Miguel P Soares

Summary

Country: Portugal

Publications

  1. ncbi request reprint Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis
    Sophie Brouard
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:17950-61. 2002
  2. doi request reprint Heme oxygenase-1: from biology to therapeutic potential
    Miguel P Soares
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, 60, 2780 156, Oeiras, Portugal
    Trends Mol Med 15:50-8. 2009
  3. doi request reprint Immunoregulatory effects of HO-1: how does it work?
    Miguel P Soares
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Curr Opin Pharmacol 9:482-9. 2009
  4. ncbi request reprint Heme oxygenase-1 in organ transplantation
    Miguel P Soares
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal, Oeiras, Portugal
    Front Biosci 12:4932-45. 2007
  5. ncbi request reprint Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation
    Miguel P Soares
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 172:3553-63. 2004
  6. pmc Oxidized hemoglobin is an endogenous proinflammatory agonist that targets vascular endothelial cells
    Gabriela Silva
    Instituto Gulbenkian de Ciencia, Oeiras 2780 156, Portugal
    J Biol Chem 284:29582-95. 2009
  7. ncbi request reprint Heme oxygenase-1 inhibits the expression of adhesion molecules associated with endothelial cell activation via inhibition of NF-kappaB RelA phosphorylation at serine 276
    Mark P Seldon
    Instituto Gulbenkian de Ciencia, Apartado 14, Oeiras, Portugal
    J Immunol 179:7840-51. 2007
  8. ncbi request reprint Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs
    Kenichiro Yamashita
    Immunobiology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    FASEB J 20:776-8. 2006
  9. pmc Heme oxygenase-1 affords protection against noncerebral forms of severe malaria
    Elsa Seixas
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Proc Natl Acad Sci U S A 106:15837-42. 2009
  10. doi request reprint Metabolic adaptation to tissue iron overload confers tolerance to malaria
    Raffaella Gozzelino
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    Cell Host Microbe 12:693-704. 2012

