Gabriela R Moura

Summary

Affiliation: University of Aveiro
Country: Portugal

Publications

  1. pmc Codon-triplet context unveils unique features of the Candida albicans protein coding genome
    Gabriela R Moura
    Department of Biology and CESAM, University of Aveiro, 3810 193 Aveiro, Portugal
    BMC Genomics 8:444. 2007
  2. pmc Comparative context analysis of codon pairs on an ORFeome scale
    Gabriela Moura
    Centre for Cell Biology, Department of Biology, University of Aveiro, 3810 193 Aveiro, Portugal
    Genome Biol 6:R28. 2005
  3. pmc A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans
    Ana C Gomes
    CESAM and Department of Biology, University of Aveiro, 3810 193 Aveiro, Portugal
    Genome Biol 8:R206. 2007
  4. pmc Critical roles for a genetic code alteration in the evolution of the genus Candida
    Raquel M Silva
    Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal
    EMBO J 26:4555-65. 2007
  5. pmc Dre-miR-2188 targets Nrp2a and mediates proper intersegmental vessel development in zebrafish embryos
    Ana R Soares
    RNA Biology Laboratory, Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal
    PLoS ONE 7:e39417. 2012
  6. pmc Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast
    João A Paredes
    RNA Biology Laboratory, Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal
    BMC Biol 10:55. 2012
  7. pmc Species-specific codon context rules unveil non-neutrality effects of synonymous mutations
    Gabriela R Moura
    RNA Biology Laboratory, Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal
    PLoS ONE 6:e26817. 2011
  8. pmc A genetic code alteration is a phenotype diversity generator in the human pathogen Candida albicans
    Isabel Miranda
    Department of Biology, Centro de Estudos do Ambiente e do Mar, University of Aveiro, Aveiro, Portugal
    PLoS ONE 2:e996. 2007
  9. doi request reprint The genetic code of the fungal CTG clade
    Manuel A S Santos
    RNA Biology Laboratory, Department of Biology and CESAM, University of Aveiro, Campus de Santiago, 3810 193 Aveiro, Portugal
    C R Biol 334:607-11. 2011
  10. pmc The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation
    Raquel M Silva
    Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal
    PLoS ONE 4:e5212. 2009

