Jun Qian

Summary

Publications

  1. pmc GTPase regulator associated with the focal adhesion kinase (GRAF) transcript was down-regulated in patients with myeloid malignancies
    Zhen Qian
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, China
    J Exp Clin Cancer Res 29:111. 2010
  2. doi request reprint Methylation of DAPK1 promoter: frequent but not an adverse prognostic factor in myelodysplastic syndrome
    J Qian
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu, China
    Int J Lab Hematol 32:74-81. 2010
  3. doi request reprint Aberrant methylation of the death-associated protein kinase 1 (DAPK1) CpG island in chronic myeloid leukemia
    Jun Qian
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu, PR China
    Eur J Haematol 82:119-23. 2009
  4. doi request reprint IDH1 and IDH2 mutation analysis in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome
    Jiang Lin
    Laboratory Center, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, People s Republic of China
    Ann Hematol 91:519-25. 2012
  5. doi request reprint Aberrant hypomethylation of SALL4 gene is associated with intermediate and poor karyotypes in acute myeloid leukemia
    Ji Chun Ma
    Laboratory Center, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, PR China
    Clin Biochem 46:304-7. 2013
  6. doi request reprint Aberrant hypomethylation of SALL4 gene in patients with myelodysplastic syndrome
    Jiang Lin
    Laboratory Center, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, PR China
    Leuk Res 37:71-5. 2013
  7. pmc Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome
    Jiang Lin
    Department of Haematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu, People s Republic of China
    PLoS ONE 6:e26906. 2011
  8. doi request reprint Abnormal methylation of GRAF promoter Chinese patients with acute myeloid leukemia
    Jun Qian
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, China
    Leuk Res 35:783-6. 2011
  9. doi request reprint Development of a high-resolution melting analysis for the detection of the SF3B1 mutations
    Jing Yang
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, People s Republic of China
    Genet Test Mol Biomarkers 17:342-7. 2013
  10. doi request reprint [Expression of SALL4 gene in patients with acute and chronic myeloid leukemia]
    Qin Chen
    Department of Hematology, the Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 21:315-9. 2013