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis
    Sophie Brouard
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:17950-61. 2002
    ..e. c-IAP2 and A1, to protect EC from TNF-alpha-mediated apoptosis. This effect is dependent on the ability of HO-1/CO to activate the p38 MAPK signal transduction pathway...
  2. doi request reprint Heme oxygenase-1: from biology to therapeutic potential
    Miguel P Soares
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, 60, 2780 156, Oeiras, Portugal
    Trends Mol Med 15:50-8. 2009
    ..Here, we present a model for the beneficial actions of the products of heme degradation, and we discuss the potential clinical applications of enhancing the HO-1 system...
  3. doi request reprint Immunoregulatory effects of HO-1: how does it work?
    Miguel P Soares
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Curr Opin Pharmacol 9:482-9. 2009
    ..We will argue that the salutary effects of HO-1 are also exerted via its cytoprotective action, which sustains tissue function and prevents unfettered immune activation by endogenous proinflammatory ligands released from injured cells...
  4. ncbi request reprint Heme oxygenase-1 in organ transplantation
    Miguel P Soares
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal, Oeiras, Portugal
    Front Biosci 12:4932-45. 2007
    ....
  5. ncbi request reprint Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation
    Miguel P Soares
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 172:3553-63. 2004
    ..This effect of HO-1 is mediated by bilirubin and/or by a decrease of free intracellular Fe2+ but probably not by biliverdin or carbon monoxide...
  6. pmc Oxidized hemoglobin is an endogenous proinflammatory agonist that targets vascular endothelial cells
    Gabriela Silva
    Instituto Gulbenkian de Ciencia, Oeiras 2780 156, Portugal
    J Biol Chem 284:29582-95. 2009
    ..In conclusion, oxidized hemoglobin, i.e. ferryl hemoglobin, acts as a proinflammatory agonist that targets vascular endothelial cells...
  7. ncbi request reprint Heme oxygenase-1 inhibits the expression of adhesion molecules associated with endothelial cell activation via inhibition of NF-kappaB RelA phosphorylation at serine 276
    Mark P Seldon
    Instituto Gulbenkian de Ciencia, Apartado 14, Oeiras, Portugal
    J Immunol 179:7840-51. 2007
    ..In conclusion, we demonstrate a novel mechanism via which HO-1 down-modulates the proinflammatory phenotype of activated EC, i.e., the inhibition of RelA phosphorylation at Ser(276)...
  8. ncbi request reprint Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs
    Kenichiro Yamashita
    Immunobiology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    FASEB J 20:776-8. 2006
    ....
  9. pmc Heme oxygenase-1 affords protection against noncerebral forms of severe malaria
    Elsa Seixas
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Proc Natl Acad Sci U S A 106:15837-42. 2009
    ..In conclusion, we describe a mechanism of host defense against Plasmodium infection, based on tissue cytoprotection against free heme and limiting disease severity irrespectively of parasite burden...
  10. doi request reprint Metabolic adaptation to tissue iron overload confers tolerance to malaria
    Raffaella Gozzelino
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    Cell Host Microbe 12:693-704. 2012
    ..Mimicking FtH's antioxidant effect or inhibiting JNK activation pharmacologically confers therapeutic tolerance to malaria in mice. Thus, FtH provides metabolic adaptation to tissue Fe overload, conferring tolerance to malaria...
  11. ncbi request reprint Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts
    Kenichiro Yamashita
    Department of Surgery, Immunobiology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, Boston, MA 02215, USA
    FASEB J 18:765-7. 2004
    ..These findings support the potential use of biliverdin, a natural product, in transplantation and other T cell mediated immune disorders...
  12. ncbi request reprint Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells
    James McDaid
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 19:458-60. 2005
    ....
  13. ncbi request reprint Donor treatment with carbon monoxide can yield islet allograft survival and tolerance
    Hongjun Wang
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, RN 361, Boston, MA 02215, USA
    Diabetes 54:1400-6. 2005
    ..Our present findings show that induction of HO-1 in, or administration of CO to, only the donor, islets, or the recipient or combinations of such treatments improve allogeneic islet survival...
  14. ncbi request reprint The antiapoptotic effect of heme oxygenase-1 in endothelial cells involves the degradation of p38 alpha MAPK isoform
    Gabriela Silva
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    J Immunol 177:1894-903. 2006
    ..In conclusion, the antiapoptotic effect of HO-1 in EC is dependent on the degradation of p38alpha by the 26S proteasome and on the expression of p38beta...
  15. doi request reprint Sickle hemoglobin confers tolerance to Plasmodium infection
    Ana Ferreira
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Cell 145:398-409. 2011
    ..Our findings provide insight into molecular mechanisms via which sickle Hb confers host tolerance to severe forms of malaria...
  16. ncbi request reprint Modulation of endothelial cell apoptosis by heme oxygenase-1-derived carbon monoxide
    Miguel P Soares
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Antioxid Redox Signal 4:321-9. 2002
    ....
  17. doi request reprint A central role for free heme in the pathogenesis of severe malaria: the missing link?
    Ana Ferreira
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    J Mol Med (Berl) 86:1097-111. 2008
    ....
  18. doi request reprint Mechanisms of cell protection by heme oxygenase-1
    Raffaella Gozzelino
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Annu Rev Pharmacol Toxicol 50:323-54. 2010
    ..This cytoprotective effect inhibits the pathogenesis of a variety of immune-mediated inflammatory diseases...
  19. ncbi request reprint Carbon monoxide protects pancreatic beta-cells from apoptosis and improves islet function/survival after transplantation
    Lukas Gunther
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 51:994-9. 2002
    ..These findings suggest a potential therapeutic application for CO in improving islet function/survival after transplantation in humans...
  20. doi request reprint A central role for free heme in the pathogenesis of severe sepsis
    Rasmus Larsen
    Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Sci Transl Med 2:51ra71. 2010
    ..Finally, the lethal outcome of septic shock in patients was also associated with reduced HPX serum concentrations. We propose that targeting free heme by HPX might be used therapeutically to treat severe sepsis...
  21. ncbi request reprint Heme oxygenase-1 is not required for mouse regulatory T cell development and function
    Santiago Zelenay
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, 6, Apartado 14, 2780 901 Oeiras, Portugal
    Int Immunol 19:11-8. 2007
    ..Finally, we conclude that under physiological conditions in mice, Treg development, maintenance and function are independent of HO-1 activity...
  22. ncbi request reprint Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
    Ana Pamplona
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    Nat Med 13:703-10. 2007
    ..These effects were mediated by the binding of CO to hemoglobin, preventing hemoglobin oxidation and the generation of free heme, a molecule that triggers ECM pathogenesis...
  23. ncbi request reprint Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation
    Robert Ollinger
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Circulation 112:1030-9. 2005
    ....
  24. pmc Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation
    Angelo A Chora
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal Departamento de Imunologia, Faculdade de Ciencias Medicas, Universidade Nova de Lisboa, Lisbon, Portugal
    J Clin Invest 117:438-47. 2007
    ..In conclusion, HO-1 or exposure to its end product CO counters autoimmune neuroinflammation and thus might be used therapeutically to treat MS...
  25. ncbi request reprint Heme oxygenase-1-derived carbon monoxide protects hearts from transplant associated ischemia reperfusion injury
    Yorihiro Akamatsu
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 18:771-2. 2004
    ..The observation that exposure of the donor and the graft to CO is sufficient to afford this protective effect should have important clinical implications in terms of preventing IRI associated with heart transplantation in humans...
  26. ncbi request reprint Expression of protective genes in human renal allografts: a regulatory response to injury associated with graft rejection
    Yingyos Avihingsanon
    Division of Immunology, Department of Medicine, Immunobiology Research Center, Harvard Medical School, Boston, MA 02215, USA
    Transplantation 73:1079-85. 2002
    ..Little is known of the pattern of expression of such protective genes and the implication thereof in clinical transplantation...
  27. ncbi request reprint Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury
    Leo E Otterbein
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Montefiore University Hospital, Pittsburgh, Pennsylvania, USA
    Nat Med 9:183-90. 2003
    ..These findings demonstrate a protective role for CO in vascular injury and support its use as a therapeutic agent...
  28. ncbi request reprint Heme oxygenase-1: unleashing the protective properties of heme
    Leo E Otterbein
    Division of Pulmonary and Critical Care Medicine, Montifiore University Hospital, University of Pittsburgh School of Medicine, 3459 5th Avenue, Pittsburgh, PA 15213, USA
    Trends Immunol 24:449-55. 2003
    ..This Review is the third in a series on the regulation of the immune system by metabolic pathways...
  29. doi request reprint Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection
    Sabrina Epiphanio
    Unidade de Malaria, Instituto de Medicina Molecular, Universidade de Lisboa, 1649 028 Lisboa, Portugal
    Cell Host Microbe 3:331-8. 2008
    ....
  30. ncbi request reprint Different faces of the heme-heme oxygenase system in inflammation
    Frank A D T G Wagener
    Department of Tumor Immunology, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Pharmacol Rev 55:551-71. 2003
    ..Pre-induction of HO activity has been demonstrated to ameliorate inflammation and mediate potent resistance to oxidative injury. A better understanding of the complex heme-heme..