The risk is in the air: Intranasal administration of MPTP to rats reproducing clinical features of Parkinson's diseaseRui D S Prediger
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC Campus Trindade, Florianopolis SC 88049 900, Brazil
Exp Neurol 202:391-403. 2006
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Risk is in the air: an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of Parkinson's diseaseRui D S Prediger
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Florianopolis, SC, Brazil
Ann N Y Acad Sci 1170:629-36. 2009
..n. MPTP rat model may provide insight into the underlying mechanisms of PD pathogenesis, potentially leading to the development of new therapeutic strategies for this devastating disease...
- Effects of acute administration of the hydroalcoholic extract of mate tea leaves (Ilex paraguariensis) in animal models of learning and memory
Rui D S Prediger
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina UFSC, Campus Universitario, Trindade, Florianopolis SC 88049 900, Brazil
J Ethnopharmacol 120:465-73. 2008
..Our previous study indicated that the hydroalcoholic extract of Ilex paraguariensis presents an antiparkinsonian profile in reserpine- and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP)-treated rodents...
- Genetic deletion or antagonism of kinin B(1) and B(2) receptors improves cognitive deficits in a mouse model of Alzheimer's disease
R D S Prediger
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Campus Universitario, Trindade, Florianopolis SC 88049 900, Brazil
Neuroscience 151:631-43. 2008
..Therefore, selective kinin receptor antagonists, especially the new orally active non-peptide antagonists, might represent drugs of potential interest for the treatment of AD...
- Single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice models early preclinical phase of Parkinson's disease
Rui D S Prediger
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Florianopolis, SC, Brazil
Neurotox Res 17:114-29. 2010
..n. administration of MPTP represents a valuable mouse model for the study of the early stages of PD and for testing new therapeutic strategies to restore sensorial and cognitive processes in PD...
- Anxiety in Parkinson's disease: a critical review of experimental and clinical studies
Rui D S Prediger
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina UFSC, 88049 900 Florianopolis, SC, Brazil
Neuropharmacology 62:115-24. 2012
..This article is part of a Special Issue entitled 'Anxiety and Depression'...
- Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms
Rui D S Prediger
Departamento de Farmacologia, Centro de Ciencias Biologicas, Hospital Universitario, Universidade Federal de Santa Catarina, UFSC, Florianopolis SC, Brazil
J Alzheimers Dis 20:S205-20. 2010
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- Intranasal administration of neurotoxicants in animals: support for the olfactory vector hypothesis of Parkinson's disease
Rui D S Prediger
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Campus Trindade, Florianopolis, SC, 88049 900, Brazil
Neurotox Res 21:90-116. 2012
..More research is needed, however, on this and other ecologically valid models...
- The intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a new rodent model to test palliative and neuroprotective agents for Parkinson's disease
Rui D S Prediger
Departamento de Farmacologia, Universidade Federal de Santa Catarina, Campus Trindade, 88049 900, Florianopolis, SC, Brazil
Curr Pharm Des 17:489-507. 2011
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- Mice with genetic deletion of the heparin-binding growth factor midkine exhibit early preclinical features of Parkinson's disease
Rui D S Prediger
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Campus Trindade, Florianopolis, SC, 88049 900, Brazil
J Neural Transm 118:1215-25. 2011
..Therefore, Mdk(-/-) mice may represent a promising animal model for the study of the early stages of PD and for testing new therapeutic strategies to restore sensorial and cognitive processes in PD...
- Increased sensitivity of adolescent spontaneously hypertensive rats, an animal model of attention deficit hyperactivity disorder, to the locomotor stimulation induced by the cannabinoid receptor agonist WIN 55,212-2
Pablo Pandolfo
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Florianopolis SC 88049 900, Brazil
Eur J Pharmacol 563:141-8. 2007
..The present results indicate strain- and age-related effects of cannabinoids on locomotor activity in rats, extending the notion that adolescence and ADHD represent risk factors for the increased sensitivity to the effects of drugs...
- Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β(1-40) administration in mice: evidence for dissociation between cognitive deficits and neuronal damage
Tetsadê C B Piermartiri
Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Trindade, 88040 900 Florianopolis, SC, Brazil
Exp Neurol 226:274-84. 2010
..In addition, the present findings suggest that the spatial learning and memory deficits induced by Aβ peptides in rodents may not be entirely related to neuronal damage...
- Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorder
Vanessa A Pires
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, Santa Catarina, Brazil
Behav Pharmacol 20:134-45. 2009
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- The role of TNF-alpha signaling pathway on COX-2 upregulation and cognitive decline induced by beta-amyloid peptide
Rodrigo Medeiros
Departamento de Farmacologia, Universidade Federal de Santa Catarina, Santa Catarina, Brazil
Behav Brain Res 209:165-73. 2010
..Therefore, selective TNF-alpha inhibitors may be potentially interesting tools for AD drug development...
- Chronic caffeine treatment during prepubertal period confers long-term cognitive benefits in adult spontaneously hypertensive rats (SHR), an animal model of attention deficit hyperactivity disorder (ADHD)
Vanessa A Pires
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Campus Universitario Trindade, 88049 900 Florianopolis, SC, Brazil
Behav Brain Res 215:39-44. 2010
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- Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid beta protein
Rodrigo Medeiros
Departamento de Farmacologia, Centro de Ciencias Biologicas, Hospital Universitário Universidade Federal de Santa Catarina, 88049 900, Florianopolis, Santa Catarina, Brazil
J Neurosci 27:5394-404. 2007
..These results provide new insights in mouse models of AD, revealing TNF-alpha and iNOS as central mediators of Abeta action. These pathways might be targeted for AD drug development...
- Differential susceptibility following beta-amyloid peptide-(1-40) administration in C57BL/6 and Swiss albino mice: Evidence for a dissociation between cognitive deficits and the glutathione system response
Rui D S Prediger
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, 88040 900 Florianopolis, SC, Brazil
Behav Brain Res 177:205-13. 2007
..In addition, the present findings suggest that the spatial learning and memory deficits induced by beta-amyloid peptides in rodents may not be entirely related to glutathione-dependent antioxidant response...
- Lithium and valproate prevent olfactory discrimination and short-term memory impairments in the intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) rat model of Parkinson's disease
Adalberto A Castro
Departamento de Farmacologia, Universidade Federal de Santa Catarina, Campus Trindade, Florianopolis, SC, 88049 900, Brazil
Behav Brain Res 229:208-15. 2012
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- Effects of traumatic brain injury of different severities on emotional, cognitive, and oxidative stress-related parameters in mice
Marcelo L Schwarzbold
Centro de Neurociências Aplicadas, Hospital Universitario, Universidade Federal de Santa Catarina, Florianopolis, Brazil
J Neurotrauma 27:1883-93. 2010
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- Central nervous system activity of the proanthocyanidin-rich fraction obtained from Croton celtidifolius in rats
Eduardo L G Moreira
Departamento de Farmacologia, Universidade Federal de Santa Catarina, Florianopolis, Brazil
J Pharm Pharmacol 62:1061-8. 2010
..The aim of the present study was to evaluate the possible neurobehavioural effects in rats of the proanthocyanidin-rich fraction (PRF) isolated from the bark of Croton celtidifolius (Euphorbiaceae)...
- Altered emotionality leads to increased pain tolerance in amyloid beta (Abeta1-40) peptide-treated mice
Fabrício A Pamplona
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, Florianopolis, SC 88049 900, Brazil
Behav Brain Res 212:96-102. 2010
..These results suggest that Abeta(1-40) peptide increases pain tolerance, but not pain sensitivity in mice, which seems to be linked to alterations in cognitive/emotional components of pain processing...
- Involvement of phosphoinositide 3-kinase gamma in the neuro-inflammatory response and cognitive impairments induced by beta-amyloid 1-40 peptide in mice
Giselle F Passos
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, Santa Catarina, Brazil
Brain Behav Immun 24:493-501. 2010
..Our data suggests that inhibition of PI3Kgamma may represent a novel therapeutic target for treating AD patients...
- Blockade of adenosine A2A receptors reverses short-term social memory impairments in spontaneously hypertensive rats
Rui D S Prediger
Departamento de Farmacologia, , Universidade Federal de Santa Catarina, UFSC, Campus Trindade, , SC, Brazil
Behav Brain Res 159:197-205. 2005
..These results demonstrate an impairment of short-term social memory in SHR and the involvement of the adenosine A2A receptors in this alteration...
