Adelino Leite-Moreira#

Summary

Affiliation: University of Porto
Country: Portugal

Publications

  1. ncbi request reprint Modulation of myocardial function by pyruvate
    A F Leite-Moreira
    Serviço de Fisiologia, Faculdade de Medicina, Universidade do Porto, Porto, Portugal
    Rev Port Cardiol 21:437-45. 2002
  2. ncbi request reprint Ghrelin reverses molecular, structural and hemodynamic alterations of the right ventricle in pulmonary hypertension
    Tiago Henriques-Coelho
    Serviço de Fisiologia, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
    Rev Port Cardiol 25:55-63. 2006
  3. ncbi request reprint Endothelin ETA receptors and endothelium partially mediate the positive inotropic and lusitropic effects of angiotensin II
    Paulo Castro-Chaves
    Department of Physiology, Faculty of Medicine, University of Porto, Alameda Prof Hernani Monteiro, 4200 319 Porto, Portugal
    Eur J Pharmacol 544:91-6. 2006
  4. ncbi request reprint Left ventricular hypertrophy in isolated aortic stenosis: primetime for the ventricle
    Cristina Gavina
    Servico de Cardiologia, Hospital Sao Joao, Porto, Portugal
    Curr Pharm Biotechnol 13:2503-14. 2012
  5. ncbi request reprint Understanding the molecular and cellular changes behind aortic valve stenosis
    Ines Falcao-Pires
    Department of Physiology, Faculty of Medicine, Alameda Professor Hernani Monteiro, 4200 319 Porto, Portugal
    Curr Pharm Biotechnol 13:2485-96. 2012
  6. doi request reprint Intraventricular pressure gradients throughout the cardiac cycle: effects of ischaemia and modulation by afterload
    Miguel Guerra
    Department of Physiology and Cardiothoracic Surgery, Cardiovascular R and D Unit, Faculty of Medicine, University of Porto, Alameda Professor Hernani Monteiro, 4200 319 Porto, Portugal
    Exp Physiol 98:149-60. 2013
  7. doi request reprint Diastolic tolerance to systolic pressures closely reflects systolic performance in patients with coronary heart disease
    Adelino F Leite-Moreira
    Cardiovascular R and D Unit, Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, Hospital Sao Joao, Universidade do Porto, Alameda Professor Hernani Monteiro, 4200 319, Porto, Portugal
    Basic Res Cardiol 107:251. 2012
  8. pmc Rationale, design and methodology for Intraventricular Pressure Gradients Study: a novel approach for ventricular filling assessment in normal and falling hearts
    Miguel Guerra
    Faculty of Medicine of University of Oporto, Department of Physiology, Alameda Professor Hernani Monteiro, Porto, Portugal
    J Cardiothorac Surg 6:67. 2011
  9. ncbi request reprint Genetic polymorphisms and stroke risk
    Adelino F Leite-Moreira
    Serviço de Fisiologia, Faculdade de Medicina, Universidade do Porto, Porto, Portugal
    Rev Port Cardiol 23:359-62. 2004
  10. pmc Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect
    Adelino F Leite-Moreira
    Department of Physiology, Faculty of Medicine, University of Porto, Porto 4200 319, Portugal
    Br J Pharmacol 147:690-7. 2006

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Modulation of myocardial function by pyruvate
    A F Leite-Moreira
    Serviço de Fisiologia, Faculdade de Medicina, Universidade do Porto, Porto, Portugal
    Rev Port Cardiol 21:437-45. 2002
    ..The main objective of the present work was to clarify the mechanisms underlying this inotropic effect...
  2. ncbi request reprint Ghrelin reverses molecular, structural and hemodynamic alterations of the right ventricle in pulmonary hypertension
    Tiago Henriques-Coelho
    Serviço de Fisiologia, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
    Rev Port Cardiol 25:55-63. 2006
    ..Chronic ghrelin administration attenuates MCT-induced pulmonary hypertension, vascular remodeling and RV hypertrophy. These results suggest a potential therapeutic role for the ghrelin-growth hormone axis in pulmonary hypertension...
