Jaime Prat

Summary

Publications

  1. ncbi request reprint New insights into ovarian cancer pathology
    J Prat
    Department of Pathology, Hospital de Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Ann Oncol 23:x111-7. 2012
  2. doi request reprint Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features
    Jaime Prat
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Sant Quinti 87 89, 08041 Barcelona, Spain
    Virchows Arch 460:237-49. 2012
  3. doi request reprint Expression profiling of 22 genes involved in the PI3K-AKT pathway identifies two subgroups of high-grade endometrial carcinomas with different molecular alterations
    Lluis Catasus
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Mod Pathol 23:694-702. 2010
  4. ncbi request reprint Synchronous endometrioid carcinomas of the uterine corpus and ovary: alterations in the beta-catenin (CTNNB1) pathway are associated with independent primary tumors and favorable prognosis
    Julie A Irving
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Hum Pathol 36:605-19. 2005
  5. ncbi request reprint Molecular genetic alterations in endometrioid carcinomas of the ovary: similar frequency of beta-catenin abnormalities but lower rate of microsatellite instability and PTEN alterations than in uterine endometrioid carcinomas
    Lluis Catasus
    Department of Pathology, Santa Creu and Santa Pau Hospital, Autonomous University of Barcelona, Spain
    Hum Pathol 35:1360-8. 2004
  6. doi request reprint Molecular events in endometrial carcinosarcomas and the role of high mobility group AT-hook 2 in endometrial carcinogenesis
    Laura Romero-Pérez
    Department of Pathology, Instituto de Biomedicina de Sevilla IBiS, Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla, 41013 Sevilla, Spain
    Hum Pathol 44:244-54. 2013
  7. ncbi request reprint Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma
    Enrique Lerma
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Virchows Arch 452:65-74. 2008
  8. ncbi request reprint PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters
    Lluis Catasus
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Mod Pathol 21:131-9. 2008
  9. doi request reprint Exon 20 PIK3CA mutations decreases survival in aggressive (HER-2 positive) breast carcinomas
    Enrique Lerma
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Virchows Arch 453:133-9. 2008
  10. doi request reprint Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis
    Lluis Catasus
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Mod Pathol 22:522-9. 2009

Collaborators

Detail Information

Publications58

  1. ncbi request reprint New insights into ovarian cancer pathology
    J Prat
    Department of Pathology, Hospital de Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Ann Oncol 23:x111-7. 2012
    ..This presentation summarizes recent advances in the molecular pathology which have greatly improved our understanding of the biology of ovarian carcinoma and are also relevant to patient management...
  2. doi request reprint Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features
    Jaime Prat
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Sant Quinti 87 89, 08041 Barcelona, Spain
    Virchows Arch 460:237-49. 2012
    ..This review summarizes recent advances in the molecular pathology which have greatly improved our understanding of the biology of ovarian carcinoma and are also relevant to patient management...
  3. doi request reprint Expression profiling of 22 genes involved in the PI3K-AKT pathway identifies two subgroups of high-grade endometrial carcinomas with different molecular alterations
    Lluis Catasus
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Mod Pathol 23:694-702. 2010
    ..Identification of these subgroups can provide insight into the biology of these tumors and may facilitate the development of future treatments...
  4. ncbi request reprint Synchronous endometrioid carcinomas of the uterine corpus and ovary: alterations in the beta-catenin (CTNNB1) pathway are associated with independent primary tumors and favorable prognosis
    Julie A Irving
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Hum Pathol 36:605-19. 2005
    ..Furthermore, our data show that molecular genetic classification of synchronous independent versus metastatic tumors based on beta -catenin expression/mutation correlates with clinical outcome...
  5. ncbi request reprint Molecular genetic alterations in endometrioid carcinomas of the ovary: similar frequency of beta-catenin abnormalities but lower rate of microsatellite instability and PTEN alterations than in uterine endometrioid carcinomas
    Lluis Catasus
    Department of Pathology, Santa Creu and Santa Pau Hospital, Autonomous University of Barcelona, Spain
    Hum Pathol 35:1360-8. 2004
    ..Alterations in beta-catenin and PTEN genes, as well as MSI, are frequent in low-stage ovarian carcinomas of endometrioid type that have a favorable prognosis...