- Activation of adenosine A1 receptors reduces anxiety-like behavior during acute ethanol withdrawal (hangover) in mice
Rui D S Prediger
Departamento de Farmacologia, , Universidade Federal de Santa Catarina, UFSC, , Santa Catarina, Brazil
Neuropsychopharmacology 31:2210-20. 2006
..These results reinforce the notion of the involvement of adenosine receptors in the anxiety-like responses and indicate the potential of adenosine A1 receptor agonists to reduce the anxiogenic effects during ethanol withdrawal...
- Modulation of short-term social memory in rats by adenosine A1 and A(2A) receptors
Rui D S Prediger
Departamento de Farmacologia, , Universidade Federal de Santa Catarina, UFSC, , SC 88049-900, Brazil
Neurosci Lett 376:160-5. 2005
..These results indicate that adenosine modulates the short-term social memory in rats by acting on both A1 and A(2A) receptors, with adenosine receptor agonists and antagonists, respectively, disrupting and enhancing the social memory...
- Differential gender-related susceptibility to learning and memory deficits in mice submitted to neonatal freezing microgyria model
Daniel Rial
Departamento de Farmacologia, UFSC, Florianopolis, SC, Brazil
Brain Res Bull 79:177-81. 2009
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- Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats. Involvement of adenosine A1 and A2A receptors
Rui D S Prediger
Departamento de Farmacologia, , Universidade Federal de Santa Catarina, UFSC, Campus Trindade, , SC, Brazil
Neurobiol Aging 26:957-64. 2005
..The present results suggest the participation of adenosine receptors in the control of olfactory functions and confirm the potential of caffeine for the treatment of aged-related cognitive decline...
- Antioxidant responses and lipid peroxidation following intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in rats: increased susceptibility of olfactory bulb
Jeferson Franco
Departamento de Ciencias Fisiologicas, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, 88049 900, Florianopolis SC, Brazil
Life Sci 80:1906-14. 2007
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- Pilocarpine improves olfactory discrimination and social recognition memory deficits in 24 month-old rats
Rui D S Prediger
Departamento de Farmacologia, , Universidade Federal de Santa Catarina, UFSC, Campus Trindade, 88049-900, , Brazil
Eur J Pharmacol 531:176-82. 2006
..The present results extend the notion of the participation of muscarinic receptors in control of olfactory functions and reinforce the potential of muscarinic receptor agonists for the treatment of age-related cognitive decline...
- Facilitation of short-term social memory by ethanol in rats is mediated by dopaminergic receptors
Rui D S Prediger
Departamento de Farmacologia, Universidade Federal de Santa Catarina, Rua Ferreira Lima 82, , SC, Brazil
Behav Brain Res 153:149-57. 2004
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- Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: involvement of hippocampal plasticity via AKT, CREB and BDNF signaling
Aderbal S Aguiar
Departamento de Farmacologia, Universidade Federal de Santa Catarina, 88049 900 Florianopolis, SC, Brazil
Mech Ageing Dev 132:560-7. 2011
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- Caffeine improves spatial learning deficits in an animal model of attention deficit hyperactivity disorder (ADHD) -- the spontaneously hypertensive rat (SHR)
Rui D S Prediger
Departamento de Farmacologia, , Universidade Federal de Santa Catarina, UFSC, , SC, Brasil
Int J Neuropsychopharmacol 8:583-94. 2005
..In addition, the present findings indicate that the spatial learning deficit in SHR is not directly related to hypertension...
- Neuroprotective effects of agmatine in mice infused with a single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Filipe C Matheus
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, UFSC, 88049 900 Florianopolis, SC, Brazil
Behav Brain Res 235:263-72. 2012
..These results provide new insights in experimental models of PD, indicating that agmatine represents a potential therapeutic tool for the management of cognitive and motor symptoms of PD, together with its neuroprotective effects...
