Karin Przyklenk

Summary

Publications

  1. ncbi request reprint Cardioprotection 'outside the box'--the evolving paradigm of remote preconditioning
    Karin Przyklenk
    Department of Emergency Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Basic Res Cardiol 98:149-57. 2003
  2. ncbi request reprint Reduction of infarct size with D-myo-inositol trisphosphate: role of PI3-kinase and mitochondrial K(ATP) channels
    Karin Przyklenk
    Dept of Emergency Medicine, Univ of Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 290:H830-6. 2006
  3. ncbi request reprint Brief apnea induces myocardial ischemic tolerance by an opioid-insensitive mechanism
    Eric W Dickson
    Department of Emergency Medicine, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Cardiovasc Pathol 13:225-9. 2004
  4. doi request reprint Aging mouse hearts are refractory to infarct size reduction with post-conditioning
    Karin Przyklenk
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Am Coll Cardiol 51:1393-8. 2008
  5. ncbi request reprint First molecular evidence that inositol trisphosphate signaling contributes to infarct size reduction with preconditioning
    Karin Przyklenk
    Dept of Emergency Medicine, Univ of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 291:H2008-12. 2006
  6. ncbi request reprint Postconditioning via stuttering reperfusion limits myocardial infarct size in rabbit hearts: role of ERK1/2
    Chad E Darling
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Physiol Heart Circ Physiol 289:H1618-26. 2005
  7. pmc Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes
    Karin Przyklenk
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Antioxid Redox Signal 14:781-90. 2011
  8. ncbi request reprint In vitro platelet responsiveness to adenosine-mediated "preconditioning" is age-dependent
    Karin Przyklenk
    Departments of Emergency Medicine and Anesthesiology, University of Massachusetts Medical School, 55 Lake Avenue, Worcester, MA 01655, USA
    J Thromb Thrombolysis 19:5-10. 2005
  9. ncbi request reprint Pretreatment with D-myo-inositol trisphosphate reduces infarct size in rabbit hearts: role of inositol trisphosphate receptors and gap junctions in triggering protection
    Karin Przyklenk
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, 01655, USA
    J Pharmacol Exp Ther 314:1386-92. 2005
  10. doi request reprint Remote-conditioning ischemia provides a potential approach to mitigate contrast medium-induced reduction in kidney function: a retrospective observational cohort study
    Peter Whittaker
    Department of Emergency Medicine, Wayne State University, Detroit, Mich, USA
    Cardiology 119:145-50. 2011

