Animal models of Huntington's disease: implications in uncovering pathogenic mechanisms and developing therapiesLin-hui Wang
Department of Physiology, Soochow University School of Medicine, Suzhou 215123, China
Acta Pharmacol Sin 27:1287-302. 2006
..In this review we discussed usefulness and limitations of various animal and cellular models of HD in uncovering molecular mechanisms of pathogenesis and developing novel therapies for HD...
- Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription
Kimberly B Kegel
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
J Biol Chem 277:7466-76. 2002
..Proteolysis of mutant huntingtin may alter nuclear functions by disrupting protein complexes and inappropriately repressing transcription in HD...
- Autophagy regulates the processing of amino terminal huntingtin fragments
Zheng-Hong Qin
Laboratory of Cellular Neurobiology, Masschusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
Hum Mol Genet 12:3231-44. 2003
..These results suggest that autophagy plays a critical role in the degradation of N-terminal htt. Altered processing of mutant htt by autophagy and cathepsin D may contribute to HD pathogenesis...
The prosurvival role of autophagy in Resveratrol-induced cytotoxicity in human U251 glioma cellsJun Li
Department of Pharmacology, Soochow University School of Medicine, Suzhou, PR China
BMC Cancer 9:215. 2009
..Previous study reported that resveratrol has anti-tumor activity. In this study, we investigated the involvement of autophagy in the resveratrol-induced apoptotic death of human U251 glioma cells...
- A short-chain alpha-neurotoxin from Naja naja atra produces potent cholinergic-dependent analgesia
Hui Ling Zhang
Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, China ReceptoPharm, Plantation, Florida, USA E mail
Neurosci Bull 22:103-9. 2006
..The central cholinergic system but not opioid system appears to be involved in the antinociceptive action of CT...
- Mitochondrial dysfunction and Huntington disease
Wei Yan Zhang
SooChow University School of Life Sciences Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China E mail
Neurosci Bull 22:129-36. 2006
..The gene coding Huntingtin has been identified, but the pathogenic mechanisms of the disease are still not fully understood. This paper reviews the involvement of mitochondrial dysfunction in pathogenesis of HD...
- Analgesic effects of receptin, a chemically modified cobratoxin from Thailand cobra venom
Hui Ling Zhang
Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China ReceptoPharm Inc, Florida 33324, USA E mail
Neurosci Bull 22:267-73. 2006
..The central cholinergic system and opioid peptidergic system appear not to be involved in the antinociceptive action of REC...
- Regulatory genes controlling neural stem cells differentiation into neurons
Li Zhang
Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China E mail
Neurosci Bull 22:294-300. 2006
..In this paper, we summarized the recent findings on the gene regulation of NSCs differentiation into neuronal cells...
- Inflammatory mechanism in ischemic neuronal injury
Ya Dan Wen
Department of Pharmacology, Soochow University, School of Medicine, Suzhou 215123, China E mail
Neurosci Bull 22:171-82. 2006
..While many studies have tested these hypotheses, the significance of inflammation in stroke models is inconclusive. This review summarizes data regarding roles of cell adhesion molecules, astrocytes, microglia and leukocytes in stroke...
- Development of novel therapies for Huntington's disease: hope and challenge
Zheng Hong Qin
Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, China
Acta Pharmacol Sin 26:129-42. 2005
..There is a large body of encouraging news on novel therapeutic developments. The present paper reviews drugs used for symptomatic treatment of HD and experimental therapies targeting HD molecular pathology...
- Huntingtin processing in pathogenesis of Huntington disease
Zheng Hong Qin
Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, China
Acta Pharmacol Sin 25:1243-9. 2004
..This review focused on the role of proteases in huntingtin cleavage and degradation and the contribution of altered processing of mutant huntingtin to HD pathogenesis...
- Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction
Zheng Hong Qin
Laboratory of Cellular Neurobiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neurosci 24:269-81. 2004
..Results suggest that accumulation of a nonfibrillar form of mutant htt in the cytoplasm contributes to neuronal dysfunction by sequestering proteins involved in vesicle trafficking...
