Joana A Palha

Summary

Affiliation: University of Minho
Country: Portugal

Publications

  1. ncbi request reprint Thyroid hormones and retinoids: a possible link between genes and environment in schizophrenia
    Joana Almeida Palha
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    Brain Res Rev 51:61-71. 2006
  2. doi request reprint Blood-brain-barriers in aging and in Alzheimer's disease
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, Braga 4710 057, Portugal
    Mol Neurodegener 8:38. 2013
  3. pmc The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury
    Chris Pickering
    Uppsala University, Department of Neuroscience, Functional Pharmacology, BMC, Box 593, SE 75124, Uppsala, Sweden
    BMC Neurosci 9:97. 2008
  4. ncbi request reprint Transthyretin as a thyroid hormone carrier: function revisited
    Joana Almeida Palha
    Life and Health Sciences Research Institute, Health Sciences School, University of Minho, Braga, Portugal
    Clin Chem Lab Med 40:1292-300. 2002
  5. pmc Transcriptome signature of the adult mouse choroid plexus
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    Fluids Barriers CNS 8:10. 2011
  6. ncbi request reprint Association of the gene encoding neurogranin with schizophrenia in males
    Dina Ruano
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    J Psychiatr Res 42:125-33. 2008
  7. pmc The choroid plexus response to a repeated peripheral inflammatory stimulus
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    BMC Neurosci 10:135. 2009
  8. doi request reprint Kinetic profile of the transcriptome changes induced in the choroid plexus by peripheral inflammation
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
    J Cereb Blood Flow Metab 29:921-32. 2009
  9. pmc Lipocalin-2 is involved in emotional behaviors and cognitive function
    Ana C Ferreira
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho Braga, Portugal ICVS 3B s PT Government Associate Laboratory Braga Guimarães, Portugal
    Front Cell Neurosci 7:122. 2013
  10. pmc Lipocalin 2 is present in the EAE brain and is modulated by natalizumab
    Fernanda Marques
    School of Health Sciences, Life and Health Sciences Research Institute ICVS, University of Minho Braga, Portugal
    Front Cell Neurosci 6:33. 2012

Collaborators

  • Fernanda Marques
  • Giovanni Coppola
  • Ann B Goodman
  • Mara H Hutz
  • Maria J Saraiva
  • Susana Ares
  • Isabel Coelho
  • Yurii S Aulchenko
  • Dina Ruano
  • João Carlos Sousa
  • Nuno Sousa
  • Ana C Ferreira
  • Antonio Macedo
  • Jose Valente
  • Paulo Belmonte-de-Abreu
  • Clarissa S Gama
  • Carlos Pato
  • Peter Heutink
  • João C Sousa
  • Margarida Correia-Neves
  • Ashley Novais
  • Ana Mendanha Falcão
  • Sandro D Mesquita
  • Maria J Costeira
  • Chris Pickering
  • Maria J Soares
  • Maria H Azevedo
  • Maria I Lobato
  • Maria Helena Azevedo
  • Maria Ines Lobato
  • Maria João Soares
  • Mónica Mendes Sousa
  • Vitor Pinto
  • Sandro Dá Mesquita
  • Nadine C Santos
  • Gabriella Morreale de Escobar
  • Pedro Oliveira
  • Helgi B Schioth
  • Robert Fredriksson
  • Maria Hägglund
  • Joanna Szmydynger-Chodobska
  • Malin C Lagerström
  • Adam Chodobski
  • Linn Waller
  • João José Cerqueira
  • Isabel Cardoso
  • Eduardo Dias-Ferreira
  • Ana Dourado
  • Ana Isabel Magalhães
  • Liliana de Sousa
  • Clarissa Gama
  • Vítor Santos
  • Catarina Grandela
  • Javier Fernandez-Ruiz
  • Rosario de Miguel
  • Rui Fernandes
  • Ana Taboada
  • Paulo Vieira

