Paula I Moreira

Summary

Affiliation: University of Coimbra
Country: Portugal

Publications

  1. ncbi request reprint Is intraneuronal amyloid beta-peptide accumulation the trigger of Alzheimer's disease pathophysiology?
    Paula I Moreira
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Alzheimers Dis 6:433-4; discussion 443-9. 2004
  2. pmc Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities
    Cristina Carvalho
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Diabetes 61:1234-42. 2012
  3. ncbi request reprint Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins
    S Cardoso
    Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal
    Curr Mol Med 13:586-601. 2013
  4. ncbi request reprint Therapeutic options in Alzheimer's disease
    Paula I Moreira
    Case Western Reserve University, Department of Pathology, Cleveland, Ohio 44106, USA
    Expert Rev Neurother 6:897-910. 2006
  5. ncbi request reprint Therapeutic potential of oxidant mechanisms in Alzheimer's disease
    Paula I Moreira
    Case Western Reserve University, Institute of Pathology, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Expert Rev Neurother 4:995-1004. 2004
  6. doi request reprint Alzheimer's disease and diabetes: an integrative view of the role of mitochondria, oxidative stress, and insulin
    Paula I Moreira
    Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    J Alzheimers Dis 30:S199-215. 2012
  7. doi request reprint Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia
    Susana Cardoso
    Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    Biochim Biophys Acta 1802:942-51. 2010
  8. doi request reprint The impairment of insulin signaling in Alzheimer's disease
    Emanuel Candeias
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    IUBMB Life 64:951-7. 2012
  9. ncbi request reprint Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes
    Cristina Carvalho
    Center for Neuroscience and Cell Biology, Faculty of Sciences and Technology, University of Coimbra, 3000 354 Coimbra, Portugal
    Curr Neurovasc Res 7:288-300. 2010
  10. ncbi request reprint Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease
    Sónia C Correia
    Center for Neuroscience and Cell Biology, Laboratory of Physiology Faculty of Medicine, University of Coimbra, 3000 354 Coimbra, Portugal
    Curr Alzheimer Res 10:406-19. 2013

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Is intraneuronal amyloid beta-peptide accumulation the trigger of Alzheimer's disease pathophysiology?
    Paula I Moreira
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Alzheimers Dis 6:433-4; discussion 443-9. 2004
  2. pmc Metabolic alterations induced by sucrose intake and Alzheimer's disease promote similar brain mitochondrial abnormalities
    Cristina Carvalho
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Diabetes 61:1234-42. 2012
    ..These results show that in mice, the metabolic alterations associated to diabetes contribute to the development of AD-like pathologic features...
  3. ncbi request reprint Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins
    S Cardoso
    Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal
    Curr Mol Med 13:586-601. 2013
    ..Finally, we will discuss neuronal UCPs as possible therapeutic targets for the treatment of diabetes-associated central complications and neurodegenerative diseases, namely Alzheimer's and Parkinson's diseases...
  4. ncbi request reprint Therapeutic options in Alzheimer's disease
    Paula I Moreira
    Case Western Reserve University, Department of Pathology, Cleveland, Ohio 44106, USA
    Expert Rev Neurother 6:897-910. 2006
    ..The possibility that oxidative stress is a primary event in AD indicates that antioxidant-based therapies are perhaps the most promising weapons against this devastating neurodegenerative disorder...
  5. ncbi request reprint Therapeutic potential of oxidant mechanisms in Alzheimer's disease
    Paula I Moreira
    Case Western Reserve University, Institute of Pathology, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Expert Rev Neurother 4:995-1004. 2004
    ..Currently, antioxidant strategies appear to be the most encouraging therapeutics in reducing the clinical manifestation and evolution of Alzheimer's disease...
  6. doi request reprint Alzheimer's disease and diabetes: an integrative view of the role of mitochondria, oxidative stress, and insulin
    Paula I Moreira
    Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    J Alzheimers Dis 30:S199-215. 2012
    ..A better understanding of the key mechanisms underlying the interaction between AD and diabetes is needed for the design of effective preventive and therapeutic strategies...
