Manuel R Teixeira

Summary

Country: Portugal

Publications

  1. pmc Potential downstream target genes of aberrant ETS transcription factors are differentially affected in Ewing's sarcoma and prostate carcinoma
    Maria J Camões
    Department of Genetics, Portuguese Oncology Institute Porto, Porto, Portugal
    PLoS ONE 7:e49819. 2012
  2. pmc Cysteine-rich secretory protein-3 (CRISP3) is strongly up-regulated in prostate carcinomas with the TMPRSS2-ERG fusion gene
    Franclim R Ribeiro
    Department of Genetics, Portuguese Oncology Institute Porto, Porto, Portugal
    PLoS ONE 6:e22317. 2011
  3. pmc Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patients
    J D Barros-Silva
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Br J Cancer 100:487-93. 2009
  4. pmc Li-Fraumeni-like syndrome associated with a large BRCA1 intragenic deletion
    Amanda Gonçalves Silva
    International Center for Research and Training, A C Camargo Cancer Hospital, Sao Paulo, Brazil
    BMC Cancer 12:237. 2012
  5. pmc Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci
    Marianne Berg
    Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway
    Mol Cancer 9:100. 2010
  6. doi request reprint Feasibility of differential diagnosis of kidney tumors by comparative genomic hybridization of fine needle aspiration biopsies
    Joana Vieira
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Genes Chromosomes Cancer 49:935-47. 2010
  7. doi request reprint FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer
    Paula Paulo
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Genes Chromosomes Cancer 51:240-9. 2012
  8. ncbi request reprint Overexpression of the mitotic checkpoint genes BUB1 and BUBR1 is associated with genomic complexity in clear cell kidney carcinomas
    Mafalda Pinto
    Department of Genetics, Portuguese Oncology Institute, 4200 072 Porto, Portugal
    Cell Oncol 30:389-95. 2008
  9. pmc Chromosome copy number changes carry prognostic information independent of KIT/PDGFRA point mutations in gastrointestinal stromal tumors
    Mara Silva
    Department of Genetics, Portuguese Oncology Institute Porto, Rua Dr, António Bernardino Almeida, 4200 072 Porto, Portugal
    BMC Med 8:26. 2010
  10. doi request reprint A novel exonic rearrangement affecting MLH1 and the contiguous LRRFIP2 is a founder mutation in Portuguese Lynch syndrome families
    Manuela Pinheiro
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Genet Med 13:895-902. 2011

Detail Information

Publications72

  1. pmc Potential downstream target genes of aberrant ETS transcription factors are differentially affected in Ewing's sarcoma and prostate carcinoma
    Maria J Camões
    Department of Genetics, Portuguese Oncology Institute Porto, Porto, Portugal
    PLoS ONE 7:e49819. 2012
    ..We conclude that aberrant ETS transcription factors modulate target genes differently in ESFT and PCa...
  2. pmc Cysteine-rich secretory protein-3 (CRISP3) is strongly up-regulated in prostate carcinomas with the TMPRSS2-ERG fusion gene
    Franclim R Ribeiro
    Department of Genetics, Portuguese Oncology Institute Porto, Porto, Portugal
    PLoS ONE 6:e22317. 2011
    ..In particular, we show that CRISP3 is a direct target of ERG that is strongly overexpressed in PCa with the TMPRSS2-ERG fusion gene...
  3. pmc Association of ERBB2 gene status with histopathological parameters and disease-specific survival in gastric carcinoma patients
    J D Barros-Silva
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Br J Cancer 100:487-93. 2009
    ....
  4. pmc Li-Fraumeni-like syndrome associated with a large BRCA1 intragenic deletion
    Amanda Gonçalves Silva
    International Center for Research and Training, A C Camargo Cancer Hospital, Sao Paulo, Brazil
    BMC Cancer 12:237. 2012
    ..Germline point mutations in BRCA1, BRCA2, and TP53 genes are associated with high risk of breast cancer. Large rearrangements involving these genes are also implicated in the HBC phenotype...
  5. pmc Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci
    Marianne Berg
    Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway
    Mol Cancer 9:100. 2010
    ..Integration analysis of CNV and genome wide mRNA expression data, available for the same tumors, was performed to identify a restricted candidate gene list...
  6. doi request reprint Feasibility of differential diagnosis of kidney tumors by comparative genomic hybridization of fine needle aspiration biopsies
    Joana Vieira
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Genes Chromosomes Cancer 49:935-47. 2010
    ..2%, respectively. The positive predictive value and specificity of copy number profiles was 100%. We demonstrate that genetic diagnosis by CGH on FNA biopsies can improve differential diagnosis in patients with kidney tumors...
