Affiliation: University of Aveiro
- Fardilha M, Esteves S, Korrodi Gregório L, Vintém A, Domingues S, Rebelo S, et al. Identification of the human testis protein phosphatase 1 interactome. Biochem Pharmacol. 2011;82:1403-15 pubmed publisher..In fact, such diversity in PP1 regulators makes them excellent targets for pharmacological intervention. ..
- Silva J, Yoon S, De Bock P, Goltsev A, Gevaert K, Mendes J, et al. Construction and analysis of a human testis/sperm-enriched interaction network: Unraveling the PPP1CC2 interactome. Biochim Biophys Acta Gen Subj. 2017;1861:375-385 pubmed publisher..We demonstrated for the first time the interaction between PPP1CC2 and AKAP4 in human spermatozoa and the potential of the complex as contraceptive target. ..
- Korrodi Gregório L, Abrantes J, Müller T, Melo Ferreira J, Marcus K, da Cruz e Silva O, et al. Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes. BMC Evol Biol. 2013;13:242 pubmed publisher..The results show that contrary to initial observations PPP1R2-related pseudogenes are not simple bystanders of the evolutionary process but may rather be at the origin of genes with novel functions. ..
- Korrodi Gregório L, Ferreira M, Vintém A, Wu W, Müller T, Marcus K, et al. Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa. BMC Cell Biol. 2013;14:15 pubmed publisher..An intriguing possibility is that a switch in PPP1CC2 inhibitory subunits could be the trigger for sperm motility in the epididymis and/or sperm hyperactivation in the female reproductive tract. ..