  7. doi request reprint Cortical and hippocampal mitochondria bioenergetics and oxidative status during hyperglycemia and/or insulin-induced hypoglycemia
    Susana Cardoso
    Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    Biochim Biophys Acta 1802:942-51. 2010
    ..These results suggest that the poor glycemic control that occurs in type 1 diabetic patients undergoing insulin therapy may have detrimental effects in brain areas involved in learning and memory...
  8. doi request reprint The impairment of insulin signaling in Alzheimer's disease
    Emanuel Candeias
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    IUBMB Life 64:951-7. 2012
    ..The impact of insulin signaling impairment in brain aging and AD is also discussed. Finally, we present evidence supporting the notion that insulin is a link between diabetes and AD...
  9. ncbi request reprint Chronic hypoxia potentiates age-related oxidative imbalance in brain vessels and synaptosomes
    Cristina Carvalho
    Center for Neuroscience and Cell Biology, Faculty of Sciences and Technology, University of Coimbra, 3000 354 Coimbra, Portugal
    Curr Neurovasc Res 7:288-300. 2010
    ..Further, synaptosomes and brain vessels are differently affected by aging and chronic hypoxia supporting the idea of the existence of tissue-specific susceptibilities...
  10. ncbi request reprint Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease
    Sónia C Correia
    Center for Neuroscience and Cell Biology, Laboratory of Physiology Faculty of Medicine, University of Coimbra, 3000 354 Coimbra, Portugal
    Curr Alzheimer Res 10:406-19. 2013
    ....
  11. ncbi request reprint Doxorubicin increases the susceptibility of brain mitochondria to Ca(2+)-induced permeability transition and oxidative damage
    Susana Cardoso
    Department of Zoology, Faculty of Sciences and Technology, University of Coimbra, 3000 354 Coimbra, Portugal
    Free Radic Biol Med 45:1395-402. 2008
    ..Altogether our results show that DOX treatment increases the susceptibility of brain mitochondria to Ca(2+)-induced PTP opening and oxidative stress, predisposing brain cells to degeneration and death...
  12. ncbi request reprint Estradiol affects liver mitochondrial function in ovariectomized and tamoxifen-treated ovariectomized female rats
    Paula I Moreira
    Center for Neuroscience and Cell Biology, University of Coimbra, 3005 504 Coimbra, Portugal
    Toxicol Appl Pharmacol 221:102-10. 2007
    ..Since mitochondrial dysfunction is a triggering event of cell degeneration and death, the use of exogenous E2 must be carefully considered...
  13. ncbi request reprint Metformin promotes isolated rat liver mitochondria impairment
    Cristina Carvalho
    Department of Zoology Faculty of Sciences and Technology, University of Coimbra, Coimbra 3000 354, Portugal
    Mol Cell Biochem 308:75-83. 2008
    ..Taken together, our results show that metformin can promote liver mitochondria injury predisposing to cell death...
  14. ncbi request reprint Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure
    Paula I Moreira
    Center for Neuroscience and Cell Biology, Department of Zoology, Faculty of Sciences and Technology, University of Coimbra, 3004 517 Coimbra, Portugal
    J Biol Chem 281:10143-52. 2006
    ..This new piece of information provides a basis for the development of new and promising anticancer therapeutic strategies...
  15. pmc Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease
    Renato X Santos
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Antioxid Redox Signal 18:2444-57. 2013
    ..The role of mitochondria in aging and in pathophysiological processes is constantly being unraveled, and their involvement in neurodegenerative processes, such as Alzheimer's disease (AD), is very well known...
  16. pmc Mitochondria: a therapeutic target in neurodegeneration
    Paula I Moreira
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Biochim Biophys Acta 1802:212-20. 2010
    ..Furthermore, we will briefly discuss the novel action of the antihistamine drug Dimebon on mitochondria...
