Vitor Costa

Summary

Affiliation: Rua do Campo Alegre
Country: Portugal

Publications

  1. ncbi request reprint Protein oxidation, repair mechanisms and proteolysis in Saccharomyces cerevisiae
    Vitor Costa
    IBMC, Instituto de Biologia Molecular e Celular, Porto, Portugal
    IUBMB Life 59:293-8. 2007
  2. pmc Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism
    António Rego
    Departamento de Biologia, Centro de Biologia Molecular e Ambiental, Universidade do Minho, Braga, Portugal
    PLoS ONE 7:e48571. 2012
  3. pmc Quercetin protects Saccharomyces cerevisiae against oxidative stress by inducing trehalose biosynthesis and the cell wall integrity pathway
    Rita Vilaça
    Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal
    PLoS ONE 7:e45494. 2012
  4. doi request reprint Activation of the Hog1p kinase in Isc1p-deficient yeast cells is associated with mitochondrial dysfunction, oxidative stress sensitivity and premature aging
    António Daniel Barbosa
    IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre, 823, 4150 180 Porto, Portugal
    Mech Ageing Dev 133:317-30. 2012
  5. pmc Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis
    Teresa Almeida
    IBMC, Instituto de Biologia Molecular e Celular, Grupo de Microbiologia Celular e Aplicada, 4150 180 Porto, Portugal
    Mol Biol Cell 19:865-76. 2008
  6. pmc Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells
    António Daniel Barbosa
    IBMC, Instituto de Biologia Molecular e Celular, Grupo de Microbiologia Celular e Aplicada, Rua do Campo Alegre, 823, 4150 180 Porto, Portugal
    Mol Microbiol 81:515-27. 2011
  7. ncbi request reprint The Pep4p vacuolar proteinase contributes to the turnover of oxidized proteins but PEP4 overexpression is not sufficient to increase chronological lifespan in Saccharomyces cerevisiae
    Marta Marques
    IBMC, Instituto de Biologia Molecular e Celular, Grupo de Microbiologia Celular e Aplicada, Rua do Campo Alegre, 823, 4150 180 Porto, Portugal
    Microbiology 152:3595-605. 2006
  8. ncbi request reprint Quercetin increases oxidative stress resistance and longevity in Saccharomyces cerevisiae
    Iracema Belinha
    Centro de Investigacao em Quimica, Departamento de Quimica, Faculdade de Ciencias, IBMC, Instituto de Biologia Molecular e Celular, Grupo de Microbiologia Celular e Aplicada, Universidade do Porto, Porto, Portugal
    J Agric Food Chem 55:2446-51. 2007
  9. pmc Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity
    Ana Mesquita
    Instituto de Investigação em Ciências da Vida e Saúde, Escola de Ciências da Saúde, Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Proc Natl Acad Sci U S A 107:15123-8. 2010
  10. doi request reprint Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1
    Rita Vilaça
    IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre, 823, 4150 180, Porto, Portugal ICBAS, Instituto de Ciencias Biomedicas Abel Salazar, Departamento de Biologia Molecular, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050 313, Porto, Portugal
    Mol Microbiol 91:438-51. 2014

Collaborators

  • Pedro Moradas-Ferreira
  • Manuela Corte-Real
  • Stefan Hohmann
  • William C Burhans
  • Clara Pereira
  • Nuno Santarém
  • Laura Carreto
  • Peter W Piper
  • Rita Vilaça
  • António Daniel Barbosa
  • Maria Amélia Amorim
  • Teresa Almeida
  • Yusuf A Hannun
  • Nicholas Harris
  • Marta Marques
  • Nabil Matmati
  • Cláudia Bessa
  • Marta Vaz Mendes
  • Susana Rodrigues Chaves
  • António Rego
  • Vanda Mendes
  • Ana Mesquita
  • Nuno Mateus
  • Victor de Freitas
  • Sandra Carvalho
  • Bruno Almeida
  • Paula Ludovico
  • Pedro Rodrigues
  • Iracema Belinha
  • Dominik Mojzita
  • Maria A Amorim
  • Mehdi Mollapour
  • Joana Gaifem
  • Maria Clara Sa Miranda
  • André Nadais
  • Elísio Silva
  • Vitor Teixeira
  • Cláudia Maciel
  • Lucília Saraiva
  • Sara Gomes
  • Jorge Goncalves
  • Mariana Leão
  • Helena Pereira
  • Maria João Sousa
  • João Graça
  • Margarida Costa
  • Hugo Osorio
  • Jacek Bielawski
  • Mariana Alves
  • Kellie J Sims
  • Martin Weinberger
  • Cecília Leão
  • Alexandra Silva
  • Belém Sampaio-Marques
  • Fernando Rodrigues
  • Helena Castro
  • Tania Cruz
  • Ana M Tomás
  • Rui D Silva
  • Marcus Bachler
  • Morag MacLean

