O A B da Cruz e Silva

Summary

Affiliation: University of Aveiro
Country: Portugal

Publications

  1. pmc Complexing Aβ prevents the cellular anomalies induced by the Peptide alone
    A G Henriques
    Laboratorio de Neurociencias, Centro de Biologia Celular, SACS, Universidade de Aveiro, Aveiro, Portugal
    J Mol Neurosci 53:661-8. 2014
  2. pmc Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes
    Luís Korrodi-Gregório
    CIBIO UP, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Universidade do Porto, InBIO, Laboratório Associado, Campus Agrário de Vairão, Vairao, Portugal
    BMC Evol Biol 13:242. 2013
  3. pmc Alphabeta hinders nuclear targeting of AICD and Fe65 in primary neuronal cultures
    A G Henriques
    Laboratorio de Neurociencias, Centro de Biologia Celular, SACS, Universidade de Aveiro, Campus de Santiago, Aveiro, Portugal
    J Mol Neurosci 39:248-55. 2009
  4. pmc Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa
    Luís Korrodi-Gregório
    Laboratory of Signal Transduction, Centre for Cell Biology, Biology Department, University of Aveiro, 3810 193 Aveiro, Portugal
    BMC Cell Biol 14:15. 2013
  5. ncbi request reprint Wnt signalling is a relevant pathway contributing to amyloid beta- peptide-mediated neuropathology in Alzheimer's disease
    Odete A B da Cruz e Silva
    Laboratorio de Neurociencias, Centro de Biologia Celular, Secção Autónoma de Ciências da Saúde, Universidade de Aveiro, 3810 193 Aveiro, Portugal
    CNS Neurol Disord Drug Targets 9:720-6. 2010
  6. pmc Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C
    Odete A B da Cruz e Silva
    Laboratorio de Neurociencias, Centro de Biologia Celular, Universidade de Aveiro, Aveiro, Portugal
    J Neurochem 108:319-30. 2009
  7. pmc Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated
    Sandra I Vieira
    Neuroscience, Centre for Cell Biology, Health Sciences Department SACS, University of Aveiro, Aveiro 3810, Portugal
    Mol Neurodegener 5:40. 2010
  8. ncbi request reprint In vitro performance assessment of new brushite-forming Zn- and ZnSr-substituted beta-TCP bone cements
    S Pina
    Department of Ceramics and Glass Engineering, University of Aveiro, CICECO, 3810 193 Aveiro, Portugal
    J Biomed Mater Res B Appl Biomater 94:414-20. 2010
  9. ncbi request reprint Synthesis, mechanical and biological characterization of ionic doped carbonated hydroxyapatite/β-tricalcium phosphate mixtures
    S Kannan
    Department of Ceramics and Glass Engineering, University of Aveiro, CICECO, Aveiro, Portugal
    Acta Biomater 7:1835-43. 2011
  10. ncbi request reprint Biological responses of brushite-forming Zn- and ZnSr- substituted beta-tricalcium phosphate bone cements
    S Pina
    Dept of Ceramics and Glass Engineering, University of Aveiro, CICECO, 3810 193 Aveiro, Portugal
    Eur Cell Mater 20:162-77. 2010

Collaborators

  • S Pina
  • J M Oliveira
  • James Lah
  • S Kannan
  • M Fardilha
  • Jens Wiltfang
  • Luís Korrodi-Gregório
  • A G Henriques
  • Katrin Marcus
  • Thorsten Müller
  • E F da Cruz e Silva
  • Edgar F da Cruz e Silva
  • Sandra I Vieira
  • R Ruivo
  • B Gomes
  • José Melo-Ferreira
  • Ana Paula Vintém
  • Monica Ferreira
  • Srinivasan Vijayaraghavan
  • David L Brautigan
  • Wenjuan Wu
  • Joana Abrantes
  • Pedro J Esteves
  • Sam Gandy
  • Sandra Rebelo
  • Scott A Small
  • Rachel Lane
  • Hermann Esselmann
  • S I Vieira