  6. doi request reprint Molecular events in endometrial carcinosarcomas and the role of high mobility group AT-hook 2 in endometrial carcinogenesis
    Laura Romero-Pérez
    Department of Pathology, Instituto de Biomedicina de Sevilla IBiS, Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla, 41013 Sevilla, Spain
    Hum Pathol 44:244-54. 2013
    ....
  7. ncbi request reprint Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma
    Enrique Lerma
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Virchows Arch 452:65-74. 2008
    ..03) and decrease in host inflammatory response (p = 0.01). Fas-R expression by tumor cells seems unrelated to stage or lymphoid infiltrate. Tumor production of Fas-L may represent an attempt to destroy the host's lymphocytic reaction...
  8. ncbi request reprint PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters
    Lluis Catasus
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Mod Pathol 21:131-9. 2008
    ....
  9. doi request reprint Exon 20 PIK3CA mutations decreases survival in aggressive (HER-2 positive) breast carcinomas
    Enrique Lerma
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Virchows Arch 453:133-9. 2008
    ..Exon 20 PIK3CA mutations are relatively frequent in Her-2+ tumors and shorten survival, whereas neither exons 9 and 20 mutations seem related with "triple negative" breast carcinomas...
  10. doi request reprint Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis
    Lluis Catasus
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Mod Pathol 22:522-9. 2009
    ..000) than patients with only p53 alterations. Such a relationship was lost when we considered exon 9 PIK3CA mutations. Our results contribute to further characterize the molecular genetic model for endometrial carcinogenesis...
  11. ncbi request reprint The FOXO1-miR27 tandem regulates myometrial invasion in endometrioid endometrial adenocarcinoma
    Ana Mozos
    Department of Pathology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Hum Pathol 45:942-51. 2014
    ..In conclusion, we propose that the miR27-FOXO1 tandem inhibits apoptosis and represents an alternative pathway for tumor cell survival in PIK3CA-nonmutated EEC. ..
  12. doi request reprint Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma
    Maria Angeles Castilla
    Department of Pathology, Hospital Universitario Virgen del Rocío IBIS, Instituto de Biomedicina de Sevilla, Sevilla, Spain
    J Pathol 223:72-80. 2011
    ..These data suggest that in human ECS, the interplay between transcriptional repressors of E-cadherin and miRNAs provides a link between EMT-activation and the maintenance of stemness...
  13. ncbi request reprint Malignant mullerian mixed tumor arising from ovarian serous carcinoma: a clinicopathologic and molecular study of two cases
    Alberto Gallardo
    Department of Pathology, Hospital Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Int J Gynecol Pathol 21:268-72. 2002
    ..Identical p53 mutations were detected in the primary ovarian carcinoma and the subsequent MMMT in each case...
  14. doi request reprint Gene expression analysis identifies two groups of ovarian high-grade serous carcinomas with different prognosis
    Inigo Espinosa
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research IBB Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Mod Pathol 24:846-54. 2011
    ..Furthermore, co-expression of caspase-3 and XIAP identified high-grade serous carcinomas with different prognosis (P=0.03). Our results suggest that there are different biological subtypes of high-grade serous carcinomas...
  15. doi request reprint Endometrial stromal sarcomas with sex cord differentiation are associated with PHF1 rearrangement
    Emanuela D'Angelo
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institut of Biomedical Research IIB Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 37:514-21. 2013
    ..008). In our series, all ESSs showing sex cords had PHF1 genetic rearrangement, suggesting that such rearrangements may induce sex cord differentiation...
  16. doi request reprint Prognostic significance of FOXL2 mutation and mRNA expression in adult and juvenile granulosa cell tumors of the ovary
    Emanuela D'Angelo
    Department of Pathology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Mod Pathol 24:1360-7. 2011
    ..Our data suggest that FOXL2 mutation and mRNA expression are of prognostic importance in both adult and juvenile granulosa cell tumors...
