Ana E Sousa

Summary

Country: Portugal

Publications

  1. ncbi request reprint CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load
    Ana E Sousa
    Clinical Immunology Unit Institute of Molecular Medicine, Faculty of Medicine of Lisbon, Lisbon, Portugal
    J Immunol 169:3400-6. 2002
  2. doi request reprint Memory and naive-like regulatory CD4+ T cells expand during HIV-2 infection in direct association with CD4+ T-cell depletion irrespectively of viremia
    Russell B Foxall
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
    AIDS 25:1961-70. 2011
  3. doi request reprint Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation
    Rita I Azevedo
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
    Biol Blood Marrow Transplant 19:703-12. 2013
  4. ncbi request reprint Rate of increase in circulating IL-7 and loss of IL-7Ralpha expression differ in HIV-1 and HIV-2 infections: two lymphopenic diseases with similar hyperimmune activation but distinct outcomes
    Adriana S Albuquerque
    Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
    J Immunol 178:3252-9. 2007
  5. pmc Gag-specific CD4+ T-cell frequency is inversely correlated with proviral load and directly correlated with immune activation in infection with human immunodeficiency virus type 2 (HIV-2) but not HIV-1
    Russell B Foxall
    Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av Prof Egas Moniz, 1649 028 Lisboa, Portugal
    J Virol 82:9795-9. 2008
  6. doi request reprint Increased frequency of CD25dimCD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1
    Russell B Foxall
    Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av Prof Egas Moniz, 1649 028 Lisboa, Portugal
    Clin Immunol 127:158-67. 2008
  7. ncbi request reprint Monocyte-mediated T cell suppression by HIV-2 envelope proteins
    Rita Cavaleiro
    Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
    Eur J Immunol 37:3435-44. 2007
  8. pmc Efficient thymopoiesis contributes to the maintenance of peripheral CD4 T cells during chronic human immunodeficiency virus type 2 infection
    David Gautier
    Departement de Virologie, Institut Pasteur, 28 rue du Dr Roux, 75015, Paris, France
    J Virol 81:12685-8. 2007
  9. ncbi request reprint Low CD4 T-cell counts despite low levels of circulating HIV: insights from the comparison of HIV-1 infected patients with a discordant response to antiretroviral therapy to patients with untreated advanced HIV-2 disease
    Adriana S Albuquerque
    Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av Prof Egas Moniz, 1649 028, Lisboa, Portugal
    Clin Immunol 125:67-75. 2007
  10. pmc Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
    Rui Soares
    Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av Prof Egas Moniz, 1649 028 Lisboa, Portugal
    J Virol 80:12425-9. 2006

Collaborators

  • Perpetua Gomes
  • Zvi Grossman
  • Adriana S Albuquerque
  • Russell B Foxall
  • Rui M M Victorino
  • Rui S Soares
  • Catarina S Cortesão
  • Rita Cavaleiro
  • Rita I Azevedo
  • Rita Tendeiro
  • David Gautier
  • Rui Soares
  • Miguel Martins
  • Dário Ligeiro
  • Maria V D Soares
  • João F Lacerda
  • António P Baptista
  • Stéphanie Beq
  • Alice Ribeiro
  • Remi Cheynier
  • Francisco Antunes
  • Jeffrey L Platt
  • Gregory J Brunn
  • Margarida Lucas
  • Manuela Doroana
  • Catarina Cortesão
  • Adriana Albuquerque
  • Miguel Garcia
  • Russell Foxall

Detail Information

Publications11

  1. ncbi request reprint CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load
    Ana E Sousa
    Clinical Immunology Unit Institute of Molecular Medicine, Faculty of Medicine of Lisbon, Lisbon, Portugal
    J Immunol 169:3400-6. 2002
    ....
  2. doi request reprint Memory and naive-like regulatory CD4+ T cells expand during HIV-2 infection in direct association with CD4+ T-cell depletion irrespectively of viremia
    Russell B Foxall
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
    AIDS 25:1961-70. 2011
    ..Although both HIV infections are associated with hyperimmune activation and CD4(+) T-cell lymphopenia, most HIV-2-positive individuals display slower disease progression and low-to-undetectable viremia...
  3. doi request reprint Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation
    Rita I Azevedo
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
    Biol Blood Marrow Transplant 19:703-12. 2013
    ..Overall, our data suggest that long-term immune reconstitution was successfully achieved after haploidentical HSCT, a process that appears to have largely relied on de novo T cell production...
  4. ncbi request reprint Rate of increase in circulating IL-7 and loss of IL-7Ralpha expression differ in HIV-1 and HIV-2 infections: two lymphopenic diseases with similar hyperimmune activation but distinct outcomes
    Adriana S Albuquerque
    Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
    J Immunol 178:3252-9. 2007
    ....
  5. pmc Gag-specific CD4+ T-cell frequency is inversely correlated with proviral load and directly correlated with immune activation in infection with human immunodeficiency virus type 2 (HIV-2) but not HIV-1
    Russell B Foxall
    Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av Prof Egas Moniz, 1649 028 Lisboa, Portugal
    J Virol 82:9795-9. 2008
    ..Our data suggest a potential link between HIV-2-specific CD4 responses, immune activation, and viral control, which may in turn relate to the better prognosis associated with HIV-2 infection...
  6. doi request reprint Increased frequency of CD25dimCD4+ T-cells in HIV-2 infection, a naturally occurring attenuated form of HIV-1
    Russell B Foxall
    Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av Prof Egas Moniz, 1649 028 Lisboa, Portugal
    Clin Immunol 127:158-67. 2008
    ..Identification of the underlying mechanisms regulating this population in HIV-1 and HIV-2 infections may provide a rational for novel therapeutic strategies...
  7. ncbi request reprint Monocyte-mediated T cell suppression by HIV-2 envelope proteins
    Rita Cavaleiro
    Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
    Eur J Immunol 37:3435-44. 2007
    ..We hypothesize that the HIV-2 envelope immunosuppressive properties limit bursts of T cell activation, thus reducing viremia and contributing to the slow rate of disease progression that characterizes HIV-2 disease...
  8. pmc Efficient thymopoiesis contributes to the maintenance of peripheral CD4 T cells during chronic human immunodeficiency virus type 2 infection
    David Gautier
    Departement de Virologie, Institut Pasteur, 28 rue du Dr Roux, 75015, Paris, France
    J Virol 81:12685-8. 2007
    ..The correlation between higher thymic production and lower CD4 T-cell loss in these patients suggests that efficient thymopoiesis is implicated in the long-lasting maintenance of CD4 T-cell counts in HIV-2 disease...
  9. ncbi request reprint Low CD4 T-cell counts despite low levels of circulating HIV: insights from the comparison of HIV-1 infected patients with a discordant response to antiretroviral therapy to patients with untreated advanced HIV-2 disease
    Adriana S Albuquerque
    Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av Prof Egas Moniz, 1649 028, Lisboa, Portugal
    Clin Immunol 125:67-75. 2007
    ....
  10. pmc Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection
    Rui Soares
    Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av Prof Egas Moniz, 1649 028 Lisboa, Portugal
    J Virol 80:12425-9. 2006
    ..Similar levels of proviral DNA were found in the two infection categories. Thus, the reduced viremia and slow rate of CD4 decline that characterize HIV-2 infection seem to be unrelated to coreceptor availability...
  11. ncbi request reprint CD4+ T-cell depletion in HIV infection: are we closer to understanding the cause?
    Zvi Grossman
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Nat Med 8:319-23. 2002