Robert M Post

Summary

Publications

  1. doi request reprint Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and Germany
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
    Int Clin Psychopharmacol 26:96-106. 2011
  2. ncbi request reprint Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers
    Gabriele S Leverich
    Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    Am J Psychiatry 163:232-9. 2006
  3. ncbi request reprint Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
  4. doi request reprint Relationship of prior antidepressant exposure to long-term prospective outcome in bipolar I disorder outpatients
    Robert M Post
    Bipolar Collaborative Network, Bethesda, Maryland, USA
    J Clin Psychiatry 73:924-30. 2012
  5. ncbi request reprint An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003
  6. ncbi request reprint A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:396-406. 2003
  7. ncbi request reprint Preliminary findings of uncoupling of flow and metabolism in unipolar compared with bipolar affective illness and normal controls
    Robert T Dunn
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, 10 Center Drive MSC 1272, Bethesda, MD 20892 1272, USA
    Psychiatry Res 140:181-98. 2005
  8. ncbi request reprint Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
  9. doi request reprint Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Bethesda, MD 20814, USA
    J Clin Psychiatry 71:864-72. 2010
  10. ncbi request reprint Coadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizures
    Zhang Jin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Pharmacol Biochem Behav 74:565-71. 2003

Detail Information

Publications48

  1. doi request reprint Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and Germany
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
    Int Clin Psychopharmacol 26:96-106. 2011
    ....
  2. ncbi request reprint Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers
    Gabriele S Leverich
    Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    Am J Psychiatry 163:232-9. 2006
    ..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression...
  3. ncbi request reprint Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
    ..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness...
  4. doi request reprint Relationship of prior antidepressant exposure to long-term prospective outcome in bipolar I disorder outpatients
    Robert M Post
    Bipolar Collaborative Network, Bethesda, Maryland, USA
    J Clin Psychiatry 73:924-30. 2012
    ..The long-term impact of prior antidepressant exposure on the subsequent course of bipolar illness remains controversial...
  5. ncbi request reprint An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003
    ..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed...
  6. ncbi request reprint A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:396-406. 2003
    ..This paper reviews new data on: (1) depression in bipolar illness, (2) switch rates on ADs and (3) risks of AD discontinuation that are pertinent to the ongoing discussion and recommendations...
  7. ncbi request reprint Preliminary findings of uncoupling of flow and metabolism in unipolar compared with bipolar affective illness and normal controls
    Robert T Dunn
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, 10 Center Drive MSC 1272, Bethesda, MD 20892 1272, USA
    Psychiatry Res 140:181-98. 2005
    ....
  8. ncbi request reprint Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
    ..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder...
  9. doi request reprint Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Bethesda, MD 20814, USA
    J Clin Psychiatry 71:864-72. 2010
    ..We examined the influence of age at onset of illness and the delay in time to first treatment on morbidity in adulthood...
  10. ncbi request reprint Coadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizures
    Zhang Jin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Pharmacol Biochem Behav 74:565-71. 2003
    ..These data indicate that cotreatment with either GBP or MK-801 slows tolerance development to the anticonvulsant effects of LTG on kindled seizures. Therapeutic implications of the present study remain to be explored...
  11. ncbi request reprint Intensity-dependent regional cerebral blood flow during 1-Hz repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers studied with H215O positron emission tomography: II. Effects of prefrontal cortex rTMS
    Andrew M Speer
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10 Room 5N234, Bethesda, MD 20892 1430, USA
    Biol Psychiatry 54:826-32. 2003
    ..We examined intensity-related changes in brain activity with positron emission tomography (PET) in normal volunteers during rTMS delivered to the left PFC...
  12. ncbi request reprint The poor prognosis of childhood-onset bipolar disorder
    Gabriele S Leverich
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Pediatr 150:485-90. 2007
    ..We examined age of onset of bipolar disorder as a potential course-of-illness modifier with the hypothesis that early onset will engender more severe illness...
  13. ncbi request reprint Convergences in course of illness and treatments of the epilepsies and recurrent affective disorders
    Robert M Post
    Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD, USA
    Clin EEG Neurosci 35:14-24. 2004
    ..Caveats in the use of this model and convergences and divergences in its predictive validity for seizures and affective disorders are noted...
