Catarina R Oliveira

Summary

Affiliation: University of Coimbra
Country: Portugal

Publications

  1. pmc Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort
    Rita J Guerreiro
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, USA
    BMC Neurol 6:24. 2006
  2. pmc Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide--characterization of morphological features of cell death
    Vilma A Sardao
    Center for Neurosciences and Cellular Biology, University of Coimbra, Coimbra, Portugal
    BMC Cell Biol 8:11. 2007
  3. ncbi request reprint Research on aging in Portugal
    C Resende Oliveira
    Department of Biochemistry and Centre for Neurosciences, Faculty of Medicine, University of Coimbra, Rua Larga, 3004 504 Coimbra, Portugal
    Exp Gerontol 36:1599-607. 2001
  4. ncbi request reprint Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies
    C Pereira
    Center for Neuroscience and Cell Biology and Institute of Biochemistry, Faculty of Medicine of Coimbra, University of Coimbra, 3004 504 Coimbra, Portugal
    Curr Drug Targets CNS Neurol Disord 4:383-403. 2005
  5. ncbi request reprint Neurodegenerative pathways in Parkinson's disease: therapeutic strategies
    S M Cardoso
    Center for Neuroscience and Cell Biology and Institute of Biochemistry, Faculty of Medicine of Coimbra, University of Coimbra, 3004 504 Coimbra, Portugal
    Curr Drug Targets CNS Neurol Disord 4:405-19. 2005
  6. ncbi request reprint Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway
    Paula M Canas
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    J Neurosci 29:14741-51. 2009
  7. ncbi request reprint An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity
    Elisabete Ferreiro
    Center for Neuroscience and Cell Biology of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurobiol Dis 23:669-78. 2006
  8. doi request reprint FK506 ameliorates cell death features in Huntington's disease striatal cell models
    Tatiana R Rosenstock
    Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Neurochem Int 59:600-9. 2011
  9. pmc Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities
    Cristina Carvalho
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Diabetes 61:1234-42. 2012
  10. doi request reprint Amyloid β-induced ER stress is enhanced under mitochondrial dysfunction conditions
    Rui O Costa
    Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Neurobiol Aging 33:824.e5-16. 2012

Collaborators

Detail Information

Publications74

  1. pmc Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort
    Rita J Guerreiro
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, USA
    BMC Neurol 6:24. 2006
    ..Several reports have tested the association of HFE variants with neurodegenerative diseases, such as AD and PD with conflicting results...
  2. pmc Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide--characterization of morphological features of cell death
    Vilma A Sardao
    Center for Neurosciences and Cellular Biology, University of Coimbra, Coimbra, Portugal
    BMC Cell Biol 8:11. 2007
    ..The objective of this work was to characterize, through vital imaging, morphological alterations and the appearance of apoptotic hallmarks, with a special focus on mitochondrial changes, upon exposure of H9c2 cells to tBHP...
  3. ncbi request reprint Research on aging in Portugal
    C Resende Oliveira
    Department of Biochemistry and Centre for Neurosciences, Faculty of Medicine, University of Coimbra, Rua Larga, 3004 504 Coimbra, Portugal
    Exp Gerontol 36:1599-607. 2001
    ..This is a crucial step toward improving present knowledge, ensuring application of experimental and statistical results to the clinical care of the aging population, and attract young investigators to this field...
  4. ncbi request reprint Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies
    C Pereira
    Center for Neuroscience and Cell Biology and Institute of Biochemistry, Faculty of Medicine of Coimbra, University of Coimbra, 3004 504 Coimbra, Portugal
    Curr Drug Targets CNS Neurol Disord 4:383-403. 2005
    ....
  5. ncbi request reprint Neurodegenerative pathways in Parkinson's disease: therapeutic strategies
    S M Cardoso
    Center for Neuroscience and Cell Biology and Institute of Biochemistry, Faculty of Medicine of Coimbra, University of Coimbra, 3004 504 Coimbra, Portugal
    Curr Drug Targets CNS Neurol Disord 4:405-19. 2005
    ..This review will discuss the current understanding of the mechanisms underlying Parkinson's disease pathogenesis, focusing on the current and potential therapeutic strategies for human treatment...
