Cecilia M Arraiano


Affiliation: Universidade Nova de Lisboa
Country: Portugal


  1. Mil Homens D, Barahona S, Moreira R, Silva I, Pinto S, Fialho A, et al. Stress Response Protein BolA Influences Fitness and Promotes Salmonella enterica Serovar Typhimurium Virulence. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..Therefore, this study is of utmost importance for understanding the genetic and molecular bases involved in the regulation of Salmonella virulence and may contribute to future industrial and public health care applications. ..
  2. Pobre V, Arraiano C. Characterizing the Role of Exoribonucleases in the Control of Microbial Gene Expression: Differential RNA-Seq. Methods Enzymol. 2018;612:1-24 pubmed publisher
    ..Although the methods described in this chapter were applied to the study of the exoribonucleases, they can also be used for other differential RNA-Seq studies. ..
  3. Dressaire C, Pobre V, Laguerre S, Girbal L, Arraiano C, Cocaign Bousquet M. PNPase is involved in the coordination of mRNA degradation and expression in stationary phase cells of Escherichia coli. BMC Genomics. 2018;19:848 pubmed publisher
    ..This work had identified PNPase as a central player associated with mRNA degradation in stationary phase. ..
  4. Saramago M, Bárria C, Arraiano C, Domingues S. Ribonucleases, antisense RNAs and the control of bacterial plasmids. Plasmid. 2015;78:26-36 pubmed publisher
    ..In this review we highlight the role of RNases in the precise modulation of antisense RNAs that control plasmid replication, maintenance and transfer. ..
  5. Domingues S, Moreira R, Andrade J, Dos Santos R, Bárria C, Viegas S, et al. The role of RNase R in trans-translation and ribosomal quality control. Biochimie. 2015;114:113-8 pubmed publisher
    ..RNase R is thus emerging as a key factor in ensuring translation accuracy. This review focuses on issues related to the quality control of translation, with special emphasis on the role of RNase R. ..
  6. request reprint
    Arraiano C, Matos R, Barbas A. RNase II: the finer details of the Modus operandi of a molecular killer. RNA Biol. 2010;7:276-81 pubmed
    ..coli RNase II but the synergies between the functional and structural studies have shown that our findings have implications in the understanding the similar mode of action of other RNase II family members. ..
  7. Arraiano C, Andrade J, Domingues S, Guinote I, Malecki M, Matos R, et al. The critical role of RNA processing and degradation in the control of gene expression. FEMS Microbiol Rev. 2010;34:883-923 pubmed publisher
    ..In general, RNases act as a global regulatory network extremely important for the regulation of RNA levels. ..
  8. Casinhas J, Matos R, Haddad N, Arraiano C. Biochemical characterization of Campylobacter jejuni PNPase, an exoribonuclease important for bacterial pathogenicity. Biochimie. 2018;147:70-79 pubmed publisher
    ..These findings will be helpful to develop new strategies for fighting against C. jejuni and may be extrapolated to other foodborne pathogens. ..
  9. Malecki M, Bárria C, Arraiano C. Characterization of the RNase R association with ribosomes. BMC Microbiol. 2014;14:34 pubmed publisher
    ..This study leads us to conclude that RNase R can interact with ribosomal proteins and that this interaction may be a result of this enzyme involvement in the ribosome quality control. ..

More Information


  1. Dressaire C, Moreira R, Barahona S, Alves de Matos A, Arraiano C. BolA is a transcriptional switch that turns off motility and turns on biofilm development. MBio. 2015;6:e02352-14 pubmed publisher
    ..The molecular studies of different lifestyles coupled with the comprehension of the BolA functions may be an important step for future perspectives, with health care and biotechnology applications. ..
  2. Pobre V, Arraiano C. Next generation sequencing analysis reveals that the ribonucleases RNase II, RNase R and PNPase affect bacterial motility and biofilm formation in E. coli. BMC Genomics. 2015;16:72 pubmed publisher
    ..Our results show that the three exoribonucleases affect cell motility and biofilm formation that are two very important factors for cell survival, especially for pathogenic cells. ..