Maria J Saraiva

Summary

Affiliation: Rua do Campo Alegre
Country: Portugal

Publications

  1. ncbi request reprint Transthyretin mutations in hyperthyroxinemia and amyloid diseases
    M J Saraiva
    Amyloid Unit, Institute for Molecular and Cellular Biology and Instituto de Ciências Biomédicas, Universidade do Porto, Porto, Portugal
    Hum Mutat 17:493-503. 2001
  2. pmc Extracellular matrix markers for disease progression and follow-up of therapies in familial amyloid polyneuropathy V30M TTR-related
    I Cardoso
    Molecular Neurobiology Unit, IBMC Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal
    Dis Markers 25:37-47. 2008
  3. ncbi request reprint Transthyretin deposition in familial amyloidotic polyneuropathy
    M J Saraiva
    Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal
    Curr Med Chem 19:2304-11. 2012
  4. pmc Synergy of combined doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models
    Isabel Cardoso
    Molecular Neurobiology Unit, IBMC Instituto de Biologia Molecular e Celular, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    J Transl Med 8:74. 2010
  5. ncbi request reprint Familial amyloidotic polyneuropathy: protein aggregation in the peripheral nervous system
    Maria João Saraiva
    Molecular Neurobiology, Instituto de Biologia Molecular e Celular, University of Porto, Portugal
    J Mol Neurosci 23:35-40. 2004
  6. ncbi request reprint Hereditary transthyretin amyloidosis: molecular basis and therapeutical strategies
    Maria João Mascarenhas Saraiva
    Amyloid Unit, Institute for Cellular and Molecular Biology, University of Porto, R Campo Alegre, 823 4150 180 Porto, Portugal
    Expert Rev Mol Med 4:1-11. 2002
  7. ncbi request reprint Cellular consequences of transthyretin deposition
    Maria J Saraiva
    Instituto de Biologia Molecular e Celular, Instituto de Ci ncias Biom dicas Abel Salazar, University of Porto, Portugal
    Amyloid 10:13-6. 2003
  8. ncbi request reprint First Spanish family with familial amyloidotic polyneuropathy associated to TTR Thr49Ile mutation
    Maria Joao Saraiva
    Amyloid Unit, Instituto de Biologia Molecular e Celular, Rua do Campo Alegre, no 823, Porto, Portugal
    Amyloid 10:34-5. 2003
  9. ncbi request reprint Transthyretin amyloidosis: a tale of weak interactions
    M J Saraiva
    Amyloid Unit, Instituto Biologia Molecular e Celular, and Instituto de Ciências Biomédicas, Universidade do Porto, R Campo Alegre, 823, 4150, Porto, Portugal
    FEBS Lett 498:201-3. 2001
  10. doi request reprint Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity
    Carolina E Fleming
    Instituto de Biologia Molecular e Celular IBMC, Nerve Regeneration Group and Molecular Neurobiology Group, 4150 180 Porto, Portugal
    J Neurosci 29:3220-32. 2009