  7. doi request reprint FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer
    Paula Paulo
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Genes Chromosomes Cancer 51:240-9. 2012
    ..015). We report that FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer and that intratumor genetic heterogeneity of ETS rearrangements can occasionally be found in index primary tumors...
  8. ncbi request reprint Overexpression of the mitotic checkpoint genes BUB1 and BUBR1 is associated with genomic complexity in clear cell kidney carcinomas
    Mafalda Pinto
    Department of Genetics, Portuguese Oncology Institute, 4200 072 Porto, Portugal
    Cell Oncol 30:389-95. 2008
    ....
  9. pmc Chromosome copy number changes carry prognostic information independent of KIT/PDGFRA point mutations in gastrointestinal stromal tumors
    Mara Silva
    Department of Genetics, Portuguese Oncology Institute Porto, Rua Dr, António Bernardino Almeida, 4200 072 Porto, Portugal
    BMC Med 8:26. 2010
    ..The relative contribution of such alterations for the biology and clinical behavior of GIST, however, remains elusive...
  10. doi request reprint A novel exonic rearrangement affecting MLH1 and the contiguous LRRFIP2 is a founder mutation in Portuguese Lynch syndrome families
    Manuela Pinheiro
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Genet Med 13:895-902. 2011
    ..Although Lynch syndrome is characterized by marked genetic heterogeneity, some specific mutations are observed at high frequency in well-defined populations or ethnic groups due to founder effects...
  11. doi request reprint CSF1R copy number changes, point mutations, and RNA and protein overexpression in renal cell carcinomas
    Maria J Soares
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Mod Pathol 22:744-52. 2009
    ..Our data allow us to conclude that CSF1R plays a relevant role in clear cell renal cell carcinoma carcinogenesis and raise the possibility that CSF1R may represent a future valuable therapeutic target in these patients...
  12. pmc Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin
    Manuela Pinheiro
    Department of Genetics, Portuguese Oncology Institute Porto, Rua Dr, António Bernardino Almeida, 4200 072 Porto, Portugal
    BMC Cancer 10:587. 2010
    ..We aimed to identify potential differences among genetic alterations in distal colon and rectal carcinomas as compared to cancers arising elsewhere in the large bowel...
  13. ncbi request reprint High promoter methylation levels of APC predict poor prognosis in sextant biopsies from prostate cancer patients
    Rui Henrique
    Department of Pathology, Portuguese Oncology Institute Porto, Portugal
    Clin Cancer Res 13:6122-9. 2007
    ....
  14. doi request reprint Expression pattern of the septin gene family in acute myeloid leukemias with and without MLL-SEPT fusion genes
    Joana Santos
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Leuk Res 34:615-21. 2010
    ....
  15. pmc Promoter methylation and large intragenic rearrangements of DPYD are not implicated in severe toxicity to 5-fluorouracil-based chemotherapy in gastrointestinal cancer patients
    Joana Savva-Bordalo
    Department of Medical Oncology, Portuguese Oncology Institute Porto, Portugal
    BMC Cancer 10:470. 2010
    ..Severe toxicity to 5-fluorouracil (5-FU) based chemotherapy in gastrointestinal cancer has been associated with constitutional genetic alterations of the dihydropyrimidine dehydrogenase gene (DPYD)...
  16. ncbi request reprint Quantitative hypermethylation of a small panel of genes augments the diagnostic accuracy in fine-needle aspirate washings of breast lesions
    Carmen Jeronimo
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino Almeida, Porto, Portugal
    Breast Cancer Res Treat 109:27-34. 2008
    ..We hypothesized that comprehensive breast cancer methylation profiling might provide biomarkers for diagnostic assessment of suspicious breast lesions using fine needle aspiration biopsy (FNA)...
  17. ncbi request reprint Relative copy number gain of MYC in diagnostic needle biopsies is an independent prognostic factor for prostate cancer patients
    Franclim R Ribeiro
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Eur Urol 52:116-25. 2007
    ..Because CGH may be difficult to implement in the clinical practice, we tested the feasibility of using a three-color fluorescent assay to assess 8q status in diagnostic, paraffin-embedded biopsy samples from prostate cancer patients...