  17. doi request reprint Insulin is a two-edged knife on the brain
    Susana Cardoso
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal Department of Zoology, University of Coimbra, Coimbra, Portugal
    J Alzheimers Dis 18:483-507. 2009
    ..Finally, the potential therapeutic effect of insulin and insulin sensitizers will be examined...
  18. pmc Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover
    Xiongwei Zhu
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Free Radic Biol Med 52:699-704. 2012
    ..These findings directly implicate lipid crosslinking peroxidation products as accumulating not in the lesions or the lipofuscin pathways, but instead in a distinct pathway, GVD, that accumulates cytosolic proteins...
  19. ncbi request reprint Oxidative stress: the old enemy in Alzheimer's disease pathophysiology
    Paula I Moreira
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Curr Alzheimer Res 2:403-8. 2005
    ....
  20. ncbi request reprint CoQ10 therapy attenuates amyloid beta-peptide toxicity in brain mitochondria isolated from aged diabetic rats
    Paula I Moreira
    Center for Neuroscience and Cell Biology, Department of Zoology Faculty of Sciences and Technology, University of Coimbra, 3004 517 Coimbra, Portugal
    Exp Neurol 196:112-9. 2005
    ....
  21. ncbi request reprint Therapeutic opportunities in Alzheimer disease: one for all or all for one?
    Michael W Marlatt
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
    Curr Med Chem 12:1137-47. 2005
    ..In this review, the scientific basis for common AD therapeutics as well as the efficacy of these treatments will be discussed...
  22. ncbi request reprint Increased autophagic degradation of mitochondria in Alzheimer disease
    Paula I Moreira
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    Autophagy 3:614-5. 2007
    ..The study of autophagy in Alzheimer disease could clarify the mechanisms underlying this neurodegenerative disorder and, eventually, help in the development of new therapeutic strategies...
  23. ncbi request reprint Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes
    Sónia Correia
    Center for Neuroscience and Cell Biology, Institute of Physiology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Med Chem 4:358-64. 2008
    ..These results indicate that metformin protects against diabetes-associated oxidative stress suggesting that metformin could be an effective neuroprotective agent...
  24. ncbi request reprint A second look into the oxidant mechanisms in Alzheimer's disease
    Paula I Moreira
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
    Curr Neurovasc Res 2:179-84. 2005
    ....
  25. doi request reprint Mitochondria from distinct tissues are differently affected by 17β-estradiol and tamoxifen
    Paula I Moreira
    Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    J Steroid Biochem Mol Biol 123:8-16. 2011
    ..These results indicate that E2 and/or TAM have tissue-specific effects suggesting that TAM and hormonal replacement therapies may have some side effects that should be carefully considered...
  26. ncbi request reprint Compensatory responses induced by oxidative stress in Alzheimer disease
    Paula I Moreira
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44100, USA
    Biol Res 39:7-13. 2006
    ..These findings suggest that Alzheimer disease is associated with a novel balance in oxidant homeostasis...
  27. pmc Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia
    Cristina Carvalho
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    J Bioenerg Biomembr 41:433-40. 2009
    ..Here we discuss the role of mitochondria in AD putting focus on the activation of hypoxia-mediated mitochondrial pathways, which could eventually lead to cell degeneration and death...
  28. doi request reprint Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: role of mitochondrial reactive oxygen species and HIF-1α
    Sónia C Correia
    Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    Neurobiol Dis 45:206-18. 2012
    ....
  29. ncbi request reprint Tau phosphorylation in Alzheimer's disease: pathogen or protector?
    Hyoung gon Lee
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106 USA
    Trends Mol Med 11:164-9. 2005
    ....
  30. doi request reprint Alzheimer disease as a vascular disorder: where do mitochondria fit?
    Sónia C Correia
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Exp Gerontol 47:878-86. 2012
    ..The understanding of the mitochondrial mechanisms underlying AD pathology is critical to design more effective strategies to halt or delay disease progression...
  31. doi request reprint Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease
    Paula I Moreira
    Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, Coimbra, Portugal
    Methods Mol Biol 610:419-34. 2010
    ..Therefore, IRPs are considered to be the central control components of cellular iron concentration...
