Raquel Chaves

Summary

Affiliation: Vila Real
Country: Portugal

Publications

  1. pmc ERBB2 in Cat Mammary Neoplasias Disclosed a Positive Correlation between RNA and Protein Low Expression Levels: A Model for erbB-2 Negative Human Breast Cancer
    Sara Santos
    Institute for Biotechnology and Bioengineering, Centre of Genomics and Biotechnology, University of Tras os Montes and Alto Douro, Vila Real, Portugal
    PLoS ONE 8:e83673. 2013
  2. pmc Hidden heterochromatin: Characterization in the Rodentia species Cricetus cricetus, Peromyscus eremicus (Cricetidae) and Praomys tullbergi (Muridae)
    Ana Paço
    Institute for Biotechnology and Bioengineering, Centre of Genetics and Biotechnology, University of Tras os Montes and Alto Douro, Vila Real Portugal
    Genet Mol Biol 32:58-68. 2009
  3. pmc Defining the sister rat mammary tumor cell lines HH-16 cl.2/1 and HH-16.cl.4 as an in vitro cell model for Erbb2
    Sandra Louzada
    Center of Genomics and Biotechnology, Institute for Biotechnology and Bioengineering, University of Trás os Montes and Alto Douro IBB CGB UTAD, Vila Real, Portugal
    PLoS ONE 7:e29923. 2012
  4. pmc TWIST1 Gene: First Insights in Felis catus
    Cláudia S Baptista
    Department of Veterinary Clinics, Institute of Biomedical Sciences Abel Salazar ICBAS, University of Porto, Largo Prof Abel Salazar, 2, 4099 003 Porto, Portugal
    Curr Genomics 11:212-20. 2010
  5. doi request reprint Praomys tullbergi (Muridae, Rodentia) genome architecture decoded by comparative chromosome painting with Mus and Rattus
    Raquel Chaves
    Centre of Genomics and Biotechnology, Institute for Biotechnology and Bioengineering, University of Trás os Montes and Alto Douro IBB CGB UTAD, Vila Real, Portugal
    Chromosome Res 20:673-83. 2012
  6. ncbi request reprint Multidirectional chromosome painting between the Hirola antelope (Damaliscus hunteri, Alcelaphini, Bovidae), sheep and human
    Raquel Chaves
    Department of Genetics and Biotechnology, Centre of Genetics and Biotechnology, University of Trás os Montes and Alto Douro CGB UTAD, P 5000 911 Vila Real, Portugal
    Chromosome Res 12:495-503. 2004
  7. pmc Phylogenetic relationships and the primitive X chromosome inferred from chromosomal and satellite DNA analysis in Bovidae
    Raquel Chaves
    Department of Genetics and Biotechnology, Centre of Genetics and Biotechnology CGB, University of Trás os Montes and Alto Douro UTAD, P 5000 911 Vila Real, Portugal
    Proc Biol Sci 272:2009-16. 2005
  8. ncbi request reprint Complex satellite DNA reshuffling in the polymorphic t(1;29) Robertsonian translocation and evolutionarily derived chromosomes in cattle
    R Chaves
    Department of Genetics and Biotechnology, Centre of Genetics and Biotechnology ICETA UTAD, University of Tras os Montes and Alto Douro, P 5000 911 Vila Real, Portugal
    Chromosome Res 11:641-8. 2003
  9. ncbi request reprint Molecular cytogenetic analysis and centromeric satellite organization of a novel 8;11 translocation in sheep: a possible intermediate in biarmed chromosome evolution
    Raquel Chaves
    Department of Genetics and Biotechnology, Centre of Genetics and Biotechnology ICETA UTAD, University of Tras os Montes and Alto Douro, P 5000 911Vila Real, Portugal
    Mamm Genome 14:706-10. 2003
  10. ncbi request reprint Comparative analysis (Hippotragini versus Caprini, Bovidae) of X-chromosome's constitutive heterochromatin by in situ restriction endonuclease digestion: X-chromosome constitutive heterochromatin evolution
    Raquel Chaves
    Department of Genetics and Biotechnology, Centre of Genetics and Biotechnology ICETA UTAD, University of Tras os Montes and Alto Douro, P 5000 911 Vila Real, Portugal
    Genetica 121:315-25. 2004