  3. ncbi request reprint Endothelin ETA receptors and endothelium partially mediate the positive inotropic and lusitropic effects of angiotensin II
    Paulo Castro-Chaves
    Department of Physiology, Faculty of Medicine, University of Porto, Alameda Prof Hernani Monteiro, 4200 319 Porto, Portugal
    Eur J Pharmacol 544:91-6. 2006
    ..In conclusion, angiotensin-II has a dose-dependent positive inotropic effect that depends, to a great extent, on endothelin ETA receptor activation and intact endocardial endothelium...
  4. ncbi request reprint Left ventricular hypertrophy in isolated aortic stenosis: primetime for the ventricle
    Cristina Gavina
    Servico de Cardiologia, Hospital Sao Joao, Porto, Portugal
    Curr Pharm Biotechnol 13:2503-14. 2012
    ..Further evidence, with well designed clinical trials, is needed but the spotlight must be in the ventricle, not the valve...
  5. ncbi request reprint Understanding the molecular and cellular changes behind aortic valve stenosis
    Ines Falcao-Pires
    Department of Physiology, Faculty of Medicine, Alameda Professor Hernani Monteiro, 4200 319 Porto, Portugal
    Curr Pharm Biotechnol 13:2485-96. 2012
    ..In the present review, we focused on the molecular and cellular mechanisms underlying degenerative AVS and its myocardial impact...
  6. doi request reprint Intraventricular pressure gradients throughout the cardiac cycle: effects of ischaemia and modulation by afterload
    Miguel Guerra
    Department of Physiology and Cardiothoracic Surgery, Cardiovascular R and D Unit, Faculty of Medicine, University of Porto, Alameda Professor Hernani Monteiro, 4200 319 Porto, Portugal
    Exp Physiol 98:149-60. 2013
    ..Moreover, we show that the IVPG, a marker of normal left ventricular function, can be attenuated, lost entirely or even reversed after regional acute ischaemia and afterload elevations...
  7. doi request reprint Diastolic tolerance to systolic pressures closely reflects systolic performance in patients with coronary heart disease
    Adelino F Leite-Moreira
    Cardiovascular R and D Unit, Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, Hospital Sao Joao, Universidade do Porto, Alameda Professor Hernani Monteiro, 4200 319, Porto, Portugal
    Basic Res Cardiol 107:251. 2012
    ..When cardiac function deteriorates, the LV becomes less tolerant, responding with slowed relaxation and increased filling pressures. This increase is exacerbated by volume loading...
  8. pmc Rationale, design and methodology for Intraventricular Pressure Gradients Study: a novel approach for ventricular filling assessment in normal and falling hearts
    Miguel Guerra
    Faculty of Medicine of University of Oporto, Department of Physiology, Alameda Professor Hernani Monteiro, Porto, Portugal
    J Cardiothorac Surg 6:67. 2011
    ....
  9. ncbi request reprint Genetic polymorphisms and stroke risk
    Adelino F Leite-Moreira
    Serviço de Fisiologia, Faculdade de Medicina, Universidade do Porto, Porto, Portugal
    Rev Port Cardiol 23:359-62. 2004
  10. pmc Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect
    Adelino F Leite-Moreira
    Department of Physiology, Faculty of Medicine, University of Porto, Porto 4200 319, Portugal
    Br J Pharmacol 147:690-7. 2006
    ..This represents a novel mechanism of acute neurohumoral modulation of diastolic function, suggesting that AngII is a powerful regulator of cardiac filling...
  11. ncbi request reprint The role of titin in the modulation of cardiac function and its pathophysiological implications
    Ricardo Castro-Ferreira
    Serviço de Fisiologia, Faculdade de Medicina, Universidade do Porto, Portugal
    Arq Bras Cardiol 96:332-9. 2011
    ....