  18. pmc Deregulation of PAX2 expression in renal cell tumours: mechanisms and potential use in differential diagnosis
    Patrícia Patrício
    Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute Porto, Porto, Portugal
    J Cell Mol Med 17:1048-58. 2013
    ..The biological rationale lies on the causal relation between Pax-2 expression and chromosome 10 monosomy, but not PAX2 promoter methylation, in chrRCC...
  19. pmc High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer
    Joana G Guedes
    Departments of Genetics, Portuguese Oncology Institute, Porto, Portugal
    BMC Cancer 13:169. 2013
    ....
  20. ncbi request reprint Epigenetic regulation of Wnt signaling pathway in urological cancer
    Vera L Costa
    Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute at Porto, Porto, Portugal
    Epigenetics 5:343-51. 2010
    ..We concluded that epigenetic deregulation of Wnt pathway inhibitors may contribute to aberrant activation of Wnt signaling pathway in bladder, prostate and renal tumors...
  21. doi request reprint Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes
    Bárbara Mesquita
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Breast Cancer Res Treat 138:37-45. 2013
    ....
  22. ncbi request reprint Multimodal genetic diagnosis of solid variant alveolar rhabdomyosarcoma
    Nuno Cerveira
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Cancer Genet Cytogenet 163:138-43. 2005
    ..Furthermore, our findings and previous studies indicate that there are no apparent genetic differences between solid variant and typical ARMS...
  23. pmc Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors
    Vera L Costa
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    BMC Cancer 7:133. 2007
    ..In this study we aimed at defining a quantitative gene promoter methylation panel that might identify the most prevalent types of renal cell tumors...
  24. doi request reprint Genetic and clinical characterization of 45 acute leukemia patients with MLL gene rearrangements from a single institution
    Nuno Cerveira
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Mol Oncol 6:553-64. 2012
    ....
  25. ncbi request reprint MT1G hypermethylation is associated with higher tumor stage in prostate cancer
    Rui Henrique
    Department of Genetics, Portuguese Oncology Institute, Porto, Rua Dr Antonio Bernardino Almeida, 4200 072 Porto, Portugal
    Cancer Epidemiol Biomarkers Prev 14:1274-8. 2005
    ..Metallothioneins control the bioavailability of zinc and one isoform, MT1G, was reported down-regulated in prostate cancer. Here, we investigated whether promoter methylation might cause MT1G silencing in prostate cancer...
  26. doi request reprint Coexistence of alternative MLL-SEPT9 fusion transcripts in an acute myeloid leukemia with t(11;17)(q23;q25)
    Joana Santos
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, Porto, Portugal
    Cancer Genet Cytogenet 197:60-4. 2010
    ..This is the first description of a MLL-SEPT9 fusion resulting in coexistence of two alternative splicing variants, each of which previously found isolated in myeloid leukemias...
  27. pmc Novel 5' fusion partners of ETV1 and ETV4 in prostate cancer
    João D Barros-Silva
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Neoplasia 15:720-6. 2013
    ....
  28. doi request reprint Cryptic chromosome rearrangement resulting in SYT-SSX2 fusion gene in a monophasic synovial sarcoma
    Lurdes Torres
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Cancer Genet Cytogenet 187:45-9. 2008
    ..We uncovered a complex cryptic rearrangement that gives rise to the characteristic SYT-SSX2 fusion gene in a monophasic synovial sarcoma...
  29. doi request reprint International distribution and age estimation of the Portuguese BRCA2 c.156_157insAlu founder mutation
    Ana Peixoto
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, Porto 4200 072, Portugal
    Breast Cancer Res Treat 127:671-9. 2011
    ..We recommend that all suspected HBOC families from Portugal or with Portuguese ancestry are specifically tested for this rearrangement...
  30. doi request reprint Relative 8q gain predicts disease-specific survival irrespective of the TMPRSS2-ERG fusion status in diagnostic biopsies of prostate cancer
    João D Barros-Silva
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Genes Chromosomes Cancer 50:662-71. 2011
    ..We conclude that relative 8q gain in diagnostic needle biopsies is a poor prognostic factor independent of the TMPRSS2-ERG fusion gene status and of standard clinicopathological parameters...
  31. doi request reprint Detailed analysis of expression and promoter methylation status of apoptosis-related genes in prostate cancer
    João R Carvalho
    Portuguese Oncology Institute, Porto, Portugal
    Apoptosis 15:956-65. 2010
    ..In addition, BCL2 was also found to be frequently silenced in PCa due to aberrant promoter methylation, thus supporting a future role for apoptosis-targeted therapy in prostate cancer...