Collaborators

Detail Information

Publications30

  1. pmc ERBB2 in Cat Mammary Neoplasias Disclosed a Positive Correlation between RNA and Protein Low Expression Levels: A Model for erbB-2 Negative Human Breast Cancer
    Sara Santos
    Institute for Biotechnology and Bioengineering, Centre of Genomics and Biotechnology, University of Tras os Montes and Alto Douro, Vila Real, Portugal
    PLoS ONE 8:e83673. 2013
    ..We would like to emphasise that the recurrent occurrence of low erbB-2 expression levels in cat mammary tumours, suggests the cat mammary neoplasias as a valuable model for erbB-2 negative HBC. ..
  2. pmc Hidden heterochromatin: Characterization in the Rodentia species Cricetus cricetus, Peromyscus eremicus (Cricetidae) and Praomys tullbergi (Muridae)
    Ana Paço
    Institute for Biotechnology and Bioengineering, Centre of Genetics and Biotechnology, University of Tras os Montes and Alto Douro, Vila Real Portugal
    Genet Mol Biol 32:58-68. 2009
    ..The high level of sequence heterogeneity identified in the CH of the three genomes suggests the coexistence of different satellite DNA families, or variants of these families in these genomes...
  3. pmc Defining the sister rat mammary tumor cell lines HH-16 cl.2/1 and HH-16.cl.4 as an in vitro cell model for Erbb2
    Sandra Louzada
    Center of Genomics and Biotechnology, Institute for Biotechnology and Bioengineering, University of Trás os Montes and Alto Douro IBB CGB UTAD, Vila Real, Portugal
    PLoS ONE 7:e29923. 2012
    ....
  4. pmc TWIST1 Gene: First Insights in Felis catus
    Cláudia S Baptista
    Department of Veterinary Clinics, Institute of Biomedical Sciences Abel Salazar ICBAS, University of Porto, Largo Prof Abel Salazar, 2, 4099 003 Porto, Portugal
    Curr Genomics 11:212-20. 2010
    ..These results give the first insights regarding the TWIST1 gene in cat but further studies are required in order to establish, or not, its role in tumor formation and progression in veterinary oncology...
  5. doi request reprint Praomys tullbergi (Muridae, Rodentia) genome architecture decoded by comparative chromosome painting with Mus and Rattus
    Raquel Chaves
    Centre of Genomics and Biotechnology, Institute for Biotechnology and Bioengineering, University of Trás os Montes and Alto Douro IBB CGB UTAD, Vila Real, Portugal
    Chromosome Res 20:673-83. 2012
    ..tullbergi genome architecture...
  6. ncbi request reprint Multidirectional chromosome painting between the Hirola antelope (Damaliscus hunteri, Alcelaphini, Bovidae), sheep and human
    Raquel Chaves
    Department of Genetics and Biotechnology, Centre of Genetics and Biotechnology, University of Trás os Montes and Alto Douro CGB UTAD, P 5000 911 Vila Real, Portugal
    Chromosome Res 12:495-503. 2004
    ..This study demonstrates that multidirectional chromosome painting will be a valuable tool for the investigation of the dynamics of chromosome evolution in exotic bovid species...
  7. pmc Phylogenetic relationships and the primitive X chromosome inferred from chromosomal and satellite DNA analysis in Bovidae
    Raquel Chaves
    Department of Genetics and Biotechnology, Centre of Genetics and Biotechnology CGB, University of Trás os Montes and Alto Douro UTAD, P 5000 911 Vila Real, Portugal
    Proc Biol Sci 272:2009-16. 2005
    ....
  8. ncbi request reprint Complex satellite DNA reshuffling in the polymorphic t(1;29) Robertsonian translocation and evolutionarily derived chromosomes in cattle
    R Chaves
    Department of Genetics and Biotechnology, Centre of Genetics and Biotechnology ICETA UTAD, University of Tras os Montes and Alto Douro, P 5000 911 Vila Real, Portugal
    Chromosome Res 11:641-8. 2003
    ....
  9. ncbi request reprint Molecular cytogenetic analysis and centromeric satellite organization of a novel 8;11 translocation in sheep: a possible intermediate in biarmed chromosome evolution
    Raquel Chaves
    Department of Genetics and Biotechnology, Centre of Genetics and Biotechnology ICETA UTAD, University of Tras os Montes and Alto Douro, P 5000 911Vila Real, Portugal
    Mamm Genome 14:706-10. 2003
    ..Chr 1 has lost the satellite I hybridization patterns. The novel t(8;11) provides strong evidence for an intermediate step in evolution of the biarmed chromosomes in sheep...
  10. ncbi request reprint Comparative analysis (Hippotragini versus Caprini, Bovidae) of X-chromosome's constitutive heterochromatin by in situ restriction endonuclease digestion: X-chromosome constitutive heterochromatin evolution
    Raquel Chaves