- The exercise redox paradigm in the Down's syndrome: improvements in motor function and increases in blood oxidative status in young adults
Aderbal S Aguiar
Departamento de Farmacologia, Universidade Federal de Santa Catarina, Campus Trindade, Florianopolis, SC, 88049 900, Brazil
J Neural Transm 115:1643-50. 2008
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- Adenosine A1 receptors modulate the anxiolytic-like effect of ethanol in the elevated plus-maze in mice
Rui D S Prediger
Departamento de Farmacologia, , Universidade Federal de Santa Catarina, UFSC, Rua Ferreira Lima 82, , SC 88015-420, Brazil
Eur J Pharmacol 499:147-54. 2004
..6 g/kg). These results reinforce the involvement of adenosine in anxiety and suggest that the activation of adenosine A1 receptors, but not adenosine A(2A) receptors, mediate the anxiolytic-like effect induced by ethanol in mice...
- Physical exercise improves motor and short-term social memory deficits in reserpinized rats
Aderbal S Aguiar
Laboratório Experimental de Doenças Neurodegenerativas, Departamento de Farmacologia, Universidade Federal de Santa Catarina UFSC, 88049 900 Florianopolis, SC, Brazil
Brain Res Bull 79:452-7. 2009
..Our results reinforce the potential of low to moderate physical exercise as a useful tool in the prevention of motor and cognitive impairments associated to CNS monoaminergic depletion...
- Proanthocyanidin-rich fraction from Croton celtidifolius Baill confers neuroprotection in the intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine rat model of Parkinson's disease
Eduardo L G Moreira
Departamento de Farmacologia, Universidade Federal de Santa Catarina, Florianopolis, SC 88049 900, Brazil
J Neural Transm 117:1337-51. 2010
..celtidifolius may represent a promising therapeutic tool in PD, thus being able to prevent both motor and non-motor early symptoms of PD, together with its neuroprotective potential...
- The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats
Fabrício A Pamplona
Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Campus Universitario Trindade, Florianopolis, Santa Catarina, 88049 900, Brazil
Psychopharmacology (Berl) 188:641-9. 2006
..However, the effects of CB1 cannabinoid receptor activation in this response remain unclear...
- Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus
Claudia P Figueiredo
Programa de Pós Graduação em Neurociências, Departamento Ciencias Fisiologicas, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
Peptides 32:781-9. 2011
..GIPR is expressed in human HIP and Cx. There was a time and region dependent increase of GIPR expression in the HIP and Cx after Pilo-SE that was inversely associated to neuronal degeneration...
- Blockade of adenosine and dopamine receptors inhibits the development of rapid tolerance to ethanol in mice
Luciano C Batista
Departamento de Farmacologia, Universidade Federal de Santa Catarina, Campus Trindade, 88049-900, , SC, Brazil
Psychopharmacology (Berl) 181:714-21. 2005
..5-1.0 mg/kg, i.p.) or sulpiride (1.0-3.0 mg/kg, i.p.). CONCLUSIONS: Our results suggest that the rapid tolerance to ethanol-induced motor impairment in mice may be modulated by adenosine A1 receptors and dopamine D1 receptors...
- Ethanol improves short-term social memory in rats. Involvement of opioid and muscarinic receptors
Rui D S Prediger
Departamento de Farmacologia, , Universidade Federal de Santa Catarina, UFSC, Rua Ferreira Lima 82, , Brazil
Eur J Pharmacol 462:115-23. 2003
..In addition, these findings confirm that the social recognition test in rats is a useful and reliable model to investigate short-term memory affected by ethanol...
In vivo manganese exposure modulates Erk, Akt and Darpp-32 in the striatum of developing rats, and impairs their motor functionFabiano M Cordova
Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, Brazil
PLoS ONE 7:e33057. 2012
..Furthermore, some of the molecular and behavioral events, which are perturbed by early Mn exposure are not directly related to the production of oxidative stress...
- A new naphthoquinone isolated from the bulbs of Cipura paludosa and pharmacological activity of two main constituents
Priscila Batista Tessele
Núcleo de Investigações Químico Farmacêuticas NIQFAR and Programa de Mestrado em Ciências Farmacêuticas, Universidade do Vale do Itajai UNIVALI, Itajai, SC, Brazil
Planta Med 77:1035-43. 2011
..paludosa contain pharmacologically active constituents that possess antinociceptive and anti-inflammatory activity, justifying, at least in part, its popular therapeutic use for treating conditions associated with pain...
