A Cristina Rego

Summary

Affiliation: University of Coimbra
Country: Portugal

Publications

  1. ncbi request reprint Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non-desensitizing AMPA receptors in hippocampal cultures
    A Cristina Rego
    Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    J Neurochem 86:792-804. 2003
  2. ncbi request reprint Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases
    A Cristina Rego
    Institute of Biochemistry, Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Neurochem Res 28:1563-74. 2003
  3. ncbi request reprint Molecular targets and therapeutic strategies in Huntington's disease
    A Cristina Rego
    Faculty of Medicine, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Curr Drug Targets CNS Neurol Disord 4:361-81. 2005
  4. doi request reprint FK506 ameliorates cell death features in Huntington's disease striatal cell models
    Tatiana R Rosenstock
    Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Neurochem Int 59:600-9. 2011
  5. doi request reprint Mitochondrial-dependent apoptosis in Huntington's disease human cybrids
    Ildete L Ferreira
    Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Exp Neurol 222:243-55. 2010
  6. ncbi request reprint Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine
    Teresa Cunha-Oliveira
    Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Brain Res 1089:44-54. 2006
  7. ncbi request reprint Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons
    Teresa Cunha-Oliveira
    Institute of Biochemistry, University of Coimbra, Coimbra, Portugal
    J Neurochem 101:543-54. 2007
  8. doi request reprint Glutathione redox cycle dysregulation in Huntington's disease knock-in striatal cells
    Márcio Ribeiro
    CNC Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Free Radic Biol Med 53:1857-67. 2012
  9. doi request reprint Dysregulation of CREB activation and histone acetylation in 3-nitropropionic acid-treated cortical neurons: prevention by BDNF and NGF
    Sandra Almeida
    Center for Neuroscience and Cell Biology, Faculty of Medicine, Institute of Biochemistry, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurotox Res 17:399-405. 2010
  10. doi request reprint BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons
    Sandra Almeida
    Institute of Biochemistry, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004 504, Portugal
    Neurobiol Dis 35:448-56. 2009

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non-desensitizing AMPA receptors in hippocampal cultures
    A Cristina Rego
    Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    J Neurochem 86:792-804. 2003
    ..Taken together, these data make important contributions to the elucidation of the downstream pathways activated in AMPA receptor-mediated excitotoxicity in cultured rat hippocampal neurones...
  2. ncbi request reprint Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases
    A Cristina Rego
    Institute of Biochemistry, Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Neurochem Res 28:1563-74. 2003
    ....
  3. ncbi request reprint Molecular targets and therapeutic strategies in Huntington's disease
    A Cristina Rego
    Faculty of Medicine, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Curr Drug Targets CNS Neurol Disord 4:361-81. 2005
    ..We delineate the molecular and cellular rationale underlying the development of new pharmaceutical interventions that offer new hope of future treatment for HD patients worldwide...
  4. doi request reprint FK506 ameliorates cell death features in Huntington's disease striatal cell models
    Tatiana R Rosenstock
    Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Neurochem Int 59:600-9. 2011
    ..The results suggest that FK506 may be neuroprotective against apoptosis and necrosis under mild cell death stimulus in the presence of FLmHtt...
  5. doi request reprint Mitochondrial-dependent apoptosis in Huntington's disease human cybrids
    Ildete L Ferreira
    Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Exp Neurol 222:243-55. 2010
    ..Additionally, increased mitochondrial Bim and Bak levels, and a slight release of cytochrome c in untreated HD cybrids may help to explain their moderate susceptibility to mitochondrial-dependent apoptosis...
  6. ncbi request reprint Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine
    Teresa Cunha-Oliveira
    Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Brain Res 1089:44-54. 2006
    ..Our results demonstrate that although both amphetamine and cocaine activate the mitochondrial apoptotic pathway in cortical neurons, amphetamine is more likely to promote apoptosis...