  12. pmc Current perspectives in diastolic dysfunction and diastolic heart failure
    Adelino F Leite-Moreira
    Department of Physiology, Faculty of Medicine, University of Porto, Alameda Professor Hernani Monteiro, 4200 319 Porto, Portugal
    Heart 92:712-8. 2006
  13. ncbi request reprint Physiological, pathological and potential therapeutic roles of ghrelin
    Adelino F Leite-Moreira
    Department of Physiology, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    Drug Discov Today 12:276-88. 2007
    ..Here, we provide an overview of the physiological effects of ghrelin and of its pathological and potential therapeutic roles...
  14. doi request reprint Toll-like receptors as therapeutic targets in gastrointestinal diseases
    Pedro Pimentel-Nunes
    Department of Physiology, Cardiovascular Research and Development Unit, University of Porto, Al Prof Hernani Monteiro, 4200 319, Portugal
    Expert Opin Ther Targets 14:347-68. 2010
    ..Recent evidence associates numerous pathophysiological processes and diseases with dysregulated activation of these receptors, conferring a potential therapeutic value to their modulation...
  15. ncbi request reprint Inotropic effects of ETB receptor stimulation and their modulation by endocardial endothelium, NO, and prostaglandins
    Adelino F Leite-Moreira
    Department of Physiology, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    Am J Physiol Heart Circ Physiol 287:H1194-9. 2004
    ....
  16. ncbi request reprint Modulation of the positive inotropic effect of pyruvate by energetic substrate availability
    Adelino F Leite-Moreira
    Department of Physiology, Faculty of Medicine, University of Porto, Porto, Portugal
    Acta Cardiol 58:519-25. 2003
    ..We conclude that, in rabbit papillary muscles, the positive inotropic effect of pyruvate is modulated by the availability of metabolic substrates and presumably does not depend on its mitochondrial uptake...
  17. ncbi request reprint Myocardial effects of ETB receptor stimulation
    Adelino F Leite-Moreira
    Serviço de Fisiologia, Faculdade de Medicina, Universidade do Porto, Porto
    Rev Port Cardiol 21:1009-16. 2002
    ..In this study we investigated the myocardial effects of selective ETB receptor stimulation...
  18. ncbi request reprint ET-1 increases distensibility of acutely loaded myocardium: a novel ETA and Na+/H+ exchanger-mediated effect
    Adelino F Leite-Moreira
    Department of Physiology, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    Am J Physiol Heart Circ Physiol 284:H1332-9. 2003
    ..ET-1 therefore increased diastolic distensibility of acutely loaded human and nonhuman myocardium. This effect is mediated by ET(A) receptors, requires Na(+)/H(+) exchanger activation, and cannot be elicited by Ca(2+)...
  19. ncbi request reprint [Mechanisms underlying endothelin-1 effects on myocardial function]
    A F Leite-Moreira
    Serviço de Fisiologia da Faculdade de Medicina da Universidade do Porto Centro de Cirurgia Cardio Torácica do Hospital de São João
    Rev Port Cardiol 20:291-5. 2001
    ..Its effects on the intrinsic properties of the myocardium were recently described. The present study investigated the mechanisms underlying those effects...
  20. ncbi request reprint [Interaction between load and beta-adrenergic stimulation in the modulation of diastolic function]
    A F Leite-Moreira
    Serviço de Fisiologia da Faculdade de Medicina da Universidade do Porto, Porto, Portugal
    Rev Port Cardiol 20:57-62. 2001
    ..This diastolic dysfunction was attributed to the concomitant slowing of relaxation. The present study investigated to what extent beta-adrenergic stimulation could influence this effect...
  21. ncbi request reprint The physiology of left ventricular pressure fall
    A F Leite-Moreira
    Department of Physiology, Faculty of Medicine, University of Porto, Porto Division of Cardiology, University of Antwerp, Belgium
    Rev Port Cardiol 19:1015-21. 2000
    ..LVP fall may provide useful and quantitative information on systolic LV function if measurements are performed under different conditions of systolic load...
  22. ncbi request reprint Load as an acute determinant of end-diastolic pressure-volume relation
    A F Leite-Moreira
    Department of Physiology, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    Am J Physiol Heart Circ Physiol 280:H51-9. 2001
    ..In conclusion, load is an acute determinant of the ED P-V relation, which, therefore, does not provide a load-independent assessment of diastolic function...