    Department of Genetics and Biotechnology, Centre of Genetics and Biotechnology ICETA UTAD, University of Tras os Montes and Alto Douro, P 5000 911 Vila Real, Portugal
    Genetica 121:315-25. 2004
    ..Evolutionary considerations were draw based on the results obtained. The technology used here for the analysis of the Bovidae X-chromosome CH showed to be more evolutionary informative than the classical approaches...
  11. ncbi request reprint High-resolution comparative chromosome painting in the Arizona collared peccary (Pecari tajacu, Tayassuidae): a comparison with the karyotype of pig and sheep
    Filomena Adega
    Department of Genetics and Biotechnology, Centre of Genetics and Biotechnology CGB, University of Trás os Montes and Alto Douro UTAD, 5001 801, Vila Real, Portugal
    Chromosome Res 14:243-51. 2006
    ..This considerable rearrangement indicates subspecies or even species status of both peccary populations, as it should present a significant barrier for their hybridization...
  12. doi request reprint Sequence variation and mRNA expression of the TWIST1 gene in cats with mammary hyperplasia and neoplasia
    Cláudia S Baptista
    Department of Veterinary Clinics, Institute of Biomedical Sciences Abel Salazar, University of Porto ICBAS UP, Largo Prof Abel Salazar, 2, 4099 003 Porto, Portugal
    Vet J 191:203-7. 2012
    ..535delG and GQ167299:g.460C>T. There was no association between these sequence alterations and TWIST1 mRNA levels...
  13. doi request reprint Different evolutionary trails in the related genomes Cricetus cricetus and Peromyscus eremicus (Rodentia, Cricetidae) uncovered by orthologous satellite DNA repositioning
    Sandra Louzada
    Institute for Biotechnology and Bioengineering, Centre of Genetics and Biotechnology, University of Trás os Montes and Alto Douro IBB CGB UTAD, Apdo 1013, 5001 801 Vila Real, Portugal
    Micron 39:1149-55. 2008
    ..cricetus and P. eremicus species...
  14. ncbi request reprint The karyotype and sex chromosomes of Praomys tullbergi (Muridae, Rodentia): a detailed characterization
    Susana Meles
    Institute for Biotechnology and Bioengineering, Centre of Genetics and Biotechnology, University of Trás os Montes and Alto Douro CGB UTAD IBB, Vila Real, Portugal
    Micron 39:559-68. 2008
    ....
  15. doi request reprint Suiformes orthologous satellite DNAs as a hallmark of Pecari tajacu and Tayassu pecari (Tayassuidae) evolutionary rearrangements
    Filomena Adega
    Institute for Biotechnology and Bioengineering, Centre of Genetics and Biotechnology, University of Tras os Montes and Alto Douro, Apdo 1013, 5001 801 Vila Real, Portugal
    Micron 39:1281-7. 2008
    ....
  16. pmc Sequence Variants and Haplotype Analysis of Cat ERBB2 Gene: A Survey on Spontaneous Cat Mammary Neoplastic and Non-Neoplastic Lesions
    Sara Santos
    Institute for Biotechnology and Bioengineering, Centre of Genomics and Biotechnology, University of Trás os Montes and Alto Douro IBB, CGB UTAD, Quinta de Prados, 5001 801 Vila Real, Portugal E Mails S S E B D S H G P
    Int J Mol Sci 13:2783-800. 2012
    ....
  17. ncbi request reprint Amplification of the major satellite DNA family (FA-SAT) in a cat fibrosarcoma might be related to chromosomal instability
    Sara Santos
    Department of Genetics and Biotechnology, Centre of Genetics and Biotechnology, University of Tras os Montes and Alto Douro, P 5001 801 Vila Real, Portugal
    J Hered 97:114-8. 2006
    ....
  18. doi request reprint An efficient protocol for genomic DNA extraction from formalin-fixed paraffin-embedded tissues
    Sara Santos
    Institute for Biotechnology and Bioengineering, Centre of Genetics and Biotechnology, University of Trás os Montes and Alto Douro CGB UTAD IBB, Quinta de Prados, Apdo 1013, 5001 801 Vila Real, Portugal
    Res Vet Sci 86:421-6. 2009
    ..The DNA fragments obtained were further sequenced. This protocol was able to provide FFPET gDNA that can be amplified and sequenced for larger fragments up to 1182bp...
  19. ncbi request reprint Chromosomal evolution and phylogenetic analyses in Tayassu pecari and Pecari tajacu (Tayassuidae): tales from constitutive heterochromatin
    F Adega
    Laboratório Associado Institute for Biotechnology and Bioengineering, Centre of Genetics and Biotechnology, University of Tras os Montes and Alto Douro, P 5001 801 Vila Real, Portugal
    J Genet 86:19-26. 2007
    ..This idea is supported by several other studies that analysed nuclear and mitochondrial sequences of the living peccary species. Finally, the tayassuid X chromosome primitive form seems to be the one of Tayassu pecari...
  20. ncbi request reprint Chromosomal localization of the major satellite DNA family (FA-SAT) in the domestic cat
