Colin C Pritchard

Summary

Publications

  1. pmc Plasma processing conditions substantially influence circulating microRNA biomarker levels
    Heather H Cheng
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 8:e64795. 2013
  2. pmc Validation and implementation of targeted capture and sequencing for the detection of actionable mutation, copy number variation, and gene rearrangement in clinical cancer specimens
    Colin C Pritchard
    Department of Laboratory Medicine, University of Washington, Seattle, Washington Electronic address
    J Mol Diagn 16:56-67. 2014
  3. pmc ColoSeq provides comprehensive lynch and polyposis syndrome mutational analysis using massively parallel sequencing
    Colin C Pritchard
    Department of Laboratory Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
    J Mol Diagn 14:357-66. 2012
  4. pmc COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma
    Colin C Pritchard
    Department of Laboratory Medicine, University of Washington, Seattle, USA
    BMC Clin Pathol 10:6. 2010
  5. doi request reprint A mosaic PTEN mutation causing Cowden syndrome identified by deep sequencing
    Colin C Pritchard
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    Genet Med 15:1004-7. 2013
  6. pmc MicroRNA profiling: approaches and considerations
    Colin C Pritchard
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    Nat Rev Genet 13:358-69. 2012
  7. doi request reprint MSIplus for Integrated Colorectal Cancer Molecular Testing by Next-Generation Sequencing
    Jennifer A Hempelmann
    Department of Laboratory Medicine, University of Washington, Seattle, Washington
    J Mol Diagn 17:705-14. 2015
  8. pmc Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy
    Michael Y Zhang
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nat Genet 47:180-5. 2015
  9. pmc Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer
    Colin C Pritchard
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    Nat Commun 5:4988. 2014
  10. pmc Single molecule molecular inversion probes for targeted, high-accuracy detection of low-frequency variation
    Joseph B Hiatt
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Genome Res 23:843-54. 2013

Collaborators

  • Stephen J Salipante
  • Mary Claire King
  • Muneesh Tewari
  • Eric Q Konnick
  • Paul J Goodfellow
  • Marshall S Horwitz
  • Wendy Raskind
  • Andrew Adey
  • Alex S Nord
  • Joseph B Hiatt
  • Colm Morrissey
  • Tom Walsh
  • Elizabeth M Swisher
  • Michael Y Zhang
  • Jennifer A Hempelmann
  • Brian H Shirts
  • Heather H Cheng
  • John K Chan
  • Ming Lee
  • Robert Burger
  • Maria I Harrell
  • Mark Brady
  • Michael J Birrer
  • Barbara M Norquist
  • Kimberly R Kalli
  • Scott H Kaufmann
  • Robert Hershberg
  • Heather Lankes
  • Bradley J Monk
  • Christopher J Mariani
  • Siobán B Keel
  • R Coleman Lindsley
  • Bradford S Schwartz
  • Lucy A Godley
  • Sheena M Scroggins
  • Akiko Shimamura
  • Ryan S Basom
  • Keith R Loeb
  • Janis L Abkowitz
  • Inga Hofmann
  • Suleyman Gulsuner
  • Marilyn Sanchez-Bonilla
  • David A Williams
  • Melissa Forouhar
  • Jeffrey J Delrow
  • Rafael Márquez
  • Jane E Churpek
  • Scott A Coats
  • Barbara Neistadt
  • Boglarka Gyurkocza
  • Ming K Lee
  • Karen Koehler
  • Tatyana Vlaskin
  • Judith Martin
  • Silvia Casadei
  • Robert J Livingston
  • Angela Jacobson
  • Shawnia Ryan
  • Jason W Chien
  • Marc T Goodman
  • Jonathan F Tait
  • Evan M Kroh
  • Yeonju Kim
  • Hye Son Yi
  • Keith D Eaton