  14. ncbi request reprint Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 12723, USA
    J Clin Psychiatry 64:680-90; quiz 738-9. 2003
    ..The detailed course and pattern of illness emerging despite comprehensive treatment with mood stabilizers and adjunctive agents have previously not been well delineated...
  15. ncbi request reprint Early physical and sexual abuse associated with an adverse course of bipolar illness
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network and the Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3S 239, Bethesda, MD 20892 1272, USA
    Biol Psychiatry 51:288-97. 2002
    ..There is growing awareness of the association between physical and sexual abuse and subsequent development of psychopathology, but little is known, however, about their relationship to the longitudinal course of bipolar disorder...
  16. ncbi request reprint Principal components of the Beck Depression Inventory and regional cerebral metabolism in unipolar and bipolar depression
    Robert T Dunn
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892 1272, USA
    Biol Psychiatry 51:387-99. 2002
    ..Then, comparing unipolars and bipolars, these symptom clusters were examined for interrelationships, and for relationships to regional cerebral metabolism for glucose measured by positron emission tomography...
  17. pmc Interregional cerebral metabolic associativity during a continuous performance task (Part I): healthy adults
    Mark W Willis
    Uniformed Services University of the Health Sciences, PHS, HHS, Bethesda, MD, USA
    Psychiatry Res 164:16-29. 2008
    ..These analytical data may help to confirm known functional and neuroanatomical relationships, elucidate others as yet unreported, and serve as a basis for comparison to patients with psychiatric illness...
  18. doi request reprint Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder
    Robert M Post
    Bipolar Collaborative Network, 5415 West Cedar Lane Suite 201B, Bethesda, MD 20814, USA
    J Affect Disord 147:288-94. 2013
    ....
  19. ncbi request reprint Decreased expression of mineralocorticoid receptor mRNA in the prefrontal cortex in schizophrenia and bipolar disorder
    Guo Qiang Xing
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Int J Neuropsychopharmacol 7:143-53. 2004
    ..Whether these findings may be linked to the abnormal prefrontal function, HPA axis activation, or the deficits in SWS found in these major psychiatric illnesses remains to be further explored...
  20. ncbi request reprint Unidirectional cross-tolerance from levetiracetam to carbamazepine in amygdala-kindled seizures
    Zhang Jin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, U S A
    Epilepsia 44:1487-93. 2003
    ..The present study was designed to determine whether cross-tolerance occurs between levetiracetam (LEV) and carbamazepine (CBZ) in amygdala-kindled rats...
  21. ncbi request reprint Is there progression from irritability/dyscontrol to major depressive and manic symptoms? A retrospective community survey of parents of bipolar children
    Emily L Fergus
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    J Affect Disord 77:71-8. 2003
    ..The current study sought to trace parents' retrospective report of yearly occurrence of symptoms in a sample of children with and without a diagnosis of bipolar disorder in the community...
  22. ncbi request reprint Left prefrontal-repetitive transcranial magnetic stimulation (rTMS) and regional cerebral glucose metabolism in normal volunteers
    Timothy A Kimbrell
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Psychiatry Res 115:101-13. 2002
    ..While these results are in the predicted direction, further studies using other designs and higher intensities and frequencies of rTMS are indicated to better describe the local and distant changes induced by rTMS...
  23. ncbi request reprint Treatment of rapid-cycling bipolar disorder
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, MD, USA
    CNS Spectr 9:1-11. 2004
  24. ncbi request reprint A potential cholinergic mechanism of procaine's limbic activation
    Brenda E Benson
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, MD 20892 1272, USA
    Neuropsychopharmacology 29:1239-50. 2004
    ..v. procaine's emotional and sensory effects in man. These findings are consistent with other evidence of cholinergic modulation of mood and emotion...
  25. doi request reprint Earliest symptoms discriminating juvenile-onset bipolar illness from ADHD
    David A Luckenbaugh
    Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD, USA
    Bipolar Disord 11:441-51. 2009
    ....
