A P Marreilha Dos Santos
Marreilha dos Santos A, Santos D, Au C, Milatovic D, Aschner M, Batoréu M. Antioxidants prevent the cytotoxicity of manganese in RBE4 cells. Brain Res. 2008;1236:200-5 pubmed publisher
dos Santos A, Milatovic D, Au C, Yin Z, Batoreu M, Aschner M. Rat brain endothelial cells are a target of manganese toxicity. Brain Res. 2010;1326:152-61 pubmed publisher
..cells exposed to Mn alone. We conclude that Mn induces direct injury to mitochondria in RBE4 cells. The ensuing impairment in energy metabolism and redox status may modify the restrictive properties of the BBB compromising its function. ..
Santos A, Lucas R, Andrade V, Mateus M, Milatovic D, Aschner M, et al
. Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity. Toxicol Appl Pharmacol. 2012;258:394-402 pubmed publisher
..Taken together, these results establish that both PAS and Ebs are efficacious in reducing Mn body burden, neuroinflammation, oxidative stress and locomotor activity impairments in a rat model of Mn-induced toxicity. ..
Andrade V, Mateus M, Batoreu M, Aschner M, Marreilha dos Santos A. Changes in rat urinary porphyrin profiles predict the magnitude of the neurotoxic effects induced by a mixture of lead, arsenic and manganese. Neurotoxicology. 2014;45:168-77 pubmed publisher
..Our work strongly suggests that the use of a linear combination of urinary prophyrin levels accurately predicts the magnitude of motor impairments in rats that is induced by a mixture of Pb, As and Mn. ..
Marreilha dos Santos A, Lopes Santos M, Batoréu M, Aschner M. Prolactin is a peripheral marker of manganese neurotoxicity. Brain Res. 2011;1382:282-90 pubmed publisher
..Male Wistar rats (180-200g) were injected intraperitoneally with 4 or 8 doses of Mn (10mg/kg). Mn exposure was evaluated by analysis of Mn levels in brain and blood along with biochemical end-points (see below)...
Andrade V, Aschner M, Marreilha dos Santos A. Neurotoxicity of Metal Mixtures. Adv Neurobiol. 2017;18:227-265 pubmed publisher
..More detailed information on Pb, Mn, Al, Hg, Cu, and Zn is available in other chapters. A major focus of the chapter will be on Pb toxicity and its interaction with other metals. ..