  6. ncbi request reprint Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway
    Paula M Canas
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    J Neurosci 29:14741-51. 2009
    ....
  7. ncbi request reprint An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity
    Elisabete Ferreiro
    Center for Neuroscience and Cell Biology of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurobiol Dis 23:669-78. 2006
    ....
  8. doi request reprint FK506 ameliorates cell death features in Huntington's disease striatal cell models
    Tatiana R Rosenstock
    Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Neurochem Int 59:600-9. 2011
    ..The results suggest that FK506 may be neuroprotective against apoptosis and necrosis under mild cell death stimulus in the presence of FLmHtt...
  9. pmc Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities
    Cristina Carvalho
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Diabetes 61:1234-42. 2012
    ..These results show that in mice, the metabolic alterations associated to diabetes contribute to the development of AD-like pathologic features...
  10. doi request reprint Amyloid β-induced ER stress is enhanced under mitochondrial dysfunction conditions
    Rui O Costa
    Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Neurobiol Aging 33:824.e5-16. 2012
    ..This study further supports the close communication between ER and mitochondria during apoptosis in AD...
  11. doi request reprint Mitochondrial-dependent apoptosis in Huntington's disease human cybrids
    Ildete L Ferreira
    Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Exp Neurol 222:243-55. 2010
    ..Additionally, increased mitochondrial Bim and Bak levels, and a slight release of cytochrome c in untreated HD cybrids may help to explain their moderate susceptibility to mitochondrial-dependent apoptosis...
  12. ncbi request reprint Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum
    Ricardo J Rodrigues
    Centre for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    J Neurochem 92:433-41. 2005
    ..This emphasizes the role of the modulation of glutamate release as a likely mechanism of action of these receptors both in striatal neuroprotection and in Parkinson's disease...
  13. ncbi request reprint Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis
    Joana Gil
    Institute of Biochemistry, Faculty of Medicine, University of Coimbra and Center for Neuroscience and Cell Biology of Coimbra, Coimbra, Portugal
    Free Radic Biol Med 35:1500-14. 2003
    ..Thus, endogenous ROS generation and the rise in intracellular calcium are important inter-players in STS-triggered apoptosis. Furthermore, the antioxidants may help to prolong retinal cell survival upon apoptotic cell death...
  14. doi request reprint Neuroprotective effects of statins in an in vitro model of Alzheimer's disease
    Ana Catarina R G Fonseca
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    J Alzheimers Dis 17:503-17. 2009
    ..Moreover, our results revealed that simvastatin, at neuroprotective concentrations against Abeta-induced toxicity, is not able to activate Akt or ERK2, two signaling kinases with neuroprotective roles against apoptosis...
  15. doi request reprint Glutathione redox cycle dysregulation in Huntington's disease knock-in striatal cells
    Márcio Ribeiro
    CNC Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Free Radic Biol Med 53:1857-67. 2012
    ..Data further suggest that boosting of GSH-related antioxidant defense mechanisms induced by FL-mHtt is insufficient to counterbalance increased ROS formation and emergent apoptotic features in HD striatal cells...
  16. pmc Ubiquitin proteasome system in Parkinson's disease: a keeper or a witness?
    Diogo Martins-Branco
    CNC Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
    Exp Neurol 238:89-99. 2012
    ..The aim of this work was to evaluate the role of ubiquitin-proteasome system (UPS) on mitochondrial-driven alpha-synuclein (aSN) clearance in in vitro, ex vivo and in vivo Parkinson's disease (PD) cellular models...
  17. ncbi request reprint Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus
    Ricardo J Rodrigues
    Centre for Neurosciences of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    J Neurosci 25:6286-95. 2005
    ..This provides coincident functional and molecular evidence that P2 receptors are present and act presynaptically as a modulatory system controlling hippocampal glutamate release...
