António E Pinto

Summary

Country: Portugal

Publications

  1. doi request reprint DNA ploidy is an independent predictor of survival in breast invasive ductal carcinoma: a long-term multivariate analysis of 393 patients
    António E Pinto
    Servico de Anatomia Patologica, Instituto Português de Oncologia de Lisboa, EPE, Lisbon, Portugal
    Ann Surg Oncol 20:1530-7. 2013
  2. doi request reprint S-phase fraction and ploidy as predictive markers in primary disease and recurrence of papillary thyroid carcinoma
    António E Pinto
    Serviço de Anatomia Patológicado, Instituto Português de Oncologia de Lisboa, EPE, Lisbon, Portugal
    Clin Endocrinol (Oxf) 77:302-9. 2012
  3. ncbi request reprint Prognostic biomarkers in renal cell carcinoma: relevance of DNA ploidy in predicting disease-related survival
    A E Pinto
    Pathology Service, Instituto Portugues de Oncologia de Francisco Gentil, CROL, SA, Lisbon, Portugal
    Int J Biol Markers 20:249-56. 2005
  4. ncbi request reprint DNA flow cytometry but not telomerase activity as predictor of disease-free survival in pT1-2/N0/G2 breast cancer
    António E Pinto
    Serviço de Anatomia Patológica do Instituto Português de Oncologia de Lisboa, E P E, Portugal
    Pathobiology 73:63-70. 2006
  5. pmc Frequent 7q gains in flow cytometric multiploid/hypertetraploid breast carcinomas: a study of chromosome imbalances by comparative genomic hybridisation
    A E Pinto
    Department of Pathology, CROL, SA, Lisbon, Portugal
    J Clin Pathol 59:367-72. 2006
  6. ncbi request reprint Correlations of cell cycle regulators (p53, p21, pRb and mdm2) and c-erbB-2 with biological markers of proliferation and overall survival in breast cancer
    António E Pinto
    Departamento de Patologia Morfologica, Instituto Portugues de Oncologia de Francisco Gentil, Centro Regional Oncológico de Lisboa, SA, Portugal
    Pathology 37:45-50. 2005
  7. ncbi request reprint Aneuploidy and high S-phase as biomarkers of poor clinical outcome in poorly differentiated and anaplastic thyroid carcinoma
    António E Pinto
    Servico de Anatomia Patologica, Instituto Português Oncologia de Lisboa, E P E, Lisbon, Portugal
    Oncol Rep 20:913-9. 2008
  8. doi request reprint Clinical implications of molecular markers in follicular cell-derived thyroid cancer
    António E Pinto
    Servico de Anatomia Patologica, Instituto Português de Oncologia de Lisboa, EPE, Rua Professor Lima Basto, 1099 023 Lisbon, Portugal
    Expert Rev Mol Diagn 9:679-94. 2009
  9. doi request reprint BCL-6 oncoprotein in breast cancer: loss of expression in disease progression
    António E Pinto
    Servico de Anatomia Patologica, Instituto Português de Oncologia de Lisboa, E P E, Lisboa, Portugal
    Pathobiology 76:235-42. 2009
  10. ncbi request reprint Male and female breast cancer--differences in DNA ploidy, p21 and p53 expression reinforce the possibility of distinct pathways of oncogenesis
    Saudade André
    Servico de Anatomia Patologica, Instituto Português de Oncologia de Lisboa Francisco Gentil, E P E, Lisboa, Portugal
    Pathobiology 74:323-7. 2007