  23. ncbi request reprint [Diastolic function modulation by load. Physiological basis and clinical implications]
    A F Leite-Moreira
    Serviço de Fisiologia, Faculdade de Medicina, Universidade do Porto
    Rev Port Cardiol 18:991-9. 1999
    ..We recently showed that a substantial afterload elevation induces a marked slowing of relaxation. In this study we investigated the repercussion of such slowing on late LV filling...
  24. ncbi request reprint Afterload induced changes in myocardial relaxation: a mechanism for diastolic dysfunction
    A F Leite-Moreira
    Department of Physiology, Faculty of Medicine, University of Porto, Portugal
    Cardiovasc Res 43:344-53. 1999
    ..It is well known that high afterload slows myocardial relaxation. This contribution investigated to what extent afterload elevation could also affect LV filling pressures including end-diastolic LV pressure (LVP)...
  25. ncbi request reprint Load dependence of left ventricular contraction and relaxation. Effects of caffeine
    A F Leite-Moreira
    Laboratory of Physiology, Faculty of Medicine, Alameda Professor Hernani Monteiro, Portugal
    Basic Res Cardiol 94:284-93. 1999
    ..Load dependence of left ventricular (LV) contraction and relaxation was investigated at baseline and after alteration of intracellular calcium handling by caffeine...
  26. ncbi request reprint Obligatory role of the endocardial endothelium in the increase of myocardial distensibility induced by endothelin-1
    Carmen Bras-Silva
    Department of Physiology, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    Exp Biol Med (Maywood) 231:876-81. 2006
    ..No significant effects were elicited by IRL-1620 in RT. ET-1-induced increase in myocardial distensibility, previously shown to be mediated by ET(A) receptor stimulation, requires an intact EE and active endothelial ET(B1) receptors...
  27. ncbi request reprint Urotensin II acutely increases myocardial length and distensibility: potential implications for diastolic function and ventricular remodeling
    Ana Patrícia Fontes-Sousa
    Department of Physiology, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    Naunyn Schmiedebergs Arch Pharmacol 376:107-15. 2007
    ..This represents a novel mechanism of acute neurohumoral modulation of diastolic function, suggesting that U-II is an important regulator of cardiac filling...
  28. ncbi request reprint Impaired response to ET(B) receptor stimulation in heart failure: functional evidence of endocardial endothelial dysfunction?
    Carmen Bras-Silva
    Department of Physiology, Faculty of Medicine, University of Porto, Portugal
    Exp Biol Med (Maywood) 231:893-8. 2006
    ....
  29. ncbi request reprint Negative inotropic effect of selective AT2 receptor stimulation and its modulation by the endocardial endothelium
    Paulo Castro-Chaves
    Department of Physiology, Faculty of Medicine, Alameda Prof Hernani Monteiro, 4200 319 Porto, Portugal
    Eur J Pharmacol 578:261-9. 2008
    ..Such findings may help to better understand the therapeutic effects of selective AT(1) antagonists, which are increasingly used for treating cardiovascular diseases...
  30. ncbi request reprint Inotropic and lusitropic effects of ghrelin and their modulation by the endocardial endothelium, NO, prostaglandins, GHS-R1a and KCa channels
    João Bruno Soares
    Department of Physiology, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    Peptides 27:1616-23. 2006
    ..The negative inotropic effect is partly mediated by KCa channels, while the earlier onset of relaxation is modulated by prostaglandins and NO...
  31. ncbi request reprint Modulation of the myocardial effects of selective ETB receptor stimulation and its implications for heart failure
    Carmen Bras-Silva
    Serviço de Fisiologia da Faculdade de Medicina da Universidade do Porto, Porto, Portugal
    Rev Port Cardiol 24:1125-33. 2005
    ..The aim of the present study was to investigate the mechanisms underlying the myocardial effects of selective ET(B) receptor stimulation...