  32. pmc A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia
    Nuno Cerveira
    Department of Genetics of the Portuguese Oncology Institute, Porto, Portugal
    BMC Cancer 10:518. 2010
    ..In this work we present the identification of a novel MLL fusion partner in a pediatric patient with de novo biphenotypic acute leukemia...
  33. doi request reprint Mitochondrial genome alterations in rectal and sigmoid carcinomas
    Manuela Pinheiro
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Cancer Lett 280:38-43. 2009
    ..In conclusion, mitochondrial genome alterations are common in both rectal and sigmoid carcinomas and may contribute to their pathogenesis...
  34. pmc POU1F1 is a novel fusion partner of NUP98 in acute myeloid leukemia with t(3;11)(p11;p15)
    Susana Lisboa
    Department of Genetics, Portuguese Oncology Institute, Rua Dr, António Bernardino de Almeida, 4200 072, Porto, Portugal
    Mol Cancer 12:5. 2013
    ..NUP98 gene rearrangements have been reported in acute myeloid leukemia, giving rise to fusion proteins that seem to function as aberrant transcription factors, and are thought to be associated with poor prognosis...
  35. doi request reprint Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples
    Vera L Costa
    Cancer Epigenetics Group, Portuguese Oncology Institute Porto, Porto, Portugal
    Clin Cancer Res 16:5842-51. 2010
    ..To identify a panel of epigenetic biomarkers for accurate bladder cancer (BlCa) detection in urine sediments...
  36. ncbi request reprint Molecular characterization of a rare MLL-AF4 (MLL-AFF1) fusion rearrangement in infant leukemia
    Susana Bizarro
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Cancer Genet Cytogenet 178:61-4. 2007
    ..In summary, we have characterized at both the RNA and the DNA level a rare MLL-AF4 fusion variant that was presumably mediated by Alu repeats or polypurine and polypyrimidine tracts located in the vicinity of genomic breakpoints...
  37. pmc Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements
    Paula Paulo
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Neoplasia 14:600-11. 2012
    ....
  38. ncbi request reprint TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers
    Vera L Costa
    Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute, Porto, Portugal
    Epigenetics 6:1120-30. 2011
    ..However, additional efforts are required to increase the assay's sensitivity, enabling the simultaneous non-invasive screening of urological tumors in a single voided urine analysis...
  39. doi request reprint Acute megakaryoblastic leukemia with a four-way variant translocation originating the RBM15-MKL1 fusion gene
    Lurdes Torres
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Pediatr Blood Cancer 56:846-9. 2011
    ..The RBM15-MKL1 fusion transcript was detected by RT-PCR and confirmed by sequencing analyses. FISH analyses revealed the presence of the four-way translocation t(1;22;17;18)(p13;q13;q22;q12)...
  40. doi request reprint TP53 germline mutations in Portugal and genetic modifiers of age at cancer onset
    Carla Pinto
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Fam Cancer 8:383-90. 2009
    ..A negative correlation between telomere length and age of cancer onset was found in patients with germline TP53 mutation, whereas no such correlation was found in controls or in patients with wild-type TP53...
  41. ncbi request reprint Statistical dissection of genetic pathways involved in prostate carcinogenesis
    Franclim R Ribeiro
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Genes Chromosomes Cancer 45:154-63. 2006
    ..We conclude that significant differences exist in the genetic profile of organ-confined, locally invasive, and advanced prostate cancer and that genetic features may carry prognostic information independently of Gleason grade...
  42. pmc TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions
    Nuno Cerveira
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Neoplasia 8:826-32. 2006
    ....
  43. doi request reprint The c.156_157insAlu BRCA2 rearrangement accounts for more than one-fourth of deleterious BRCA mutations in northern/central Portugal
    Ana Peixoto
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, 4200 072, Porto, Portugal
    Breast Cancer Res Treat 114:31-8. 2009
    ....
  44. doi request reprint Comparison of methodologies for KRAS mutation detection in metastatic colorectal cancer
    Pedro Pinto
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Cancer Genet 204:439-46. 2011
    ..0139), high resolution melting (P=0.0004), and SNaPshot (P=0.00001), but no statistically significant differences were found among the three methodologies with higher sensitivity...
  45. ncbi request reprint Genomic characterization of two large Alu-mediated rearrangements of the BRCA1 gene
    Ana Peixoto
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, Porto, Portugal
    J Hum Genet 58:78-83. 2013
    ..To conclude, we describe the breakpoints of two novel large deletions involving the BRCA1 gene and analysis of their genomic context allowed us to gain insight about the respective mutational mechanism...