Detail Information

Publications21

  1. doi request reprint DNA ploidy is an independent predictor of survival in breast invasive ductal carcinoma: a long-term multivariate analysis of 393 patients
    António E Pinto
    Servico de Anatomia Patologica, Instituto Português de Oncologia de Lisboa, EPE, Lisbon, Portugal
    Ann Surg Oncol 20:1530-7. 2013
    ..To evaluate "classic" prognostic parameters, as well as DNA ploidy and S-phase fraction (SPF), in relation to disease-free (DFS) and disease-specific (DSS) survival in breast invasive ductal carcinoma (IDC) with long-term follow-up study...
  2. doi request reprint S-phase fraction and ploidy as predictive markers in primary disease and recurrence of papillary thyroid carcinoma
    António E Pinto
    Serviço de Anatomia Patológicado, Instituto Português de Oncologia de Lisboa, EPE, Lisbon, Portugal
    Clin Endocrinol (Oxf) 77:302-9. 2012
    ..To investigate the prognostic influence of DNA ploidy and S-phase fraction (SPF) on disease-free (DFS) and overall survival (OS) of patients with primary disease and loco-regional lymph node recurrence of papillary thyroid carcinoma (PTC)...
  3. ncbi request reprint Prognostic biomarkers in renal cell carcinoma: relevance of DNA ploidy in predicting disease-related survival
    A E Pinto
    Pathology Service, Instituto Portugues de Oncologia de Francisco Gentil, CROL, SA, Lisbon, Portugal
    Int J Biol Markers 20:249-56. 2005
    ..To investigate the prognostic value of DNA ploidy, Ki-67 index and p53 expression in relation to disease-related survival in a consecutive series of patients with renal cell carcinoma (RCC)...
  4. ncbi request reprint DNA flow cytometry but not telomerase activity as predictor of disease-free survival in pT1-2/N0/G2 breast cancer
    António E Pinto
    Serviço de Anatomia Patológica do Instituto Português de Oncologia de Lisboa, E P E, Portugal
    Pathobiology 73:63-70. 2006
    ....
  5. pmc Frequent 7q gains in flow cytometric multiploid/hypertetraploid breast carcinomas: a study of chromosome imbalances by comparative genomic hybridisation
    A E Pinto
    Department of Pathology, CROL, SA, Lisbon, Portugal
    J Clin Pathol 59:367-72. 2006
    ..To investigate underlying genetic events associated with complex DNA ploidy breast carcinomas...
  6. ncbi request reprint Correlations of cell cycle regulators (p53, p21, pRb and mdm2) and c-erbB-2 with biological markers of proliferation and overall survival in breast cancer
    António E Pinto
    Departamento de Patologia Morfologica, Instituto Portugues de Oncologia de Francisco Gentil, Centro Regional Oncológico de Lisboa, SA, Portugal
    Pathology 37:45-50. 2005
    ....
  7. ncbi request reprint Aneuploidy and high S-phase as biomarkers of poor clinical outcome in poorly differentiated and anaplastic thyroid carcinoma
    António E Pinto
    Servico de Anatomia Patologica, Instituto Português Oncologia de Lisboa, E P E, Lisbon, Portugal
    Oncol Rep 20:913-9. 2008
    ..The results indicate that aneuploidy and high SPF are biomarkers of poor clinical outcome in PDTC and ATC, which may provide useful prognostic information with a potentially therapeutic impact in patient management...
  8. doi request reprint Clinical implications of molecular markers in follicular cell-derived thyroid cancer
    António E Pinto
    Servico de Anatomia Patologica, Instituto Português de Oncologia de Lisboa, EPE, Rua Professor Lima Basto, 1099 023 Lisbon, Portugal
    Expert Rev Mol Diagn 9:679-94. 2009
    ..Besides increasing our comprehension of cancer biology, either genetic alterations or gene expression profiles implicated in thyroid carcinogenesis shed new light on innovative diagnostic procedures as well as on targeted therapies...
  9. doi request reprint BCL-6 oncoprotein in breast cancer: loss of expression in disease progression
    António E Pinto
    Servico de Anatomia Patologica, Instituto Português de Oncologia de Lisboa, E P E, Lisboa, Portugal
    Pathobiology 76:235-42. 2009
    ..To investigate the biological role of BCL-6 oncoprotein in breast cancer disease progression (recurrence and metastasis)...
  10. ncbi request reprint Male and female breast cancer--differences in DNA ploidy, p21 and p53 expression reinforce the possibility of distinct pathways of oncogenesis
    Saudade André
    Servico de Anatomia Patologica, Instituto Português de Oncologia de Lisboa Francisco Gentil, E P E, Lisboa, Portugal
    Pathobiology 74:323-7. 2007
    ..The purpose of this study was to compare the immunohistochemical profile of cell cycle inhibitors of G1/S phase transition (p21, p53 and pRb), Ki-67 proliferation marker and DNA ploidy in male (MBC) and female breast cancer (FBC)...
  11. ncbi request reprint Independent prognostic value of hormone receptor expression and S-phase fraction in advanced breast cancer
    António E Pinto
    Department of Anatomic Pathology, Instituto Portugues de Oncologia de Francisco Gentil, Centro de Lisboa, Lisbon, Portugal
