Peter Pushko

Summary

Publications

  1. pmc Incorporation of high levels of chimeric human immunodeficiency virus envelope glycoproteins into virus-like particles
    Bao Zhong Wang
    Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    J Virol 81:10869-78. 2007
  2. pmc Cross-clade protective immune responses to influenza viruses with H5N1 HA and NA elicited by an influenza virus-like particle
    Rick A Bright
    Novavax, Inc, Rockville, Maryland, USA
    PLoS ONE 3:e1501. 2008
  3. ncbi request reprint Influenza virus-like particles comprised of the HA, NA, and M1 proteins of H9N2 influenza virus induce protective immune responses in BALB/c mice
    Peter Pushko
    Novavax, Inc, Vaccine Technologies, 1 Taft Court, Rockville, MD 20850, USA
    Vaccine 23:5751-9. 2005
  4. ncbi request reprint Evaluation of influenza virus-like particles and Novasome adjuvant as candidate vaccine for avian influenza
    Peter Pushko
    Novavax Inc, 9920 Belward Campus Drive, Rockville, MD 20850, USA
    Vaccine 25:4283-90. 2007
  5. doi request reprint Influenza virus-like particle can accommodate multiple subtypes of hemagglutinin and protect from multiple influenza types and subtypes
    Peter Pushko
    Medigen, Inc, 4539 Metropolitan Court, Frederick, MD, USA
    Vaccine 29:5911-8. 2011
  6. doi request reprint Recombinant H1N1 virus-like particle vaccine elicits protective immunity in ferrets against the 2009 pandemic H1N1 influenza virus
    Peter Pushko
    Novavax, Inc, 9920 Belward Campus Drive, Rockville, MD 20850, USA
    Vaccine 28:4771-6. 2010
  7. doi request reprint Intranasal vaccination with H5, H7 and H9 hemagglutinins co-localized in a virus-like particle protects ferrets from multiple avian influenza viruses
    Irina Tretyakova
    Medigen, Inc, 4539 Metropolitan Court, Frederick, MD, USA
    Virology 442:67-73. 2013
  8. ncbi request reprint Influenza virus-like particles elicit broader immune responses than whole virion inactivated influenza virus or recombinant hemagglutinin
    Rick A Bright
    Novavax, Inc, Rockville, MD 20850, USA
    Vaccine 25:3871-8. 2007
  9. pmc Novel vaccine against Venezuelan equine encephalitis combines advantages of DNA immunization and a live attenuated vaccine
    Irina Tretyakova
    Medigen, Inc, 4539 Metropolitan Court, Frederick, MD 21704, USA
    Vaccine 31:1019-25. 2013
  10. ncbi request reprint Evaluation of HBs, HBc, and frCP virus-like particles for expression of human papillomavirus 16 E7 oncoprotein epitopes
    Paul Pumpens
    Biomedical Research and Study Centre, University of Latvia, Riga, Latvia, Lithuania
    Intervirology 45:24-32. 2002

