The Adaptive Behaviour Dementia Questionnaire (ABDQ): screening questionnaire for dementia in Alzheimer's disease in adults with Down syndromeV Prasher
The Greenfields, Monyhull, Monyhull Hall Road, Kings Norton, Birmingham B30 3QQ, UK
Res Dev Disabil 25:385-97. 2004
..The scale has good reliability and validity, with an overall accuracy of 92%. It is the first clinical tool designed specifically to screen for dementia in Alzheimer's disease in adults with Down syndrome...
Review of donepezil, rivastigmine, galantamine and memantine for the treatment of dementia in Alzheimer's disease in adults with Down syndrome: implications for the intellectual disability populationV P Prasher
The Greenfields, Birmingham, UK
Int J Geriatr Psychiatry 19:509-15. 2004
..Future clinical and research issues are discussed...
Fifteen-year follow-up of thyroid status in adults with Down syndromeV Prasher
The Greenfields, Birmingham, UK
J Intellect Disabil Res 55:392-6. 2011
..The natural history of thyroid function in adults with Down syndrome is relatively unknown with limited long-term follow-up data...
Longitudinal changes in adaptive behavior in adults with Down syndrome: interim findings from a longitudinal studyV P Prasher
Department of Psychiatry, Queen Elizabeth Psychiatric Hospital, University of Birmingham, United Kingdom
Am J Ment Retard 103:40-6. 1998
..For subjects with no significant medical disorder (physical or psychological), no decline was seen. This longitudinal study confirms previously reported findings...
Plasma beta-amyloid and duration of Alzheimer's disease in adults with Down syndromeV P Prasher
Monyhull Hospital, Liverpool John Moore University, c o The Greenfields, Monyhull, Birmingham, UK
Int J Geriatr Psychiatry 25:202-7. 2010
..To investigate the relation of plasma levels of Abeta peptides (Abeta1-40 and Abeta1-42) and apolipoprotein E (APOE) genotype to dementia status, and the duration of Alzheimer's disease (AD) in adults with Down syndrome (DS)...
Significant effect of APOE epsilon 4 genotype on the risk of dementia in Alzheimer's disease and mortality in persons with Down syndromeV P Prasher
The Greenfields, Monyhull Hospital, Birmingham, UK
Int J Geriatr Psychiatry 23:1134-40. 2008
..The effect of allelic variants of Apolipoprotein (APOE) gene in development and progression of DAD and mortality in persons with DS is examined...
Total serum cholesterol levels and Alzheimer's dementia in patients with Down syndromeV P Prasher
Liverpool John Moore University, c o Greenfields, Monyhull, Birmingham, UK
Int J Geriatr Psychiatry 23:937-42. 2008
..Hypercholesterolaemia has been reported as a risk factor for DAD in the general population. This study investigated the role of serum cholesterol levels in the onset of DAD in the DS population...
Natural history of thyroid function in adults with Down syndrome--10-year follow-up studyV Prasher
Greenfields, Kings Norton, Birmingham, UK
J Intellect Disabil Res 51:312-7. 2007
..The natural history of thyroid function in adults with Down syndrome (DS) is unknown...
Misdiagnosis of thyroid disorders in down syndrome: time to re-examine the myth?V Prasher
Monyhull Hospital, Birmingham B30 3QQ, UK
Am J Ment Retard 110:23-7. 2005
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Weight loss in adults with Down syndrome and with dementia in Alzheimer's diseaseV P Prasher
Greenfields, Monyhull Hall Road, Kings Norton, Birmingham B30 3QQ, UK
Res Dev Disabil 25:1-7. 2004
..This study highlights important research and clinical issues regarding weight loss and nutrition in Down syndrome adults with dementia...
Long term safety and efficacy of donepezil in the treatment of dementia in Alzheimer's disease in adults with Down syndrome: open label studyV P Prasher
Monyhull Hospital, Birmingham, UK
Int J Geriatr Psychiatry 18:549-51. 2003
Magnetic resonance imaging, Down's syndrome and Alzheimer's disease: research and clinical implicationsV Prasher
The Greenfields, Monyhull Hospital, Kings Norton, Birmingham, UK
J Intellect Disabil Res 47:90-100. 2003
..Neuro-imaging is a relatively new form of detecting the changes associated with dementia. The present study investigated the role of magnetic resonance imaging (MRI) in diagnosing AD in adults with Down's syndrome (DS)...
A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Down syndrome and Alzheimer's disease--pilot studyVee P Prasher
Monyhull Hospital, Monyhull Hall Road, Kings Norton, Birmingham, B30 3QB, UK
Int J Geriatr Psychiatry 17:270-8. 2002
..This study investigated the safety and efficacy of the drug to treat Down syndrome (DS) adults with mild to moderate AD...
Down syndrome and thyroid disorders: a reviewV P Prasher
Department of Psychiatry, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Edgbaston, England, UK
Downs Syndr Res Pract 6:25-42. 1999
..Historical, epidemiological, immunological, diagnostic and treatment issues are addressed. Recommendations for future management and research are considered...