Detail Information

Publications11

  1. pmc Complexing Aβ prevents the cellular anomalies induced by the Peptide alone
    A G Henriques
    Laboratorio de Neurociencias, Centro de Biologia Celular, SACS, Universidade de Aveiro, Aveiro, Portugal
    J Mol Neurosci 53:661-8. 2014
    ..In hence, given that Aβ decreases the levels of proteins involved in its own clearance, this may contribute to the mechanisms underlying AD pathology...
  2. pmc Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes
    Luís Korrodi-Gregório
    CIBIO UP, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Universidade do Porto, InBIO, Laboratório Associado, Campus Agrário de Vairão, Vairao, Portugal
    BMC Evol Biol 13:242. 2013
    ..This is the case of the Protein phosphatase 1 regulatory subunit 2 (PPP1R2) or inhibitor-2 gene family, for which several incomplete copies exist scattered throughout the genome...
  3. pmc Alphabeta hinders nuclear targeting of AICD and Fe65 in primary neuronal cultures
    A G Henriques
    Laboratorio de Neurociencias, Centro de Biologia Celular, SACS, Universidade de Aveiro, Campus de Santiago, Aveiro, Portugal
    J Mol Neurosci 39:248-55. 2009
    ..In effect, Abeta can trigger a physiological negative feedback mechanism that modulates its own production...
  4. pmc Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa
    Luís Korrodi-Gregório
    Laboratory of Signal Transduction, Centre for Cell Biology, Biology Department, University of Aveiro, 3810 193 Aveiro, Portugal
    BMC Cell Biol 14:15. 2013
    ..Preliminary results have shown a protein phosphatase inhibitor activity resembling PPP1R2 in bovine and primate spermatozoa...
  5. ncbi request reprint Wnt signalling is a relevant pathway contributing to amyloid beta- peptide-mediated neuropathology in Alzheimer's disease
    Odete A B da Cruz e Silva
    Laboratorio de Neurociencias, Centro de Biologia Celular, Secção Autónoma de Ciências da Saúde, Universidade de Aveiro, 3810 193 Aveiro, Portugal
    CNS Neurol Disord Drug Targets 9:720-6. 2010
    ..Consequently this peptide and the downstream signalling cascades are presently considered as potential therapeutic targets...
  6. pmc Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C
    Odete A B da Cruz e Silva
    Laboratorio de Neurociencias, Centro de Biologia Celular, Universidade de Aveiro, Aveiro, Portugal
    J Neurochem 108:319-30. 2009
    ..These data have implications for the design of amyloid-lowering strategies based on modulating PKC activity...
  7. pmc Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated
    Sandra I Vieira
    Neuroscience, Centre for Cell Biology, Health Sciences Department SACS, University of Aveiro, Aveiro 3810, Portugal
    Mol Neurodegener 5:40. 2010
    ..Further, the motif(s) in APP that regulate its sorting to the TGN have not been characterized...
  8. ncbi request reprint In vitro performance assessment of new brushite-forming Zn- and ZnSr-substituted beta-TCP bone cements
    S Pina
    Department of Ceramics and Glass Engineering, University of Aveiro, CICECO, 3810 193 Aveiro, Portugal
    J Biomed Mater Res B Appl Biomater 94:414-20. 2010
    ..Human osteosarcoma-derived MG63 cell line proved the nontoxicity of the cement powders, using the resazurin metabolic assay...
  9. ncbi request reprint Synthesis, mechanical and biological characterization of ionic doped carbonated hydroxyapatite/β-tricalcium phosphate mixtures
    S Kannan
    Department of Ceramics and Glass Engineering, University of Aveiro, CICECO, Aveiro, Portugal
    Acta Biomater 7:1835-43. 2011
    ..Further, the powders enable pre-osteoblastic differentiation in a similar manner to control cells, as indirectly measured by ALP activity and Type-I collagen medium secretion...
  10. ncbi request reprint Biological responses of brushite-forming Zn- and ZnSr- substituted beta-tricalcium phosphate bone cements
    S Pina
    Dept of Ceramics and Glass Engineering, University of Aveiro, CICECO, 3810 193 Aveiro, Portugal
    Eur Cell Mater 20:162-77. 2010
    ..These novel results indicate that the investigated ZnCPC and ZnSrCPC cements are both biocompatible and osteoconductive, being good candidate materials to use as bone substitutes...
  11. doi request reprint Understanding fatty acid metabolism through an active learning approach
    M Fardilha
    Centro de Biologia Celular, Universidade de Aveiro, Aveiro, Portugal Secção Autónoma de Ciências da Saúde, Universidade de Aveiro, Aveiro, Portugal
    Biochem Mol Biol Educ 38:65-9. 2010
    ..Our initial analysis of the learning outcomes permits us to conclude that the approach undertaken yields results that surpass the traditional teaching methods...