  18. ncbi request reprint Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes
    Sónia Correia
    Center for Neuroscience and Cell Biology, Institute of Physiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Med Chem 4:358-64. 2008
    ..These results indicate that metformin protects against diabetes-associated oxidative stress suggesting that metformin could be an effective neuroprotective agent...
  19. ncbi request reprint Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP(106-126)
    Elisabete Ferreiro
    Center for Neuroscience and Cell Biology, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    J Neurochem 104:766-76. 2008
    ....
  20. doi request reprint Dysregulation of CREB activation and histone acetylation in 3-nitropropionic acid-treated cortical neurons: prevention by BDNF and NGF
    Sandra Almeida
    Center for Neuroscience and Cell Biology, Faculty of Medicine, Institute of Biochemistry, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurotox Res 17:399-405. 2010
    ....
  21. ncbi request reprint Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures
    Liliana Bernardino
    Center for Neuroscience and Cell Biology, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    J Neurosci 25:6734-44. 2005
    ..Together, these findings are relevant for understanding the role of proinflammatory cytokines and microglia activation in acute and chronic excitotoxic conditions...
  22. ncbi request reprint Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure
    Paula I Moreira
    Center for Neuroscience and Cell Biology, Department of Zoology, Faculty of Sciences and Technology, University of Coimbra, 3004 517 Coimbra, Portugal
    J Biol Chem 281:10143-52. 2006
    ..This new piece of information provides a basis for the development of new and promising anticancer therapeutic strategies...
  23. ncbi request reprint Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes
    Cristina Carvalho
    Center for Neuroscience and Cell Biology, Faculty of Sciences and Technology, University of Coimbra, 3000 354 Coimbra, Portugal
    Curr Neurovasc Res 7:288-300. 2010
    ..Further, synaptosomes and brain vessels are differently affected by aging and chronic hypoxia supporting the idea of the existence of tissue-specific susceptibilities...
  24. ncbi request reprint CoQ10 therapy attenuates amyloid beta-peptide toxicity in brain mitochondria isolated from aged diabetic rats
    Paula I Moreira
    Center for Neuroscience and Cell Biology, Department of Zoology Faculty of Sciences and Technology, University of Coimbra, 3004 517 Coimbra, Portugal
    Exp Neurol 196:112-9. 2005
    ....
  25. ncbi request reprint Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats
    Paula I Moreira
    Center for Neuroscience and Cell Biology, University of Coimbra, 3005 504 Coimbra, Portugal
    Toxicol Appl Pharmacol 221:102-10. 2007
    ..Since mitochondrial dysfunction is a triggering event of cell degeneration and death, the use of exogenous E2 must be carefully considered...
  26. ncbi request reprint Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats
    Nelson Rebola
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Eur J Neurosci 18:820-8. 2003
    ..These results indicate that, although adenosine might inhibit the onset of epileptogenesis, once kindling is installed, the efficiency of the adenosine inhibitory system is impaired...
  27. ncbi request reprint Different roles of adenosine A1, A2A and A3 receptors in controlling kainate-induced toxicity in cortical cultured neurons
    Nelson Rebola
    Center for Neurosciences of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Portugal
    Neurochem Int 47:317-25. 2005
    ....
  28. doi request reprint BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons
    Sandra Almeida
    Institute of Biochemistry, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004 504, Portugal
    Neurobiol Dis 35:448-56. 2009
    ..This effect was due to an increase in the degradation rates of Bim. Our data support an important role for BDNF, in protecting cortical neurons against apoptotic cell death caused by inhibition of mitochondrial complex II...
  29. doi request reprint Galantamine protects against oxidative stress induced by amyloid-beta peptide in cortical neurons
    Joana B Melo
    Center for Neurosciences and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Eur J Neurosci 29:455-64. 2009
    ..Overall, these results constitute the first evidence that galantamine can prevent the neuronal oxidative damage induced by Abeta, providing an in vitro basis for the beneficial actions of galantamine in the AD neurodegenerative process...
