Rong Qi

Summary

Publications

  1. pmc PEG-conjugated PAMAM dendrimers mediate efficient intramuscular gene expression
    Rong Qi
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, Beijing, China
    AAPS J 11:395-405. 2009
  2. pmc Efficient in vitro siRNA delivery and intramuscular gene silencing using PEG-modified PAMAM dendrimers
    Yin Tang
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, 38 Xueyuan Road, Beijing, 100083, China
    Mol Pharm 9:1812-21. 2012
  3. doi request reprint Protective effects and mechanisms of G5 PAMAM dendrimers against acute pancreatitis induced by caerulein in mice
    Yin Tang
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing, China
    Biomacromolecules 16:174-82. 2015
  4. doi request reprint Oral absorption enhancement of probucol by PEGylated G5 PAMAM dendrimer modified nanoliposomes
    Qian Ma
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, Beijing 100191, China
    Mol Pharm 12:665-74. 2015
  5. pmc The role of caveolin-1 and syndecan-4 in the internalization of PEGylated PAMAM dendrimer polyplexes into myoblast and hepatic cells
    Wenwen Shen
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing, China Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, China
    Eur J Pharm Biopharm 88:658-63. 2014
  6. doi request reprint Reduced high density lipoprotein cholesterol in severe hypertriglyceridemic ApoCIII transgenic mice via lowered hepatic ApoAI synthesis
    Yingchun Han
    Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing, 100191, China
    Biochem Biophys Res Commun 462:420-5. 2015
  7. ncbi request reprint Recent advances of dendrimers in delivery of genes and drugs
    Yu Gao
    Institute of Cardiovascular Science, Peking University, Beijing, P R China
    Mini Rev Med Chem 8:889-900. 2008
  8. pmc The mechanism of polyplex internalization into cells: testing the GM1/caveolin-1 lipid raft mediated endocytosis pathway
    Rong Qi
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, Beijing 100083, China
    Mol Pharm 7:267-79. 2010

Collaborators

  • Yun He
  • Yu Gao
  • Siling Wang
  • Lu Liu
  • Qiang Zhang
  • Yingchun Han
  • George Liu
  • Wenwen Shen
  • Yin Tang
  • Mark M Banaszak Holl
  • Qian Ma
  • Huayu Zhang
  • Maomao Yu
  • Mallory A van Dongen
  • Yanzhi Li
  • Yini Cao
  • Cong Chen
  • Bing He
  • Yunan Wang
  • Xin Cui
  • Yuhui Wang
  • Lu Xu
  • Yang Bing Li
  • Mallory van Dongen
  • Bo Wang
  • Xiao Yan Gu
  • Danielle M Zurcher
  • Ri Yuan Lin

Detail Information

Publications8

  1. pmc PEG-conjugated PAMAM dendrimers mediate efficient intramuscular gene expression
    Rong Qi
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, Beijing, China
    AAPS J 11:395-405. 2009
    ..Therefore, G5-8% PEG and G6-8% PEG possess a great potential for gene delivery both in vivo and in vitro...
  2. pmc Efficient in vitro siRNA delivery and intramuscular gene silencing using PEG-modified PAMAM dendrimers
    Yin Tang
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, 38 Xueyuan Road, Beijing, 100083, China
    Mol Pharm 9:1812-21. 2012
    ..We further demonstrated in vivo that intramuscular delivery of GFP-siRNA using PEG-modified dendrimer significantly suppressed GFP expression in both transiently adenovirus infected C57BL/6 mice and GFP transgenic mice...
  3. doi request reprint Protective effects and mechanisms of G5 PAMAM dendrimers against acute pancreatitis induced by caerulein in mice
    Yin Tang
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing, China
    Biomacromolecules 16:174-82. 2015
    ....
  4. doi request reprint Oral absorption enhancement of probucol by PEGylated G5 PAMAM dendrimer modified nanoliposomes
    Qian Ma
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, Beijing 100191, China
    Mol Pharm 12:665-74. 2015
    ..Our results demonstrated that PB-liposome/G5-PEG significantly increased the oral absorption of PB and therefore significantly improved its pharmacodynamic effects. ..
  5. pmc The role of caveolin-1 and syndecan-4 in the internalization of PEGylated PAMAM dendrimer polyplexes into myoblast and hepatic cells
    Wenwen Shen
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing, China Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, China
    Eur J Pharm Biopharm 88:658-63. 2014
    ..This study gives a clue how to take strategies by up- or down-regulation of the expressions of syndecan-4 and caveolin-1 to improve in vivo gene delivery efficiency of the PEG-PAMAM dendrimers in clinical transgenic therapy...
  6. doi request reprint Reduced high density lipoprotein cholesterol in severe hypertriglyceridemic ApoCIII transgenic mice via lowered hepatic ApoAI synthesis
    Yingchun Han
    Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing, 100191, China
    Biochem Biophys Res Commun 462:420-5. 2015
    ..Further examination demonstrated that hepatic but not intestinal ApoAI mRNA was significantly reduced. Therefore, the decreased ApoAI synthesis might be accounted for the lower plasma HDL level in ApoCIII transgenic mice. ..
  7. ncbi request reprint Recent advances of dendrimers in delivery of genes and drugs
    Yu Gao
    Institute of Cardiovascular Science, Peking University, Beijing, P R China
    Mini Rev Med Chem 8:889-900. 2008
    ..In the paper the recent advances of dendrimer in gene transfer vehicles and drug delivery are separately reviewed. These advances illustrate the direction of the future development of dendrimers...
  8. pmc The mechanism of polyplex internalization into cells: testing the GM1/caveolin-1 lipid raft mediated endocytosis pathway
    Rong Qi
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, Beijing 100083, China
    Mol Pharm 7:267-79. 2010
    ..Cholera toxin B subunit was employed as a positive control for uptake in all cases. No evidence was found for a GM1/caveolin-1 lipid raft mediated endocytosis mechanism for the generation 5 and 7 poly(amidoamine) dendrimer polyplexes...