- Dual roles of NF-kappaB in cell survival and implications of NF-kappaB inhibitors in neuroprotective therapy
Zheng Hong Qin
Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China
Acta Pharmacol Sin 28:1859-72. 2007
..This paper will also focus on the effects of various NF-kappaB inhibitors on neuroprotection in certain pathological conditions to speculate if NF-kappaB is a potential target for neuroprotective therapy...
- p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum
Xing Ding Zhang
Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
Autophagy 5:339-50. 2009
..These results suggest that p53 plays roles in signaling both autophagy and apoptosis. Autophagy, at least partially, contributes to neurodegeneration induced by mitochondria dysfunction...
Down-regulation of Bcl-2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatumXing Ding Zhang
Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
J Neurosci Res 87:3600-10. 2009
..Bcl-2 thus plays important roles in mitochondria dysfunction-induced apoptotic death of stritatal neurons by modulating both autophagic and apoptotic processes...
- Susceptibility of striatal neurons to excitotoxic injury correlates with basal levels of Bcl-2 and the induction of P53 and c-Myc immunoreactivity
Zhong qin Liang
Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, P R China
Neurobiol Dis 20:562-73. 2005
..The selective vulnerability of striatal medium spiny neurons to degeneration in a rodent model of Huntington's disease appears to correlate with their low levels of Bcl-2-i and high levels of induced p53-i and c-Myc-i...
- Neuroprotective effects of prostaglandin A(1) in rat models of permanent focal cerebral ischemia are associated with nuclear factor-kappaB inhibition and peroxisome proliferator-activated receptor-gamma up-regulation
Hui Ling Zhang
Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
J Neurosci Res 86:1132-41. 2008
..These findings suggest that PGA(1)-mediated neuroprotective effect against ischemia appears to be associated with blocking NF-kappaB activation and likely with up-regulating PPAR-gamma expression...
- NF-kappaB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53
Zhong qin Liang
Department of Pharmacology, Soochow University School of Medicine, Suzhou Singapore Industrial Park, Suzhou 215123, China
Brain Res 1145:190-203. 2007
..These results suggest that NF-kappaB activation contributes, at least in part, to oxidative stress-induced degeneration of dopaminergic neurons through a NF-kappaB-dependent p53-signaling pathway...
- Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity
Xueyi Li
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Mol Cell Biol 29:6106-16. 2009
..We propose a novel mechanism for cellular dysfunction by the HD mutation arising from the inhibition of Rab11 activity and a deficit in vesicle formation at recycling endosomes...
- Huntingtin associates with acidic phospholipids at the plasma membrane
Kimberly B Kegel
Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Biol Chem 280:36464-73. 2005
..Our data support a new model in which huntingtin directly binds membranes through electrostatic interactions with acidic phospholipids...
- An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid
Yan Wang
Department of Pharmacology and Laboratory of Aging and Nervous Diseases SZS0703, Soochow University School of Medicine, Suzhou, China
Autophagy 4:214-26. 2008
..These results suggest that over-stimulation of KA receptors can activate autophagy. The autophagic mechanism participates in programmed cell death through regulating the mitochondria-mediated apoptotic pathway...
- Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning
Rui Sheng
Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
Autophagy 8:310-25. 2012
..These results demonstrated that pre-activation of autophagy by ischemic preconditioning can boost endogenous defense mechanisms to upregulate molecular chaperones, and hence reduce excessive ER stress during fatal ischemia...
- Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways
Ya Dan Wen
Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
Autophagy 4:762-9. 2008
..These results demonstrate that ischemic insult activates autophagy and an autophagic mechanism may contribute to ischemic neuronal injury. Thus, autophagy may be a potential target for developing a novel therapy for stroke...
- Nuclear factor-kappaB-dependent cyclin D1 induction and DNA replication associated with N-methyl-D-aspartate receptor-mediated apoptosis in rat striatum
Zhong qin Liang
Department of Pharmacology, Soochow University School of Medicine, Suzhou, China
J Neurosci Res 85:1295-309. 2007
..Excitotoxin-induced neuronal apoptosis may thus result from, at least partially, a failed cell cycle attempt...
- Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia
Ai Ping Qin
Department of Pharmacology, Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
Autophagy 6:738-53. 2010
..These results suggest that ischemia or hypoxia-induced autophagic/lysosomal pathway activation may at least partly contribute to ischemic injury of astrocytes...
- The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1
Jun Chao Wu
Department of Pharmacology, Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China
Acta Pharmacol Sin 33:743-51. 2012
..Huntingtin protein (Htt) was a neuropathological hallmark in human Huntington's Disease. The study aimed to investigate whether the macroautophagy regulator, Beclin1, was involved in the degradation of Htt...
- Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine
Xi Feng Fei
Department of Pharmacology, Soochow University School of Medicine, Suzhou, China
Brain Res 1264:85-97. 2009
..These findings suggest that olomoucine may exert neuroprotective effects through inhibiting cathepsin L nuclear translocation and activating autophagy...
- Inhibitory effect of crotoxin on the pain-evoked discharge of neurons in thalamic parafascicular nucleus in rats
Qi Zhu
Department of Neurobiology, School of Medicine, Soochow University, Ren Ai Road, Dushu Lake Campus, Suzhou Industrial Park, Suzhou 215123, PR China
Toxicon 51:102-11. 2008
..The results suggested that Cro has an analgesic effect, which is mediated, at least partially, by the central serotonergic system...
- Effects of LY294002 on the invasiveness of human gastric cancer in vivo in nude mice
Chun gen Xing
Department of General Surgery, The Second Affiliated Hospital, Soochow University, Suzhou 215006, Jiangsu Province, China
World J Gastroenterol 15:5044-52. 2009
..To investigate the effects of class I phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 on the invasiveness and related mechanisms of implanted tumors of SGC7901 human gastric carcinoma cells in nude mice...
- Cathepsin B contributes to traumatic brain injury-induced cell death through a mitochondria-mediated apoptotic pathway
Cheng Liang Luo
Department of Forensic Medicine, Soochow University, Suzhou, China
J Neurosci Res 88:2847-58. 2010
..The results imply that cathepsin B contributes to TBI-induced cell death through the present programmed cell necrosis and mitochondria-mediated apoptotic pathways...
- Involvement of cholinergic system in suppression of formalin-induced inflammatory pain by cobratoxin
Gao Na Shi
Department of Pharmacology, Soochow University School of Pharmacy, Suzhou, China
Acta Pharmacol Sin 32:1233-8. 2011
..Conclusion:The results suggest that CTX exerts an antinociceptive effect in formalin-induced inflammatory pain, which appears to be mediated by mAChR and α7-nAChR...
- Protective effect of Ginkgolids (A+B) is associated with inhibition of NIK/IKK/IkappaB/NF-kappaB signaling pathway in a rat model of permanent focal cerebral ischemia
Xuan Wang
Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
Brain Res 1234:8-15. 2008
..The present study evaluated the effects of GKAB on NIK/IKK/IkappaB/NF-kappaB signaling pathway in a rat model of permanent focal cerebral ischemia...
- Blocking NF-κB nuclear translocation leads to p53-related autophagy activation and cell apoptosis
Bao song Zhu
Department of General Surgery, The Second Affiliated Hospital, Soochow University, Suzhou, Jiangsu Province, China
World J Gastroenterol 17:478-87. 2011
..To investigate the anti-tumor effects of nuclear factor-κB (NF-κB) inhibitor SN50 and related mechanisms of SGC7901 human gastric carcinoma cells...
- Combined prostaglandin E1 and lithium exert potent neuroprotection in a rat model of cerebral ischemia
Rui Sheng
Department of Pharmacology, Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
Acta Pharmacol Sin 32:303-10. 2011
..The effects of the mixture on protein expression of heat shock proteins (HSPs), p53, and Bcl-2 were also determined...
- Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia
Xi hui Xu
Laboratory of Aging and Nervous Disease, Soochow University School of Medicine, Suzhou, China
Acta Pharmacol Sin 28:1097-104. 2007
....