  32. pmc Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease?
    Sónia C Correia
    Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, Portugal
    Ageing Res Rev 10:264-73. 2011
    ....
  33. ncbi request reprint New insights into the mechanisms of mitochondrial preconditioning-triggered neuroprotection
    Sónia C Correia
    Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
    Curr Pharm Des 17:3381-9. 2011
    ....
  34. doi request reprint Nucleic acid oxidation in Alzheimer disease
    Paula I Moreira
    Center for Neuroscience and Cell Biology, Institute of Physiology Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Free Radic Biol Med 44:1493-505. 2008
    ..Furthermore, we outline the mechanisms of nucleic acid oxidation and repair. Finally, evidence showing the occurrence of nucleic acid oxidation in Alzheimer disease will be discussed...
  35. doi request reprint Nuclear and mitochondrial DNA oxidation in Alzheimer's disease
    Renato X Santos
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Free Radic Res 46:565-76. 2012
    ..Moreover, we will highlight the mechanisms of DNA oxidation and repair. Importantly, we will discuss evidence relating the DNA repair machinery and accumulated DNA oxidation with Alzheimer's disease...
  36. pmc Vascular oxidative stress in Alzheimer disease
    Xiongwei Zhu
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurol Sci 257:240-6. 2007
    ..Here, we discuss vascular factors in relation to Alzheimer disease and review hypoperfusion as a potential cause by triggering mitochondrial dysfunction and increased oxidative stress initiating the pathogenic process...
  37. ncbi request reprint Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations
    Quan Liu
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Free Radic Biol Med 38:746-54. 2005
    ....
  38. ncbi request reprint Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress
    Luís Rato
    CICS UBI Health Sciences Research Centre, University of Beira Interior, 6201 506 Covilhã, Portugal CNC Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    Biochim Biophys Acta 1837:335-44. 2014
    ..This study gives new insights into overall testicular bioenergetics at this prodromal stage of disease. ..
  39. ncbi request reprint Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes
    Paula I Moreira
    Center for Neuroscience and Cell Biology, Institute of Physiology, Faculty of Medicine, University of Coimbra, 3004 354 Coimbra, Portugal
    J Neurol Sci 257:206-14. 2007
    ..This review is primarily focused in the discussion of brain mitochondrial dysfunction as a link between diabetes and Alzheimer's disease...
  40. ncbi request reprint Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease
    Xiongwei Zhu
    Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, Ohio 44106, USA
    J Alzheimers Dis 9:147-53. 2006
    ....
  41. ncbi request reprint Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?
    Rudy J Castellani
    University of Maryland, Department of Pathology, Baltimore, MD 21201, USA
    Expert Rev Neurother 7:473-85. 2007
    ..An acceptance that lesion-based therapies do not address etiology or rate-limiting pathogenic factors is probably necessary for the best chance of significant advances that have thus far been elusive...
  42. doi request reprint Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation
    Sónia C Correia
    Center for Neuroscience and Cell Biology, University of Coimbra, 3000 354 Coimbra, Portugal
    Brain Res 1441:64-78. 2012
    ..Understanding the key mechanisms underlying this deleterious interaction may provide opportunities for the design of effective therapeutic strategies...
  43. ncbi request reprint Autophagocytosis of mitochondria is prominent in Alzheimer disease
    Paula I Moreira
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    J Neuropathol Exp Neurol 66:525-32. 2007
    ..Whether increased autophagocytosis is a consequence of an increased turnover of mitochondria or whether the mitochondria in Alzheimer disease are more susceptible to autophagy remains to be resolved...
  44. doi request reprint Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases
    Sónia C Correia
    Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, Coimbra, Portugal
    Adv Exp Med Biol 724:205-21. 2012
    ..This chapter highlights how mitochondrial pathobiology might contribute to neurodegeneration in Alzheimer's, Parkinson's and Huntington's diseases...