Detail Information

Publications22

  1. ncbi request reprint Thyroid hormones and retinoids: a possible link between genes and environment in schizophrenia
    Joana Almeida Palha
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    Brain Res Rev 51:61-71. 2006
    ..This review highlights selective evidence supporting the retinoid and thyroid hormone hypotheses of schizophrenia...
  2. doi request reprint Blood-brain-barriers in aging and in Alzheimer's disease
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, Braga 4710 057, Portugal
    Mol Neurodegener 8:38. 2013
    ..Herein, we provide a review on how the brain barriers change during aging and in AD and how these processes impact on brain function. ..
  3. pmc The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury
    Chris Pickering
    Uppsala University, Department of Neuroscience, Functional Pharmacology, BMC, Box 593, SE 75124, Uppsala, Sweden
    BMC Neurosci 9:97. 2008
    ..We also identified a Drosophila sequence, DmCG15744, which shares a common ancestor with the entire Group III of Adhesion GPCRs, and also contains Ig, LRR and HBD domains which were observed in mammalian GPR125...
  4. ncbi request reprint Transthyretin as a thyroid hormone carrier: function revisited
    Joana Almeida Palha
    Life and Health Sciences Research Institute, Health Sciences School, University of Minho, Braga, Portugal
    Clin Chem Lab Med 40:1292-300. 2002
    ..This evidence agrees with the free hormone hypothesis which states that the biologically significant fraction, that is taken up by the tissues, is the free circulating hormone...
  5. pmc Transcriptome signature of the adult mouse choroid plexus
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    Fluids Barriers CNS 8:10. 2011
    ..abstract:..
  6. ncbi request reprint Association of the gene encoding neurogranin with schizophrenia in males
    Dina Ruano
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    J Psychiatr Res 42:125-33. 2008
    ..This evidence, implicating NRGN in schizophrenia, introduces another player into the glutamatergic hypothesis of schizophrenia...
  7. pmc The choroid plexus response to a repeated peripheral inflammatory stimulus
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    BMC Neurosci 10:135. 2009
    ..As part of the barriers that separate the blood from the brain, the choroid plexus conveys inflammatory immune signals into the brain, largely through alterations in the composition of the cerebrospinal fluid...
  8. doi request reprint Kinetic profile of the transcriptome changes induced in the choroid plexus by peripheral inflammation
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
    J Cereb Blood Flow Metab 29:921-32. 2009
    ..By modulating the composition of the cerebrospinal fluid, which will ultimately influence the brain parenchyma, the choroid plexus response to inflammation may be of relevance in brain homeostasis in health and disease...
  9. pmc Lipocalin-2 is involved in emotional behaviors and cognitive function
    Ana C Ferreira
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho Braga, Portugal ICVS 3B s PT Government Associate Laboratory Braga Guimarães, Portugal
    Front Cell Neurosci 7:122. 2013
    ....
  10. pmc Lipocalin 2 is present in the EAE brain and is modulated by natalizumab
    Fernanda Marques
    School of Health Sciences, Life and Health Sciences Research Institute ICVS, University of Minho Braga, Portugal
    Front Cell Neurosci 6:33. 2012
    ..The findings support lipocalin 2 as a valuable molecule for the diagnostic/monitoring panel of MS...
  11. ncbi request reprint Lipocalin 2 is a choroid plexus acute-phase protein
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
    J Cereb Blood Flow Metab 28:450-5. 2008
    ..This study shows that the LCN2 is produced by the CP as a component of the innate immune response that protects the central nervous system from infection...
  12. pmc Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of the choroid plexus
    Sandro D Mesquita
    School of Health Sciences, Life and Health Sciences Research Institute ICVS, University of Minho Braga, Portugal
    Front Cell Neurosci 6:25. 2012
    ....
  13. pmc Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia
    Joana A Palha
    Life and Health Sciences Research Institute, School of Health Sciences, University of Minho Braga, Portugal
    Front Cell Neurosci 6:31. 2012
    ..Here we propose that altered CP/CSF dynamics during neurodevelopment may be considered a risk, causative and/or participating factor for development of schizophrenia...
  14. pmc The path from the choroid plexus to the subventricular zone: go with the flow!
    Ana Mendanha Falcão
    School of Health Sciences, Life and Health Sciences Research Institute ICVS, University of Minho Braga, Portugal
    Front Cell Neurosci 6:34. 2012
    ..By giving particular emphasizes to growth factors and axonal guidance molecules we will illustrate how CP-born molecules might play an important role in the SVZ niche cell population dynamics...
  15. ncbi request reprint Transthyretin: no association between serum levels or gene variants and schizophrenia
    Dina Ruano
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    J Psychiatr Res 41:667-72. 2007
    ..In addition, serum TTR and RBP levels did not differ between mentally healthy and schizophrenic individuals. In conclusion, our data does not support an involvement of the TTR gene in the pathophysiology of schizophrenia...
  16. doi request reprint Iodine status of pregnant women and their progeny in the Minho Region of Portugal
    Maria J Costeira
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    Thyroid 19:157-63. 2009
    ..The objective of this study was to evaluate in the Minho region of Portugal the iodine status of women throughout pregnancy and after delivery, and of their offspring...
  17. ncbi request reprint Transthyretin influences spatial reference memory
    João Carlos Sousa
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Neurobiol Learn Mem 88:381-5. 2007
    ..As a result, no significant differences were found in this spatial reference task in old mice. Our data show that the absence of TTR seems to accelerate the poorer cognitive performance normally associated with aging...
  18. ncbi request reprint Family-based and case-control studies reveal no association of lipocalin-type prostaglandin D2 synthase with schizophrenia
    Dina Ruano
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    Am J Med Genet B Neuropsychiatr Genet 144:642-6. 2007
    ..In addition, no transmission distortion was observed in an independent parents-offspring sample from the Azorean Islands. Our data do not support the involvement of the PTGDS gene in the etiology of schizophrenia...
  19. ncbi request reprint Transthyretin and Alzheimer's disease: where in the brain?
    João Carlos Sousa
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    Neurobiol Aging 28:713-8. 2007
    ..The relevance of TTR to AD should now take into consideration TTR production by the choroid plexus and its ability, in the CSF, to sequester the amyloid beta peptide...
  20. ncbi request reprint NR4A2 and schizophrenia: lack of association in a Portuguese/Brazilian study
    Dina Ruano
    Health Sciences School, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Am J Med Genet B Neuropsychiatr Genet 128:41-5. 2004
    ..The study failed to identify any of the described mutations in patients or controls. Nevertheless, these negative results do not exclude altered expression of nuclear receptors in schizophrenia or the presence of other mutations...
  21. ncbi request reprint Transthyretin is involved in depression-like behaviour and exploratory activity
    João Carlos Sousa
    Institute for Molecular and Cell Biology, Porto, Portugal
    J Neurochem 88:1052-8. 2004
    ..This report represents the first clear indication that TTR plays a role in behaviour, probably by modulation of the noradrenergic system...
  22. pmc Evidence for early cytotoxic aggregates in transgenic mice for human transthyretin Leu55Pro
    Mónica Mendes Sousa
    Amyloid Unit, Instituto de Biologia Molecular e Celular, Porto, Portugal
    Am J Pathol 161:1935-48. 2002
    ..The TTR-Leu55Pro X TTR-KO mice here described are an important tool for the dual purpose of investigating factors involved in amyloidogenesis and in cytotoxicity of deposited TTR...