- The role of post-translational modifications of huntingtin in the pathogenesis of Huntington's disease
Yan Wang
Department of Pharmacology, Laboratory of Aging and Nervous Diseases SZS0703, Soochow University School of Medicine, Suzhou 215123, China
Neurosci Bull 26:153-62. 2010
..Therefore, identifying signaling pathways of Htt modification and evaluating the significance of Htt modifications would lead to a better understanding of the normal function of wild-type Htt and the pathogenic mechanisms of mutant Htt...
- Mechanisms of lysosomal proteases participating in cerebral ischemia-induced neuronal death
Ai Ping Qin
Department of Pharmacology, Laboratory of Aging and Nervous Disease, Soochow University School of Medicine, Suzhou 215123, China
Neurosci Bull 24:117-23. 2008
..Moreover, the research related to the selective cathepsin inhibitors may provide a novel therapeutic target for treating stroke and promoting recovery...
- Autophagic and apoptotic mechanisms of curcumin-induced death in K562 cells
Yan li Jia
Department of Pharmacology, Soochow University School of Medicine, Suzhou, China
J Asian Nat Prod Res 11:918-28. 2009
..Overall, these results suggest that curcumin induces autophagic and apoptotic death of K562 cells. These findings suggest that both apoptotic and autophagic mechanisms contribute to the curcumin-induced K562 cell death...
- The roles of the proteasome pathway in signal transduction and neurodegenerative diseases
Jiao Jiao Chen
Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
Neurosci Bull 24:183-94. 2008
..This paper reviews the biological functions of proteasome in signal transduction and its potential roles in neurodegenerative diseases...
- Bilobalide inhibits 6-OHDA-induced activation of NF-kappaB and loss of dopaminergic neurons in rat substantia nigra
Ling Yun Li
Department of Pharmacology, Soochow University School of Medicine, Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou 215123, China
Acta Pharmacol Sin 29:539-47. 2008
..To investigate the effects of bilobalide on the activation of NF-kappaB, and apoptosis of dopaminergic neurons induced by 6-hydroxydopamine (6-OHDA)...
- Dysfunction of nucleus accumbens-1 activates cellular senescence and inhibits tumor cell proliferation and oncogenesis
Yi Zhang
Department of Pharmacology, College of Pharmaceutical Sciences, Cyrus Tang Hematology Center, Soochow University, Suzhou, Jiangsu, China
Cancer Res 72:4262-75. 2012
....
- Effect of curcumin on the adhesion of platelets to brain microvascular endothelial cells in vitro
Li Zhang
Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou 215123, China
Acta Pharmacol Sin 29:800-7. 2008
..To determine whether curcumin prevents the adhesion of platelets to brain microvascular endothelial cells (BMECs) cultured in vitro...
- Molecular and cellular mechanisms of excitotoxic neuronal death
Yan Wang
Department of Pharmacology and Laboratory of Aging and Nervous Diseases SZS0703, Soochow University School of Medicine, WenJing Road, 215123 Suzhou, China
Apoptosis 15:1382-402. 2010
..This review discusses the current understanding of the molecular and cellular mechanisms of excitotoxicity and their roles in the pathogenesis of diseases of the central nervous system...
- Autophagy is involved in cytotoxic effects of crotoxin in human breast cancer cell line MCF-7 cells
Ci hui Yan
Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China
Acta Pharmacol Sin 28:540-8. 2007
..To investigate the role of crotoxin (CrTX)-induced autophagy in the death of MCF-7 cells, a caspase-3-deficient, human breast cancer cell line...
- Suppression of complete Freund's adjuvant-induced adjuvant arthritis by cobratoxin
Yan Li Liu
College of Pharmacy, Soochow University, Suzhou, China
Acta Pharmacol Sin 30:219-27. 2009
..The present study evaluated the anti-inflammatory and anti-nociceptive effects of CTX on adjuvant arthritis (AA) in rats...
- [Association of PARK 16 polymorphisms with Parkinson's disease in Han population of Suzhou area]
Dong Hui Li
Department of Neurology, Second Affiliated Hospital, Soochow University, Suzhou 215004, China
Zhonghua Yi Xue Za Zhi 91:296-300. 2011
..To investigate whether there is an association of PARK 16 locus with Parkinson's disease (PD) in Han population of Suzhou area...
