Ana Faria

Summary

Affiliation: University of Porto
Country: Portugal

Publications

  1. doi request reprint Flavonoid metabolites transport across a human BBB model
    Ana Faria
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal Chemistry Investigation Centre CIQ, Department of Chemistry, Faculty of Sciences, University of Porto, 4169 007 Porto, Portugal Faculty of Nutrition and Food Sciences, University of Porto, 4200 465 Porto, Portugal Electronic address
    Food Chem 149:190-6. 2014
  2. doi request reprint The bioactivity of pomegranate: impact on health and disease
    Ana Faria
    Biochemistry Department U38 FCT, Faculty of Medicine, University of Porto, 4200 319, Porto, Portugal
    Crit Rev Food Sci Nutr 51:626-34. 2011
  3. doi request reprint Insights into the putative catechin and epicatechin transport across blood-brain barrier
    Ana Faria
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Al Prof Hernani Monteiro, 4200 319 Porto, Portugal
    Food Funct 2:39-44. 2011
  4. pmc Intestinal oxidative state can alter nutrient and drug bioavailability
    Ana Faria
    University of Porto, Porto, Portugal
    Oxid Med Cell Longev 2:322-7. 2009
  5. doi request reprint Blueberry anthocyanins and pyruvic acid adducts: anticancer properties in breast cancer cell lines
    Ana Faria
    Department of Biochemistry U38 FCT, Faculty of Medicine of the University of Porto, 4200 319 Porto, Portugal
    Phytother Res 24:1862-9. 2010
  6. pmc Impact of culture media glucose levels on the intestinal uptake of organic cations
    Ana Faria
    Department of Biochemistry, Faculty of Medicine, University of Porto, Alameda Prof Hernani Monteiro, 4200 319, Porto, Portugal
    Cytotechnology 62:23-9. 2010
  7. doi request reprint Flavonoid transport across RBE4 cells: A blood-brain barrier model
    Ana Faria
    Department of Biochemistry, University of Porto, Portugal
    Cell Mol Biol Lett 15:234-41. 2010
  8. doi request reprint Absorption of anthocyanins through intestinal epithelial cells - Putative involvement of GLUT2
    Ana Faria
    Department of Chemistry, Chemistry Investigation Centre, University of Porto, Portugal
    Mol Nutr Food Res 53:1430-7. 2009
  9. ncbi request reprint Pomegranate juice effects on cytochrome P450S expression: in vivo studies
    Ana Faria
    Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal
    J Med Food 10:643-9. 2007
  10. ncbi request reprint Effect of pomegranate (Punica granatum) juice intake on hepatic oxidative stress
    Ana Faria
    Dept of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Al Prof Hernani Monteiro, 4200 319, Porto, Portugal
    Eur J Nutr 46:271-8. 2007