  32. ncbi request reprint Myocardial dysfunction and neurohumoral activation without remodeling in left ventricle of monocrotaline-induced pulmonary hypertensive rats
    André P Lourenço
    Serviço de Fisiologia, Faculdade de Medicina da Universidade do Porto, Alameda Professor Hernani Monteiro, 4200 319 Porto, Portugal
    Am J Physiol Heart Circ Physiol 291:H1587-94. 2006
    ..Neuroendocrine mediators, particularly ET-1, may participate in this functional deterioration...
  33. ncbi request reprint [Nitric oxide in the physiopathology of myocardial dysfunction in heart failure]
    Carmen Bras-Silva
    Serviço de Fisiologia, Faculdade de Medicina, Universidade do Porto, Porto, Portugal
    Rev Port Cardiol 23:II105-19. 2004
    ..We also include a brief mention of therapeutic approaches are which directly or indirectly related with the bioavailability of this mediator...
  34. ncbi request reprint Contractile effects of Ghrelin and expression of its receptor GHS-R1a in normal and hypertrophic myocardium
    João Bruno Soares
    Serviço de Fisiologia da Faculdade de Medicina da Universidade do Porto, Porto, Portugal
    Rev Port Cardiol 24:1235-42. 2005
    ..This study investigated the contractile effects of ghrelin and expression of its receptor GHS-R1a in normal and hypertrophic myocardium...
  35. ncbi request reprint N-terminal-pro-B type natriuretic peptide as a useful tool to evaluate pulmonary hypertension and cardiac function in CDH infants
    Maria J Baptista
    Divisions of Pediatric Cardiology, Neonatology and Pediatric Surgery, Department of Pediatrics, Hospital S Joao, Porto, Portugal
    Neonatology 94:22-30. 2008
    ..Early NT-proBNP levels were assessed in CDH infants and correlated with cardiovascular echocardiographic parameters...
  36. ncbi request reprint Beat-to-beat modulation of right and left ventricular positive dP/dt by afterload. Implications for the evaluation of inotropy
    Jorge Correia-Pinto
    Department of Physiology, Faculty of Medicine, University of Porto, Portugal
    Acta Cardiol 58:327-34. 2003
    ..In the current study, we evaluated acute afterload dependence of dP/dtmax in both ventricles in rats...
  37. ncbi request reprint M-mode and Doppler echocardiographic reference values for male New Zealand white rabbits
    Ana Patrícia N Fontes-Sousa
    Department of Physiology, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    Am J Vet Res 67:1725-9. 2006
    ..To determine M-mode and Doppler echocardiographic reference values in healthy New Zealand white rabbits...
  38. ncbi request reprint Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension
    Tiago Henriques-Coelho
    Dept of Physiology, Faculty of Medicine, Univ of Porto, 4200 319 Porto, Portugal
    Am J Physiol Heart Circ Physiol 287:H2885-90. 2004
    ..Finally, ghrelin administration attenuated MCT-induced PH, pulmonary vascular remodeling, and RV hypertrophy, indicating that it may modulate PH...
  39. ncbi request reprint Modulation of myocardial stiffness by β-adrenergic stimulation--its role in normal and failing heart
    I Falcao-Pires
    Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, Portugal
    Physiol Res 60:599-609. 2011
    ..We conclude that beta-adrenergic stimulation is a relevant mechanism of acute neurohumoral modulation of the diastolic function. Furthermore, this study clarifies the mechanisms by which myocardial stiffness is decreased...
  40. ncbi request reprint Fetal heart development in the nitrofen-induced CDH rat model: the role of mechanical and nonmechanical factors
    Jorge Correia-Pinto
    Department of Physiology, Faculty of Medicine, University of Porto, Porto, Portugal
    J Pediatr Surg 38:1444-51. 2003
    ..The authors analyzed whether nonmechanical and mechanical factors affect cardiac growth and correlations between lung and heart weights during gestation...