  46. ncbi request reprint Haplotype and quantitative transcript analyses of Portuguese breast/ovarian cancer families with the BRCA1 R71G founder mutation of Galician origin
    Catarina Santos
    Department of Genetics, Portuguese Oncology Institute, 4200 072 Porto, Portugal
    Fam Cancer 8:203-8. 2009
    ..Furthermore, our findings indicate a common ancestry of the Portuguese and Galician families sharing this mutation...
  47. pmc Both SEPT2 and MLL are down-regulated in MLL-SEPT2 therapy-related myeloid neoplasia
    Nuno Cerveira
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    BMC Cancer 9:147. 2009
    ....
  48. ncbi request reprint Genetic diagnosis of alveolar rhabdomyosarcoma in the bone marrow of a patient without evidence of primary tumor
    Susana Lisboa
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Pediatr Blood Cancer 51:554-7. 2008
    ..These data show a case of ARMS with no evidence of primary tumor presenting the PAX7-FOXO1 fusion gene...
  49. ncbi request reprint 8q gain is an independent predictor of poor survival in diagnostic needle biopsies from prostate cancer suspects
    Franclim R Ribeiro
    Department of Genetics, Portuguese Oncology Institute Porto
    Clin Cancer Res 12:3961-70. 2006
    ..Genetic markers that could augment pretreatment prognostic information would improve the clinical management of the disease...
  50. ncbi request reprint Pathogenicity evaluation of BRCA1 and BRCA2 unclassified variants identified in Portuguese breast/ovarian cancer families
    Catarina Santos
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    J Mol Diagn 16:324-34. 2014
    ..This work highlights the contribution of DNA, RNA, and in silico data to assess the pathogenicity of BRCA1/2 VUS, which, in turn, allows more accurate genetic counseling and clinical management of the families carrying them...
  51. doi request reprint EGFR exon mutation distribution and outcome in non-small-cell lung cancer: a Portuguese retrospective study
    Ramon Andrade de Mello
    Department of Medical Oncology, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, 4200 079 Porto, Portugal
    Tumour Biol 33:2061-8. 2012
    ..5 months (2-70) (exon 21) (p = n.a). This study suggests that the EGFR mutation is herein observed in a higher proportion than expected for a Caucasian population, and OS is a little less than that published in the literature...
  52. ncbi request reprint Expression changes of the MAD mitotic checkpoint gene family in renal cell carcinomas characterized by numerical chromosome changes
    Mafalda Pinto
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, 4200 072, Porto, Portugal
    Virchows Arch 450:379-85. 2007
    ..We conclude that expression changes in mitotic arrest deficiency genes (MAD1, MAD2L1, and MAD2L2) play a role in renal carcinogenesis characterized by multiple numerical chromosome abnormalities...
  53. pmc Comparison of chromosomal and array-based comparative genomic hybridization for the detection of genomic imbalances in primary prostate carcinomas
    Franclim R Ribeiro
    Department of Genetics, Portuguese Oncology Institute Porto, Portugal
    Mol Cancer 5:33. 2006
    ....
  54. doi request reprint Hereditary gastrointestinal stromal tumors sharing the KIT Exon 17 germline mutation p.Asp820Tyr develop through different cytogenetic progression pathways
    Isabel Veiga
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Genes Chromosomes Cancer 49:91-8. 2010
    ....
  55. pmc Altered expression of MGMT in high-grade gliomas results from the combined effect of epigenetic and genetic aberrations
    João Ramalho-Carvalho
    Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute Porto, Porto, Portugal
    PLoS ONE 8:e58206. 2013
    ..Hence, evaluation of copy number alterations might add relevant prognostic and predictive information concerning response to alkylating agent-based chemotherapy...
  56. ncbi request reprint Intratumor genomic heterogeneity in breast cancer with clonal divergence between primary carcinomas and lymph node metastases
    Lurdes Torres
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, Porto, Portugal
    Breast Cancer Res Treat 102:143-55. 2007
    ....
  57. ncbi request reprint Adenomas and follicular carcinomas of the thyroid display two major patterns of chromosomal changes
    Patricia Castro
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Porto, Portugal
    J Pathol 206:305-11. 2005
    ....
  58. pmc No significant role for beta tubulin mutations and mismatch repair defects in ovarian cancer resistance to paclitaxel/cisplatin
    Bárbara Mesquita
    Department of Genetics, Portuguese Oncology Institute, 4200 072 Porto, Portugal
    BMC Cancer 5:101. 2005
    ..Our goals were to investigate whether TUBB mutations and mismatch repair defects underlie paclitaxel and cisplatin resistance...