Collaborators

Detail Information

Publications24

  1. doi request reprint Flavonoid metabolites transport across a human BBB model
    Ana Faria
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal Chemistry Investigation Centre CIQ, Department of Chemistry, Faculty of Sciences, University of Porto, 4169 007 Porto, Portugal Faculty of Nutrition and Food Sciences, University of Porto, 4200 465 Porto, Portugal Electronic address
    Food Chem 149:190-6. 2014
    ..Overall, this work suggests that flavonoids are capable of crossing the BBB and reaching the central nervous system...
  2. doi request reprint The bioactivity of pomegranate: impact on health and disease
    Ana Faria
    Biochemistry Department U38 FCT, Faculty of Medicine, University of Porto, 4200 319, Porto, Portugal
    Crit Rev Food Sci Nutr 51:626-34. 2011
    ..In addition, pomegranate inhibits the activation of inflammatory pathways including, but not limited to, the NFκ-B pathway. Anti-cancer effects with the most impressive data have been demonstrated so far in prostate cancer...
  3. doi request reprint Insights into the putative catechin and epicatechin transport across blood-brain barrier
    Ana Faria
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Al Prof Hernani Monteiro, 4200 319 Porto, Portugal
    Food Funct 2:39-44. 2011
    ....
  4. pmc Intestinal oxidative state can alter nutrient and drug bioavailability
    Ana Faria
    University of Porto, Porto, Portugal
    Oxid Med Cell Longev 2:322-7. 2009
    ..The results indicate that modifications in the cellular oxidative state modulate MPP+ uptake by Caco-2 cells. Such modifications may reflect in changes of nutrient and drug bioavailability...
  5. doi request reprint Blueberry anthocyanins and pyruvic acid adducts: anticancer properties in breast cancer cell lines
    Ana Faria
    Department of Biochemistry U38 FCT, Faculty of Medicine of the University of Porto, 4200 319 Porto, Portugal
    Phytother Res 24:1862-9. 2010
    ..The anthocyanin-pyruvic acid adduct extract showed a more pronounced effect in MDA-MB-231, suggesting an effect independent of estrogen receptors...
  6. pmc Impact of culture media glucose levels on the intestinal uptake of organic cations
    Ana Faria
    Department of Biochemistry, Faculty of Medicine, University of Porto, Alameda Prof Hernani Monteiro, 4200 319, Porto, Portugal
    Cytotechnology 62:23-9. 2010
    ..Hence, results obtained in these conditions must be analysed with great care, since extracellular glucose levels may originate changes in organic cation nutrient and drug bioavailability...
  7. doi request reprint Flavonoid transport across RBE4 cells: A blood-brain barrier model
    Ana Faria
    Department of Biochemistry, University of Porto, Portugal
    Cell Mol Biol Lett 15:234-41. 2010
    ..This transport was not influenced by the presence of 0.1% ethanol. In conclusion, the tested flavonoids were capable of crossing this blood-brain barrier model...
  8. doi request reprint Absorption of anthocyanins through intestinal epithelial cells - Putative involvement of GLUT2
    Ana Faria
    Department of Chemistry, Chemistry Investigation Centre, University of Porto, Portugal
    Mol Nutr Food Res 53:1430-7. 2009
    ..However, the malvidin aglycone was tested and had no effect. In conclusion, anthocyanins could be absorbed through Caco-2 cells, and can interfere with their own transport and also with glucose intestinal uptake...
  9. ncbi request reprint Pomegranate juice effects on cytochrome P450S expression: in vivo studies
    Ana Faria
    Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal
    J Med Food 10:643-9. 2007
    ..Prevention of procarcinogen activation through CYP activity/expression inhibition may be involved in pomegranate juice's effect on tumor initiation, promotion, and progression...
  10. ncbi request reprint Effect of pomegranate (Punica granatum) juice intake on hepatic oxidative stress
    Ana Faria
    Dept of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Al Prof Hernani Monteiro, 4200 319, Porto, Portugal
    Eur J Nutr 46:271-8. 2007
    ..Additionally, RT-PCR results showed that GST and GS transcription were also decreased in this group. These results are compatible with a protective effect of PJ against systemic oxidative stress in mice...
  11. doi request reprint Methotrexate enhances 3T3-L1 adipocytes hypertrophy
    Claudia Marques
    Departamento de Bioquímica U38 FCT, Faculdade de Medicina, Universidade do Porto, Alameda Prof Hernani Monteiro, 4200 319, Oporto, Portugal
    Cell Biol Toxicol 29:293-302. 2013
    ..These results demonstrate that methotrexate interferes with adipocyte proliferation and promotes the hypertrophic growth of adipocytes. These molecular effects may have implications on metabolic profile of RA patients treated with MTX. ..
  12. doi request reprint Characterization and modulation of glucose uptake in a human blood-brain barrier model
    Manuela Meireles
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Al Prof Hernani Monteiro, 4200 319, Porto, Portugal
    J Membr Biol 246:669-77. 2013
    ..Quercetin and myricetin decreased [³H]-DG uptake, and glucuronic acid-conjugated quercetin did not have any effect. These cells expressed GLUT1, GLUT3 and SGLT1 mRNA...