Collaborators

Detail Information

Publications12

  1. pmc Incorporation of high levels of chimeric human immunodeficiency virus envelope glycoproteins into virus-like particles
    Bao Zhong Wang
    Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    J Virol 81:10869-78. 2007
    ..HIV Env specific monoclonal antibody binding results showed that chimeric Env-containing VLPs retained conserved epitopes and underwent conformational changes upon CD4 binding...
  2. pmc Cross-clade protective immune responses to influenza viruses with H5N1 HA and NA elicited by an influenza virus-like particle
    Rick A Bright
    Novavax, Inc, Rockville, Maryland, USA
    PLoS ONE 3:e1501. 2008
    ....
  3. ncbi request reprint Influenza virus-like particles comprised of the HA, NA, and M1 proteins of H9N2 influenza virus induce protective immune responses in BALB/c mice
    Peter Pushko
    Novavax, Inc, Vaccine Technologies, 1 Taft Court, Rockville, MD 20850, USA
    Vaccine 23:5751-9. 2005
    ..Thus, VLPs represent a potential strategy for the development of human vaccines against avian influenza H9N2 viruses...
  4. ncbi request reprint Evaluation of influenza virus-like particles and Novasome adjuvant as candidate vaccine for avian influenza
    Peter Pushko
    Novavax Inc, 9920 Belward Campus Drive, Rockville, MD 20850, USA
    Vaccine 25:4283-90. 2007
    ..Positive effect of the adjuvant was also detected using the rH9 vaccine. The results have implications for the development of safe and effective vaccines for avian influenza viruses with pandemic potential...
  5. doi request reprint Influenza virus-like particle can accommodate multiple subtypes of hemagglutinin and protect from multiple influenza types and subtypes
    Peter Pushko
    Medigen, Inc, 4539 Metropolitan Court, Frederick, MD, USA
    Vaccine 29:5911-8. 2011
    ..We conclude that this technology may represent a novel strategy for rapid development of trivalent seasonal and pandemic vaccines...
  6. doi request reprint Recombinant H1N1 virus-like particle vaccine elicits protective immunity in ferrets against the 2009 pandemic H1N1 influenza virus
    Peter Pushko
    Novavax, Inc, 9920 Belward Campus Drive, Rockville, MD 20850, USA
    Vaccine 28:4771-6. 2010
    ..Moreover, a single 15mug dose of H1N1 VLPs resulted in complete virus clearance in the ferret lung. These results provide support for the use of recombinant influenza VLP vaccine as an effective strategy against pandemic H1N1 virus...
  7. doi request reprint Intranasal vaccination with H5, H7 and H9 hemagglutinins co-localized in a virus-like particle protects ferrets from multiple avian influenza viruses
    Irina Tretyakova
    Medigen, Inc, 4539 Metropolitan Court, Frederick, MD, USA
    Virology 442:67-73. 2013
    ..Intranasal vaccination of ferrets with the VLPs resulted in induction of serum antibody responses and efficient protection against experimental challenges with H5N1, H7N2, and H9N2 viruses...
  8. ncbi request reprint Influenza virus-like particles elicit broader immune responses than whole virion inactivated influenza virus or recombinant hemagglutinin
    Rick A Bright
    Novavax, Inc, Rockville, MD 20850, USA
    Vaccine 25:3871-8. 2007
    ..Interestingly, VLPs elicited antibodies that recognized a broader panel of antigenically distinct H3N2 viral isolates compared to rHA or WIV in a hemagglutination-inhibition (HAI) assay...
  9. pmc Novel vaccine against Venezuelan equine encephalitis combines advantages of DNA immunization and a live attenuated vaccine
    Irina Tretyakova
    Medigen, Inc, 4539 Metropolitan Court, Frederick, MD 21704, USA
    Vaccine 31:1019-25. 2013
    ..To our knowledge, this is the first example of launching a clinical live-attenuated vaccine from recombinant plasmid DNA in vivo...
  10. ncbi request reprint Evaluation of HBs, HBc, and frCP virus-like particles for expression of human papillomavirus 16 E7 oncoprotein epitopes
    Paul Pumpens
    Biomedical Research and Study Centre, University of Latvia, Riga, Latvia, Lithuania
    Intervirology 45:24-32. 2002
    ....
  11. ncbi request reprint Venezuelan equine encephalitis replicon immunization overcomes intrinsic tolerance and elicits effective anti-tumor immunity to the 'self' tumor-associated antigen, neu in a rat mammary tumor model
    Edward L Nelson
    Department of Medicine, Division of Hematology Oncology, School of Medicine and Molecular Biology and Biochemistry, University of California, Irvine, CA 97697 4060, USA
    Breast Cancer Res Treat 82:169-83. 2003
    ..These data support the continued development and potential clinical application of this alphaviral replicon vector system and the use of appropriately designed target antigen sequences for anti-tumor immunotherapy...
  12. pmc Evaluation in nonhuman primates of vaccines against Ebola virus
    Thomas W Geisbert
    U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
    Emerg Infect Dis 8:503-7. 2002
    ..The disease observed in primates differed from that in rodents, suggesting that rodent models of EBOV may not predict the efficacy of candidate vaccines in primates and that protection of primates may require different mechanisms...