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Genomes and Genes | Isabel Sá-CorreiaSummaryCountry: Portugal Publications
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Publications
Identification of candidate genes for yeast engineering to improve bioethanol production in very high gravity and lignocellulosic biomass industrial fermentationsFrancisco B Pereira
IBB, Institute of Biotechnology and Bioengineering, Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal
Biotechnol Biofuels 4:57. 2011..abstract:..
Drug:H+ antiporters in chemical stress response in yeastIsabel Sá-Correia
Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, 1049 001 Lisboa, Portugal
Trends Microbiol 17:22-31. 2009..Finally, the extrapolation of the gathered knowledge on the MDR phenomenon in yeast to pathogenic fungi and higher eukaryotes is discussed...- 2D electrophoresis-based expression proteomics: a microbiologist's perspectiveIsabel Sá-Correia
Institute for Biotechnology and Bioengineering, Biological Sciences Research Group, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Technical University of Lisbon, Av Rovisco Pais, Lisbon, Portugal
Expert Rev Proteomics 7:943-53. 2010.... - Saccharomyces cerevisiae multidrug transporter Qdr2p (Yil121wp): localization and function as a quinidine resistance determinantRita C Vargas
Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
Antimicrob Agents Chemother 48:2531-7. 2004..Although QDR2 transcription was not enhanced in response to quinidine, the results confirmed that Qdr2p is involved in the active export of quinidine out of the cell, thus conferring resistance to the drug... - Adaptation of Saccharomyces cerevisiae to the herbicide 2,4-dichlorophenoxyacetic acid, mediated by Msn2p- and Msn4p-regulated genes: important role of SPI1T Simoes
Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
Appl Environ Microbiol 69:4019-28. 2003..Consistent with this concept, the concentration of (14)C-labeled 2,4-D in 2,4-D-energized adapted Deltaspi1 mutant cells and the consequent intracellular acidification are higher than in wild-type cells... 
Yeast adaptation to mancozeb involves the up-regulation of FLR1 under the coordinate control of Yap1, Rpn4, Pdr3, and Yrr1Miguel Cacho Teixeira
IBB CEBQ, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisboa, Portugal
Biochem Biophys Res Commun 367:249-55. 2008....- Identification of genes required for maximal tolerance to high-glucose concentrations, as those present in industrial alcoholic fermentation media, through a chemogenomics approachMiguel C Teixeira
IBB Institute for Biotechnology and Bioengineering, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Lisboa, Portugal
OMICS 14:201-10. 2010.... - Yeast response and tolerance to polyamine toxicity involving the drug : H+ antiporter Qdr3 and the transcription factors Yap1 and Gcn4Miguel C Teixeira
Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, 1049 001 Lisboa, Portugal
Microbiology 157:945-56. 2011.... - TFRank: network-based prioritization of regulatory associations underlying transcriptional responsesJoana P Gonçalves
Knowledge Discovery and Bioinformatics Group, INESC ID, Portugal
Bioinformatics 27:3149-57. 2011..In a preliminary study in human, TFRank unveiled regulators involved in breast tumor growth and metastasis when applied to genes whose expression signatures correlated with short interval to metastasis... - The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinant of resistance to quinidine, barban, cisplatin, and bleomycinSandra Tenreiro
Biological Sciences Research Group, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
Biochem Biophys Res Commun 327:952-9. 2005.... - AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiaeSandra Tenreiro
Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Avenida Rovisco Pais, 1049 001 Lisbon, Portugal
Biochem Biophys Res Commun 292:741-8. 2002..The encoded putative transporter was localized in the plasma membrane by fluorescence microscopy observation of the overproduced Aqr1-GFP fusion protein distribution... - Quantitative- and phospho-proteomic analysis of the yeast response to the tyrosine kinase inhibitor imatinib to pharmacoproteomics-guided drug line extensionSandra C dos Santos
Institute for Biotechnology and Bioengineering IBB, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Technical University of Lisbon, Lisbon, Portugal
OMICS 16:537-51. 2012.... - Increased expression of the yeast multidrug resistance ABC transporter Pdr18 leads to increased ethanol tolerance and ethanol production in high gravity alcoholic fermentationMiguel C Teixeira