- A function of huntingtin in guanine nucleotide exchange on Rab11
Xueyi Li
Laboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
Neuroreport 19:1643-7. 2008
..These data suggest a role for huntingtin in a complex that activates Rab11...
- Dynamic effects of autophagy on arsenic trioxide-induced death of human leukemia cell line HL60 cells
Ya Ping Yang
Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
Acta Pharmacol Sin 29:123-34. 2008
..To evaluate the contribution of an autophagic mechanism to the As2O3- induced death of human acute myeloid leukaemia cell line HL60 cells...
- Cobratoxin inhibits pain-evoked discharge of neurons in thalamic parafascicular nucleus in rats: involvement of cholinergic and serotonergic systems
Bo Chao Cheng
Department of Neurobiology and Medical Psychology, Medical College, Soochow University, Suzhou 215123, PR China
Toxicon 54:224-32. 2009
....
- Current understanding on the pathogenesis of polyglutamine diseases
Xiao Hui He
Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou 215123, China
Neurosci Bull 26:247-56. 2010
....
- Poloxamer-188 Attenuates TBI-Induced Blood-Brain Barrier Damage Leading to Decreased Brain Edema and Reduced Cellular Death
Hai Jun Bao
Institute of Forensic Sciences, Soochow University, Suzhou, 215123, Jiangsu, China
Neurochem Res 37:2856-67. 2012
..Plasmalemma permeability may be a potential target for TBI treatment...
- Synergistic effects of prostaglandin E1 and lithium in a rat model of cerebral ischemia
Rong Han
Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou 215123, China
Acta Pharmacol Sin 29:1141-9. 2008
..The present study was undertaken to examine if lithium could potentiate the neuroprotection of PGE1 against cerebral ischemia, and if the synergetic effects take place at the level of HSPs...
- Strategies for short hairpin RNA delivery in cancer gene therapy
Shou li Wang
Soochow University School of Medicine, Department of Pathology, Suzhou 215123, China
Expert Opin Biol Ther 9:1357-68. 2009
....
- LY294002 induces p53-dependent apoptosis of SGC7901 gastric cancer cells
Chun gen Xing
Department of General Surgery, The Second Affiliated Hospital, Soochow University, Suzhou 215004, China
Acta Pharmacol Sin 29:489-98. 2008
..To study the effects of LY294002, an inhibitor of class I phosphatidylinositol 3-kinase (PI3K), on proliferation and apoptosis of SGC7901 gastric cancer cells...
- Expression of elongation factor-2 kinase contributes to anoikis resistance and invasion of human glioma cells
Li Zhang
Department of Pharmacology, College of Pharmaceutical Science, Soochow University, Suzhou, China
Acta Pharmacol Sin 32:361-7. 2011
..To determine whether elongation factor-2 kinase (eEF-2 kinase) contributes to the malignant phenotype of glioblastoma multiforme by promoting the migration and invasion of glioma cells. The mechanism involved was also explored...
- Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases
Xiao Xia Dong
Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
Acta Pharmacol Sin 30:379-87. 2009
..This review discusses the current understanding of excitotoxic mechanisms and how they are involved in the pathogenesis of neurodegenerative diseases...
- The role of p53 in cell metabolism
Xing Ding Zhang
Department of Pharmacology and Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
Acta Pharmacol Sin 31:1208-12. 2010
..In addition, p53 regulates autophagy to provide cell metabolites for surviving through damage regulated autophagy modulator (DRAM1). Here we review the recent findings to elucidate the important role of p53 in cell metabolism...
- [Expression of cathepsin-B and -D in rat's brain after traumatic brain injury]
Yan Bo Zhang
Department of Forensic Medicine of Suzhou University, Suzhou 215123, China
Fa Yi Xue Za Zhi 22:404-6, 410. 2006
..To study the expression of cathepsin-B and -D in different time point after traumatic brain injury...