  45. doi request reprint Impact of STZ-induced hyperglycemia and insulin-induced hypoglycemia in plasma amino acids and cortical synaptosomal neurotransmitters
    Susana Cardoso
    Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    Synapse 65:457-66. 2011
    ..These results show that in the presence of a metabolic insult a higher release of excitatory amino acids occurs, which may underlay the neuronal injury observed in type 1 diabetic patients under insulin therapy...
  46. ncbi request reprint Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts
    Paula I Moreira
    Center for Neuroscience and Cell Biology, University of Coimbra, 3004 517 Coimbra, Portugal
    J Alzheimers Dis 12:195-206. 2007
    ..These data suggest mitochondria are important in oxidative damage that occurs in AD. As such, antioxidant therapies based on lipoic acid and N-acetyl cysteine supplementation may be promising...
  47. ncbi request reprint Metal ions and oxidative protein modification in neurological disease
    Lawrence M Sayre
    Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    Ann Ist Super Sanita 41:143-64. 2005
    ....
  48. ncbi request reprint Presenilin mutation: a deadly first hit in Alzheimer disease. A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice"
    Xiongwei Zhu
    Institute of Pathology, Case Western Reserve University, OH 44106, USA
    Free Radic Biol Med 40:737-9. 2006
  49. ncbi request reprint Hydroxytamoxifen protects against oxidative stress in brain mitochondria
    Paula I Moreira
    Centre for Neuroscience of Coimbra, University Coimbra, Coimbra, Portugal
    Biochem Pharmacol 68:195-204. 2004
    ....
  50. ncbi request reprint Insulin protects against amyloid beta-peptide toxicity in brain mitochondria of diabetic rats
    Paula I Moreira
    Center for Neuroscience of Coimbra, Department of Zoology, Faculty of Sciences and Technology, University of Coimbra, 3004 517 Coimbra, Portugal
    Neurobiol Dis 18:628-37. 2005
    ....
  51. pmc Alzheimer's disease: diverse aspects of mitochondrial malfunctioning
    Renato X Santos
    Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, Coimbra, Portugal
    Int J Clin Exp Pathol 3:570-81. 2010
    ....
  52. ncbi request reprint Effects of estrogen in the brain: is it a neuroprotective agent in Alzheimer's disease?
    Sónia C Correia
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    Curr Aging Sci 3:113-26. 2010
    ....
  53. ncbi request reprint The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease
    Paula I Moreira
    Department of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA
    Mech Ageing Dev 127:501-6. 2006
    ..However, in the initial stages of disease development, neurons adapt to the oxidative environment through the development of compensatory responses resulting in a shift of neuronal priority from normal function to basic survival...
  54. pmc SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization
    Lydia W S Finley
    Department of Pathology, The Paul F Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 19:416-28. 2011
    ..Finally, we find that SIRT3 overexpression represses glycolysis and proliferation in breast cancer cells, providing a metabolic mechanism for tumor suppression...
  55. ncbi request reprint Iron: the Redox-active center of oxidative stress in Alzheimer disease
    Rudy J Castellani
    Department of Pathology, University of Maryland, Baltimore, MD, USA
    Neurochem Res 32:1640-5. 2007
    ..In this review, we discuss the role of iron in the progression of AD...
  56. ncbi request reprint Alzheimer disease and the role of free radicals in the pathogenesis of the disease
    Paula I Moreira
    Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004 517 Coimbra, Portugal
    CNS Neurol Disord Drug Targets 7:3-10. 2008
    ..However, during the progression of the disease, the antioxidant activity of both agents is either overwhelmed or, according to others, evolves into pro-oxidant activity resulting in the exacerbation of reactive species production...
  57. ncbi request reprint Mitochondria as a therapeutic target in Alzheimer's disease and diabetes
    Paula I Moreira
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    CNS Neurol Disord Drug Targets 8:492-511. 2009
    ..Here we also discuss in vitro, in vivo and clinical studies that examined the effect of mitochondria-directed therapeutics particularly mitochondrial target antioxidants and Szeto-Schiller peptides...
  58. pmc A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease
    Renato X Santos
    Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, Coimbra, Portugal
    J Alzheimers Dis 20:S401-12. 2010
    ....