  26. ncbi request reprint Intensity-dependent regional cerebral blood flow during 1-Hz repetitive transcranial magnetic stimulation (rTMS) in healthy volunteers studied with H215O positron emission tomography: I. Effects of primary motor cortex rTMS
    Andrew M Speer
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Building 10 Room 5N234, Bethesda, MD 20892 1430, USA
    Biol Psychiatry 54:818-25. 2003
    ..We combined the administration of varying intensities of 1-Hz rTMS of the motor cortex with simultaneous positron emission tomography (PET) to delineate local and distant effects on brain activity...
  27. doi request reprint Acquired lithium resistance revisited: discontinuation-induced refractoriness versus tolerance
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201B, Bethesda, MD 20814, United States
    J Affect Disord 140:6-13. 2012
    ..While some patients fail to respond to lithium from the outset, others are initially responsive and then develop treatment resistance. These acquired forms of lithium resistance have received relatively little clinical attention...
  28. ncbi request reprint The impact of bipolar depression
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, MD, USA
    J Clin Psychiatry 66:5-10. 2005
    ..Early and accurate diagnosis, aggressive management, and earlier prophylactic treatment regimens are needed to overcome the impact of depressive episodes in patients with bipolar disorder...
  29. ncbi request reprint Clinical predictors of response to lamotrigine and gabapentin monotherapy in refractory affective disorders
    Gabriela V Obrocea
    National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892, USA
    Biol Psychiatry 51:253-60. 2002
    ..The objective of the current study was to examine possible clinical predictors of positive response to lamotrigine or gabapentin monotherapy in treatment-refractory affectively ill patients...
  30. doi request reprint Bipolar disorder and substance misuse: pathological and therapeutic implications of their comorbidity and cross-sensitisation
    Robert M Post
    MD, Head, Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
    Br J Psychiatry 202:172-6. 2013
    ..Bipolar disorder has a high co-occurrence with substance use disorders, but the pathophysiological mechanisms have not been adequately explored...
  31. ncbi request reprint The benzodiazepine partial inverse agonist Ro15-4513 alters anticonvulsant and lethal effects of carbamazepine in amygdala-kindled rats
    Zhang Jin Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Neurosci Lett 329:253-6. 2002
    ..The potential clinical implications for CBZ-induced toxicity and overdose remain to be explored...
  32. doi request reprint Mechanisms of illness progression in the recurrent affective disorders
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, USA
    Neurotox Res 18:256-71. 2010
    ....
  33. ncbi request reprint The health care crisis of childhood-onset bipolar illness: some recommendations for its amelioration
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health NIMH, National Institutes of Health NIH, Bldg 10, Rm 3S329, 10 Center Drive, Bethesda, MD 20892, USA
    J Clin Psychiatry 67:115-25. 2006
    ..To describe new data on the incidence and impact of childhood- and adolescent-onset bipolar illness and make recommendations to help accelerate the acquisition of knowledge in this area...
  34. ncbi request reprint Unique design issues in clinical trials of patients with bipolar affective disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bldg 10, Rm 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    J Psychiatr Res 37:61-73. 2003
    ..Acceptance of a wider variety of clinical trial designs may help facilitate the funding and accelerate the acquisition of new data on treatment of bipolar illness...
  35. ncbi request reprint Thirty years of clinical experience with carbamazepine in the treatment of bipolar illness: principles and practice
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, Maryland, USA
    CNS Drugs 21:47-71. 2007
    ..More precise clinical and biological predictors and correlates of individual clinical responsiveness to carbamazepine and other mood stabilisers are eagerly awaited...
  36. doi request reprint Neurobiological correlates of illness progression in the recurrent affective disorders
    Robert M Post
    Bipolar Collaborative Network, 5415 W Cedar Lane, Suite 201 B, Bethesda, MD 20814, United States
    J Psychiatr Res 46:561-73. 2012
    ..As such, earlier and more sustained long-term prophylaxis to attempt to reduce these adverse outcomes is indicated...