  17. ncbi request reprint Is loss of heterozygosity at 9q22.3 (PTCH gene) and 19p13.3 (STK11 gene) involved in the pathogenesis of ovarian stromal tumors?
    Takahiro Tsuji
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, 08025 Barcelona, Spain
    Hum Pathol 36:792-6. 2005
    ....
  18. doi request reprint Bcl-10 protein highly correlates with the expression of phosphorylated p65 NF-kappaB in peripheral T-cell lymphomas and is associated with clinical outcome
    Javier Briones
    Departments of Clinical Haematology and Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Histopathology 54:478-85. 2009
    ..The aim was to investigate the relationship between the expression of PKC theta, Bcl-10 and P-p65(Ser536) proteins and their prognostic significance in peripheral T-cell lymphomas (PTCLs)...
  19. doi request reprint Transitional cell tumors of the ovary: a comparative clinicopathologic, immunohistochemical, and molecular genetic analysis of Brenner tumors and transitional cell carcinomas
    Miriam Cuatrecasas
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Am J Surg Pathol 33:556-67. 2009
    ....
  20. ncbi request reprint Expression profile of heptahelical putative membrane progesterone receptors in epithelial ovarian tumors
    Marisa Romero-Sánchez
    Hospital de la Santa Creu i Sant Pau, Autonomous University, 08025 Barcelona, Spain
    Hum Pathol 39:1026-33. 2008
    ....
  21. doi request reprint Ovarian clear cell carcinomas: RHO GTPases may contribute to explain their singular biologic behavior
    Belén Canet
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research IBB Sant Pau, Autonomous University of Barcelona, 08025 Barcelona, Spain
    Hum Pathol 42:833-9. 2011
    ..04). ARHGDIA, CDC42, RHOA, and RHOC expression may contribute to explain the different stage at diagnosis of clear cell and high-grade serous carcinomas. RHOA may cause resistance of high-grade serous carcinoma to chemotherapy...
  22. doi request reprint Risk factors associated with the occurrence of breast cancer after bilateral salpingo-oophorectomy in high-risk women
    Teresa Ramon Y Cajal
    Department of Medical Oncology, Hospital Sant Pau, Barcelona, Spain
    Cancer Epidemiol 35:78-82. 2011
    ..The goal of this study was to determine the incidence of subsequent breast cancer (BC) in a high-risk population and to identify clinical and epidemiological predictors of BC following BSO...
  23. doi request reprint Uterine leiomyosarcomas: tumor size, mitotic index, and biomarkers Ki67, and Bcl-2 identify two groups with different prognosis
    Emanuela D'Angelo
    Department of Pathology, Institut of Biomedical Research, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Gynecol Oncol 121:328-33. 2011
    ..Although most tumors are associated with poor prognosis even when apparently confined to the uterus (stage I), some cases that exhibited morphologic features of malignancy had prolonged survival...
  24. doi request reprint Triple negative breast carcinomas: similarities and differences with basal like carcinomas
    Enrique Lerma
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Appl Immunohistochem Mol Morphol 17:483-94. 2009
    ..Recent studies suggest that basal like carcinomas are originated from mammary stem cells...
  25. doi request reprint Repression of E-cadherin by SNAIL, ZEB1, and TWIST in invasive ductal carcinomas of the breast: a cooperative effort?
    Nuria Montserrat
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, 08025 Barcelona, Spain
    Hum Pathol 42:103-10. 2011
    ....
  26. ncbi request reprint Endometrial carcinoma: pathology and genetics
    Jaime Prat
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Pathology 39:72-87. 2007
    ..This article reviews the genetic changes of endometrial carcinogenesis in the light of morphological features of the tumours and their precursors...
  27. ncbi request reprint The STK11/LKB1 Peutz-Jegher gene is not involved in the pathogenesis of sporadic sex cord-stromal tumors, although loss of heterozygosity at 19p13.3 indicates other gene alteration in these tumors
    Noriko Kato
    Department of Pathology, Autonomous University of Barcelona, Barcelona, Spain
    Hum Pathol 35:1101-4. 2004
    ..Our results indicate that LOH at 19p13.3 in sporadic SCSTs targets a gene different from STK11, and may play a role in the pathogenesis of sporadic SCSTs, especially in tumors containing sex cord derivatives...
