Sandra Tenreiro

Summary

Country: Portugal

Publications

  1. ncbi The multidrug resistance transporters of the major facilitator superfamily, 6 years after disclosure of Saccharomyces cerevisiae genome sequence
    Isabel Sá-Correia
    Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisboa, Portugal
    J Biotechnol 98:215-26. 2002
  2. ncbi The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinant of resistance to quinidine, barban, cisplatin, and bleomycin
    Sandra Tenreiro
    Biological Sciences Research Group, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
    Biochem Biophys Res Commun 327:952-9. 2005
  3. ncbi Saccharomyces cerevisiae multidrug resistance transporter Qdr2 is implicated in potassium uptake, providing a physiological advantage to quinidine-stressed cells
    Rita C Vargas
    IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisboa, Portugal
    Eukaryot Cell 6:134-42. 2007
  4. ncbi Yeast response and tolerance to polyamine toxicity involving the drug : H+ antiporter Qdr3 and the transcription factors Yap1 and Gcn4
    Miguel C Teixeira
    Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, 1049 001 Lisboa, Portugal
    Microbiology 157:945-56. 2011
  5. ncbi Saccharomyces cerevisiae multidrug transporter Qdr2p (Yil121wp): localization and function as a quinidine resistance determinant
    Rita C Vargas
    Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
    Antimicrob Agents Chemother 48:2531-7. 2004
  6. ncbi Adaptive response to the antimalarial drug artesunate in yeast involves Pdr1p/Pdr3p-mediated transcriptional activation of the resistance determinants TPO1 and PDR5
    Marta Alenquer
    Biological Sciences Research Group, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Lisbon, Portugal
    FEMS Yeast Res 6:1130-9. 2006
  7. ncbi AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae
    Sandra Tenreiro
    Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Avenida Rovisco Pais, 1049 001 Lisbon, Portugal
    Biochem Biophys Res Commun 292:741-8. 2002
  8. ncbi Transcriptomic profiling of the Saccharomyces cerevisiae response to quinine reveals a glucose limitation response attributable to drug-induced inhibition of glucose uptake
    Sandra C dos Santos
    Institute for Biotechnology and Bioengineering IBB, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisbon, Portugal
    Antimicrob Agents Chemother 53:5213-23. 2009

Collaborators

Detail Information

Publications8

  1. ncbi The multidrug resistance transporters of the major facilitator superfamily, 6 years after disclosure of Saccharomyces cerevisiae genome sequence
    Isabel Sá-Correia
    Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisboa, Portugal
    J Biotechnol 98:215-26. 2002
    ..Most of the present knowledge on these putative drug:H(+)-antiporters was driven by disclosure of S. cerevisiae genome sequence, in April 1996, being a paradigm of post-genomic research...
  2. ncbi The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinant of resistance to quinidine, barban, cisplatin, and bleomycin
    Sandra Tenreiro
    Biological Sciences Research Group, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
    Biochem Biophys Res Commun 327:952-9. 2005
    ....
  3. ncbi Saccharomyces cerevisiae multidrug resistance transporter Qdr2 is implicated in potassium uptake, providing a physiological advantage to quinidine-stressed cells
    Rita C Vargas
    IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisboa, Portugal
    Eukaryot Cell 6:134-42. 2007
    ..Second, the amino acid pool is higher in Deltaqdr2 cells than in wild-type cells, indicating that QDR2 expression is, directly or indirectly, involved in amino acid homeostasis...
  4. ncbi Yeast response and tolerance to polyamine toxicity involving the drug : H+ antiporter Qdr3 and the transcription factors Yap1 and Gcn4
    Miguel C Teixeira
    Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, 1049 001 Lisboa, Portugal
    Microbiology 157:945-56. 2011
    ....
  5. ncbi Saccharomyces cerevisiae multidrug transporter Qdr2p (Yil121wp): localization and function as a quinidine resistance determinant
    Rita C Vargas
    Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
    Antimicrob Agents Chemother 48:2531-7. 2004
    ..Although QDR2 transcription was not enhanced in response to quinidine, the results confirmed that Qdr2p is involved in the active export of quinidine out of the cell, thus conferring resistance to the drug...
  6. ncbi Adaptive response to the antimalarial drug artesunate in yeast involves Pdr1p/Pdr3p-mediated transcriptional activation of the resistance determinants TPO1 and PDR5
    Marta Alenquer
    Biological Sciences Research Group, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Lisbon, Portugal
    FEMS Yeast Res 6:1130-9. 2006
    ..Maximum TPO1 mRNA levels were rapidly reduced to basal values following adaptation of the yeast population to artesunate, while high PDR5 levels were maintained during drug-stressed exponential growth...
  7. ncbi AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae
    Sandra Tenreiro
    Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Avenida Rovisco Pais, 1049 001 Lisbon, Portugal
    Biochem Biophys Res Commun 292:741-8. 2002
    ..The encoded putative transporter was localized in the plasma membrane by fluorescence microscopy observation of the overproduced Aqr1-GFP fusion protein distribution...
  8. ncbi Transcriptomic profiling of the Saccharomyces cerevisiae response to quinine reveals a glucose limitation response attributable to drug-induced inhibition of glucose uptake
    Sandra C dos Santos
    Institute for Biotechnology and Bioengineering IBB, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisbon, Portugal
    Antimicrob Agents Chemother 53:5213-23. 2009
    ..We propose that PfHT1 is an interesting candidate quinine target possibly involved in quinine import in P. falciparum, an uptake mechanism postulated in recent studies to occur through a still-unidentified importer(s)...