Collaborators

Detail Information

Publications40

  1. pmc GTPase regulator associated with the focal adhesion kinase (GRAF) transcript was down-regulated in patients with myeloid malignancies
    Zhen Qian
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, China
    J Exp Clin Cancer Res 29:111. 2010
    ..The aim of this study was to investigate the expression level of GRAF gene in those patients with myeloid malignancies including acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and chronic myeloid leukemia (CML)...
  2. doi request reprint Methylation of DAPK1 promoter: frequent but not an adverse prognostic factor in myelodysplastic syndrome
    J Qian
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu, China
    Int J Lab Hematol 32:74-81. 2010
    ..05). Aberrant methylation of DAPK1 gene promoter had no influence on the prognosis of MDS despite of its increasing occurrence during disease progression...
  3. doi request reprint Aberrant methylation of the death-associated protein kinase 1 (DAPK1) CpG island in chronic myeloid leukemia
    Jun Qian
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu, PR China
    Eur J Haematol 82:119-23. 2009
    ..776, P = 0.005). In one patient, the status of DAPK1 methylation became positive on the transition from CP to AP and BC. These results suggested that DAPK1 promoter methylation might play a significant role in the progression of CML...
  4. doi request reprint IDH1 and IDH2 mutation analysis in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome
    Jiang Lin
    Laboratory Center, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, People s Republic of China
    Ann Hematol 91:519-25. 2012
    ..177 and 0.407, respectively). In conclusion, IDH1/2 mutations are recurrent but rare molecular aberrations in Chinese AML and MDS...
  5. doi request reprint Aberrant hypomethylation of SALL4 gene is associated with intermediate and poor karyotypes in acute myeloid leukemia
    Ji Chun Ma
    Laboratory Center, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, PR China
    Clin Biochem 46:304-7. 2013
    ..Overexpression of SALL4 has been found in several cancers. The present study was aimed to investigate the methylation status of SALL4 promoter region in acute myeloid leukemia (AML)...
  6. doi request reprint Aberrant hypomethylation of SALL4 gene in patients with myelodysplastic syndrome
    Jiang Lin
    Laboratory Center, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, PR China
    Leuk Res 37:71-5. 2013
    ..0 months vs. 20.0 months), the difference was not statistically significant (P=0.430). These findings suggest that hypomethylation of SALL4 promoter is a common event in MDS...
  7. pmc Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome
    Jiang Lin
    Department of Haematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu, People s Republic of China
    PLoS ONE 6:e26906. 2011
    ..We conclude that DNMT3A R882 mutations are recurrent molecular aberrations in AML and MDS, and may be an adverse prognostic event in MDS...
  8. doi request reprint Abnormal methylation of GRAF promoter Chinese patients with acute myeloid leukemia
    Jun Qian
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, China
    Leuk Res 35:783-6. 2011
    ..64 vs 6.42, P=0.005). These findings suggest that the hypermethylation of GRAF promoter might be one of early events in the development of AML...
  9. doi request reprint Development of a high-resolution melting analysis for the detection of the SF3B1 mutations
    Jing Yang
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, People s Republic of China
    Genet Test Mol Biomarkers 17:342-7. 2013
    ..3% of patients were detected with SF3B1 mutations (p=0.006). In conclusion, a rapid, reproducible, sensitive, and high-throughput HRMA assay has been established for the scanning of SF3B1 mutations...
  10. doi request reprint [Expression of SALL4 gene in patients with acute and chronic myeloid leukemia]
    Qin Chen
    Department of Hematology, the Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 21:315-9. 2013
    ..95 - 1.017) and 0.997 (95% confidence interval: 0.986 - 1.007) respectively. It is concluded that SALL4 expression is a common molecular event and can be considered as a molecular marker for assisting diagnosis of AML and CML...
  11. doi request reprint SF3B1 mutation is a rare event in Chinese patients with acute and chronic myeloid leukemia
    Jing Yang
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, People s Republic of China
    Clin Biochem 46:701-3. 2013
    ..The frequency and clinical relevance of SF3B1 mutations have been rarely studied in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). The present study was aimed to analyze the frequency of SF3B1 mutations in AML and CML...
  12. doi request reprint Overexpression of miR-378 is frequent and may affect treatment outcomes in patients with acute myeloid leukemia
    Jun Qian
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu, People s Republic of China
    Leuk Res 37:765-8. 2013
    ..049). These findings suggest that miR-378 up-regulation is a common event and might have an adverse impact on prognosis in AML...
  13. ncbi request reprint [Alteration of methylation status of death-associated protein kinase (dapk) gene promoter in patients with acute myeloid leukemia]
    Jun Qian
    Department of Hematology, Jiangsu University Affiliated People Hospital, Zhenjiang 212002, Jiangsu Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:1390-4. 2010
    ..It is concluded that dapk gene hypermethylation may be a common molecular event in AML...
  14. doi request reprint Aberrant methylation of DNA-damage-inducible transcript 3 promoter is a common event in patients with myelodysplastic syndrome
    Jiang Lin
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, 8 Dianli Road, Zhenjiang, 212002, China
    Leuk Res 34:991-4. 2010