    S Santos
    Department of Genetics and Biotechnology, Centre of Genetics and Biotechnology of the University of Trás os Montes and Alto Douro CGB UTAD, Vila Real, Portugal
    Cytogenet Genome Res 107:119-22. 2004
    ....
  21. ncbi request reprint In situ hybridization and chromosome banding in mammalian species
    R Chaves
    Department of Genetics and Biotechnology, ICETA UTAD, University of Trásos Montes and Alto Douro, Vila Real, Portugal
    Cytogenet Genome Res 96:113-6. 2002
    ..The method is of widespread utility in comparative genomics and genome organization programmes...
  22. ncbi request reprint A complex intersex condition in a Holstein calf
    R Payan-Carreira
    CECAV, UTAD, Vila Real, Portugal
    Anim Reprod Sci 103:154-63. 2008
    ..This is an unusual situation of gonadal dysplasia combined with genital tract anomalies in cattle, probably associated to a genetic defect...
  23. ncbi request reprint Identification, characterization and clinical implications of two markers detected at prenatal diagnosis
    Rosário Pinto Leite
    Serviço de Genética, Centro Hospitalar de Vila Real Peso da Régua, Av da Noruega, Vila Real, Portugal
    Prenat Diagn 26:920-4. 2006
    ..In this article, we identified and characterized two de novo supernumerary marker chromosomes in a mosaic form at prenatal diagnosis...
  24. ncbi request reprint Chromosome restriction enzyme digestion in domestic pig (Sus scrofa) constitutive heterochromatin arrangement
    Filomena Adega
    Department of Genetics and Biotechnology, Centre of Genetics and Biotechnology CGB University of Trás os Montes and Alto Douro, UTAD, Vila Real, Portugal
    Genes Genet Syst 80:49-56. 2005
    ..The work presented here is useful not only for fundamental studies of chromosome banding and constitutive heterochromatin, but also offers a new approach for pig clinical cytogenetics...
  25. pmc An efficient method for genomic DNA extraction from different molluscs species
    Jorge C Pereira
    Institute for Biotechnology and Bioengineering, Center of Genomics and Biotechnology, University of Trás os Montes and Alto Douro IBB CGB UTAD, Apdo1013, Vila Real 5001 801, Portugal E Mails J C P E B H G P
    Int J Mol Sci 12:8086-95. 2011
    ..Moreover, the genomic DNA isolated, demonstrated to be suitable for several downstream molecular techniques, such as PCR sequencing among others...
  26. ncbi request reprint Chemical carcinogenesis
    Paula A Oliveira
    Department of Veterinary Sciences, CECAV, University of Tras os Montes and Alto Douro, Vila Real, Portugal
    An Acad Bras Cienc 79:593-616. 2007
    ....
  27. ncbi request reprint Chromosomal organization of simple sequence repeats in the Pacific oyster (Crassostrea gigas): (GGAT)(4), (GT)(7) and (TA)(10) chromosome patterns
    K Bouilly
    Institute for Biotechnology and Bioengineering, Centre of Genetics and Biotechnology, University of Tras os Montes and Alto Douro, IBB CGB UTAD, 5001 801 Vila Real, Portugal
    J Genet 87:119-25. 2008
    ..This technique can be a useful tool for oyster comparative studies and to understand genome organization in different oyster taxa...
  28. ncbi request reprint Physical organization of the 1.709 satellite IV DNA family in Bovini and Tragelaphini tribes of the Bovidae: sequence and chromosomal evolution
    F Adega
    Department of Genetics and Biotechnology, Centre of Genetics and Biotechnology CGB, University of Trás os Montes and Alto Douro UTAD, Vila Real, Portugal
    Cytogenet Genome Res 114:140-6. 2006
    ....
  29. doi request reprint Satellite DNA in the karyotype evolution of domestic animals--clinical considerations
    F Adega
    Institute for Biotechnology and Bioengineering, Centre of Genetics and Biotechnology, University of Tras os Montes and Alto Douro, Vila Real, Portugal
    Cytogenet Genome Res 126:12-20. 2009
    ..Throughout this review we will focus on the evidences that associate satellite DNAs and constitutive heterochromatin to the process of chromosome evolution and consequently to domestic species genome's remodeling...
  30. ncbi request reprint Endonuclease banding reveals that atrazine-induced aneuploidy resembles spontaneous chromosome loss in Crassostrea gigas
    Karine Bouilly
    IFREMER, Laboratoire de Genetique et Pathologie, La Tremblade, France
    Genome 48:177-80. 2005
    ..Further investigation is required to enable a better understanding of aneuploidy in oysters, especially with respect to why some chromosomes are more easily lost than others, and why cells tolerate the loss of these chromosomes...