Collaborators

Detail Information

Publications20

  1. pmc Codon-triplet context unveils unique features of the Candida albicans protein coding genome
    Gabriela R Moura
    Department of Biology and CESAM, University of Aveiro, 3810 193 Aveiro, Portugal
    BMC Genomics 8:444. 2007
    ....
  2. pmc Comparative context analysis of codon pairs on an ORFeome scale
    Gabriela Moura
    Centre for Cell Biology, Department of Biology, University of Aveiro, 3810 193 Aveiro, Portugal
    Genome Biol 6:R28. 2005
    ....
  3. pmc A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans
    Ana C Gomes
    CESAM and Department of Biology, University of Aveiro, 3810 193 Aveiro, Portugal
    Genome Biol 8:R206. 2007
    ..Genetic code alterations have been reported in mitochondrial, prokaryotic, and eukaryotic cytoplasmic translation systems, but their evolution and how organisms cope and survive such dramatic genetic events are not understood...
  4. pmc Critical roles for a genetic code alteration in the evolution of the genus Candida
    Raquel M Silva
    Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal
    EMBO J 26:4555-65. 2007
    ..This study highlights unanticipated roles for codon identity redefinition during the evolution of the genus Candida, and strongly suggests that genetic code alterations create genetic barriers that speed up speciation...
  5. pmc Dre-miR-2188 targets Nrp2a and mediates proper intersegmental vessel development in zebrafish embryos
    Ana R Soares
    RNA Biology Laboratory, Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal
    PLoS ONE 7:e39417. 2012
    ..We have recently predicted that Neuropilin2a (Nrp2a), a vascular endothelial growth factor receptor which is essential for normal developmental angiogenesis in zebrafish, is a dre-miR-2188 target...
  6. pmc Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast
    João A Paredes
    RNA Biology Laboratory, Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal
    BMC Biol 10:55. 2012
    ..Paradoxically, such errors can generate advantageous phenotypic diversity in fungi and bacteria through poorly understood molecular processes...
  7. pmc Species-specific codon context rules unveil non-neutrality effects of synonymous mutations
    Gabriela R Moura
    RNA Biology Laboratory, Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal
    PLoS ONE 6:e26817. 2011
    ..The data available show that codon-context has direct impact on both translation accuracy and efficiency, but one does not yet understand how it affects these two translation variables or whether context biases shape gene evolution...
  8. pmc A genetic code alteration is a phenotype diversity generator in the human pathogen Candida albicans
    Isabel Miranda
    Department of Biology, Centro de Estudos do Ambiente e do Mar, University of Aveiro, Aveiro, Portugal
    PLoS ONE 2:e996. 2007
    ..We are using this codon identity redefinition as a model system to elucidate the evolution of genetic code alterations...
  9. doi request reprint The genetic code of the fungal CTG clade
    Manuel A S Santos
    RNA Biology Laboratory, Department of Biology and CESAM, University of Aveiro, Campus de Santiago, 3810 193 Aveiro, Portugal
    C R Biol 334:607-11. 2011
    ..Here, we review the most recent results and concepts arising from the study of this codon reassignment and we highlight how its study is changing our views of the evolution of the genetic code...
  10. pmc The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation
    Raquel M Silva
    Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal
    PLoS ONE 4:e5212. 2009
    ....
  11. doi request reprint Development of the genetic code: insights from a fungal codon reassignment
    Gabriela R Moura
    Department of Biology and CESAM, University of Aveiro, 3810 193 Aveiro, Portugal
    FEBS Lett 584:334-41. 2010
    ..Here we explore the hypothesis that codon misreading and reassignment played fundamental roles in the development of the genetic code and we show how a fungal codon reassignment is enlightening its evolution...
  12. doi request reprint Genetic code ambiguity: an unexpected source of proteome innovation and phenotypic diversity
    Gabriela R Moura
    Department of Biology and CESAM, University of Aveiro, 3810 193 Aveiro, Portugal
    Curr Opin Microbiol 12:631-7. 2009
    ..A brief introduction to the molecular nature of translational error is provided; however, detailed information on the mechanistic aspects of mistranslation or comprehensive literature reviews of this topic should be obtained elsewhere...
  13. pmc Parallel DNA pyrosequencing unveils new zebrafish microRNAs
    Ana R Soares
    RNA Biology Laboratory, Department of Biology and CESAM, University of Aveiro, Aveiro 3810 193, Portugal
    BMC Genomics 10:195. 2009
    ....
  14. doi request reprint Ethanol exposure induces upregulation of specific microRNAs in zebrafish embryos
    Ana Raquel Soares
    RNA Biology Laboratory, Department of Biology, CESAM, University of Aveiro, 3810 193 Aveiro, Portugal
    Toxicol Sci 127:18-28. 2012
    ..The conservation of affected mechanisms among vertebrates leads us to postulate that similar miRNA deregulation occurs in humans, highlighting a relevant role of miRNAs in ethanol toxicology...
  15. ncbi request reprint Driving change: the evolution of alternative genetic codes
    Manuel A S Santos
    Centre for Cell Biology, Department of Biology, University of Aveiro, 3810 193 Aveiro, Portugal
    Trends Genet 20:95-102. 2004
    ....
  16. ncbi request reprint Yeast as a model organism for studying the evolution of non-standard genetic codes
    Raquel M Silva
    Functional Evolutionary Genomics Laboratory of the Centre for Cell Biology, Department of Biology, University of Aveiro, 3810 193 Aveiro, Portugal
    Brief Funct Genomic Proteomic 3:35-46. 2004
    ..Additionally, the importance of using Saccharomyces cerevisiae as a model organism for elucidating the evolutionary pathway of the Candida and other genetic code changes is emphasised...
  17. ncbi request reprint Computational and statistical methodologies for ORFeome primary structure analysis
    Gabriela Moura
    Department of Biology, University of Aveiro
    Methods Mol Biol 395:449-62. 2007
    ..Here, we describe these methodologies in detail and show how they can be used for analysis of ORFs of any genome sequenced...
  18. pmc Large scale comparative codon-pair context analysis unveils general rules that fine-tune evolution of mRNA primary structure
    Gabriela Moura
    Department of Biology, Center for Environmental and Marine Studies, University of Aveiro, Aveiro, Portugal
    PLoS ONE 2:e847. 2007
    ..CONCLUSIONS: The data highlight fundamental differences between prokaryotic and eukaryotic mRNA decoding rules, which are partially independent of codon usage...
  19. pmc Reversion of a fungal genetic code alteration links proteome instability with genomic and phenotypic diversification
    Ana R Bezerra
    RNA Biology Laboratory, Department of Biology and Centre for Environmental and Marine Studies, University of Aveiro, 3810 193 Aveiro, Portugal
    Proc Natl Acad Sci U S A 110:11079-84. 2013
    ..They also explain the high heterozygosity of the C. albicans genome and open the door to produce microorganisms with genetic code alterations for basic and applied research. ..
  20. ncbi request reprint Stop codon decoding in Candida albicans: from non-standard back to standard
    Gabriela Moura
    Centre for Cell Biology, Department of Biology, University of Aveiro, 3810 193 Aveiro, Portugal
    Yeast 19:727-33. 2002
    ..The data therefore show that the only aberrant event mediated by the ser-tRNA(CAG) is decoding of the leu-CUG codon as serine...