  28. ncbi request reprint Endocervical-like mucinous borderline tumors of the ovary: a clinicopathologic analysis of 31 cases
    Ingrid M Rodriguez
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Sant Antoni Ma Claret 167, Autonomous University of Barcelona, 08025 Barcelona, Spain
    Am J Surg Pathol 28:1311-8. 2004
    ..The frequency of occurrence and criteria for the diagnosis of intraepithelial carcinoma and microinvasion in ELMBT are discussed...
  29. doi request reprint Uterine sarcomas: a review
    Emanuela D'Angelo
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Sant Antoni M Claret, 167, 08025 Barcelona, Spain
    Gynecol Oncol 116:131-9. 2010
    ..Currently, there is no consensus on risk factors for adverse outcome. This review summarizes the available clinicopathological data on uterine sarcomas classified by the WHO diagnostic criteria...
  30. ncbi request reprint Microsatellite instability and immunostaining for MSH-2 and MLH-1 in cutaneous and internal tumors from patients with the Muir-Torre syndrome
    Pilar Machin
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
    J Cutan Pathol 29:415-20. 2002
    ..Currently, MTS is regarded as a variant of the hereditary non-polyposis colon cancer syndrome (HNPCC). Both MTS and HNPCC are secondary to germline mutations in DNA mismatch repair genes (mainly MSH-2 and MLH-1)...
  31. ncbi request reprint Promoter hypermethylation contributes to TIMP3 down-regulation in high stage endometrioid endometrial carcinomas
    Lluis Catasus
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research, Autonomous University of Barcelona, Barcelona, Spain
    Histopathology 62:632-41. 2013
    ..However, little is known regarding the silencing effect of TIMP3 promoter hypermethylation on gene and protein expression in endometrial carcinomas and its prognostic significance...
  32. ncbi request reprint Malignant mesonephric tumors of the female genital tract: a clinicopathologic study of 9 cases
    Sílvia Bagué
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Am J Surg Pathol 28:601-7. 2004
    ..Surgery alone appears to be the treatment of choice. In contrast, MMMTs may present in advanced stage and are aggressive tumors, similar to malignant mixed müllerian tumors...
  33. doi request reprint CDC42-positive macrophages may prevent malignant transformation of ovarian endometriosis
    Belén Canet
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research IIB Sant Pau, Autonomous University of Barcelona, Barcelona 08041, Spain
    Hum Pathol 43:720-5. 2012
    ..065; 28% versus 5%, P = .046). Our results raise the possibility that CDC42-positive macrophages may prevent the development of endometrioid and clear cell carcinomas...
  34. doi request reprint Epithelial to mesenchymal transition in early stage endometrioid endometrial carcinoma
    Nuria Montserrat
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, 08041 Barcelona, Spain
    Hum Pathol 43:632-43. 2012
    ..Our findings suggest that epithelial to mesenchymal transition regulators are implicated in myometrial invasion of endometrioid endometrial carcinoma and may be potential therapeutic targets through the MAPK/ERK pathway...
  35. ncbi request reprint Comparative clinicopathologic and immunohistochemical analysis of uterine sarcomas diagnosed using the World Health Organization classification system
    Emanuela D'Angelo
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona 08025, Spain
    Hum Pathol 40:1571-85. 2009
    ..It may be possible to identify a subset of leiomyosarcomas with a favorable prognosis based on staining with a panel of immunomarkers for cell proliferation and apoptosis...
  36. ncbi request reprint Serous borderline tumors of the ovary: a long-term follow-up study of 137 cases, including 18 with a micropapillary pattern and 20 with microinvasion
    Jaime Prat
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autoamous University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 26:1111-28. 2002
    ..The micropapillary pattern alone does not imply an unfavorable prognosis; only micropapillary tumors associated with invasive implants behave aggressively...