  7. ncbi request reprint Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons
    Teresa Cunha-Oliveira
    Institute of Biochemistry, University of Coimbra, Coimbra, Portugal
    J Neurochem 101:543-54. 2007
    ..Pure heroin hydrochloride similarly decreased metabolic viability but only slightly activated caspase 3. Altogether, our data suggest an important role for mitochondria in mediating street heroin neurotoxic effects...
  8. doi request reprint Glutathione redox cycle dysregulation in Huntington's disease knock-in striatal cells
    Márcio Ribeiro
    CNC Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Free Radic Biol Med 53:1857-67. 2012
    ..Data further suggest that boosting of GSH-related antioxidant defense mechanisms induced by FL-mHtt is insufficient to counterbalance increased ROS formation and emergent apoptotic features in HD striatal cells...
  9. doi request reprint Dysregulation of CREB activation and histone acetylation in 3-nitropropionic acid-treated cortical neurons: prevention by BDNF and NGF
    Sandra Almeida
    Center for Neuroscience and Cell Biology, Faculty of Medicine, Institute of Biochemistry, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurotox Res 17:399-405. 2010
    ....
  10. doi request reprint BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons
    Sandra Almeida
    Institute of Biochemistry, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004 504, Portugal
    Neurobiol Dis 35:448-56. 2009
    ..This effect was due to an increase in the degradation rates of Bim. Our data support an important role for BDNF, in protecting cortical neurons against apoptotic cell death caused by inhibition of mitochondrial complex II...
  11. doi request reprint Neurotoxicity of heroin-cocaine combinations in rat cortical neurons
    Teresa Cunha-Oliveira
    Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004 517 Coimbra, Portugal
    Toxicology 276:11-7. 2010
    ..Since impairment of the prefrontal cortex is involved in the loss of impulse control observed in drug addicts, the data presented here may contribute to explain the increase in treatment failure observed in speedball abusers...
  12. ncbi request reprint FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures
    Sandra Almeida
    Center for Neuroscience and Cell Biology of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurobiol Dis 17:435-44. 2004
    ..Altogether, the results suggest that FK506 neuroprotection against 3-NP-induced apoptosis is associated with the redistribution of Bcl-2 and Bax in the mitochondrial membrane...
  13. pmc Compromised mitochondrial complex II in models of Machado-Joseph disease
    Mario N Laco
    CNC Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Biochim Biophys Acta 1822:139-49. 2012
    ..Our results suggest that mitochondrial complex II activity is moderately compromised in MJD, which may designate a common feature in polyglutamine toxicity...
  14. doi request reprint Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3beta signaling pathways and changes in protein expression
    Ana I Duarte
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Biochim Biophys Acta 1783:994-1002. 2008
    ..These and previous data implicate insulin as a promising neuroprotective agent against oxidative stress associated with neurodegenerative diseases...
  15. ncbi request reprint Insulin neuroprotection against oxidative stress in cortical neurons--involvement of uric acid and glutathione antioxidant defenses
    Ana I Duarte
    Department of Zoology, Faculty of Sciences and Technology, Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    Free Radic Biol Med 39:876-89. 2005
    ..Thus, insulin may be useful in preventing oxidative stress-mediated injury that occurs in several neurodegenerative disorders...
  16. ncbi request reprint Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress
    Ana I Duarte
    Department of Zoology, Center for Neuroscience and Cell Biology, University of Coimbra, 3004 504 Coimbra, Portugal
    Diabetes 55:2863-70. 2006
    ....
  17. doi request reprint An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease
    Paula I Moreira
    Center for Neuroscience and Cell Biology, Faculty of Medicine, Institute of Physiology, Department of Zoology, University of Coimbra, Coimbra, Portugal
    J Alzheimers Dis 16:741-61. 2009
    ..Understanding the key mechanisms involved in the etiopathogenesis of Alzheimer's disease may provide opportunities for the design of efficacious preventive and therapeutic strategies...
  18. ncbi request reprint Trolox protection of myelin membrane in hydrogen peroxide-treated mature oligodendrocytes
    Rita Perfeito
    Faculty of Medicine, Center for Neuroscience and Cell Biology and Institute of Biochemistry, University of Coimbra, Coimbra, Portugal
    Free Radic Res 41:444-51. 2007
    ..In contrast, incubation with Trolox completely prevented H(2)O(2)-induced decrease in MBP expression, suggesting that vitamin E analogues may prevent against oligodendrocyte oxidative damage...