  41. ncbi request reprint [Renin-angiotensin system and its role in cardiovascular physiopathology and therapy]
    Paulo Castro-Chaves
    Serviço de Fisiologia, Faculdade de Medicina, Universidade do Porto, Porto, Portugal
    Rev Port Cardiol 23:II61-77. 2004
    ..Although many of the mechanisms underlying these actions are not fully understood, there are no doubts about the beneficial effects of inhibiting this system in the treatment of several cardiovascular diseases...
  42. ncbi request reprint Stem cells and myocardial regeneration
    Teresa Pinto-Almeida
    Serviço de Fisiologia da Faculdade de Medicina da Universidade do Porto, Porto, Portugal
    Rev Port Cardiol 23:1163-80. 2004
    ..In this review, we will focus on the different types of SCs tested in the heart, their advantages and limitations, and their potential therapeutic applications...
  43. doi request reprint Thymulin inhibits monocrotaline-induced pulmonary hypertension modulating interleukin-6 expression and suppressing p38 pathway
    Tiago Henriques-Coelho
    Department of Physiology, Faculty of Medicine, University of Porto, Porto, Portugal
    Endocrinology 149:4367-73. 2008
    ..The pulmonary thymulin effect was likely mediated through suppression of p38 pathway...
  44. doi request reprint Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle
    João Bruno Soares
    Department of Physiology, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    Peptides 29:1255-70. 2008
    ..In this review, we summarize the steps which lead to the production of the different ghrelin gene products and examine the most significant differences between them in terms of structure and actions...
  45. ncbi request reprint Cardiac, skeletal, and smooth muscle regulation by ghrelin
    Adelino F Leite-Moreira
    Department of Physiology, Faculty of Medicine, University of Porto, Alameda Professor Hernani Monteiro, 4200 319, Porto, Portugal
    Vitam Horm 77:207-38. 2008
    ..In the skeletal muscle, ghrelin regulates resting membrane potential. In conclusion, there are increasing evidences that ghrelin is a peptide with paracrine actions that can modulate cardiac, smooth, and skeletal muscle functions...
  46. ncbi request reprint Apelin: a novel neurohumoral modulator of the cardiovascular system. Pathophysiologic importance and potential use as a therapeutic target
    Ines Falcao-Pires
    Serviço de Fisiologia da Faculdade de Medicina da Universidade do Porto, Porto, Portugal
    Rev Port Cardiol 24:1263-76. 2005
    ....
  47. ncbi request reprint Remote myocardium gene expression after 30 and 120 min of ischaemia in the rat
    Miguel S Guerra
    Department of Physiology, Faculty of Medicine, University of Porto, Portugal
    Exp Physiol 91:473-80. 2006
    ..These changes are different in the two ventricles and in the same direction as those observed in heart failure...
  48. ncbi request reprint Activation profile of pro-inflammatory cytokines in acute cardiac overload
    Roberto Júnior Roncon-Albuquerque
    Serviço de Fisiologia, Faculdade de Medicina do Porto, Porto, Portugal
    Rev Port Cardiol 24:1369-78. 2005
    ..In the present study, we investigated the effects of acute volume and RV pressure overload on biventricular hemodynamics and myocardial gene expression of IL-6 and TNF-alpha...
  49. ncbi request reprint Cardiovascular endothelins: essential regulators of cardiovascular homeostasis
    Friedrich Brunner
    Department of Pharmacology and Toxicology, University of Graz, Universitatsplatz 2, 8010 Graz, Austria
    Pharmacol Ther 111:508-31. 2006
    ....
  50. ncbi request reprint How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology
    Walter J Paulus
    Laboratory of Physiology, VU University Medical Center, Van der Boechorststraat, 7, 1081 BT, Amsterdam, The Netherlands
    Eur Heart J 28:2539-50. 2007
    ..The updated strategies for the diagnosis and exclusion of HFNEF are useful not only for individual patient management but also for patient recruitment in future clinical trials exploring therapies for HFNEF...
  51. ncbi request reprint Ghrelin expression in human and rat fetal lungs and the effect of ghrelin administration in nitrofen-induced congenital diaphragmatic hernia
    Marta Santos
    Life and Health Sciences Research Institute, University of Minho, Portugal
    Pediatr Res 59:531-7. 2006
    ....