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Transthyretin mutations in hyperthyroxinemia and amyloid diseases
    M J Saraiva
    Amyloid Unit, Institute for Molecular and Cellular Biology and Instituto de Ciências Biomédicas, Universidade do Porto, Porto, Portugal
    Hum Mutat 17:493-503. 2001
    ..Current TTR mutations and their significance are briefly reviewed here...
  2. pmc Extracellular matrix markers for disease progression and follow-up of therapies in familial amyloid polyneuropathy V30M TTR-related
    I Cardoso
    Molecular Neurobiology Unit, IBMC Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal
    Dis Markers 25:37-47. 2008
    ..Further studies in a larger number of tissue samples will indicate the application of these ECM markers in parallel with Congo Red staining in tissue characterization of pre-clinical and clinical stages in FAP and other amyloidoses...
  3. ncbi request reprint Transthyretin deposition in familial amyloidotic polyneuropathy
    M J Saraiva
    Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal
    Curr Med Chem 19:2304-11. 2012
    ..Current knowledge and hypotheses on the biology of TTR, mechanisms of TTR amyloid fibril formation, phenotypic consequences TTR amyloid deposition and pre-clinical models of the disease will be discussed...
  4. pmc Synergy of combined doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models
    Isabel Cardoso
    Molecular Neurobiology Unit, IBMC Instituto de Biologia Molecular e Celular, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    J Transl Med 8:74. 2010
    ..The observed synergistic effect of doxycycline/TUDCA in the range of human tolerable quantities, in the transgenic TTR mice models prompts their application in FAP, particularly in the early stages of disease...
  5. ncbi request reprint Familial amyloidotic polyneuropathy: protein aggregation in the peripheral nervous system
    Maria João Saraiva
    Molecular Neurobiology, Instituto de Biologia Molecular e Celular, University of Porto, Portugal
    J Mol Neurosci 23:35-40. 2004
    ..They are pivotal for testing potential drugs for TTR amyloidosis as well...
  6. ncbi request reprint Hereditary transthyretin amyloidosis: molecular basis and therapeutical strategies
    Maria João Mascarenhas Saraiva
    Amyloid Unit, Institute for Cellular and Molecular Biology, University of Porto, R Campo Alegre, 823 4150 180 Porto, Portugal
    Expert Rev Mol Med 4:1-11. 2002
    ..Major areas of research in TTR amyloidosis include: molecular mechanisms leading to fibril formation; mechanisms of fibril-induced cell death; modulators of phenotypic expression of the disease; and therapeutic strategies...
  7. ncbi request reprint Cellular consequences of transthyretin deposition
    Maria J Saraiva
    Instituto de Biologia Molecular e Celular, Instituto de Ci ncias Biom dicas Abel Salazar, University of Porto, Portugal
    Amyloid 10:13-6. 2003
    ..Inflammatory and oxidative stress pathways are triggered by fibrillar and non-fibrillar TTR deposits, a fact to take into account in future forms of FAP treatment...
  8. ncbi request reprint First Spanish family with familial amyloidotic polyneuropathy associated to TTR Thr49Ile mutation
    Maria Joao Saraiva
    Amyloid Unit, Instituto de Biologia Molecular e Celular, Rua do Campo Alegre, no 823, Porto, Portugal
    Amyloid 10:34-5. 2003
    ..The mutation was diagnosed by DNA sequencing and induced mutation restriction analysis...
  9. ncbi request reprint Transthyretin amyloidosis: a tale of weak interactions
    M J Saraiva
    Amyloid Unit, Instituto Biologia Molecular e Celular, and Instituto de Ciências Biomédicas, Universidade do Porto, R Campo Alegre, 823, 4150, Porto, Portugal
    FEBS Lett 498:201-3. 2001
    ..Avoiding tetramer dissociation and disrupting amyloid fibrils are possible avenues of therapeutic intervention based on current molecular knowledge of TTR amyloidogenesis and fibril structure...
  10. doi request reprint Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity
    Carolina E Fleming
    Instituto de Biologia Molecular e Celular IBMC, Nerve Regeneration Group and Molecular Neurobiology Group, 4150 180 Porto, Portugal
    J Neurosci 29:3220-32. 2009
    ..Additionally, TTR presence in the nerve, as is here shown, may underlie its preferential deposition in the PNS of familial amyloid polyneuropathy patients...
  11. ncbi request reprint The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin
    Eurico Morais-de-Sá
    Instituto de Biologia Molecular e Celular IBMC, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    Acta Crystallogr D Biol Crystallogr 62:512-9. 2006
    ....
  12. ncbi request reprint Structural basis for the protective role of sulfite against transthyretin amyloid formation
    Luis Gales
    Unidade de Estrutura Molecular, IBMC Instituto de Biologia Molecular e Celular, Universidade do Porto, 4150 180 Porto, Portugal