  19. pmc Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3
    Mario N Laco
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    PLoS ONE 7:e43563. 2012
    ..Based on our results we propose a model where ataxin-3 normally functions with its interactors to specify the cellular fate of ubiquitinated proteins...
  20. ncbi request reprint Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures
    Sandra I Mota
    Faculty of Medicine, and Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marques de Pombal, 3004 517 Coimbra, Portugal
    Curr Alzheimer Res 9:844-56. 2012
    ..Data largely suggest that Aβ-induced hippocampal neuronal dysfunction occurs through NMDAR-dependent microtubule disassembly associated to neurite retraction and DNA fragmentation in mature hippocampal cells...
  21. ncbi request reprint Bioenergetic dysfunction in Huntington's disease human cybrids
    I Luísa Ferreira
    Center for Neuroscience and Cell Biology, 3004 504 Coimbra, Portugal
    Exp Neurol 231:127-34. 2011
    ..Our results suggest that inherent dysfunction of mitochondria from HD patients affects cellular bioenergetics in an otherwise functional nuclear background...
  22. ncbi request reprint Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis
    Joana Gil
    Institute of Biochemistry, Faculty of Medicine, University of Coimbra and Center for Neuroscience and Cell Biology of Coimbra, Coimbra, Portugal
    Free Radic Biol Med 35:1500-14. 2003
    ..Thus, endogenous ROS generation and the rise in intracellular calcium are important inter-players in STS-triggered apoptosis. Furthermore, the antioxidants may help to prolong retinal cell survival upon apoptotic cell death...
  23. ncbi request reprint Impaired transcription in Alzheimer's disease: key role in mitochondrial dysfunction and oxidative stress
    Gladys L Caldeira
    CNC Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    J Alzheimers Dis 34:115-31. 2013
    ..In this review we focus on key transcription regulators related with mitochondrial biogenesis and antioxidant defenses that seem to be altered in AD models and also on the role of intranuclear Aβ in the pathogenesis of the disease...
  24. ncbi request reprint Bcl-2 prevents loss of cell viability and caspase activation induced by 3-nitropropionic acid in GT1-7 cells
    Olga Brito
    Institute of Biochemistry, Faculty of Medicine, and Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004 504 Coimbra, Portugal
    Ann N Y Acad Sci 1010:148-52. 2003
    ..The data suggest that irreversible inhibition of mitochondrial complex II induces apoptotic features of cell death in a process prevented by Bcl-2...
  25. ncbi request reprint Mitochondrial-associated metabolic changes and neurodegeneration in Huntington's disease - from clinical features to the bench
    Tatiana R Rosenstock
    Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Portugal
    Curr Drug Targets 11:1218-36. 2010
    ....
  26. doi request reprint Mitochondrial respiratory chain complex activity and bioenergetic alterations in human platelets derived from pre-symptomatic and symptomatic Huntington's disease carriers
    Ana C Silva
    CNC Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
    Mitochondrion 13:801-9. 2013
    ..Moreover, AMP increased in mitochondria from pre-symptomatic HD carriers. Results highlight mitochondrial changes occurring before the onset of HD clinical symptoms. ..
  27. doi request reprint Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in mice
    Frederico C Pereira
    Pharmacology and Experimental Therapeutics Biomedical Institute for Research on Light and Image IBILI, University of Coimbra, Portugal
    Neurotoxicol Teratol 34:522-9. 2012
    ..These neurochemical and glial alterations are accompanied by impairment in locomotor activity...
  28. doi request reprint BDNF and extracellular matrix regulate differentiation of mice neurosphere-derived cells into a GABAergic neuronal phenotype
    Ana Silva
    Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    J Neurosci Res 87:1986-96. 2009
    ..The results obtained in this study highlight the importance of growth factors and ECM proteins for the potential of neurosphere cells to differentiate into neurons...