- Selection of optimal sites for TGFB1 gene silencing by chitosan-TPP nanoparticle-mediated delivery of shRNA
So Ly Wang
Department of Pathology, Soochow University School of Medicine, Suzhou, China
Cancer Genet Cytogenet 190:8-14. 2009
..These data suggest that chitosan nanoparticle-mediated delivery of an shRNA produces efficient TGFB1 knockdown in rhabdomyosarcoma cells and may be a method of choice for shRNA delivery for gene therapy...
- [Advances in research of ketamine addiction mechanism]
Wei Li Liu
Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China
Fa Yi Xue Za Zhi 25:200-3, 207. 2009
....
- Neuroprotective effects of prostaglandin A1 in animal models of focal ischemia
Hui-Ling Zhang
Department of Pharmacology, Soochow University School of Medicine, 48 Ren Ming Road, Suzhou 215007, PR China
Brain Res 1039:203-6. 2005
..01) when administered immediately following permanent ischemia in rats. PGA1 treatment also significantly ameliorated motor dysfunction after brain ischemia. These results suggest that PGA1 protects neurons from ischemic injury...
- Contributions of autophagic and apoptotic mechanisms to CrTX-induced death of K562 cells
Ci-Hui Yan
Department of Pharmacology, Soochow University School of Medicine, Suzhou Institute of Chinese Materia Medica, 708 Ren Min Road, Suzhou 215007, People's Republic of China
Toxicon 47:521-30. 2006
..These results suggest that an apoptotic mechanism contributes to the Crotoxin-induced death of K562 cells, while the activation of autophagy delays neurotoxin-induced apoptosis...
- Quality control system of the endoplasmic reticulum and related diseases
Jun-chao Wu
Department of Pharmacology, School of Medicine, Soochow University, Suzhou 215123, China
Acta Biochim Biophys Sin (Shanghai) 38:219-26. 2006
..A better understanding of molecular regulation in the QC system will uncover the molecular pathogenic mechanisms of many diseases caused by protein misfolding and help discover novel strategies for preventing or treating these diseases...
- Enhancement of neuroprotection and heat shock protein induction by combined prostaglandin A1 and lithium in rodent models of focal ischemia
Xi-Hui Xu
Department of Pharmacology, Soochow University School of Medicine, Suzhou-Singopore Industrial Park, Suzhou, China
Brain Res 1102:154-62. 2006
..These studies suggest that lithium can potentiate PGA(1)'s neuroprotective effects and thus may have potential clinical value for the treatment of stroke in combination with other neuroprotective agents...
- Prostaglandin A1 inhibits rotenone-induced apoptosis in SH-SY5Y cells
Xiaoxia Wang
National Institute of Neurological Disorders and Stroke, Experimental Therapeutics Branch, Bethesda, Maryland, USA
J Neurochem 83:1094-102. 2002
..PGA1 appears to protect against rotenone-induced cell death by inducing HSPs and blocking nuclear translocation of NF-kappaB in a process that attenuates caspase-3 activation, but is not mediated by its inhibition...
- Lysosomal proteases are involved in generation of N-terminal huntingtin fragments
Yun J Kim
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Neurobiol Dis 22:346-56. 2006
..Findings implicate lysosomal proteases in formation of N-mhtt fragments and clearance of mhtt...
- Autophagy and its possible roles in nervous system diseases, damage and repair
David C Rubinsztein
Departments of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge, UK
Autophagy 1:11-22. 2005
..While many issues remain unresolved, these conditions raise the possibility that autophagy can have either deleterious or protective effects depending on the specific situation and stage in the pathological process...
- Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection
Ren-Wu Chen
Molecular Neurobiology Section, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
J Neurochem 84:566-75. 2003
..Moreover, the neuroprotective effects of lithium are mediated, at least in part, by suppressing NMDA receptor-mediated activation of the mitogen-activated protein kinase pathway...
- Downregulation of glutamate transporters is associated with elevation in extracellular glutamate concentration following rat microsphere embolism
Feng Han
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
Neurosci Lett 430:275-80. 2008
..Taken together, downregulation of glutamate transporters after ME is associated with dysregulation of basal glutamate concentrations and KCl-induced glutamate release in the brain...
