Research Topics
| Vitor CostaSummaryAffiliation: Rua do Campo Alegre Country: Portugal Publications
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Detail Information
Publications
Protein oxidation, repair mechanisms and proteolysis in Saccharomyces cerevisiaeVitor Costa
IBMC, Instituto de Biologia Molecular e Celular, Porto, Portugal
IUBMB Life 59:293-8. 2007....
Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosisTeresa Almeida
IBMC, Instituto de Biologia Molecular e Celular, Grupo de Microbiologia Celular e Aplicada, 4150 180 Porto, Portugal
Mol Biol Cell 19:865-76. 2008..These results indicate that Isc1p plays an important role in the regulation of cellular redox homeostasis, through modulation of iron levels, and of apoptosis...
Activation of the Hog1p kinase in Isc1p-deficient yeast cells is associated with mitochondrial dysfunction, oxidative stress sensitivity and premature agingAntónio Daniel Barbosa
IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre, 823, 4150 180 Porto, Portugal
Mech Ageing Dev 133:317-30. 2012..Our findings support a role for Hog1p in the regulation of mitochondrial function and suggest that constitutive activation of Hog1p is deleterious for isc1Δ cells under oxidative stress conditions and during chronological aging...- Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cellsAntónio Daniel Barbosa
IBMC, Instituto de Biologia Molecular e Celular, Grupo de Microbiologia Celular e Aplicada, Rua do Campo Alegre, 823, 4150 180 Porto, Portugal
Mol Microbiol 81:515-27. 2011..The overall results show that Isc1p is an upstream regulator of Sit4p and implicate Sit4p activation in mitochondrial dysfunction leading to the shortened chronological lifespan and oxidative stress sensitivity of isc1Δ mutants... - Quercetin protects Saccharomyces cerevisiae against oxidative stress by inducing trehalose biosynthesis and the cell wall integrity pathwayRita Vilaça
Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal
PLoS ONE 7:e45494. 2012..In this study we aimed to identify genes differentially expressed in yeast cells treated with quercetin and its role in oxidative stress protection... - The Pep4p vacuolar proteinase contributes to the turnover of oxidized proteins but PEP4 overexpression is not sufficient to increase chronological lifespan in Saccharomyces cerevisiaeMarta Marques
IBMC, Instituto de Biologia Molecular e Celular, Grupo de Microbiologia Celular e Aplicada, Rua do Campo Alegre, 823, 4150 180 Porto, Portugal
Microbiology 152:3595-605. 2006..These results indicate that Pep4p is important for protein turnover after oxidative damage; however, increased removal of oxidized proteins is not sufficient to enhance lifespan... - Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolismAntónio Rego
Departamento de Biologia, Centro de Biologia Molecular e Ambiental, Universidade do Minho, Braga, Portugal
PLoS ONE 7:e48571. 2012.... - Quercetin increases oxidative stress resistance and longevity in Saccharomyces cerevisiaeIracema Belinha
Centro de Investigacao em Quimica, Departamento de Quimica, Faculdade de Ciencias, IBMC, Instituto de Biologia Molecular e Celular, Grupo de Microbiologia Celular e Aplicada, Universidade do Porto, Porto, Portugal
J Agric Food Chem 55:2446-51. 2007..In agreement, quercetin also increased 60% chronological life span. These results support the utilization of yeast as a useful model to screen in vivo for natural antioxidants with putative health beneficial effects... - Heme as a source of iron to Leishmania infantum amastigotesSandra Carvalho
Instituto de Biologia Molecular e Celular, Porto, Portugal
Acta Trop 109:131-5. 2009..The co-existence in Leishmania amastigotes of different processes to acquire iron could constitute an infective strategy, ensuring parasites a substantial advantage in situations of iron limitation... - Overexpressed Sod1p acts either to reduce or to increase the lifespans and stress resistance of yeast, depending on whether it is Cu(2+)-deficient or an active Cu,Zn-superoxide dismutaseNicholas Harris
Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
Aging Cell 4:41-52. 2005..The same events may generate the detrimental effects that are frequently, though not universally, observed when Cu,Zn-Sod overexpression is attempted in metazoans... - Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cellsNicholas Harris
Department of Biochemistry and Molecular Biology, University College London, England, London, UK
Free Radic Biol Med 34:1599-606. 2003..Mitochondrial defects are, therefore, the probable reason that MnSOD overexpression shortens replicative life span...