Detail Information

Publications21

  1. ncbi request reprint Cardioprotection 'outside the box'--the evolving paradigm of remote preconditioning
    Karin Przyklenk
    Department of Emergency Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Basic Res Cardiol 98:149-57. 2003
    ....
  2. ncbi request reprint Reduction of infarct size with D-myo-inositol trisphosphate: role of PI3-kinase and mitochondrial K(ATP) channels
    Karin Przyklenk
    Dept of Emergency Medicine, Univ of Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 290:H830-6. 2006
    ..Thus PI3-kinase/Akt signaling and mitochondrial K(ATP) channels participate in the reduction of infarct size afforded by prophylactic administration of D-myo-Ins(1,4,5)P3...
  3. ncbi request reprint Brief apnea induces myocardial ischemic tolerance by an opioid-insensitive mechanism
    Eric W Dickson
    Department of Emergency Medicine, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Cardiovasc Pathol 13:225-9. 2004
    ..In addition, we sought to determine if infarct size reduction seen in this model was stimulated via opioid receptor activation...
  4. doi request reprint Aging mouse hearts are refractory to infarct size reduction with post-conditioning
    Karin Przyklenk
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Am Coll Cardiol 51:1393-8. 2008
    ..Our aim was to establish whether the efficacy of post-conditioning is maintained in aging hearts...
  5. ncbi request reprint First molecular evidence that inositol trisphosphate signaling contributes to infarct size reduction with preconditioning
    Karin Przyklenk
    Dept of Emergency Medicine, Univ of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 291:H2008-12. 2006
    ..56% of the LV in mutant controls). These data provide novel evidence that Ins(1,4,5)P(3) signaling contributes to infarct size reduction with PC...
  6. ncbi request reprint Postconditioning via stuttering reperfusion limits myocardial infarct size in rabbit hearts: role of ERK1/2
    Chad E Darling
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Physiol Heart Circ Physiol 289:H1618-26. 2005
    ..Thus our results implicate the involvement of ERK1/2 rather than PI3-kinase/Akt in the reduction of infarct size achieved with post-C...
  7. pmc Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes
    Karin Przyklenk
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Antioxid Redox Signal 14:781-90. 2011
    ..We provide novel evidence for a profound-but potentially reversible-diabetes-induced defect in the cardioprotective efficacy of PostC...
  8. ncbi request reprint In vitro platelet responsiveness to adenosine-mediated "preconditioning" is age-dependent
    Karin Przyklenk
    Departments of Emergency Medicine and Anesthesiology, University of Massachusetts Medical School, 55 Lake Avenue, Worcester, MA 01655, USA
    J Thromb Thrombolysis 19:5-10. 2005
    ....
  9. ncbi request reprint Pretreatment with D-myo-inositol trisphosphate reduces infarct size in rabbit hearts: role of inositol trisphosphate receptors and gap junctions in triggering protection
    Karin Przyklenk
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, 01655, USA
    J Pharmacol Exp Ther 314:1386-92. 2005
    ..These data support the concepts that infarct size reduction with D-myo-IP(3) is triggered by receptor binding and that communication via gap junctions/hemichannels is involved in initiating this protection...
  10. doi request reprint Remote-conditioning ischemia provides a potential approach to mitigate contrast medium-induced reduction in kidney function: a retrospective observational cohort study
    Peter Whittaker
    Department of Emergency Medicine, Wayne State University, Detroit, Mich, USA
    Cardiology 119:145-50. 2011
    ..73 m(2)). These results are consistent with remote ischemic conditioning providing a novel potential approach to attenuate contrast-associated renal injury...
  11. pmc Cardioprotection with adenosine: 'a riddle wrapped in a mystery'
    Karin Przyklenk
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Br J Pharmacol 145:699-700. 2005
    ....
  12. ncbi request reprint Mechanisms of myocardial ischemic preconditioning are age related: PKC-epsilon does not play a requisite role in old rabbits
    Karin Przyklenk
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Appl Physiol 95:2563-9. 2003
    ..brief PC ischemia was not associated with activation/translocation of PKC-epsilon. Thus the mechanisms responsible for PC are age related in the rabbit heart, with no apparent, requisite role of PKC-epsilon in aging animals...
  13. ncbi request reprint 'Postconditioning' the human heart: multiple balloon inflations during primary angioplasty may confer cardioprotection
    Chad E Darling
    Dept of Emergency Medicine, University of Massachusetts Medical School, 55 Lake Avenue, North Worcester, MA, 01655, USA
    Basic Res Cardiol 102:274-8. 2007
    ..05), an outcome consistent with the concept that relief of sustained ischemia in a stuttered manner (analogous to postconditioning) may evoke cardioprotection in the clinical setting...
  14. ncbi request reprint Myocardial preconditioning factors evoke mesenteric ischemic tolerance via opioid receptors and K(ATP) channels
    Eric W Dickson
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01665, USA
    Am J Physiol Heart Circ Physiol 283:H22-8. 2002
    ..Moreover, evaluation of purified subfractions of the crude PC concentrate identified a specific bioactive fraction that may participate in triggering the improved jejunal ischemic tolerance...
  15. pmc Fibrin architecture in clots: a quantitative polarized light microscopy analysis
    Peter Whittaker
    Cardiovascular Research Institute, Department of Emergency Medicine, Wayne State University, School of Medicine, Detroit, MI 48201, USA
    Blood Cells Mol Dis 42:51-6. 2009
    ..9+/-0.5 nm versus 5.4+/-1.0 nm, P<0.05). The automated polarized light analysis methods not only enabled fibrin architecture to be assessed, but also revealed structural differences in clots formed under different circumstances...
  16. ncbi request reprint Adaptation of a photochemical method to initiate recurrent platelet-mediated thrombosis in small animals
    Karin Przyklenk
    Department of Emergency Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Lasers Med Sci 22:42-5. 2007
    ....
  17. doi request reprint Platelet reactivity and the identification of acute coronary syndromes in the emergency department
    Chad E Darling
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Thromb Thrombolysis 28:31-7. 2009
    ..This review will focus on selected tests/markers of platelet function that have shown some promise with respect to the risk stratification of patients with potential ACS...
  18. ncbi request reprint Ischemic preconditioning: a plea for rationally targeted clinical trials
    Robert A Kloner
    Heart Institute, Good Samaritan Hospital, 1225 Wilshire Boulevard, Los Angeles, CA 90017, USA
    Cardiovasc Res 55:526-33. 2002
  19. ncbi request reprint Late preconditioning against myocardial stunning. Does aspirin close the "second window" of endogenous cardioprotection?
    Karin Przyklenk
    J Am Coll Cardiol 41:1195-7. 2003
  20. ncbi request reprint Stunned peri-infarct canine myocardium is characterized by degradation of troponin T, not troponin I
    David A Colantonio
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Cardiovasc Res 63:217-25. 2004
    ....
  21. ncbi request reprint The gap junction uncoupler heptanol abrogates infarct size reduction with preconditioning in mouse hearts
    Guohu Li
    Heart Institute Research, Good Samaritan Hospital and Section of Cardiology, Department of Medicine, University of Southern California, 1225 Wilshire Boulevard, Los Angeles, CA 90017 2395, USA
    Cardiovasc Pathol 11:158-65. 2002
    ....