Detail Information

Publications14

  1. ncbi request reprint Protein oxidation, repair mechanisms and proteolysis in Saccharomyces cerevisiae
    Vitor Costa
    IBMC, Instituto de Biologia Molecular e Celular, Porto, Portugal
    IUBMB Life 59:293-8. 2007
    ....
  2. pmc Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism
    António Rego
    Departamento de Biologia, Centro de Biologia Molecular e Ambiental, Universidade do Minho, Braga, Portugal
    PLoS ONE 7:e48571. 2012
    ....
  3. pmc Quercetin protects Saccharomyces cerevisiae against oxidative stress by inducing trehalose biosynthesis and the cell wall integrity pathway
    Rita Vilaça
    Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal
    PLoS ONE 7:e45494. 2012
    ..In this study we aimed to identify genes differentially expressed in yeast cells treated with quercetin and its role in oxidative stress protection...
  4. doi request reprint Activation of the Hog1p kinase in Isc1p-deficient yeast cells is associated with mitochondrial dysfunction, oxidative stress sensitivity and premature aging
    António Daniel Barbosa
    IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre, 823, 4150 180 Porto, Portugal
    Mech Ageing Dev 133:317-30. 2012
    ..Our findings support a role for Hog1p in the regulation of mitochondrial function and suggest that constitutive activation of Hog1p is deleterious for isc1Δ cells under oxidative stress conditions and during chronological aging...
  5. pmc Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis
    Teresa Almeida
    IBMC, Instituto de Biologia Molecular e Celular, Grupo de Microbiologia Celular e Aplicada, 4150 180 Porto, Portugal
    Mol Biol Cell 19:865-76. 2008
    ..These results indicate that Isc1p plays an important role in the regulation of cellular redox homeostasis, through modulation of iron levels, and of apoptosis...
  6. pmc Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells
    António Daniel Barbosa
    IBMC, Instituto de Biologia Molecular e Celular, Grupo de Microbiologia Celular e Aplicada, Rua do Campo Alegre, 823, 4150 180 Porto, Portugal
    Mol Microbiol 81:515-27. 2011
    ..The overall results show that Isc1p is an upstream regulator of Sit4p and implicate Sit4p activation in mitochondrial dysfunction leading to the shortened chronological lifespan and oxidative stress sensitivity of isc1Δ mutants...
  7. ncbi request reprint The Pep4p vacuolar proteinase contributes to the turnover of oxidized proteins but PEP4 overexpression is not sufficient to increase chronological lifespan in Saccharomyces cerevisiae
    Marta Marques
    IBMC, Instituto de Biologia Molecular e Celular, Grupo de Microbiologia Celular e Aplicada, Rua do Campo Alegre, 823, 4150 180 Porto, Portugal
    Microbiology 152:3595-605. 2006
    ..These results indicate that Pep4p is important for protein turnover after oxidative damage; however, increased removal of oxidized proteins is not sufficient to enhance lifespan...
  8. ncbi request reprint Quercetin increases oxidative stress resistance and longevity in Saccharomyces cerevisiae
    Iracema Belinha
    Centro de Investigacao em Quimica, Departamento de Quimica, Faculdade de Ciencias, IBMC, Instituto de Biologia Molecular e Celular, Grupo de Microbiologia Celular e Aplicada, Universidade do Porto, Porto, Portugal
    J Agric Food Chem 55:2446-51. 2007
    ..In agreement, quercetin also increased 60% chronological life span. These results support the utilization of yeast as a useful model to screen in vivo for natural antioxidants with putative health beneficial effects...
  9. pmc Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity
    Ana Mesquita
    Instituto de Investigação em Ciências da Vida e Saúde, Escola de Ciências da Saúde, Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Proc Natl Acad Sci U S A 107:15123-8. 2010
    ..These findings establish a role for hormesis effects of hydrogen peroxide in promoting longevity that have broad implications for understanding aging and age-related diseases...
  10. doi request reprint Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1
    Rita Vilaça
    IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre, 823, 4150 180, Porto, Portugal ICBAS, Instituto de Ciencias Biomedicas Abel Salazar, Departamento de Biologia Molecular, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050 313, Porto, Portugal
    Mol Microbiol 91:438-51. 2014
    ..These results suggest that sphingolipid signalling through Pkh1p-Sch9p mediate mitochondrial dysfunction, oxidative stress sensitivity and shortened chronological lifespan in the yeast model of Niemann-Pick type C disease. ..
  11. doi request reprint Using yeast to uncover the regulation of protein kinase Cδ by ceramide
    Cláudia Bessa
    REQUIMTE, Laboratorio de Microbiologia, Departamento de Ciencias Biologicas, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
    FEMS Yeast Res 13:700-5. 2013
    ..Altogether, these results may indicate that ceramide distinctly interfere with the activity of PKCα, δ and ζ. Most importantly, they showed that ceramide is an inhibitor of PKCδ. ..
  12. doi request reprint Heme as a source of iron to Leishmania infantum amastigotes
    Sandra Carvalho
    Instituto de Biologia Molecular e Celular, Porto, Portugal
    Acta Trop 109:131-5. 2009
    ..The co-existence in Leishmania amastigotes of different processes to acquire iron could constitute an infective strategy, ensuring parasites a substantial advantage in situations of iron limitation...
  13. ncbi request reprint Overexpressed Sod1p acts either to reduce or to increase the lifespans and stress resistance of yeast, depending on whether it is Cu(2+)-deficient or an active Cu,Zn-superoxide dismutase
    Nicholas Harris
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
    Aging Cell 4:41-52. 2005
    ..The same events may generate the detrimental effects that are frequently, though not universally, observed when Cu,Zn-Sod overexpression is attempted in metazoans...
  14. ncbi request reprint Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells
    Nicholas Harris
    Department of Biochemistry and Molecular Biology, University College London, England, London, UK
    Free Radic Biol Med 34:1599-606. 2003
    ..Mitochondrial defects are, therefore, the probable reason that MnSOD overexpression shortens replicative life span...