  30. doi request reprint Overactivation of calcineurin induced by amyloid-beta and prion proteins
    Paula Agostinho
    Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurochem Int 52:1226-33. 2008
    ..Therefore, therapeutic strategies targeting CaN might be valuable for these neurodegenerative disorders...
  31. ncbi request reprint Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats
    Ricardo J Rodrigues
    Center for Neuroscience of Coimbra, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurobiol Aging 29:1597-601. 2008
    ..Furthermore, since A(2A)R antagonists inhibit ACh release, the beneficial effects of A(2A)R antagonists on memory in aged rats might not result from ACh release modulation...
  32. ncbi request reprint Metformin promotes isolated rat liver mitochondria impairment
    Cristina Carvalho
    Department of Zoology Faculty of Sciences and Technology, University of Coimbra, Coimbra 3000 354, Portugal
    Mol Cell Biochem 308:75-83. 2008
    ..Taken together, our results show that metformin can promote liver mitochondria injury predisposing to cell death...
  33. ncbi request reprint Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity
    Sandra M Cardoso
    Laboratory of Biochemistry, Faculty of Medicine and Center for Neurosciences and Cell Biology, University Hospital, University of Coimbra, 3005 504 Coimbra, Portugal
    J Neurochem 89:1417-26. 2004
    ....
  34. doi request reprint Mitochondria from distinct tissues are differently affected by 17β-estradiol and tamoxifen
    Paula I Moreira
    Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    J Steroid Biochem Mol Biol 123:8-16. 2011
    ..These results indicate that E2 and/or TAM have tissue-specific effects suggesting that TAM and hormonal replacement therapies may have some side effects that should be carefully considered...
  35. ncbi request reprint Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex
    Nelson Rebola
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Epilepsia 46:159-65. 2005
    ..Since both A1 and A 2A receptors are prone to down- and upregulation in different stressful situations, we investigated if convulsive behavior leads to a long-term change in A1 and A 2A receptor density in the rat cerebral cortex...
  36. ncbi request reprint Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons
    Carla G Silva
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurobiol Dis 27:182-9. 2007
    ....
  37. ncbi request reprint FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures
    Sandra Almeida
    Center for Neuroscience and Cell Biology of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurobiol Dis 17:435-44. 2004
    ..Altogether, the results suggest that FK506 neuroprotection against 3-NP-induced apoptosis is associated with the redistribution of Bcl-2 and Bax in the mitochondrial membrane...
  38. pmc Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic
    Daniela M Arduino
    CNC Center for Neuroscience and Cell Biology, Institute of Biology, University of Coimbra, Coimbra, Portugal
    Hum Mol Genet 21:4680-702. 2012
    ..We uncover mitochondria and mitochondria-dependent intracellular traffic as main players in the regulation of autophagy in PD...
  39. ncbi request reprint Neurodegeneration in an Abeta-induced model of Alzheimer's disease: the role of Cdk5
    Joao P Lopes
    Center for Neuroscience and Cell Biology, Faculty of Medicine, Biochemistry Institute, University of Coimbra, 3004 Coimbra, Portugal
    Aging Cell 9:64-77. 2010
    ....
  40. ncbi request reprint ER stress-mediated apoptotic pathway induced by Abeta peptide requires the presence of functional mitochondria
    Rui O Costa
    Faculty of Medicine, Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    J Alzheimers Dis 20:625-36. 2010
    ..Our results strongly support the close communication between ER and mitochondria during apoptotic cell death induced by the Abeta peptide and provide insights into the molecular cascade of cell death in AD...
  41. doi request reprint Insulin is a two-edged knife on the brain
    Susana Cardoso
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal Department of Zoology, University of Coimbra, Coimbra, Portugal
    J Alzheimers Dis 18:483-507. 2009
    ..Finally, the potential therapeutic effect of insulin and insulin sensitizers will be examined...
