Elisa Keating

Summary

Affiliation: University of Porto
Country: Portugal

Publications

  1. ncbi request reprint Acute and chronic effects of some dietary bioactive compounds on folic acid uptake and on the expression of folic acid transporters by the human trophoblast cell line BeWo
    Elisa Keating
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    J Nutr Biochem 19:91-100. 2008
  2. doi request reprint Folic acid uptake by the human syncytiotrophoblast: interference by pharmacotherapy, drugs of abuse and pathological conditions
    Elisa Keating
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Al Prof Hernani Monteiro, 4200 319 Porto, Portugal
    Reprod Toxicol 28:511-20. 2009
  3. doi request reprint Comparison of the transport characteristics of bioactive substances in IUGR and normal placentas
    Elisa Keating
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Porto, Portugal
    Pediatr Res 66:495-500. 2009
  4. ncbi request reprint Characteristics of thiamine uptake by the BeWo human trophoblast cell line
    Elisa Keating
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    J Biochem Mol Biol 39:383-93. 2006
  5. ncbi request reprint Progesterone inhibits folic acid transport in human trophoblasts
    Elisa Keating
    Department of Biochemistry U38 FCT, Faculty of Medicine of Porto, University of Porto, Porto 4200 319, Portugal
    J Membr Biol 216:143-52. 2007
  6. ncbi request reprint Comparison of folic acid uptake characteristics by human placental choriocarcinoma cells at acidic and physiological pH
    Elisa Keating
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Porto 4200 319, Portugal
    Can J Physiol Pharmacol 84:247-55. 2006
  7. doi request reprint Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanism
    Liliana Moreira
    Department of Biochemistry U38 FCT, Faculty of Medicine of University of Porto, Alameda Prof Hernani Monteiro, 4200 319 Porto, Portugal
    Exp Cell Res 319:1784-95. 2013
  8. doi request reprint Folic acid uptake by the human syncytiotrophoblast is affected by gestational diabetes, hyperleptinemia, and TNF-α
    Joao R Araujo
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Porto, Portugal
    Pediatr Res 73:388-94. 2013
  9. ncbi request reprint Uptake of (3)H-1-methyl-4-phenylpyridinium ((3)H-MPP(+)) by human intestinal Caco-2 cells is regulated by phosphorylation/dephosphorylation mechanisms
    Fatima Martel
    Department of Biochemistry, Faculty of Medicine, 4200 319 Porto, Portugal
    Biochem Pharmacol 63:1565-73. 2002
  10. doi request reprint Oxidative stress decreases uptake of neutral amino acids in a human placental cell line (BeWo cells)
    João Ricardo Araújo
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal Electronic address
    Reprod Toxicol 40:76-81. 2013

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Acute and chronic effects of some dietary bioactive compounds on folic acid uptake and on the expression of folic acid transporters by the human trophoblast cell line BeWo
    Elisa Keating
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    J Nutr Biochem 19:91-100. 2008
    ..01%). This reduction seems to be, at least in part, due to a reduction in FRalpha expression. These results are compatible with an association between a deficient FA supply to the placenta/fetus and ethanol toxicity in pregnancy...
  2. doi request reprint Folic acid uptake by the human syncytiotrophoblast: interference by pharmacotherapy, drugs of abuse and pathological conditions
    Elisa Keating
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Al Prof Hernani Monteiro, 4200 319 Porto, Portugal
    Reprod Toxicol 28:511-20. 2009
    ..Our results suggest that inhibition of FA placental uptake may constitute one of the mechanisms involved in the fetotoxicity of many of the compounds tested...
  3. doi request reprint Comparison of the transport characteristics of bioactive substances in IUGR and normal placentas
    Elisa Keating
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Porto, Portugal
    Pediatr Res 66:495-500. 2009
    ..These results point to an effect of "compensation for the weakness" of the IUGR placenta and pose the placenta as an active mediator of the communication between maternal and fetal environments...
  4. ncbi request reprint Characteristics of thiamine uptake by the BeWo human trophoblast cell line
    Elisa Keating
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    J Biochem Mol Biol 39:383-93. 2006
    ..1 microM, respectively) inhibited (3)H-thiamine uptake, these effects being not mediated through modulation of the expression levels of either hThTr-1 or hSERT mRNA...
  5. ncbi request reprint Progesterone inhibits folic acid transport in human trophoblasts
    Elisa Keating
    Department of Biochemistry U38 FCT, Faculty of Medicine of Porto, University of Porto, Porto 4200 319, Portugal
    J Membr Biol 216:143-52. 2007
    ..These results suggest that progesterone inhibits RFC. In conclusion, our results show that progesterone, a sterol produced by the placenta, inhibits both FA uptake and efflux in BeWo cells and primary cultured human trophoblasts...
  6. ncbi request reprint Comparison of folic acid uptake characteristics by human placental choriocarcinoma cells at acidic and physiological pH
    Elisa Keating
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Porto 4200 319, Portugal
    Can J Physiol Pharmacol 84:247-55. 2006
    ..In conclusion, in BeWo cells, both RFC and receptor-mediated endocytosis seem to be involved in 3H-folic acid uptake at pH 7.5, whereas at pH 5.5, RFC and (or) a low pH-operating transporter distinct from RFC are involved...
  7. doi request reprint Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanism
    Liliana Moreira
    Department of Biochemistry U38 FCT, Faculty of Medicine of University of Porto, Alameda Prof Hernani Monteiro, 4200 319 Porto, Portugal
    Exp Cell Res 319:1784-95. 2013
    ..Our results implicate QUE and EGCG as metabolic antagonists in breast cancer cells, independently of estrogen signalling, and suggest that these flavonoids could serve as therapeutic agents/adjuvants even for ER-negative breast tumors. ..
  8. doi request reprint Folic acid uptake by the human syncytiotrophoblast is affected by gestational diabetes, hyperleptinemia, and TNF-α
    Joao R Araujo
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Porto, Portugal
    Pediatr Res 73:388-94. 2013
    ..Hence, in this work, we hypothesize that GDM may affect folic acid (FA) supply to the placenta and fetus...
  9. ncbi request reprint Uptake of (3)H-1-methyl-4-phenylpyridinium ((3)H-MPP(+)) by human intestinal Caco-2 cells is regulated by phosphorylation/dephosphorylation mechanisms
    Fatima Martel
    Department of Biochemistry, Faculty of Medicine, 4200 319 Porto, Portugal
    Biochem Pharmacol 63:1565-73. 2002
    ..Moreover, uptake of (3)H-MPP(+) by Caco-2 cells and by the extraneuronal monoamine transporter (EMT) are regulated in a very similar manner, suggesting an important participation of EMT in the intestinal uptake of this compound...
  10. doi request reprint Oxidative stress decreases uptake of neutral amino acids in a human placental cell line (BeWo cells)
    João Ricardo Araújo
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal Electronic address
    Reprod Toxicol 40:76-81. 2013
    ..In conclusion, a reduction in placental uptake of neutral amino acids may contribute to the deleterious effects of pregnancy disorders associated with OS. ..
  11. ncbi request reprint Acute effect of tea, wine, beer, and polyphenols on ecto-alkaline phosphatase activity in human vascular smooth muscle cells
    Maria R Negrão
    Department of Biochemistry, Faculty of Medicine U38 FCT, University of Porto, 4200 319 Porto, Portugal
    J Agric Food Chem 54:4982-8. 2006
    ..Although more studies must be done, the inhibition of AALTR ecto-ALP activity by polyphenolic compounds and polyphenol-containing beverages may contribute to their cardiovascular protective effects...