  29. ncbi request reprint Evidence of apoptosis and mitochondrial abnormalities in peripheral blood cells of Huntington's disease patients
    Sandra Almeida
    Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004 504 Coimbra, Portugal
    Biochem Biophys Res Commun 374:599-603. 2008
    ..Our results suggest that peripheral blood cells, in particularly B lymphocytes may reflect changes observed in HD brain...
  30. ncbi request reprint Apoptotic cell death induced by hydrogen peroxide in NT2 parental and mitochondrial DNA depleted cells
    Sandra M Cardoso
    Center for Neurosciences and Cell Biology of Coimbra, Faculty of Medicine, Institute of Biochemistry, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurochem Int 45:693-8. 2004
    ..The data support that, in general, no differences were observed in cells containing functional (rho+) or non-functional (rho0) mitochondria upon H2O2-induced apoptotic cell death...
  31. ncbi request reprint Expression of NR1/NR2B N-methyl-D-aspartate receptors enhances heroin toxicity in HEK293 cells
    António Domingues
    Institute of Biochemistry, Faculty of Medicine and Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004 504 Coimbra, Portugal
    Ann N Y Acad Sci 1074:458-65. 2006
    ..Nevertheless, no significant changes in intracellular adenosine 5'-triphosphate (ATP) were observed in cells treated with heroin. These data implicate NR2B-composed NMDAR as important mediators of heroin neurotoxicity...
  32. ncbi request reprint Differential cytotoxic responses of PC12 cells chronically exposed to psychostimulants or to hydrogen peroxide
    Teresa Cunha-Oliveira
    Center for Neuroscience and Cell Biology and Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Toxicology 217:54-62. 2006
    ..This study shows that chronic treatment of PC12 cells with cocaine or H2O2 modifies the cytotoxic response to an acute exposure to these agents...
  33. ncbi request reprint Bcl-2 overexpression protects against amyloid-beta and prion toxicity in GT1-7 neural cells
    Elisabete Ferreiro
    Institute of Biochemistry, Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    J Alzheimers Dis 12:223-8. 2007
    ....
  34. doi request reprint Mitochondrial and metabolic-based protective strategies in Huntington's disease: the case of creatine and coenzyme Q
    Luana Naia
    Center for Neuroscience and Cell Biology, University of Coimbra, 3004 504 Coimbra, Portugal
    Rev Neurosci 23:13-28. 2012
    ..Thus, we briefly discuss the role of creatine and coenzyme Q10 that target mitochondrial dysfunction and impaired bioenergetics and have been previously used in HD clinical trials...
  35. ncbi request reprint Effect of amyloid beta-peptide on permeability transition pore: a comparative study
    Paula I Moreira
    Department of Zoology, University of Coimbra, Coimbra, Portugal
    J Neurosci Res 69:257-67. 2002
    ..It can be concluded that brain and liver mitochondria show a different susceptibility to the deleterious effect of A beta peptide, brain mitochondria being more resistant to the potentiation by A beta of Ca(2+)-induced PTP...
  36. ncbi request reprint IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice
    Carla Lopes
    CNC Center for Neuroscience and Cell Biology and Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Mol Neurobiol 49:1126-42. 2014
    ..These data suggest that intranasal administration of rhIGF-1 ameliorates HD-associated glucose metabolic brain abnormalities and mice phenotype. ..
  37. ncbi request reprint Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice
    Jorge M A Oliveira
    Buck Institute for Age Research, Novato, California, USA
    J Neurochem 101:241-9. 2007
    ..These results stress the importance of assessing HD mitochondrial function in the cellular context...
  38. ncbi request reprint Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors
    Jorge M A Oliveira
    Serviço de Farmacologia da Faculdade de Farmácia, Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia, Universidade do Porto, 4050 047 Porto, Portugal
    J Neurosci 26:11174-86. 2006
    ..These findings indicate that neuroprotection induced by HDAC inhibitors involves more efficient Ca2+ handling, thus improving the neuronal ability to cope with excitotoxic stimuli...