  59. ncbi request reprint Redox metals and oxidative abnormalities in human prion diseases
    Robert B Petersen
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Acta Neuropathol 110:232-8. 2005
    ..These findings suggest an important distinction in prion-related oxidative stress, indicating that different neurodegenerative pathways are involved in different prion diseases...
  60. ncbi request reprint Type 2 diabetic and Alzheimer's disease mice present similar behavioral, cognitive, and vascular anomalies
    Cristina Carvalho
    Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
    J Alzheimers Dis 35:623-35. 2013
    ..In addition, a significant increase in Aβ levels was observed in the cortex and hippocampus of T2D mice. These results support the notion that T2D predisposes to cerebrovascular alterations, cognitive decline, and development of AD...
  61. ncbi request reprint Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen
    Paula I Moreira
    Center for Neuroscience and Cell Biology of Coimbra, Department of Zoology Faculty of Sciences and Technology, University of Coimbra, 3004 517 Coimbra, Portugal
    Neuropharmacology 48:435-47. 2005
    ..Since numerous neurodegenerative diseases are intimately related with mitochondrial dysfunction, future therapeutical strategies could be designed taking into account this protective role of tamoxifen...
  62. ncbi request reprint Oxidative damage and Alzheimer's disease: are antioxidant therapies useful?
    Paula I Moreira
    Institute of Pathology, Case Western Research University, Cleveland, OH 44106, USA
    Drug News Perspect 18:13-9. 2005
    ..However, the results obtained in clinical trials with antioxidants are promising and propel us in the search of new and more effective antioxidant therapies...
  63. doi request reprint Autophagy in Alzheimer's disease
    Paula I Moreira
    University of Coimbra, Coimbra, Portugal
    Expert Rev Neurother 10:1209-18. 2010
    ..A central issue in developing therapies for neurodegenerative diseases involves understanding why and when responses to stress or injury can help prevent neuronal degeneration and death...
  64. pmc Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
    Xinglong Wang
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 105:19318-23. 2008
    ....
  65. doi request reprint The role of iron as a mediator of oxidative stress in Alzheimer disease
    Rudy J Castellani
    Department of Pathology, University of Maryland, Baltimore, MD, USA
    Biofactors 38:133-8. 2012
    ..In this review, we discuss the role of iron in the progression of AD...
  66. ncbi request reprint Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview
    Sónia Correia
    Center for Neuroscience and Cell Biology, Institute of Physiology Faculty of Medicine, University of Coimbra, 3000 354 Coimbra, Portugal
    Mini Rev Med Chem 8:1343-54. 2008
    ..Finally, we will describe the few known side effects associated to this antidiabetic agent...
  67. doi request reprint An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease
    Paula I Moreira
    Center for Neuroscience and Cell Biology, Faculty of Medicine, Institute of Physiology, Department of Zoology, University of Coimbra, Coimbra, Portugal
    J Alzheimers Dis 16:741-61. 2009
    ..Understanding the key mechanisms involved in the etiopathogenesis of Alzheimer's disease may provide opportunities for the design of efficacious preventive and therapeutic strategies...
  68. ncbi request reprint Indices of metabolic dysfunction and oxidative stress
    Gemma Casadesus
    Department of Neuroscience, Case Western Reserve University, Cleveland, OH, USA
    Neurochem Res 32:717-22. 2007
    ..Overall, clarifying cellular and molecular manifestations involved in metabolic alterations may contribute to a better understanding of early Alzheimer disease pathophysiology...
  69. pmc Mitochondria: the missing link between preconditioning and neuroprotection
    Sónia C Correia
    Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, Coimbra, Portugal
    J Alzheimers Dis 20:S475-85. 2010
    ..The identification of intrinsic mitochondrial mechanisms involved in preconditioning will provide new insights which can be translated into potential pharmacological interventions aimed at counteracting neurodegeneration...
  70. ncbi request reprint Chronological primacy of oxidative stress in Alzheimer disease
    Mark A Smith
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Neurobiol Aging 26:579-80. 2005