  42. doi request reprint Morphological alterations induced by doxorubicin on H9c2 myoblasts: nuclear, mitochondrial, and cytoskeletal targets
    Vilma A Sardao
    Center for Neurosciences and Cellular Biology, Department of Zoology, University of Coimbra, Coimbra, Portugal
    Cell Biol Toxicol 25:227-43. 2009
    ..The results obtained also provide new and previously unknown targets that can contribute to understand the mechanisms involved in the cardiotoxicity of Dox...
  43. ncbi request reprint Mitochondrial apoptotic cell death and moderate superoxide generation upon selective activation of non-desensitizing AMPA receptors in hippocampal cultures
    A Cristina Rego
    Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    J Neurochem 86:792-804. 2003
    ..Taken together, these data make important contributions to the elucidation of the downstream pathways activated in AMPA receptor-mediated excitotoxicity in cultured rat hippocampal neurones...
  44. doi request reprint Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801
    Geanne M A Cunha
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Exp Neurol 210:776-81. 2008
    ....
  45. ncbi request reprint Insulin neuroprotection against oxidative stress in cortical neurons--involvement of uric acid and glutathione antioxidant defenses
    Ana I Duarte
    Department of Zoology, Faculty of Sciences and Technology, Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    Free Radic Biol Med 39:876-89. 2005
    ..Thus, insulin may be useful in preventing oxidative stress-mediated injury that occurs in several neurodegenerative disorders...
  46. doi request reprint Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3beta signaling pathways and changes in protein expression
    Ana I Duarte
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Biochim Biophys Acta 1783:994-1002. 2008
    ..These and previous data implicate insulin as a promising neuroprotective agent against oxidative stress associated with neurodegenerative diseases...
  47. ncbi request reprint Bioenergetic dysfunction in Huntington's disease human cybrids
    I Luísa Ferreira
    Center for Neuroscience and Cell Biology, 3004 504 Coimbra, Portugal
    Exp Neurol 231:127-34. 2011
    ..Our results suggest that inherent dysfunction of mitochondria from HD patients affects cellular bioenergetics in an otherwise functional nuclear background...
  48. ncbi request reprint Expression of AMPA/kainate receptors during development of chick embryo retina cells: in vitro versus in vivo studies
    Armando J Cristóvão
    Department of Zoology, Centre for Neuroscience of Coimbra, University of Coimbra, 3004 517 Coimbra Codex, Portugal
    Int J Dev Neurosci 20:1-9. 2002
    ....
  49. doi request reprint Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: role of mitochondrial reactive oxygen species and HIF-1α
    Sónia C Correia
    Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    Neurobiol Dis 45:206-18. 2012
    ....
  50. ncbi request reprint Oxidative stress affects synaptosomal gamma-aminobutyric acid and glutamate transport in diabetic rats: the role of insulin
    Ana I Duarte
    Center for Neuroscience of Coimbra, University of Coimbra, Coimbra, Portugal
    Diabetes 53:2110-6. 2004
    ..These results suggest that insulin modulates synaptosomal GABA and/or glutamate transport, thus having a neuroprotective role under oxidizing and/or diabetic conditions...
  51. ncbi request reprint Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies
    Joao P Lopes
    Faculty of Medicine, Center for Neuroscience and Cell Biology, Biochemistry Institute, University of Coimbra, 3004, Coimbra, Portugal
    Cell Mol Neurobiol 27:943-57. 2007
    ..This study demonstrates, for the first time, that Cdk5 is involved in PrP-neurotoxicity. Altogether, our data suggests that Cdk5 plays an active role in the pathogenesis of AD and PRE...
  52. ncbi request reprint Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-beta and prion peptides
    Joao P Lopes
    Center for Neuroscience and Cell Biology, Faculty of Medicine, Biochemistry Institute, University of Coimbra, Coimbra, Portugal
    Cell Cycle 8:97-104. 2009
    ..Therefore, cell cycle reactivation mediated by Cdk5 can underlie the neurodegenerative processes that occur in AD and PRE...