  59. doi request reprint Molecular characterization of the MLL-SEPT6 fusion gene in acute myeloid leukemia: identification of novel fusion transcripts and cloning of genomic breakpoint junctions
    Nuno Cerveira
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Haematologica 93:1076-80. 2008
    ..These data suggest that a non-homologous end-joining repair mechanism may be involved in the generation of MLL-SEPT6 rearrangements in acute myeloid leukemia...
  60. doi request reprint Desmoplastic small round cell tumor: diagnosis by fine-needle aspiration cytology
    Luís B Leça
    Department of Pathology, Portuguese Oncology Institute of Porto, Porto, Portugal
    Acta Cytol 56:576-80. 2012
    ..This tumor is characterized by a typical polyphenotypic profile with expression of epithelial, mesenchymal and neural markers. Cytogenetically, this tumor presents a unique abnormality - t(11;22)(p13;q12)...
  61. ncbi request reprint Highly sensitive detection of the MGB1 transcript (mammaglobin) in the peripheral blood of breast cancer patients
    Nuno Cerveira
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Int J Cancer 108:592-5. 2004
    ....
  62. ncbi request reprint Genomic analysis of prostate carcinoma specimens obtained via ultrasound-guided needle biopsy may be of use in preoperative decision-making
    Manuel R Teixeira
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Cancer 101:1786-93. 2004
    ....
  63. ncbi request reprint Detection of gene promoter hypermethylation in fine needle washings from breast lesions
    Carmen Jeronimo
    Department of Genetics, Portuguese Oncology Institute Porto, 4200 072 Porto, Portugal
    Clin Cancer Res 9:3413-7. 2003
    ....
  64. ncbi request reprint Structural and expression changes of septins in myeloid neoplasia
    Nuno Cerveira
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Crit Rev Oncog 15:91-115. 2009
    ....
  65. doi request reprint Cytogenetic analysis of tumor clonality
    Manuel R Teixeira
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Adv Cancer Res 112:127-49. 2011
    ....
  66. ncbi request reprint MLL-SEPTIN gene fusions in hematological malignancies
    Nuno Cerveira
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Biol Chem 392:713-24. 2011
    ....
  67. ncbi request reprint Mutations in exon 14 of dihydropyrimidine dehydrogenase and 5-Fluorouracil toxicity in Portuguese colorectal cancer patients
    Natália Salgueiro
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Genet Med 6:102-7. 2004
    ..Genetic analysis of the gene coding for dihydropyrimidine dehydrogenase has shown that mutations in exon 14, especially the splice-site mutation IVS14+1G-->A, were associated with dihydropyrimidine dehydrogenase enzymatic deficiency...
  68. doi request reprint Variability of the paracrine-induced osteoclastogenesis by human breast cancer cell lines
    João Costa-Rodrigues
    Laboratório de Farmacologia e Biocompatibilidade Celular, Faculdade de Medicina Dentaria, Universidade do Porto, Porto, Portugal
    J Cell Biochem 113:1069-79. 2012
    ....
  69. ncbi request reprint Multiple numerical chromosome aberrations in cancer: what are their causes and what are their consequences?
    Manuel R Teixeira
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Semin Cancer Biol 15:3-12. 2005
    ....
  70. ncbi request reprint Karyotypic divergence and convergence in two synchronous lung metastases of a clear cell sarcoma of tendons and aponeuroses with t(12;22)(q13;q12) and type 1 EWS/ATF1
    Manuel R Teixeira
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, 4200 072, Porto, Portugal
    Cancer Genet Cytogenet 145:121-5. 2003
    ..We conclude that both clonal divergence and convergence may be operative during tumor progression of CCS...
  71. doi request reprint Endometrial endometrioid adenocarcinoma associated with primitive neuroectodermal tumour of the uterus: a poor prognostic subtype of uterine tumours
    Carla Bartosch
    Department of Pathology, Hospital de S Joao, E P E, and Department of Pathology, Medical Faculty, University of Porto, Alameda Professor Hernani Monteiro, 4202 451, Porto, Portugal
    Med Oncol 28:1488-94. 2011
    ....
  72. ncbi request reprint Recurrent fusion oncogenes in carcinomas
    Manuel R Teixeira
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Crit Rev Oncog 12:257-71. 2006
    ....