    Biochim Biophys Acta 1774:59-64. 2007
    ..Implications of the newly observed interactions in the inhibition of fibril formation are discussed in light of the recent structural models of TTR amyloid fibrils...
  13. doi request reprint Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils
    Artur F Castro-Rodrigues
    IBMC Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal
    Acta Crystallogr D Biol Crystallogr 67:1035-44. 2011
    ....
  14. ncbi request reprint The crystal structure of transthyretin in complex with diethylstilbestrol: a promising template for the design of amyloid inhibitors
    Eurico Morais-de-Sá
    Molecular Structure and Molecular Neurobiology, Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre, Number 823, 4150 Porto, Portugal
    J Biol Chem 279:53483-90. 2004
    ..The present study gave us further insight in the molecular mechanism by which DES competes with thyroid hormone binding to TTR and highlights key interactions between DES and TTR that oppose amyloid formation...
  15. doi request reprint Fibroblasts endocytose and degrade transthyretin aggregates in transthyretin-related amyloidosis
    Yohei Misumi
    Molecular Neurobiology, IBMC Instituto de Biologia Molecular e Celular, Porto, Portugal
    Lab Invest 93:911-20. 2013
    ..The function or dysfunction of TTR clearance by fibroblasts may have important implications for the development, progression, and regression of TTR deposition in the ECM. ..
  16. ncbi request reprint The binding of xanthone derivatives to transthyretin
    Filipe Maia
    Unidade de Estrutura Molecular, IBMC Instituto de Biologia Molecular e Celular, Universidade do Porto, 4150 180 Porto, Portugal
    Biochem Pharmacol 70:1861-9. 2005
    ..Since this xanthone may play a role in the thyroxine metabolism and/or over the pathogenic process associated with the amyloid disease, these results may be explored for the design of new ligands...
  17. ncbi request reprint Immunization in familial amyloidotic polyneuropathy: counteracting deposition by immunization with a Y78F TTR mutant
    Hisayasu Terazaki
    Molecular Neurobiology, Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal
    Lab Invest 86:23-31. 2006
    ..Therefore, TTR immunization with selected TTR mutants has potential application in immune therapy for FAP...
  18. doi request reprint Presence of N-glycosylated transthyretin in plasma of V30M carriers in familial amyloidotic polyneuropathy: an escape from ERAD
    Anabela C Teixeira
    Molecular Neurobiology, Instituto de Biologia Molecular e Celular, IBMC, Porto, Portugal
    J Cell Mol Med 17:429-35. 2013
    ..Studies on the metabolism of this novel, glycosylated TTR secreted from FAP liver are warranted to provide new mechanisms in protein quality control and etiopathogenesis of the disease...
  19. pmc Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor
    Rita Costa
    Molecular Neurobiology, Instituto de Biologia Molecular e Celular, Porto, Portugal
    PLoS ONE 3:e2899. 2008
    ..TTR may prove to be a useful therapeutic agent for preventing or retarding the cerebral amyloid plaque formation implicated in AD pathology...
  20. ncbi request reprint X-ray absorption spectroscopy reveals a substantial increase of sulfur oxidation in transthyretin (TTR) upon fibrillization
    Luis Gales
    ICBAS, Instituto de Ciencias Biomedicas Abel Salazar, Universidade do Porto, Largo Prof Abel Salazar n 2, 4099 003 Porto, Portugal
    J Biol Chem 278:11654-60. 2003
    ..Further interpretation of the data reveals that there are no disulfide bridges in the fibrillar samples and suggest conformational changes in the TTR molecule, namely in strand A and/or in its vicinity, upon fibril formation...
  21. doi request reprint Transthyretin is a metallopeptidase with an inducible active site
    Márcia A Liz
    Nerve Regeneration Group, Instituto de Biologia Molecular e Celular IBMC, 4150 180 Porto, Portugal
    Biochem J 443:769-78. 2012
    ..Glu72 was identified as the general base involved in activation of the catalytic water. Our results unveil TTR as a metallopeptidase and define its catalytic machinery...
  22. pmc Distinct annular oligomers captured along the assembly and disassembly pathways of transthyretin amyloid protofibrils
    Ricardo H Pires
    Department of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    PLoS ONE 7:e44992. 2012
    ..Although annular oligomers have been detected in many amyloidogenic systems, their universality, function and molecular mechanisms of appearance are debated...
  23. ncbi request reprint Transthyretin enhances nerve regeneration
    Carolina E Fleming
    Instituto de Biologia Molecular e Celular IBMC, Molecular Neurobiology Group, Porto, Portugal
    J Neurochem 103:831-9. 2007
    ..Moreover, the assignment of a TTR function in nerve biology and repair, may explain its preferential deposition, when mutated, in the PNS of familial amyloid polyneuropathy patients...