  53. doi request reprint Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation
    Sónia C Correia
    Center for Neuroscience and Cell Biology, University of Coimbra, 3000 354 Coimbra, Portugal
    Brain Res 1441:64-78. 2012
    ..Understanding the key mechanisms underlying this deleterious interaction may provide opportunities for the design of effective therapeutic strategies...
  54. pmc Compromised mitochondrial complex II in models of Machado-Joseph disease
    Mario N Laco
    CNC Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Biochim Biophys Acta 1822:139-49. 2012
    ..Our results suggest that mitochondrial complex II activity is moderately compromised in MJD, which may designate a common feature in polyglutamine toxicity...
  55. doi request reprint Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters
    Susana Cardoso
    Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    Synapse 65:457-66. 2011
    ..These results show that in the presence of a metabolic insult a higher release of excitatory amino acids occurs, which may underlay the neuronal injury observed in type 1 diabetic patients under insulin therapy...
  56. ncbi request reprint Lack of association or linkage disequilibrium between schizophrenia and polymorphisms in the 5-HT1Dalpha and 5-HT1Dbeta autoreceptor genes: family-based association study
    Alda M Ambrósio
    Center for Neuroscience of Coimbra, Department of Neurochemistry, Faculty of Medicine, University of Coimbra, 3004 517 Coimbra, Portugal
    Am J Med Genet B Neuropsychiatr Genet 128:1-5. 2004
    ..Thus, our data provide no support for the hypothesis that polymorphisms at 5-HT1Dalpha (TaqI) and 5-HT1Dbeta (T261G and G861C) genes contributes to susceptibility to schizophrenia in the Portuguese population...
  57. ncbi request reprint Insulin protects against amyloid beta-peptide toxicity in brain mitochondria of diabetic rats
    Paula I Moreira
    Center for Neuroscience of Coimbra, Department of Zoology, Faculty of Sciences and Technology, University of Coimbra, 3004 517 Coimbra, Portugal
    Neurobiol Dis 18:628-37. 2005
    ....
  58. ncbi request reprint Subcellular localization of adenosine A(1) receptors in nerve terminals and synapses of the rat hippocampus
    Nelson Rebola
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Brain Res 987:49-58. 2003
    ....
  59. ncbi request reprint Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats
    Ana P Silva
    Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
    J Neurochem 93:163-70. 2005
    ..Taken together, these results indicate that an increased function of the NPY modulatory system in the epileptic hippocampus may contribute to basal inhibition of glutamate release and control hyperexcitability...
  60. doi request reprint Neurotoxicity of heroin-cocaine combinations in rat cortical neurons
    Teresa Cunha-Oliveira
    Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004 517 Coimbra, Portugal
    Toxicology 276:11-7. 2010
    ..Since impairment of the prefrontal cortex is involved in the loss of impulse control observed in drug addicts, the data presented here may contribute to explain the increase in treatment failure observed in speedball abusers...
  61. ncbi request reprint The role of calcineurin in amyloid-beta-peptides-mediated cell death
    Sandra M Cardoso
    Center for Neuroscience and Cell Biology of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Brain Res 1050:1-7. 2005
    ..Considering the results presented, we argue that calcineurin activation and BAD dephosphorylation are upstream in premitochondrial signaling events leading to caspase-3 activation in Abeta-peptide-treated cells...
  62. doi request reprint BDNF and extracellular matrix regulate differentiation of mice neurosphere-derived cells into a GABAergic neuronal phenotype
    Ana Silva
    Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    J Neurosci Res 87:1986-96. 2009
    ..The results obtained in this study highlight the importance of growth factors and ECM proteins for the potential of neurosphere cells to differentiate into neurons...
  63. ncbi request reprint Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress
    Ana I Duarte
    Department of Zoology, Center for Neuroscience and Cell Biology, University of Coimbra, 3004 504 Coimbra, Portugal
    Diabetes 55:2863-70. 2006
    ....