  37. ncbi request reprint Course of bipolar illness after history of childhood trauma
    Gabriele S Leverich
    Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892, USA
    Lancet 367:1040-2. 2006
  38. ncbi request reprint Neurobiology of bipolar illness: implications for future study and therapeutics
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892 1272, USA
    Ann Clin Psychiatry 15:85-94. 2003
    ..Further examination of the pathophysiology and neurobiology of bipolar illness should lead to both more effective treatments and, potentially, secondary and even primary episode prevention...
  39. ncbi request reprint Psychological complexity: barriers to its integration into the neurobiology of major psychiatric disorders
    Robert M Post
    National Institute of Mental Health BPB, Bethesda, MD 20892 1272, USA
    Dev Psychopathol 14:635-51. 2002
    ..This paper endorses renewed effort toward the multidisciplinary team approach under the leadership of a physician-scientist in order to better integrate many fields of study critical to ameliorating the effects of psychiatric illness...
  40. ncbi request reprint Utility of the daily prospective National Institute of Mental Health Life-Chart Method (NIMH-LCM-p) ratings in clinical trials of bipolar disorder
    Kirk D Denicoff
    Section on Psychobiology, Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Depress Anxiety 15:1-9. 2002
    ....
  41. ncbi request reprint Parental attitudes towards early intervention in children at high risk for affective disorders
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bldg 10, Rm 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    J Affect Disord 70:117-24. 2002
    ....
  42. ncbi request reprint Treatment of bipolar depression
    Robert M Post
    Bipolar Collaborative Network, Chevy Chase, Maryland, USA
    CNS Spectr 8:1-10; quiz 11. 2003
    ..Other adjuncts for treatment-refractory patients include monoamine oxidase inhibitors and electroconvulsive therapy...
  43. ncbi request reprint Antithyroid antibody-linked symptoms in borderline personality disorder
    Thomas D Geracioti
    Clinical Neuroendocrinology, National Institute of Mental Health, Bethesda, MD, USA
    Endocrine 21:153-8. 2003
    ..It will be of interest to determine the prevalence, pathophysiologic mechanisms, and treatment implications of this putative autoimmune- BPD link...
  44. ncbi request reprint Adjunctive strategies in the treatment of refractory bipolar depression: clinician options in the absence of a systematic database
    Robert M Post
    Biological Psychiatry Branch, National Institutes of Health, National Institute of Mental Health, Department of Health and Human Services, 10 Center Drive MSC 1272, Bldg 10, Room 3S239, Bethesda, MD 20892 1272, USA
    Expert Opin Pharmacother 6:531-46. 2005
    ....
  45. ncbi request reprint Decreased calcium-dependent constitutive nitric oxide synthase (cNOS) activity in prefrontal cortex in schizophrenia and depression
    Guoqiang Xing
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Schizophr Res 58:21-30. 2002
    ..28, P < 0.05, n = 60) and in the PMI controlled subgroup (r = 0.43, P < 0.01, n = 38). Our data provide evidence of reduced cNOS activity in the postmortem brains of patients with schizophrenia and depression...
  46. ncbi request reprint Do the epilepsies, pain syndromes, and affective disorders share common kindling-like mechanisms?
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, NIH Building 10, Bethesda, MD 20892 1272, USA
    Epilepsy Res 50:203-19. 2002
    ..Given these recognized limitations of non-homologous models, kindling may still provide insights into the longitudinal course, progression, and treatment of some neuropsychiatric syndromes that can then be directly tested in the clinic...
  47. ncbi request reprint Age, sex and laterality effects on cerebral glucose metabolism in healthy adults
    Mark W Willis
    Biological Psychiatry Branch, National Institute of Mental Health, 10 Center Drive MSC 1272, Bethesda, MD 20892 1272, USA
    Psychiatry Res 114:23-37. 2002
    ..These findings contribute toward a convergence in the literature, and the regression models of CMRglc vs. age serve as a normative database to which patients may be compared...
  48. pmc Tolerance to the prophylactic effects of carbamazepine and related mood stabilizers in the treatment of bipolar disorders
    Robert M Post
    Department of Psychiatry, George Washington University, Washington, DC, USA
    CNS Neurosci Ther 17:649-60. 2011
    ..Careful longitudinal monitoring of episode occurrence is essential to understanding tolerance development in the affective disorder and its treatment...