    ..0 months vs. 23.0 months), the difference was not statistically significant (P=0.137). These findings suggest that the hypermethylation of DDIT3 promoter might be one of early events in the development of MDS...
  15. ncbi request reprint [Scanning of c-kit gene mutations in acute myeloid leukemias using high-resolution melting analysis]
    Dong ming Yao
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang 212002, China
    Zhonghua Xue Ye Xue Za Zhi 32:21-4. 2011
    ..To detect the common mutations (D816V and N822K) of c-kit gene in acute myeloid leukemia (AML) using high-resolution melting analysis (HRM)...
  16. pmc Methylation status of DDIT3 gene in chronic myeloid leukemia
    Ya Li Wang
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu, PR China
    J Exp Clin Cancer Res 29:54. 2010
    ..The aim of this study was to investigate the methylation status of DDIT3 gene in CML patients...
  17. doi request reprint [Quantification of GRAF gene expression in patients with acute myeloid leukemia using EvaGreen real time quantitative PCR]
    Zhen Qian
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212002 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:290-3. 2010
    ..To quantify the expression level of GRAF gene in acute myeloid leukemia (AML) and analyze its clinical significance...
  18. doi request reprint Aberrant methylation of CCAAT/enhancer binding protein zeta promoter in acute myeloid leukemia
    Dong ming Yao
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, 8 Dianli Rd, Zhenjiang, Jiangsu 212002, PR China
    Leuk Res 35:957-60. 2011
    ..167, P=0.075). There was a significant correlation between C/EBPζ expression and C/EBPζ methylation in AML patients (R=0.606, P=0.002). Our data suggest that the aberrant methylation of C/EBPζ promoter may be involved in AML...
  19. doi request reprint Overexpressed let-7a-3 is associated with poor outcome in acute myeloid leukemia
    Yun Li
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu, People s Republic of China
    Leuk Res 37:1642-7. 2013
    ..029). The difference in relapse-free survival (RFS) was also significant between two groups (P=0.005). These findings suggest that let-7a-3 overexpression is a common event and is associated with poor clinical outcome in AML. ..
  20. doi request reprint Reduced expression of PDLIM4 gene correlates with good prognosis in acute myeloid leukemia
    Yun Li
    Department of Hematology, Central Laboratory, Jiangsu University People s Hospital, Zhenjiang 212002, Jiangsu Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 21:1111-5. 2013
    ..865 (95% CI: 0.801-0.930). It is concluded that reduced PDLIM4 expression is a common and favorable event for the good prognosis in AML, and can be used as a potential diagnostic biomarker of cancer. ..
  21. doi request reprint Development of high-resolution melting analysis for the detection of the MYD88 L265P mutation
    Cui Zhu Wang
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, PR China
    Clin Biochem 46:385-7. 2013
    ..The present study aimed to establish a rapid, sensitive, and reliable method using high-resolution melting analysis (HRMA) to detect MYD88 L265P mutation in DLBCL...
  22. pmc U2AF1 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome
    Jun Qian
    Department of Haematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu, People s Republic of China
    PLoS ONE 7:e45760. 2012
    ..035). No difference in the OS was observed between MDS patients with and without U2AF1 mutations. Our data show that U2AF1 mutation is a recurrent event at a low frequency in AML and MDS...
  23. doi request reprint [Quantification of the PRAME transcripts in patients with acute myeloid leukemia]
    Zhao Hui Zhu
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:149-52. 2010
    ..To analyze the expression level and clinical significance of the preferentially expressed antigen of melanoma (PRAME) transcripts in patients with acute myeloid leukemia (AML)...
  24. ncbi request reprint [Quantification of prame gene transcript in chronic myeloid leukemia]
    Zhao Hui Zhu
    Department of Hematology, Central Laboratory, Affiliated People Hospital, Jiangsu University, Zhenjiang 212002, Jiangsu Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:855-8. 2010
    ..It is concluded that the level of prame gene transcript increases in CML which associates with the progression of the disease, prame gene transcript level can be used for monitoring the disease state...
  25. ncbi request reprint [Expression of PML-RAR alpha fusion transcripts detection by using RQ-PCR]
    Lan xiu Han
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang 212002, China
    Zhonghua Xue Ye Xue Za Zhi 29:753-6. 2008
    ....
  26. doi request reprint The methylation status of the DDX43 promoter in Chinese patients with chronic myeloid leukemia
    Qin Chen
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, People s Republic of China
    Genet Test Mol Biomarkers 17:508-11. 2013
    ..469, p=0.004). Our data suggest that hypomethylation of the DDX43 promoter may be an early and frequent molecular event in the development of CML in Chinese patients...
  27. ncbi request reprint Gene expression of helicase antigen in patients with acute and chronic myeloid leukemia
    Qin Chen
    Department of Hematology, Jiangsu University People Hospital, Zhenjiang, Jiangsu Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 19:1171-5. 2011
    ..7%) (p = 0.008). It is concluded that HAGE cDNA expression is relevant to specific subtypes of AML and to the progression of CML...
  28. ncbi request reprint Association of polymorphisms of cytosine arabinoside-metabolizing enzyme gene with therapeutic efficacy for acute myeloid leukemia
    Pei Pei Xu
    Department of Hematology, Zhongda Hospital and Faculty of Oncology, Medical School, Southeast University, Nanjing, Jiangsu 210009, China
    Chin Med J (Engl) 125:2137-43. 2012
