Paulo César Bessa

Summary

Affiliation: University of Minho
Country: Portugal

Publications

  1. ncbi Osteoinduction in human fat-derived stem cells by recombinant human bone morphogenetic protein-2 produced in Escherichia coli
    Paulo C Bessa
    3B s Research Group Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Biotechnol Lett 30:15-21. 2008
  2. ncbi Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts)
    P C Bessa
    3Bs Research Group, Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    J Tissue Eng Regen Med 2:1-13. 2008
  3. ncbi Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery)
    P C Bessa
    3Bs Research Group, Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Campus de Gualtar, Braga, Portugal
    J Tissue Eng Regen Med 2:81-96. 2008
  4. ncbi Expression, purification and osteogenic bioactivity of recombinant human BMP-4, -9, -10, -11 and -14
    P C Bessa
    3B s Research Group Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimaraes, Portugal
    Protein Expr Purif 63:89-94. 2009
  5. ncbi Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs
    Paulo C Bessa
    3B s Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark, 4806 909 Taipas, Guimaraes, Portugal
    J Control Release 142:312-8. 2010
  6. ncbi Silk fibroin microparticles as carriers for delivery of human recombinant bone morphogenetic protein-2: in vitro and in vivo bioactivity
    Paulo César Bessa
    3B s Research Group Biomaterials, Biodegradables, and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Guimaraes, Portugal
    Tissue Eng Part C Methods 16:937-45. 2010
  7. ncbi Silk fibroin microparticles as carriers for delivery of human recombinant BMPs. Physical characterization and drug release
    P C Bessa
    3B s Research Group Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Ave Park, 4806 909 Taipas, Guimaraes, Portugal
    J Tissue Eng Regen Med 4:349-55. 2010

Detail Information

Publications7

  1. ncbi Osteoinduction in human fat-derived stem cells by recombinant human bone morphogenetic protein-2 produced in Escherichia coli
    Paulo C Bessa
    3B s Research Group Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Biotechnol Lett 30:15-21. 2008
    ..Bioassays performed in human fat-derived stem cells showed an increased activity of the early osteogenic marker, alkaline phosphatase, and the absence of cytotoxicity...
  2. ncbi Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts)
    P C Bessa
    3Bs Research Group, Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    J Tissue Eng Regen Med 2:1-13. 2008
    ..The purpose of this review is to cover the biological function of the main members of BMP family, the latest research on BMPs signalling pathways and advances in the production of recombinant BMPs for tissue engineering purposes...
  3. ncbi Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery)
    P C Bessa
    3Bs Research Group, Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Campus de Gualtar, Braga, Portugal
    J Tissue Eng Regen Med 2:81-96. 2008
    ..Considering the expanding number of publications in the field of BMPs, there are prospects of a brilliant future in the field of regenerative medicine of bone and cartilage with the use of BMPs...
  4. ncbi Expression, purification and osteogenic bioactivity of recombinant human BMP-4, -9, -10, -11 and -14
    P C Bessa
    3B s Research Group Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimaraes, Portugal
    Protein Expr Purif 63:89-94. 2009
    ..The described approach is a promising method for producing large amounts of different recombinant BMPs that show potential for novel biomedical applications...
  5. ncbi Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs
    Paulo C Bessa
    3B s Research Group, Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark, 4806 909 Taipas, Guimaraes, Portugal
    J Control Release 142:312-8. 2010
    ..Increased bioactivity was observed with a combined release of BMP-2 and BMP-14. This approach shows a significant potential for future tissue engineering applications in bone...
  6. ncbi Silk fibroin microparticles as carriers for delivery of human recombinant bone morphogenetic protein-2: in vitro and in vivo bioactivity
    Paulo César Bessa
    3B s Research Group Biomaterials, Biodegradables, and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Guimaraes, Portugal
    Tissue Eng Part C Methods 16:937-45. 2010
    ..Our findings show that fibroin microparticles may present an interesting option for future clinical applications in the bone tissue engineering field, and therefore, further studies have been planned...
  7. ncbi Silk fibroin microparticles as carriers for delivery of human recombinant BMPs. Physical characterization and drug release
    P C Bessa
    3B s Research Group Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Ave Park, 4806 909 Taipas, Guimaraes, Portugal
    J Tissue Eng Regen Med 4:349-55. 2010
    ..Silk fibroin microparticles can offer a promising approach for the sustained delivery of different BMPs in tissue engineering applications...