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Publications
Comparative effects of Saccharomyces cerevisiae cultivation under copper stress on the activity and kinetic parameters of plasma-membrane-bound H(+)-ATPases PMA1 and PMA2A R Fernandes
Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Lisboa, Portugal
Arch Microbiol 171:273-8. 1999....
Expression of the AZR1 gene (ORF YGR224w), encoding a plasma membrane transporter of the major facilitator superfamily, is required for adaptation to acetic acid and resistance to azoles in Saccharomyces cerevisiaeS Tenreiro
Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisboa, Portugal
Yeast 16:1469-81. 2000....
FLR1 gene (ORF YBR008c) is required for benomyl and methotrexate resistance in Saccharomyces cerevisiae and its benomyl-induced expression is dependent on pdr3 transcriptional regulatorN Brôco
Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, 1049 001 Lisboa, Portugal
Yeast 15:1595-608. 1999..Indeed, PDR3 deletion severely reduces benomyl-induced activation of FLR1 gene expression (by 85%), while the homologous Pdr1p transcription factor is apparently not involved in this activation...
Activity of plasma membrane H+-ATPase and expression of PMA1 and PMA2 genes in Saccharomyces cerevisiae cells grown at optimal and low pHV Carmelo
Laboratorio de Engenharia Bioquimica, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Av Rovisco Pais, P 1096 Lisboa Codex, Portugal
Arch Microbiol 166:315-20. 1996..As observed in response to other kinds of stress, the PMA2 promoter at the optimal pH was up to eightfold more efficient in cells grown at pH 2.5, although it remained several hundred times less efficient than that of the PMA1 gene...
Resistance and adaptation to quinidine in Saccharomyces cerevisiae: role of QDR1 (YIL120w), encoding a plasma membrane transporter of the major facilitator superfamily required for multidrug resistanceP A Nunes
Centro de Engenharia Biológia e Química, Instituto Superior Tecnico, 1049 001 Lisbon, Portugal
Antimicrob Agents Chemother 45:1528-34. 2001..However, we were not able to prove that Qdr1p is directly implicated in this export. Results clearly suggest that there are other unidentified quinidine resistance mechanisms that can be used in the absence of QDR1...
Refining current knowledge on the yeast FLR1 regulatory network by combined experimental and computational approachesM C Teixeira
IBB Institute for Biotechnology and Bioengineering, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Technical University of Lisbon, Av Rovisco Pais, 1049 001 Lisboa, Portugal
Mol Biosyst 6:2471-81. 2010....
Gellan gum biosynthesis in Sphingomonas paucimobilis ATCC 31461: genes, enzymes and exopolysaccharide production engineeringI Sá-Correia
Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, Lisbon 1049 001, Portugal
J Ind Microbiol Biotechnol 29:170-6. 2002....
Saccharomyces cerevisiae adaptation to weak acids involves the transcription factor Haa1p and Haa1p-regulated genesA R Fernandes
Biological Sciences Research Group, Centro de Engenharia Biologica e Quimica, Instituto Superior Tecnico, 1049 001 Lisboa, Portugal
Biochem Biophys Res Commun 337:95-103. 2005..The acetic acid-induced prolongation of the lag phase of unadapted cell populations lacking HAA1 or TPO3, compared with wild-type population, was correlated with the level of the acid accumulated into the stressed cells...