  13. doi request reprint Enzymatic hemisynthesis of metabolites and conjugates of anthocyanins
    Iva Fernandes
    Chemistry Investigation Centre, Department of Chemistry, University of Porto, Portugal
    J Agric Food Chem 57:735-45. 2009
    ....
  14. doi request reprint Red wine interferes with oestrogen signalling in rat hippocampus
    Rosario Monteiro
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Alameda Prof Hernani Monteiro, 4200 319 Porto, Portugal
    J Steroid Biochem Mol Biol 111:74-9. 2008
    ..Alterations in the relative abundance of ER expression may also play an important role in the protection...
  15. ncbi request reprint Antioxidant properties of prepared blueberry (Vaccinium myrtillus) extracts
    Ana Faria
    Centro de Investigacao em Quimica, Universidade do Porto, Rua do Campo Alegre 687, 4169 007 Porto, Portugal
    J Agric Food Chem 53:6896-902. 2005
    ..In addition, the antiradical properties and the reducing power of the extracts were determined by using DPPH and FRAP methods, respectively. The results from these assays were in agreement with those obtained with the liposome membranes...
  16. doi request reprint Influence of anthocyanins, derivative pigments and other catechol and pyrogallol-type phenolics on breast cancer cell proliferation
    Iva Fernandes
    Chemistry Investigation Centre CIQ, Department of Chemistry, Faculty of Sciences, University of Porto, Porto, Portugal
    J Agric Food Chem 58:3785-92. 2010
    ..However, the anthocyanin Cy-3-gluc was able to induce a downregulation of ER levels although with no significant effect on MCF-7 proliferation...
  17. ncbi request reprint Procyanidins as antioxidants and tumor cell growth modulators
    Ana Faria
    Chemistry Investigation Centre, Department of Chemistry, Faculty of Sciences, University of Porto, 4169 007 Porto, Portugal
    J Agric Food Chem 54:2392-7. 2006
    ..It is interesting to notice that the procyanidin fractions that exhibited higher antioxidant activity were the same to affect cell viability and proliferation...
  18. ncbi request reprint Modulation of MPP+ uptake by procyanidins in Caco-2 cells: involvement of oxidation/reduction reactions
    Ana Faria
    Department of Biochemistry U38 FCT, Faculty of Medicine of the University of Porto, Al Prof Hernani Monteiro, 4200 319 Porto, Portugal
    FEBS Lett 580:155-60. 2006
    ..Interactions between these compounds and drugs present in the diet may affect their absorption and bioavailability. Both the concentration and complexity of the procyanidin compounds should be taken into account in medical practice...
  19. doi request reprint Thiamine is a substrate of organic cation transporters in Caco-2 cells
    Clara Lemos
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    Eur J Pharmacol 682:37-42. 2012
    ....
  20. doi request reprint Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanism
    Liliana Moreira
    Department of Biochemistry U38 FCT, Faculty of Medicine of University of Porto, Alameda Prof Hernani Monteiro, 4200 319 Porto, Portugal
    Exp Cell Res 319:1784-95. 2013
    ..Our results implicate QUE and EGCG as metabolic antagonists in breast cancer cells, independently of estrogen signalling, and suggest that these flavonoids could serve as therapeutic agents/adjuvants even for ER-negative breast tumors. ..
  21. ncbi request reprint Modulation of breast cancer cell survival by aromatase inhibiting hop (Humulus lupulus L.) flavonoids
    Rosario Monteiro
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Alameda Prof Hernani Monteiro, 4200 319 Porto, Portugal
    J Steroid Biochem Mol Biol 105:124-30. 2007
    ....
  22. doi request reprint Modulation of adipocyte biology by δ(9)-tetrahydrocannabinol
    Diana Teixeira
    Department of Biochemistry U38 FCT, Faculty of Medicine, University of Porto, Porto, Portugal
    Obesity (Silver Spring) 18:2077-85. 2010
    ..Although these observations point toward increased AT deposition, the stimulation of adiponectin production and inhibition of lipolysis may be in favor of improved INS sensitivity under cannabinoid influence...
  23. doi request reprint Optimization and validation of organochlorine compounds in adipose tissue by SPE-gas chromatography
    Virginia C Fernandes
    REQUIMTE, Instituto Superior de Engenharia, Instituto Politécnico do Porto, Rua Dr António Bernardino de Almeida 431, 4200 072, Porto, Portugal
    Biomed Chromatogr 26:1494-501. 2012
    ..The highest percentage found of the OCC in real samples corresponded to HCB, o,p'-DDT and methoxychlor, which were detected in 80 and 95% of samples analyzed respectively...
  24. ncbi request reprint Acute effect of tea, wine, beer, and polyphenols on ecto-alkaline phosphatase activity in human vascular smooth muscle cells
    Maria R Negrão
    Department of Biochemistry, Faculty of Medicine U38 FCT, University of Porto, 4200 319 Porto, Portugal
    J Agric Food Chem 54:4982-8. 2006
    ..Although more studies must be done, the inhibition of AALTR ecto-ALP activity by polyphenolic compounds and polyphenol-containing beverages may contribute to their cardiovascular protective effects...