  37. ncbi request reprint Prognostic parameters of endometrial carcinoma
    Jaime Prat
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Hum Pathol 35:649-62. 2004
    ..This review presents the most important prognostic factors of endometrial carcinomas from the pathologist's viewpoint, and attempts to clarify existing conflicts in the classification and diagnosis of these tumors...
  38. ncbi request reprint Alterations of the p16/Rb/cyclin-D1 pathway in vulvar carcinoma, vulvar intraepithelial neoplasia, and lichen sclerosus
    Enrique Lerma
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Hum Pathol 33:1120-5. 2002
    ....
  39. doi request reprint Myometrial invasion and lymph node metastasis in endometrioid carcinomas: tumor-associated macrophages, microvessel density, and HIF1A have a crucial role
    Inigo Espinosa
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 34:1708-14. 2010
    ..The identical stroma microenvironment found in the primary and the corresponding metastatic tumor suggests that tumor stroma response is determined by the intrinsic biology of the tumor...
  40. doi request reprint Role of tumor-associated macrophages and angiogenesis in desmoid-type fibromatosis
    Stefhanie Romero
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research, Autonomous University of Barcelona, Barcelona, Spain
    Virchows Arch 461:117-22. 2012
    ..000005). Macrophages and microvessels may play an important role in the biologic behavior of DTF. This finding could help in the clinical management of patients with DTF...
  41. ncbi request reprint Membrane PKC-beta 2 protein expression predicts for poor response to chemotherapy and survival in patients with diffuse large B-cell lymphoma
    Inigo Espinosa
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Universidad Autonoma de Barcelona, Barcelona, Spain
    Ann Hematol 85:597-603. 2006
    ..4, P=0.011). Our results suggest that membrane expression of PKC-beta 2 protein on DLBCL predicts for poor survival, especially in patients with low IPI...
  42. doi request reprint Pathology of mixed Müllerian tumours
    Emanuela D'Angelo
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Best Pract Res Clin Obstet Gynaecol 25:705-18. 2011
    ..On the basis of the clonal origin of both tumour components, carcinosarcomas are currently thought to be metaplastic carcinomas rather than uterine sarcomas...
  43. doi request reprint Mullerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma
    Alberto Gallardo
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 33:278-88. 2009
    ..These findings suggest that some of the tumors currently classified as adenofibromas, on the basis of their low mitotic count and lack of significant nuclear atypia, are, in fact, well-differentiated adenosarcomas...
  44. doi request reprint Anaplastic carcinoma in mucinous ovarian tumors: a clinicopathologic study of 34 cases emphasizing the crucial impact of stage on prognosis, their histologic spectrum, and overlap with sarcomalike mural nodules
    Claudia Provenza
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Am J Surg Pathol 32:383-9. 2008
    ..These foci/nodules may exhibit rhabdoid, sarcomatoid (spindle cell), or pleomorphic features...
  45. ncbi request reprint Stromal signatures in endometrioid endometrial carcinomas
    Inigo Espinosa
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research IIB Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Mod Pathol 27:631-9. 2014
    ..Preservation of the CSF1 macrophage stromal response in the metastases leds support to targeting the CSF1 pathway in endometrioid endometrial carcinomas. ..
  46. ncbi request reprint Clonality analysis in synchronous or metachronous tumors of the female genital tract
    Xavier Matias-Guiu
    Department of Pathology, Hospital Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Int J Gynecol Pathol 21:205-11. 2002
  47. ncbi request reprint Ovarian carcinomas, including secondary tumors: diagnostically challenging areas
    Jaime Prat
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Mod Pathol 18:S99-111. 2005
    ..Krukenberg tumors are metastatic adenocarcinomas traditionally perceived as composed of mucin-filled signet-ring cells associated with a striking proliferation of the ovarian stroma but many variations on this pattern occur...
  48. ncbi request reprint Sarcoma-like mural nodules in mucinous cystic tumors of the ovary revisited: a clinicopathologic analysis of 10 additional cases
    Sílvia Bagué
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Am J Surg Pathol 26:1467-76. 2002
    ..Their coexpression of vimentin and cytokeratins is consistent with an origin from submesothelial mesenchymal cells, which undergo partial transformation into epithelial cells...
