
    Department of Pharmacology, College of Pharmaceutical Sciences, Cyrus Tang Hematology Center, Soochow University, Suzhou, Jiangsu, China
    Cancer Res 72:4262-75. 2012
    ....
  70. ncbi request reprint [Association of PARK 16 polymorphisms with Parkinson's disease in Han population of Suzhou area]
    Dong Hui Li
    Department of Neurology, Second Affiliated Hospital, Soochow University, Suzhou 215004, China
    Zhonghua Yi Xue Za Zhi 91:296-300. 2011
    ..To investigate whether there is an association of PARK 16 locus with Parkinson's disease (PD) in Han population of Suzhou area...
  71. ncbi request reprint Effect of curcumin on the adhesion of platelets to brain microvascular endothelial cells in vitro
    Li Zhang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou 215123, China
    Acta Pharmacol Sin 29:800-7. 2008
    ..To determine whether curcumin prevents the adhesion of platelets to brain microvascular endothelial cells (BMECs) cultured in vitro...
  72. ncbi request reprint Molecular and cellular mechanisms of excitotoxic neuronal death
    Yan Wang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases SZS0703, Soochow University School of Medicine, WenJing Road, 215123 Suzhou, China
    Apoptosis 15:1382-402. 2010
    ..This review discusses the current understanding of the molecular and cellular mechanisms of excitotoxicity and their roles in the pathogenesis of diseases of the central nervous system...
  73. doi request reprint NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro
    Wen Juan Wang
    Department of Pharmacology, Medical School of Soochow University, Suzhou 215123, China
    Acta Pharmacol Sin 34:681-90. 2013
    ..NVP-BEZ235 is a novel dual PI3K/mTOR inhibitor and shows dramatic effects on gliomas. The aim of this study was to investigate the effects of NVP-BEZ235 on the radiosensitivity and autophagy of glioma stem cells (GSCs) in vitro...
  74. ncbi request reprint Dynamic effects of autophagy on arsenic trioxide-induced death of human leukemia cell line HL60 cells
    Ya Ping Yang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Acta Pharmacol Sin 29:123-34. 2008
    ..To evaluate the contribution of an autophagic mechanism to the As2O3- induced death of human acute myeloid leukaemia cell line HL60 cells...
  75. doi request reprint A function of huntingtin in guanine nucleotide exchange on Rab11
    Xueyi Li
    Laboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Neuroreport 19:1643-7. 2008
    ..These data suggest a role for huntingtin in a complex that activates Rab11...
  76. ncbi request reprint Current understanding on the pathogenesis of polyglutamine diseases
    Xiao Hui He
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou 215123, China
    Neurosci Bull 26:247-56. 2010
    ....
  77. doi request reprint Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases
    Xiao Xia Dong
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Acta Pharmacol Sin 30:379-87. 2009
    ..This review discusses the current understanding of excitotoxic mechanisms and how they are involved in the pathogenesis of neurodegenerative diseases...
  78. doi request reprint Synergistic effects of prostaglandin E1 and lithium in a rat model of cerebral ischemia
    Rong Han
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou 215123, China
    Acta Pharmacol Sin 29:1141-9. 2008
    ..The present study was undertaken to examine if lithium could potentiate the neuroprotection of PGE1 against cerebral ischemia, and if the synergetic effects take place at the level of HSPs...
  79. ncbi request reprint Strategies for short hairpin RNA delivery in cancer gene therapy
    Shou li Wang
    Soochow University School of Medicine, Department of Pathology, Suzhou 215123, China
    Expert Opin Biol Ther 9:1357-68. 2009
    ....
  80. doi request reprint LY294002 induces p53-dependent apoptosis of SGC7901 gastric cancer cells
    Chun gen Xing
    Department of General Surgery, The Second Affiliated Hospital, Soochow University, Suzhou 215004, China
    Acta Pharmacol Sin 29:489-98. 2008
    ..To study the effects of LY294002, an inhibitor of class I phosphatidylinositol 3-kinase (PI3K), on proliferation and apoptosis of SGC7901 gastric cancer cells...
  81. ncbi request reprint The role of p53 in cell metabolism
    Xing Ding Zhang
    Department of Pharmacology and Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Acta Pharmacol Sin 31:1208-12. 2010
    ..In addition, p53 regulates autophagy to provide cell metabolites for surviving through damage regulated autophagy modulator (DRAM1). Here we review the recent findings to elucidate the important role of p53 in cell metabolism...