    Anal Quant Cytol Histol 24:345-54. 2002
    ..TO assess the prognostic value of immunocytochemically assessed hormone receptor expression and DNA flow cytometry data in advanced breast cancer...
  12. ncbi request reprint Underexpression of PPARgamma is associated with aneuploidy and lower differentiation of thyroid tumours of follicular origin
    Carla Espadinha
    Molecular Endocrinology Group, Molecular Pathobiology Research Centre CIPM, Portuguese Institute of Oncology of Lisbon Francisco Gentil E P E, Lisbon, Portugal
    Oncol Rep 22:907-13. 2009
    ..Therapies designed to modulate expression of PPARgamma may have an impact on the growth of thyroid neoplasias...
  13. ncbi request reprint Aneuploidy and RAS mutations are mutually exclusive events in the development of well-differentiated thyroid follicular tumours
    Ana Banito
    Centro de Investigacao de Patobiologia Molecular CIPM, Instituto Português de Oncologia de Lisboa Francisco Gentil E P E, Lisboa, Portugal
    Clin Endocrinol (Oxf) 67:706-11. 2007
    ..The aim of our study was to investigate the correlation between aneuploidy, RAS mutations and PAX8/PPARgamma gene rearrangement in thyroid follicular tumours...
  14. ncbi request reprint [DNA flow cytrometry in solid tumors]
    António E Pinto
    Departamento de Patologia Morfológica e Centro de Investigação de Patobiologia Molecular, Instituto Portugues de Oncologia de Francisco Gentil, Lisboa
    Acta Med Port 15:133-42. 2002
    ..The potential reasons for conflicting results, namely the methodological pitfalls related to the cell preparation techniques and the histogram interpretation are discussed...
  15. pmc Prognostic comparative study of S-phase fraction and Ki-67 index in breast carcinoma
    A E Pinto
    , , , Centro de Lisboa, 1099-023 Lisboa Codex, Portugal
    J Clin Pathol 54:543-9. 2001
    ..3844; p < 0.001), especially in the subgroup of diploid tumours. CONCLUSIONS: Flow cytometric SPF is a better prognosticator than the Ki-67 index, but only SPF variables applied in the whole series show potential clinical usefulness...
  16. ncbi request reprint [DNA ploidy is an independent prognostic biomarker in breast invasive ductal carcinoma]
    António E Pinto
    Servico de Anatomia Patologica, Instituto Português de Oncologia de Lisboa Francisco Gentil, E P E, Lisboa, Portugal
    Acta Med Port 25:399-407. 2012
    ..To evaluate 'classic' prognostic parameters, as well as DNA ploidy and S-phase fraction, in relation to disease-free and overall survival in breast invasive ductal carcinoma with long-term follow-up...
  17. ncbi request reprint Flow cytometric S-phase fraction as a complementary biological parameter for the cytological grading of non-Hodgkin's lymphoma
    António E Pinto
    Department of Morphologic Pathology, Portuguese Oncologic Institute, Lisbon Center, Portugal
    Diagn Cytopathol 29:194-9. 2003
    ..223). These results show that flow cytometric SPF is a valuable complementary parameter for grading NHLs on FNAC samples, but it appears to give no additional prognostic information on subset analyses...
  18. doi request reprint High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas
    Margarida M Moura
    Centro de Investigação de Patobiologia Molecular, Instituto Português de Oncologia de Lisboa Francisco Gentil E P E, Rua Prof Lima Basto, 1099 023 Lisboa, Portugal
    J Clin Endocrinol Metab 96:E863-8. 2011
    ..Sporadic medullary thyroid carcinomas (MTC) frequently harbor mutations in the RET protooncogene. We have earlier reported a series of 51 sporadic MTC with 64.7% of RET-positive and 35.3% of RET-negative cases...
  19. pmc Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas
    M M Moura
    Centro de Investigacao de Patobiologia Molecular CIPM, Instituto Português de Oncologia de Lisboa Francisco Gentil E P E, Rua Prof Lima Basto, 1099 023 Lisboa, Portugal
    Br J Cancer 100:1777-83. 2009
    ..Cases with other RET mutations have the most indolent course, and those with no RET mutations have an intermediate risk...
  20. ncbi request reprint Overall survival in advanced breast cancer: relevance of progesterone receptor expression and DNA ploidy in fine-needle aspirates of 392 patients
    A E Pinto
    Department of Pathology, Portuguese Oncological Institute, Lisbon, Portugal
    Int J Biol Markers 18:7-12. 2003
    ..These data indicate that progesterone receptor expression and DNA ploidy are independent prognostic factors in advanced breast cancer...
  21. ncbi request reprint Male breast cancer--a reappraisal of clinical and biologic indicators of prognosis
    S Andre
    Departamento de Patologia Morfologica, Instituto Portugues de Oncologia de Francisco Gentil, Centro de Lisboa, Portugal
    Acta Oncol 40:472-8. 2001
    ..Clinically useful information on the probability of relapse can be added by determining c-erbB-2 (p = 0.02) and progesterone receptors (p = 0.04) in stage III and tumor ploidy (p = 0.04) in pN1 subgroups of patients...