IBB Institute for Biotechnology and Bioengineering, Centro de Engenharia Biologica e Quimica, and Department of Bioengineering, Instituto Superior Tecnico, Technical University of Lisbon, Av Rovisco Pais, 1049 001 Lisbon, Portugal
Microb Cell Fact 11:98. 2012..A set of 21 genes encoding multidrug transporters from the ATP-Binding Cassette (ABC) Superfamily and Major Facilitator Superfamily (MFS) in S. cerevisiae were scrutinized for a role in ethanol stress resistance... - Studies on the involvement of the exopolysaccharide produced by cystic fibrosis-associated isolates of the Burkholderia cepacia complex in biofilm formation and in persistence of respiratory infectionsMónica V Cunha
Grupo de Ciências Biológicas, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
J Clin Microbiol 42:3052-8. 2004.... - The SPI1 gene, encoding a glycosylphosphatidylinositol-anchored cell wall protein, plays a prominent role in the development of yeast resistance to lipophilic weak-acid food preservativesT Simoes
Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisboa, Portugal
Appl Environ Microbiol 72:7168-75. 2006..Decreased cell wall porosity, in turn, reduces access to the plasma membrane, reducing membrane damage, intracellular acidification, and viability loss... - Identification and physical organization of the gene cluster involved in the biosynthesis of Burkholderia cepacia complex exopolysaccharideLeonilde M Moreira
Biological Sciences Research Group, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisboa, Portugal
Biochem Biophys Res Commun 312:323-33. 2003.... - Identification of a DNA-binding site for the transcription factor Haa1, required for Saccharomyces cerevisiae response to acetic acid stressNuno P Mira
IBB, Instituto Biotecnologia e Bioengenharia, Center for Biological and Chemical Engineering, Instituto Superior Tecnico, Avenida Rovisco Pais, 1049 001 Lisbon, Portugal
Nucleic Acids Res 39:6896-907. 2011..Altogether, the results obtained indicate that the minimal functional binding site of Haa1 is 5'-(G/C)(A/C)GG(G/C)G-3'. The Haa1-dependent transcriptional regulatory network active in yeast response to acetic acid stress is proposed... - Saccharomyces cerevisiae multidrug resistance transporter Qdr2 is implicated in potassium uptake, providing a physiological advantage to quinidine-stressed cellsRita C Vargas
IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisboa, Portugal
Eukaryot Cell 6:134-42. 2007..Second, the amino acid pool is higher in Deltaqdr2 cells than in wild-type cells, indicating that QDR2 expression is, directly or indirectly, involved in amino acid homeostasis... - The RIM101 pathway has a role in Saccharomyces cerevisiae adaptive response and resistance to propionic acid and other weak acidsNuno P Mira
IBB, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisboa, Portugal
FEMS Yeast Res 9:202-16. 2009.... - Insights into the mechanisms of toxicity and tolerance to the agricultural fungicide mancozeb in yeast, as suggested by a chemogenomic approachPaulo J Dias
IBB Institute for Biotechnology and Bioengineering, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Lisboa, Portugal
OMICS 14:211-27. 2010..This toxicogenomics analysis may, thus, increase the understanding of mancozeb toxicity and adaptation mechanisms in humans... - Transcriptomic profiling of the Saccharomyces cerevisiae response to quinine reveals a glucose limitation response attributable to drug-induced inhibition of glucose uptakeSandra C dos Santos
Institute for Biotechnology and Bioengineering IBB, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisbon, Portugal
Antimicrob Agents Chemother 53:5213-23. 2009..We propose that PfHT1 is an interesting candidate quinine target possibly involved in quinine import in P. falciparum, an uptake mechanism postulated in recent studies to occur through a still-unidentified importer(s)... - Genomic expression program involving the Haa1p-regulon in Saccharomyces cerevisiae response to acetic acidNuno P Mira
Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Technical University of Lisbon, Lisboa, Portugal
OMICS 14:587-601. 2010.... - The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistanceTânia R Cabrito
IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, 1049 001 Lisboa, Portugal
Biochem J 440:195-202. 2011..Taken together, the results of the present study suggest that Pdr18 plays a role in plasma membrane sterol incorporation, this physiological trait contributing to an MDR phenotype... - The multidrug resistance transporters of the major facilitator superfamily, 6 years after disclosure of Saccharomyces cerevisiae genome sequenceIsabel Sá-Correia
Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisboa, Portugal
J Biotechnol 98:215-26. 2002..Most of the present knowledge on these putative drug:H(+)-antiporters was driven by disclosure of S. cerevisiae genome sequence, in April 1996, being a paradigm of post-genomic research... - Burkholderia cenocepacia phenotypic clonal variation during a 3.5-year colonization in the lungs of a cystic fibrosis patientCarla P Coutinho
Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
Infect Immun 79:2950-60. 2011..cenocepacia variants retrieved, along with the deterioration of pulmonary function and severe oxygen limitation... - Heterologous expression of a Tpo1 homolog from Arabidopsis thaliana confers resistance to the herbicide 2,4-D and other chemical stresses in yeastTânia R Cabrito
Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
Appl Microbiol Biotechnol 84:927-36. 2009..Heterologous expression of At5g13750 in yeast also leads to increased resistance to indole-3-acetic acid (IAA), Al(3+) and Tl(3+). At5g13750 is the first plant putative MFS transporter to be suggested as possibly involved in MDR... - Adaptive response to acetic acid in the highly resistant yeast species Zygosaccharomyces bailii revealed by quantitative proteomicsJoana F Guerreiro
Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Department of Bioengineering, Instituto Superior Tecnico, Technical University of Lisbon, Portugal
Proteomics 12:2303-18. 2012..When acetic acid is the sole carbon source, results suggest the activation of gluconeogenic and pentose phosphate pathways, based on the increased content of several proteins of these pathways after glucose exhaustion... - Molecular analysis of Burkholderia cepacia complex isolates from a Portuguese cystic fibrosis center: a 7-year studyMónica V Cunha
Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Hospital de Santa Maria, Lisbon, Portugal
J Clin Microbiol 41:4113-20. 2003..Altogether, our results indicate that the use of these markers or the genomovar status in identifying patients at higher risk for infection is uncertain... - Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to acetic acidNuno P Mira
Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Technical University of Lisbon, Lisboa, Portugal
Microb Cell Fact 9:79. 2010..cerevisiae tolerance to acetic acid is essential for the rational selection of optimal fermentation conditions and the engineering of more robust industrial strains to be used in processes in which yeast is explored as cell factory... - A genome-wide screen identifies yeast genes required for protection against or enhanced cytotoxicity of the antimalarial drug quinineSandra C dos Santos
IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001, Lisbon, Portugal
Mol Genet Genomics 286:333-46. 2011..falciparum context... - Adaptive response to the antimalarial drug artesunate in yeast involves Pdr1p/Pdr3p-mediated transcriptional activation of the resistance determinants TPO1 and PDR5Marta Alenquer
Biological Sciences Research Group, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Lisbon, Portugal
FEMS Yeast Res 6:1130-9. 2006..Maximum TPO1 mRNA levels were rapidly reduced to basal values following adaptation of the yeast population to artesunate, while high PDR5 levels were maintained during drug-stressed exponential growth... - The gellan gum biosynthetic genes gelC and gelE encode two separate polypeptides homologous to the activator and the kinase domains of tyrosine autokinasesLeonilde M Moreira
Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, PT 1049 001 Lisboa, Portugal
J Mol Microbiol Biotechnol 8:43-57. 2004..The tyrosine residue at position 198 appears to be essential for the synthesis of high-molecular-weight gellan, although other tyrosine residues may additionally contribute to GelE biological function... - Quantitative proteomics (2-D DIGE) reveals molecular strategies employed by Burkholderia cenocepacia to adapt to the airways of cystic fibrosis patients under antimicrobial therapyAndreia Madeira
Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Department of Bioengineering, Instituto Superior Tecnico, Technical University of Lisbon, Lisbon, Portugal
Proteomics 11:1313-28. 2011..The quantitative comparison of the two proteomes suggests a genetic adaptation leading to increased antimicrobial resistance and bacterial persistence in the CF airways... - Adaptive response and tolerance to weak acids in Saccharomyces cerevisiae: a genome-wide viewNuno P Mira
Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Technical University of Lisbon, Lisboa, Portugal
OMICS 14:525-40. 2010..The extrapolation of the knowledge gathered in yeast to other eukaryotes is also attempted... - Insights into yeast adaptive response to the agricultural fungicide mancozeb: a toxicoproteomics approachPedro M Santos
IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisboa, Portugal
Proteomics 9:657-70. 2009..Our results also suggest that this study provided powerful indications that may be useful to expand the knowledge obtained in yeast not only to the global response to mancozeb toxicity in phytopathogenic fungi but also to humans... - Genome-wide identification of genes required for yeast growth under imatinib stress: vacuolar H+-ATPase function is an important target of this anticancer drugSandra C dos Santos
IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisboa, Portugal
OMICS 13:185-98. 2009..Results suggest that imatinib might act as an effective inhibitor of V-ATPase function in yeast, identifying V-ATPase activity and vacuolar function as novel imatinib targets... - Adaptation to beta-myrcene catabolism in Pseudomonas sp. M1: an expression proteomics analysisPedro M Santos
IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av Rovisco Pais, Lisbon, Portugal
Proteomics 9:5101-11. 2009.... - Genome-wide identification of Saccharomyces cerevisiae genes required for maximal tolerance to ethanolMiguel C Teixeira
Institute for Biotechnology and Bioengineering, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
Appl Environ Microbiol 75:5761-72. 2009..The increased expression of FPS1 confirmed the important role of this gene in alcoholic fermentation, leading to increased final ethanol concentration under conditions that lead to high ethanol production... - Genomic expression analysis reveals strategies of Burkholderia cenocepacia to adapt to cystic fibrosis patients' airways and antimicrobial therapyNuno P Mira
IBB, Institute for Biotechnology and Bioengineering, Center for Biological and Chemical Engineering, Instituto Superior Tecnico, Technical University of Lisbon, Lisbon, Portugal
PLoS ONE 6:e28831. 2011.... - Characterization of complex regulatory networks and identification of promoter regulatory elements in yeast: "in silico" and "wet-lab" approachesNuno P Mira
Institute for Biotechnology and Bioengineering, Technical University of Lisbon, Lisbon, Portugal
Methods Mol Biol 809:27-48. 2012..A set of easily accessible experimental approaches that can be used to confirm the predictions of the bioinformatic analysis is also detailed... - A genome-wide perspective on the response and tolerance to food-relevant stresses in Saccharomyces cerevisiaeMiguel C Teixeira
IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Technical University of Lisbon, 1049 001 Lisboa, Portugal
Curr Opin Biotechnol 22:150-6. 2011..The extension of the data gathered in S. cerevisiae to food spoilage fungi is considered. The relevance of the different genome-wide approaches in this context is also discussed... - Identification of regulatory modules in time series gene expression data using a linear time biclustering algorithmSara C Madeira
Universidade da Beira Interior, Covilha, KDBIO Group, INESC ID, Lisbon, Portugal
IEEE/ACM Trans Comput Biol Bioinform 7:153-65. 2010.... - Response of Pseudomonas putida KT2440 to phenol at the level of membrane proteomeCatarina Roma-Rodrigues
IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Lisboa, Portugal
J Proteomics 73:1461-78. 2010..All these mechanistic insights may be extended to Pseudomonas adaptation to solvents, of possible impact in biodegradation, bioremediation and biocatalysis... - Biochemical characterization and phylogenetic analysis of UDP-glucose dehydrogenase from the gellan gum producer Sphingomonas elodea ATCC 31461Ana Teresa Granja
IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
Appl Microbiol Biotechnol 76:1319-27. 2007..DNA sequencing of chromosomal regions adjacent to ugdG gene and sequence similarity studies suggests that this gene maps together with others presumably involved in the biosynthesis of S. elodea cell wall polysaccharides... - Yeast toxicogenomics: genome-wide responses to chemical stresses with impact in environmental health, pharmacology, and biotechnologySandra C dos Santos
Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Technical University of Lisbon Lisbon, Portugal
Front Genet 3:63. 2012.... - Functional and topological analysis of the Burkholderia cenocepacia priming glucosyltransferase BceB, involved in the biosynthesis of the cepacian exopolysaccharidePaula A Videira
