M Fardilha

Summary

Affiliation: University of Aveiro
Country: Portugal

Publications

  1. pmc An intriguing shift occurs in the novel protein phosphatase 1 binding partner, TCTEX1D4: evidence of positive selection in a pika model
    Luís Korrodi-Gregório
    Laboratory of Signal Transduction, Centre for Cell Biology, Health Sciences Department and Biology Department, University of Aveiro, Aveiro, Portugal
    PLoS ONE 8:e77236. 2013
  2. pmc TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network
    Luís Korrodi-Gregório
    Laboratory of Signal Transduction, Centre for Cell Biology, Biology Department, University of Aveiro, 3810 193 Aveiro, Portugal
    Biol Open 2:453-65. 2013
  3. ncbi request reprint Protein phosphatase 1 and its complexes in carcinogenesis
    João Figueiredo
    Centro de Biologia Celular, Universidade de Aveiro, 3810 193 Aveiro, Portugal
    Curr Cancer Drug Targets 14:2-29. 2014
  4. pmc "Omics" of human sperm: profiling protein phosphatases
    Margarida Fardilha
    Centro de Biologia Celular, Secção Autónoma de Ciências da Saúde, Departamento de Biologia, Universidade de Aveiro, Aveiro, Portugal
    OMICS 17:460-72. 2013
  5. pmc Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa
    Luís Korrodi-Gregório
    Laboratory of Signal Transduction, Centre for Cell Biology, Biology Department, University of Aveiro, 3810 193 Aveiro, Portugal
    BMC Cell Biol 14:15. 2013
  6. pmc The heterogeneous ribonuclear protein C interacts with the hepatitis delta virus small antigen
    Ana Casaca
    Unidade de Microbiologia Médica, Centro de Malaria e Outras Doencas Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal
    Virol J 8:358. 2011
  7. doi request reprint Understanding fatty acid metabolism through an active learning approach
    M Fardilha
    Centro de Biologia Celular, Universidade de Aveiro, Aveiro, Portugal Secção Autónoma de Ciências da Saúde, Universidade de Aveiro, Aveiro, Portugal
    Biochem Mol Biol Educ 38:65-9. 2010
  8. doi request reprint Identification of the human testis protein phosphatase 1 interactome
    Margarida Fardilha
    Signal Transduction Laboratory, Centre for Cell Biology, Biology Department, University of Aveiro, 3810 193 Aveiro, Portugal
    Biochem Pharmacol 82:1403-15. 2011
  9. doi request reprint Protein phosphatase 1 complexes modulate sperm motility and present novel targets for male infertility
    Margarida Fardilha
    Signal Transduction Laboratory, Centre for Cell Biology, Health Sciences Department and Biology Department, University of Aveiro, Campus de Santiago, 3810 193 Aveiro, Portugal
    Mol Hum Reprod 17:466-77. 2011
  10. ncbi request reprint The physiological relevance of protein phosphatase 1 and its interacting proteins to health and disease
    M Fardilha
    Centre for Cell Biology, University of Aveiro, Aveiro, Portugal
    Curr Med Chem 17:3996-4017. 2010

Collaborators

  • Steven Pelech
  • O A B da Cruz e Silva
  • Pedro J Esteves
  • Patricia T W Cohen
  • M Schrader
  • Mario Sousa
  • Luís Korrodi-Gregório
  • Edgar F da Cruz e Silva
  • João Figueiredo
  • Sara L C Esteves
  • Ana Casaca
  • Monica Ferreira
  • Ana Margarida Lopes
  • Ana Lemos de Matos
  • Maria João Freitas
  • Joana Abrantes
  • Ana Paula Vintém
  • Sandra Afonso
  • Katrin Marcus
  • Andrey A Lissovsky
  • Srinivasan Vijayaraghavan
  • Georg Lüers
  • David L Brautigan
  • Ann Kristin Brauns
  • Joana V Silva
  • Sandra I Vieira
  • Wenjuan Wu
  • Thorsten Müller
  • Edgar da Cruz E Silva
  • Celso Cunha