Detail Information

Publications14

  1. pmc Plasma processing conditions substantially influence circulating microRNA biomarker levels
    Heather H Cheng
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS ONE 8:e64795. 2013
    ..We provide specific practical recommendations to help minimize confounding variation attributable to plasma processing and platelet contamination...
  2. pmc Validation and implementation of targeted capture and sequencing for the detection of actionable mutation, copy number variation, and gene rearrangement in clinical cancer specimens
    Colin C Pritchard
    Department of Laboratory Medicine, University of Washington, Seattle, Washington Electronic address
    J Mol Diagn 16:56-67. 2014
    ..To best guide existing and emerging treatment regimens and facilitate integration of genomic testing with patient care, we developed a framework for data analysis, decision support, and reporting clinically actionable results...
  3. pmc ColoSeq provides comprehensive lynch and polyposis syndrome mutational analysis using massively parallel sequencing
    Colin C Pritchard
    Department of Laboratory Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
    J Mol Diagn 14:357-66. 2012
    ..ColoSeq offers a powerful, cost-effective means of genetic testing for Lynch and polyposis syndromes that eliminates the need for stepwise testing and multiple follow-up clinical visits...
  4. pmc COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma
    Colin C Pritchard
    Department of Laboratory Medicine, University of Washington, Seattle, USA
    BMC Clin Pathol 10:6. 2010
    ..Many laboratories have implemented sensitive tests for KRAS mutations, but the methods often require expensive instrumentation and reagents, parallel reactions, multiple steps, or opening PCR tubes...
  5. doi request reprint A mosaic PTEN mutation causing Cowden syndrome identified by deep sequencing
    Colin C Pritchard
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    Genet Med 15:1004-7. 2013
    ..We report a 40-year-old woman with a clinical diagnosis of Cowden syndrome including Lhermitte-Duclos disease, who had a mosaic PTEN mutation detected by next-generation deep sequencing...
  6. pmc MicroRNA profiling: approaches and considerations
    Colin C Pritchard
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    Nat Rev Genet 13:358-69. 2012
    ..Here, we review the major considerations for carrying out and interpreting results of miRNA-profiling studies...
  7. doi request reprint MSIplus for Integrated Colorectal Cancer Molecular Testing by Next-Generation Sequencing
    Jennifer A Hempelmann
    Department of Laboratory Medicine, University of Washington, Seattle, Washington
    J Mol Diagn 17:705-14. 2015
    ....
  8. pmc Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy
    Michael Y Zhang
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nat Genet 47:180-5. 2015
    ..The identification of germline predisposition to cytopenias and cancer informs the diagnosis and medical management of at-risk individuals. ..
  9. pmc Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer
    Colin C Pritchard
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    Nat Commun 5:4988. 2014
    ..Our findings identify parallels and differences in the mechanisms of hypermutation in prostate cancer compared with other MSI-associated cancers. ..
  10. pmc Single molecule molecular inversion probes for targeted, high-accuracy detection of low-frequency variation
    Joseph B Hiatt
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Genome Res 23:843-54. 2013
    ..3%-1.4%), and NRAS p.Q61R (colon, 4.7%). We anticipate that smMIP will be broadly adoptable as a practical and effective method for accurately detecting low-frequency mutations in both research and clinical settings...
  11. pmc Somatic Mosaic Mutations in PPM1D and TP53 in the Blood of Women With Ovarian Carcinoma
    Elizabeth M Swisher
    Department of Obstetrics and Gynecology, University of Washington, Seattle
    JAMA Oncol 2:370-2. 2016
    ..Somatic mosaic mutations in PPM1D have been reported in patients with breast cancer, lung cancer, and ovarian cancer (OC), but cause or effect has not been established...
  12. pmc Deep sequencing with intronic capture enables identification of an APC exon 10 inversion in a patient with polyposis
    Brian H Shirts
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    Genet Med 16:783-6. 2014
    ....
  13. doi request reprint Microsatellite instability detection by next generation sequencing
    Stephen J Salipante
    Department of Laboratory Medicine, University of Washington, Seattle WA
    Clin Chem 60:1192-9. 2014
    ..Microsatellite instability (MSI) is a useful phenotype in cancer diagnosis and prognosis. Nevertheless, methods to detect MSI status from next generation DNA sequencing (NGS) data are underdeveloped...
  14. pmc Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies
    Colin C Pritchard
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    Cancer Prev Res (Phila) 5:492-7. 2012
    ....