Biological Sciences Research Group, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Lisbon, Portugal
J Bacteriol 187:5013-8. 2005..The results of protein topology analysis using PhoA and LacZ fusions supported in silico predictions that BceB has at least six transmembrane segments and two major cytoplasmic loops comprising the conserved regions described above... - Human mesenchymal stem cell expression program upon extended ex-vivo cultivation, as revealed by 2-DE-based quantitative proteomicsAndreia Madeira
Institute for Biotechnology and Bioengineering IBB, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisboa, Portugal
PLoS ONE 7:e43523. 2012.... - Quantitative 1H-NMR-metabolomics reveals extensive metabolic reprogramming and the effect of the aquaglyceroporin FPS1 in ethanol-stressed yeast cellsArtur B Lourenço
Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Technical University of Lisbon, Lisboa, Portugal
PLoS ONE 8:e55439. 2013.... - Teaching expression proteomics: From the wet-lab to the laptopMiguel C Teixeira
IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Technical University of Lisbon, 1049 001 Lisboa, Portugal Department of Chemical and Biological Engineering, Instituto Superior Tecnico, Technical University of Lisbon, 1049 001 Lisboa, Portugal
Biochem Mol Biol Educ 37:279-86. 2009..The current role of quantitative proteomics in biological research, with emphasis on microbial stress response and on biomedical and biotechnological applications, is addressed, as a case-study, anchored on our group research activities... - Functional analysis of Burkholderia cepacia genes bceD and bceF, encoding a phosphotyrosine phosphatase and a tyrosine autokinase, respectively: role in exopolysaccharide biosynthesis and biofilm formationAna S Ferreira
Institute for Biotechnology and Bioengineering, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisboa, Portugal
Appl Environ Microbiol 73:524-34. 2007.... - Mechanistic insights into the global response to phenol in the phenol-biodegrading strain Pseudomonas sp. M1 revealed by quantitative proteomicsPedro M Santos
Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisboa, Portugal
OMICS 11:233-51. 2007..They were attributed to differences observed in the specific growth rate, in the expression of phenol catabolism, and in resistance to phenol of Pseudomonas sp. M1 grown under different conditions... - Impact of assimilable nitrogen availability in glucose uptake kinetics in Saccharomyces cerevisiae during alcoholic fermentationMargarida Palma
Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Technical University of Lisbon, 1049 001 Lisbon, Portugal
Microb Cell Fact 11:99. 2012..cerevisiae PYCC 4072, of a synthetic grape juice basal medium with either a limiting or non-limiting initial nitrogen concentration and following nitrogen supplementation of the nitrogen-depleted sluggish fermentation... - Occurrence, production, and applications of gellan: current state and perspectivesArsenio M Fialho
IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisbon, Portugal
Appl Microbiol Biotechnol 79:889-900. 2008..In addition, a highlight of the importance of gellan in industrial and medicinal applications is given... - [The clinical course of Burkholderia cepacia complex bacteria respiratory infection in cystic fibrosis patients]Susana Correia
Departamento da Crianca e da Familia, Hospital de Santa Maria, Lisboa, Portugal
Rev Port Pneumol 14:5-26. 2008..Based on the available data, it is not currently possible to outline preventive measures through the molecular characterisation of Bcc isolates, reinforcing the notion that the recommended control measures must be followed... - Characterization of the unique organization and co-regulation of a gene cluster required for phenol and benzene catabolism in Pseudomonas sp. M1Pedro M Santos
IBB, Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001, Lisboa, Portugal
J Biotechnol 131:371-8. 2007..Both promoters are phenol and benzene inducible and evidence supporting the unique sigma(54)-dependent co-regulation of the phenol/benzene inducible genes phcA and phcKLMNOP, mediated by PhcR, was obtained... - Environmental genomics: mechanistic insights into toxicity of and resistance to the herbicide 2,4-DMiguel Cacho Teixeira
IBB Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Tecnico, 1049 001 Lisboa, Portugal
Trends Biotechnol 25:363-70. 2007..This review summarizes recent mechanistic insights into 2,4-D toxicity and the corresponding adaptive responses based on studies carried out using Saccharomyces cerevisiae and Arabidopsis thaliana as model organisms...