  64. ncbi request reprint Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats
    Joao M N Duarte
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurochem Int 48:144-50. 2006
    ....
  65. doi request reprint The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway
    Elisabete Ferreiro
    Center for Neuroscience and Cell Biology, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurobiol Dis 30:331-42. 2008
    ....
  66. ncbi request reprint Effects of estrogen in the brain: is it a neuroprotective agent in Alzheimer's disease?
    Sónia C Correia
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Curr Aging Sci 3:113-26. 2010
    ....
  67. ncbi request reprint Apoptotic cell death induced by hydrogen peroxide in NT2 parental and mitochondrial DNA depleted cells
    Sandra M Cardoso
    Center for Neurosciences and Cell Biology of Coimbra, Faculty of Medicine, Institute of Biochemistry, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurochem Int 45:693-8. 2004
    ..The data support that, in general, no differences were observed in cells containing functional (rho+) or non-functional (rho0) mitochondria upon H2O2-induced apoptotic cell death...
  68. ncbi request reprint Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: relevance to Parkinson's disease
    Daniela Moniz Arduíno
    Centro de Neurociencias e Biologia Celular, Faculdade de Medicina, Universidade de Coimbra, 3004 504 Coimbra, Portugal
    Neurochem Int 55:341-8. 2009
    ....
  69. ncbi request reprint Mitochondria as a therapeutic target in Alzheimer's disease and diabetes
    Paula I Moreira
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    CNS Neurol Disord Drug Targets 8:492-511. 2009
    ..Here we also discuss in vitro, in vivo and clinical studies that examined the effect of mitochondria-directed therapeutics particularly mitochondrial target antioxidants and Szeto-Schiller peptides...
  70. doi request reprint N-acyldopamines control striatal input terminals via novel ligand-gated cation channels
    Samira G Ferreira
    Center for Neuroscience and Cell Biology of Coimbra, Department of Zoology, Faculty of Medicine, University of Coimbra, 1 Rua Larga, 3004 504 Coimbra, Portugal
    Neuropharmacology 56:676-83. 2009
    ..Altogether, novel ion channels instead of the TRPV(1)R mediate the presynaptic action of N-acyldopamines in the striatum of adult rodents...
  71. ncbi request reprint Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview
    Sónia Correia
    Center for Neuroscience and Cell Biology, Institute of Physiology Faculty of Medicine, University of Coimbra, 3000 354 Coimbra, Portugal
    Mini Rev Med Chem 8:1343-54. 2008
    ..Finally, we will describe the few known side effects associated to this antidiabetic agent...
  72. ncbi request reprint Calpain-mediated MPP+ toxicity in mitochondrial DNA depleted cells
    A Filipa Domingues
    Center for Neurosciences and Cell Biology, University of Coimbra, 3004 504 Coimbra, Portugal
    Neurotox Res 13:31-8. 2008
    ..We conclude that 1) MPP+-induced apoptosis requires functional mitochondria, 2) MPP+ activates calpains independent of respiratory chain inhibition, and 3) calpain activation mediates some aspects of MPP+ toxicity...
  73. ncbi request reprint Comparative study of microglia activation induced by amyloid-beta and prion peptides: role in neurodegeneration
    Pedro Garção
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    J Neurosci Res 84:182-93. 2006
    ..Taken together, the data indicate that Abeta and PrP peptides caused microglia activation and differentially affected cytokine secretion. The IL-6 released by reactive microglia caused neuronal injury...
  74. ncbi request reprint Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population
    Alda M Ambrósio
    Department of Neurochemistry, Faculty of Medicine, Center for Neuroscience of Coimbra, University of Coimbra, 3004 517 Coimbra, Portugal
    Psychiatry Res 125:185-91. 2004
    ..Therefore, we conclude that neither the DRD2 nor the DRD3 gene polymorphisms investigated are associated with schizophrenia in our sample...