A Pugliese

Summary

Publications

  1. ncbi The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    A Pugliese
    Diabetes Research Institute, University of Miami School of Medicine, Florida, USA
    Nat Genet 15:293-7. 1997
  2. ncbi Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs
    A Pugliese
    Immunogenetics Program, Diabetes Research Institute, University of Miami School of Medicine, Miami, Florida, USA
    J Clin Invest 107:555-64. 2001
  3. ncbi Insulin2 gene (Ins2) transcription by NOD bone marrow-derived cells does not influence autoimmune diabetes development in NOD-Ins2 knockout mice
    A Martin-Pagola
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Scand J Immunol 70:439-46. 2009
  4. ncbi Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas
    R S Dogra
    Immunogenetics Program, Diabetes Research Institute, University of Miami, FL, Miami, USA
    Diabetologia 49:953-7. 2006
  5. ncbi Sequence analysis of the diabetes-protective human leukocyte antigen-DQB1*0602 allele in unaffected, islet cell antibody-positive first degree relatives and in rare patients with type 1 diabetes
    A Pugliese
    Diabetes Research Institute, University of Miami School of Medicine, Florida 33136, USA
    J Clin Endocrinol Metab 84:1722-8. 1999
  6. ncbi Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity
    A Martin-Pagola
    Diabetes Research Institute, Leonard Miller School of Medicine, University of Miami, 1450 NW 10th Avenue, Miami, FL 33136, USA
    Diabetologia 51:1803-13. 2008
  7. ncbi A functional CD40 receptor is expressed in pancreatic beta cells
    D Klein
    Diabetes Research Institute, University of Miami School of Medicine, 1450 NW 10th Avenue, Miami, FL 33136, USA
    Diabetologia 48:268-76. 2005
  8. ncbi Combined islet and hematopoietic stem cell allotransplantation: a clinical pilot trial to induce chimerism and graft tolerance
    D Mineo
    Clinical Islet Transplant Program CITP, Diabetes Research Institute, L Miller School of Medicine, University of Miami, FL, USA
    Am J Transplant 8:1262-74. 2008

Collaborators

Detail Information

Publications8

  1. ncbi The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    A Pugliese
    Diabetes Research Institute, University of Miami School of Medicine, Florida, USA
    Nat Genet 15:293-7. 1997
    ..Higher levels of (pro)insulin in the thymus may promote negative selection (deletion) of insulin-specific T-lymphocytes which play a critical role in the pathogenesis of type-1 diabetes...
  2. ncbi Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs
    A Pugliese
    Immunogenetics Program, Diabetes Research Institute, University of Miami School of Medicine, Miami, Florida, USA
    J Clin Invest 107:555-64. 2001
    ....
  3. ncbi Insulin2 gene (Ins2) transcription by NOD bone marrow-derived cells does not influence autoimmune diabetes development in NOD-Ins2 knockout mice
    A Martin-Pagola
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Scand J Immunol 70:439-46. 2009
    ..Thus, NOD-Ins2-/- BM did not worsen diabetes in NOD recipients and Ins2 expression by NOD BM-derived cells did not delay diabetes development in NOD-Ins2-/- mice...
  4. ncbi Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas
    R S Dogra
    Immunogenetics Program, Diabetes Research Institute, University of Miami, FL, Miami, USA
    Diabetologia 49:953-7. 2006
    ..In this study we tested the hypothesis that IGRP splice variants could be differentially expressed in thymus and spleen compared with the pancreas...
  5. ncbi Sequence analysis of the diabetes-protective human leukocyte antigen-DQB1*0602 allele in unaffected, islet cell antibody-positive first degree relatives and in rare patients with type 1 diabetes
    A Pugliese
    Diabetes Research Institute, University of Miami School of Medicine, Florida 33136, USA
    J Clin Endocrinol Metab 84:1722-8. 1999
    ....
  6. ncbi Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity
    A Martin-Pagola
    Diabetes Research Institute, Leonard Miller School of Medicine, University of Miami, 1450 NW 10th Avenue, Miami, FL 33136, USA
    Diabetologia 51:1803-13. 2008
    ..We investigated whether beta cell neoformation occurs in the transplanted pancreas in patients with type 1 diabetes who had received a simultaneous pancreas-kidney transplant (SPK) and later developed recurrence of autoimmunity...
  7. ncbi A functional CD40 receptor is expressed in pancreatic beta cells
    D Klein
    Diabetes Research Institute, University of Miami School of Medicine, 1450 NW 10th Avenue, Miami, FL 33136, USA
    Diabetologia 48:268-76. 2005
    ..While neurons express the CD40 receptor, it is unknown whether islet cells also express it. We investigated CD40 expression in human and mouse pancreatic islets as well as in NIT-1 insulinoma cells...
  8. ncbi Combined islet and hematopoietic stem cell allotransplantation: a clinical pilot trial to induce chimerism and graft tolerance
    D Mineo
    Clinical Islet Transplant Program CITP, Diabetes Research Institute, L Miller School of Medicine, University of Miami, FL, USA
    Am J Transplant 8:1262-74. 2008
    ..Combined islet and HSC allotransplantation using an 'Edmonton-like' immunosuppression, without ablative conditioning, did not lead to stable chimerism and graft tolerance...