  82. pmc Expression of elongation factor-2 kinase contributes to anoikis resistance and invasion of human glioma cells
    Li Zhang
    Department of Pharmacology, College of Pharmaceutical Science, Soochow University, Suzhou, China
    Acta Pharmacol Sin 32:361-7. 2011
    ..To determine whether elongation factor-2 kinase (eEF-2 kinase) contributes to the malignant phenotype of glioblastoma multiforme by promoting the migration and invasion of glioma cells. The mechanism involved was also explored...
  83. doi request reprint Therapeutic potential of Naja naja atra venom in a rat model of diabetic nephropathy
    Gui Li Dai
    The First Affiliated Hospital of Soochow University, Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou 215006, Jiangsu, China
    Biomed Environ Sci 25:630-8. 2012
    ..To study the protective effects of naja naja atra venom (NNAV) in a rat model of diabetic nephropathy (DN)...
  84. doi request reprint Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats
    Li Luo
    School of Physical Education and Sports Science, Soochow University, Suzhou 215021, China
    Exp Gerontol 48:427-36. 2013
    ....
  85. pmc Coordination of autophagy with other cellular activities
    Yan Wang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases SZS0703, Soochow University School of Pharmaceutical Science, Suzhou 215123, China
    Acta Pharmacol Sin 34:585-94. 2013
    ..The insights gained from investigating autophagic networks should increase our understanding of their roles in human diseases and their potential as targets for therapeutic intervention...
  86. ncbi request reprint [Advances in research of ketamine addiction mechanism]
    Wei Li Liu
    Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China
    Fa Yi Xue Za Zhi 25:200-3, 207. 2009
    ....
  87. ncbi request reprint [Expression of cathepsin-B and -D in rat's brain after traumatic brain injury]
    Yan Bo Zhang
    Department of Forensic Medicine of Suzhou University, Suzhou 215123, China
    Fa Yi Xue Za Zhi 22:404-6, 410. 2006
    ..To study the expression of cathepsin-B and -D in different time point after traumatic brain injury...
  88. ncbi request reprint Selection of optimal sites for TGFB1 gene silencing by chitosan-TPP nanoparticle-mediated delivery of shRNA
    So Ly Wang
    Department of Pathology, Soochow University School of Medicine, Suzhou, China
    Cancer Genet Cytogenet 190:8-14. 2009
    ..These data suggest that chitosan nanoparticle-mediated delivery of an shRNA produces efficient TGFB1 knockdown in rhabdomyosarcoma cells and may be a method of choice for shRNA delivery for gene therapy...
  89. ncbi request reprint Lysosomal proteases are involved in generation of N-terminal huntingtin fragments
    Yun J Kim
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neurobiol Dis 22:346-56. 2006
    ..Findings implicate lysosomal proteases in formation of N-mhtt fragments and clearance of mhtt...
  90. ncbi request reprint Prostaglandin A1 inhibits rotenone-induced apoptosis in SH-SY5Y cells
    Xiaoxia Wang
    National Institute of Neurological Disorders and Stroke, Experimental Therapeutics Branch, Bethesda, Maryland, USA
    J Neurochem 83:1094-102. 2002
    ..PGA1 appears to protect against rotenone-induced cell death by inducing HSPs and blocking nuclear translocation of NF-kappaB in a process that attenuates caspase-3 activation, but is not mediated by its inhibition...
  91. ncbi request reprint Autophagy and its possible roles in nervous system diseases, damage and repair
    David C Rubinsztein
    Departments of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Autophagy 1:11-22. 2005
    ..While many issues remain unresolved, these conditions raise the possibility that autophagy can have either deleterious or protective effects depending on the specific situation and stage in the pathological process...
  92. ncbi request reprint Downregulation of glutamate transporters is associated with elevation in extracellular glutamate concentration following rat microsphere embolism
    Feng Han
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Neurosci Lett 430:275-80. 2008
    ..Taken together, downregulation of glutamate transporters after ME is associated with dysregulation of basal glutamate concentrations and KCl-induced glutamate release in the brain...
  93. ncbi request reprint Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection
    Ren Wu Chen
    Molecular Neurobiology Section, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    J Neurochem 84:566-75. 2003
    ..Moreover, the neuroprotective effects of lithium are mediated, at least in part, by suppressing NMDA receptor-mediated activation of the mitogen-activated protein kinase pathway...