Detail Information

Publications10

  1. pmc An intriguing shift occurs in the novel protein phosphatase 1 binding partner, TCTEX1D4: evidence of positive selection in a pika model
    Luís Korrodi-Gregório
    Laboratory of Signal Transduction, Centre for Cell Biology, Health Sciences Department and Biology Department, University of Aveiro, Aveiro, Portugal
    PLoS ONE 8:e77236. 2013
    ..These observations suggest pika as an ideal model to study novel PPP1 complexes regulatory mechanisms. ..
  2. pmc TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network
    Luís Korrodi-Gregório
    Laboratory of Signal Transduction, Centre for Cell Biology, Biology Department, University of Aveiro, 3810 193 Aveiro, Portugal
    Biol Open 2:453-65. 2013
    ..In essence TCTEX1D4/PPP1C complex appears to be involved in microtubule dynamics, sperm motility, acrosome reaction and in the regulation of the blood-testis barrier. ..
  3. ncbi request reprint Protein phosphatase 1 and its complexes in carcinogenesis
    João Figueiredo
    Centro de Biologia Celular, Universidade de Aveiro, 3810 193 Aveiro, Portugal
    Curr Cancer Drug Targets 14:2-29. 2014
    ..Furthermore, the possibility of PPP1/PIP complexes being considered novel targets to cancer diagnostic and therapy will be addressed. ..
  4. pmc "Omics" of human sperm: profiling protein phosphatases
    Margarida Fardilha
    Centro de Biologia Celular, Secção Autónoma de Ciências da Saúde, Departamento de Biologia, Universidade de Aveiro, Aveiro, Portugal
    OMICS 17:460-72. 2013
    ..These findings contribute to a comprehensive understanding of human sperm PPs, and warrant further research for their clinical and therapeutic significance...
  5. pmc Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa
    Luís Korrodi-Gregório
    Laboratory of Signal Transduction, Centre for Cell Biology, Biology Department, University of Aveiro, 3810 193 Aveiro, Portugal
    BMC Cell Biol 14:15. 2013
    ..Preliminary results have shown a protein phosphatase inhibitor activity resembling PPP1R2 in bovine and primate spermatozoa...
  6. pmc The heterogeneous ribonuclear protein C interacts with the hepatitis delta virus small antigen
    Ana Casaca
    Unidade de Microbiologia Médica, Centro de Malaria e Outras Doencas Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal
    Virol J 8:358. 2011
    ..Despite its simplicity, little is still known about the host factors that interact with the virus RNA and antigens being to modulate virus replication...
  7. doi request reprint Understanding fatty acid metabolism through an active learning approach
    M Fardilha
    Centro de Biologia Celular, Universidade de Aveiro, Aveiro, Portugal Secção Autónoma de Ciências da Saúde, Universidade de Aveiro, Aveiro, Portugal
    Biochem Mol Biol Educ 38:65-9. 2010
    ..Our initial analysis of the learning outcomes permits us to conclude that the approach undertaken yields results that surpass the traditional teaching methods...
  8. doi request reprint Identification of the human testis protein phosphatase 1 interactome
    Margarida Fardilha
    Signal Transduction Laboratory, Centre for Cell Biology, Biology Department, University of Aveiro, 3810 193 Aveiro, Portugal
    Biochem Pharmacol 82:1403-15. 2011
    ..In fact, such diversity in PP1 regulators makes them excellent targets for pharmacological intervention...
  9. doi request reprint Protein phosphatase 1 complexes modulate sperm motility and present novel targets for male infertility
    Margarida Fardilha
    Signal Transduction Laboratory, Centre for Cell Biology, Health Sciences Department and Biology Department, University of Aveiro, Campus de Santiago, 3810 193 Aveiro, Portugal
    Mol Hum Reprod 17:466-77. 2011
    ..Furthermore, the potential relevance of targeting PP1-PIPs complexes to infertility diagnostics and therapeutics as well as to male contraception is also discussed...
  10. ncbi request reprint The physiological relevance of protein phosphatase 1 and its interacting proteins to health and disease
    M Fardilha
    Centre for Cell Biology, University of Aveiro, Aveiro, Portugal
    Curr Med Chem 17:3996-4017. 2010
    ..Further, it compiles 129 PP1-PIP relevant physiological interactions that are well documented in the literature. Finally, the use of PIPs as therapeutic targets will be addressed...