  49. doi request reprint The EMT signaling pathways in endometrial carcinoma
    Eva Colas
    Biomedical Research Unit, Vall d Hebron Research Institute, Barcelona, Spain
    Clin Transl Oncol 14:715-20. 2012
    ..Pathways including progesterone receptor, TGFβ, ETV5 and microRNAs are deeply related to the EMT process in EC...
  50. ncbi request reprint Mucinous tumors of the ovary: a clinicopathologic analysis of 75 borderline tumors (of intestinal type) and carcinomas
    Ingrid M Rodriguez
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avda Sant Antoni Ma Claret 167, 08025 Barcelona, Spain
    Am J Surg Pathol 26:139-52. 2002
    ..The presence of anaplastic components in stage Ia (intact) carcinomas did not have an adverse effect in their outcome, even when the undifferentiated carcinomatous elements appeared in the form of mural nodules...
  51. ncbi request reprint CTNNB1 mutations and beta-catenin expression in endometrial carcinomas
    Pilar Machin
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Hum Pathol 33:206-12. 2002
    ..05). The results confirm that beta-catenin plays a role in endometrial carcinogenesis, particularly in endometrioid carcinomas. The results also suggest that MMP-7 and particularly cD may be targets of beta-catenin activation in ECs...
  52. doi request reprint Classification of ovarian carcinomas based on pathology and molecular genetics
    Emanuela D'Angelo
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Clin Transl Oncol 12:783-7. 2010
    ..In this review we summarise recent advances in the molecular pathology, which have greatly improved our understanding of the biology of ovarian carcinoma and are also relevant to patient management...
  53. ncbi request reprint Hereditary ovarian cancer
    Jaime Prat
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, 08025 Barcelona, Spain
    Hum Pathol 36:861-70. 2005
    ..Ovarian cancer in HNPCC syndrome is diagnosed at younger age than in the general population. Most tumors are low-stage well-differentiated or moderately differentiated carcinomas. Annual follow-up is recommended for these patients...
  54. ncbi request reprint Comparative findings of lymphocytic thyroiditis and thyroid lymphoma
    Enrique Lerma
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University, Barcelona, Spain
    Acta Cytol 47:575-80. 2003
    ..To compare the cytologic features of histologically proven lymphocytic (Hashimoto's) thyroiditis (Hashimoto's thyroitidis) and primary thyroid lymphomas (TL)...
  55. ncbi request reprint Effectiveness of liquid-based cytology and papanicolaou tests in a low risk population
    Enrique Lerma
    Department of Pathology, Hospital Santa Creu i Sant Pau, Barcelona, Spain
    Acta Cytol 51:399-406. 2007
    ..Pap Test and determine whether the Hybrid Capture System II (HCII) for detection of human papillomavirus (HPV) could increase the sensitivity and effectiveness of cervical screening in a low risk population...
  56. ncbi request reprint Immunohistochemical heterogeneity of breast carcinomas negative for estrogen receptors, progesterone receptors and Her2/neu (basal-like breast carcinomas)
    Enrique Lerma
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Mod Pathol 20:1200-7. 2007
    ..001) and activated caspase-3 (P=0.089). IGF-IR could be as important as EGFR for the growth of these neoplasms. Basal cell carcinoma has at least two subtypes with distinct microscopic and immunohistochemical features...
  57. doi request reprint Squamous cell carcinoma of the ovary arising from a mucinous cystic tumor of endocervical (müllerian) type
    Emanuela D'Angelo
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Int J Gynecol Pathol 29:529-32. 2010
    ..As found typically in endocervical (müllerian) mucinous tumors, numerous polymorphonuclear leukocytes were seen in the stroma and the neoplastic mucinous epithelium...
  58. ncbi request reprint Diagnostic use of immunohistochemistry in uterine mesenchymal tumors
    Emanuela D'Angelo
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Floor C 2, Sant Quintí, 87 89, 08041 Barcelona, Spain Electronic address
    Semin Diagn Pathol 31:216-22. 2014
    ....