    ..In this study, we aimed to investigate whether these five SNPs are associated with the therapeutic outcomes of Ara-C-based chemotherapy regimens in patients with AML...
  29. doi request reprint Rapid and reliable detection of IDH1 R132 mutations in acute myeloid leukemia using high-resolution melting curve analysis
    Jiang Lin
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, PR China
    Clin Biochem 44:779-83. 2011
    ..The aim of the present study was to explore the reliability of the high-resolution melting analysis (HRMA) for the identification of IDH1 R132 mutations in AML...
  30. doi request reprint Dysregulation of miR-124-1 predicts favorable prognosis in acute myeloid leukemia
    Xing xing Chen
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu, People s Republic of China
    Clin Biochem 47:63-6. 2014
    ..The present study was aimed to investigate the expression status of miR-124-1 and its clinical relevance in patients with acute myeloid leukemia (AML)...
  31. doi request reprint Rapid detection of JAK2 V617F mutation using high-resolution melting analysis with LightScanner platform
    Jun Qian
    Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, PR China
    Clin Chim Acta 411:2097-100. 2010
    ..High-resolution melt (HRM) curve analysis, a nongel-based, automated system, is introduced as a means of mutation scanning without the requirement of any post-PCR handling...
  32. ncbi request reprint [Quantitative study on C/EBP zeta gene transcripts in patients with chronic myeloid leukemia using real-time quantitative PCR]
    Jun Qian
    Department of Hematology, Renmin Affiliated Hospital, Jiangsu University, Zhenjiang, Jiangsu, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22:628-31. 2005
    ..To evaluate the significance of quantitative detection of CCAAT/enhancer binding protein zeta (C/EBP zeta) transcripts in patients with chronic myeloid leukemia (CML)...
  33. ncbi request reprint [Quantification of PML/RAR alpha fusion gene transcripts in patients with acute promyelocytic leukemia by using real-time quantitative PCR]
    Jiang Lin
    Key Laboratory of Experimental Hematolgy, Affiliated Peopleos Hospital, Jiangsu University, Zhenjiang, Jiangsu, 212002 People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:319-21. 2008
    ..To establish and evaluate a real time quantitative PCR (RQ-PCR) method for detection and quantification the PML/RAR alpha fusion gene transcripts in patients with acute promyelocytic leukemia (APL)...
  34. doi request reprint Methylation status of fragile histidine triad (FHIT) gene and its clinical impact on prognosis of patients with myelodysplastic syndrome
    Jiang Lin
    Department of Hematology, Affiliated People s Hospital, University of Jiangsu, Zhenjiang, China
    Leuk Res 32:1541-5. 2008
    ..0 months vs. 40.0 months, P=0.025). These results suggested that aberrant methylation of the FHIT gene might be one of molecular events involved in the disease progression of MDS and be an adverse prognostic factor in MDS...
  35. doi request reprint The associations of Janus kinase-2 (JAK2) A830G polymorphism and the treatment outcomes in patients with acute myeloid leukemia
    Yuejiao Zhong
    Department of Hematology, Medical School, Zhongda Hospital, Sontheast University, Nanjing, China
    Leuk Lymphoma 51:1115-20. 2010
    ..We conclude that the AA and GG genotypes of JAK2 A830G might be important markers for therapy outcomes of patients with AML in a Chinese population...
  36. ncbi request reprint [Analysis of risk factors for relapse of 82 patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation]
    Zheng Ping Yu
    Department of Hematology, Zhongda Hospital, Southeast University, Nanjing 210009, China
    Zhonghua Zhong Liu Za Zhi 33:283-6. 2011
    ..To explore the risk factors for relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and the measures of prophylaxis and treatment...
  37. doi request reprint RAS mutation analysis in a large cohort of Chinese patients with acute myeloid leukemia
    Xiaofei Yang
    The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, Jiangsu Province, 215006, PR China
    Clin Biochem 46:579-83. 2013
    ..We examined RAS mutational status and correlated this with presenting morphology, cytogenetics, clinical outcome and other gene aberrations in a large cohort of Chinese acute myeloid leukemia (AML) patients...
  38. ncbi request reprint Decreased expression of CCAAT/enhancer binding protein zeta (C/EBPzeta) in patients with different myeloid diseases
    Jun Qian
    The Department of Hematology, The First People s Hospital of Zhenjiang, Zhenjiang, Jiangsu 212002, PR China
    Leuk Res 29:1435-41. 2005
    ..60 versus 14.69, P<0.0001). Significant differences were also observed between patients with CML and with AML or MDS. These results suggest that the insufficient dosage of C/EBPzeta might be involved in the development of leukemia...
  39. ncbi request reprint [Progress of study on the transcription factor SALL4]
    Jiang Lin
    Department of Hematology, Jiangsu University Affiliated People Hospital, Zhenjiang Key Laboratory of Experimental Hematology, Zhenjiang 212002, Jiangsu Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 19:820-3. 2011
    ..This review focuses on the structure and function of SALL4 gene as well as its relevance to related diseases...
  40. ncbi request reprint [Detection of single nucleotide polymorphisms of Jak2 gene in multiple myeloma by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry]
    Yue Jiao Zhoang
    Department of Hematology, Zhongda Hospital, Southeast University Clinical Medical College, Nanjing 210009, Jiangsu Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 17:1234-7. 2009
    ..In conclusion, the method based on MALDI-TOF MS and PEX technique for detecting SNP in jak2 gene is rapid, accurate and reliable method, and can be used in clinical practice...