N S Hari Narayana Moorthy

Summary

Country: Portugal

Publications

  1. ncbi request reprint Fused aryl-phenazines: scaffold for the development of bioactive molecules
    N S Hari Narayana Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, S N, Rua do Campo Alegre, 4169 007 Porto, Portugal
    Curr Drug Targets 15:681-8. 2014
  2. ncbi request reprint Development of ribonucleotide reductase inhibitors: a review on structure activity relationships
    Narayana S H N Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, S N, Rua do Campo Alegre, 4169 007 Porto, Portugal
    Mini Rev Med Chem 13:1862-72. 2013
  3. ncbi request reprint Aryl- and heteroaryl-thiosemicarbazone derivatives and their metal complexes: a pharmacological template
    Narayana S H N Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, S N, Rua do Campo Alegre, 4169 007 Porto, Portugal
    Recent Pat Anticancer Drug Discov 8:168-82. 2013
  4. ncbi request reprint Human ether-a-go-go-related gene channel blockers and its structural analysis for drug design
    Narayana S Hari Narayana Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, 687, Rua do Campo Alegre, 4169 007 Porto, Portugal
    Curr Drug Targets 14:102-13. 2013
  5. doi request reprint Virtual screening and QSAR study of some pyrrolidine derivatives as α-mannosidase inhibitors for binding feature analysis
    N S H N Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto 687, Rua do Campo Alegre, 4169 007 Porto, Portugal
    Bioorg Med Chem 20:6945-59. 2012
  6. ncbi request reprint Structural analysis of structurally diverse α-glucosidase inhibitors for active site feature analysis
    N S Hari Narayana Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, Rua do Campo Alegre, Porto, Portugal
    J Enzyme Inhib Med Chem 27:649-57. 2012
  7. doi request reprint Analysis of van der Waals surface area properties for human ether-a-go-go-related gene blocking activity: computational study on structurally diverse compounds
    N S H N Moorthy
    REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal
    SAR QSAR Environ Res 23:521-36. 2012
  8. ncbi request reprint In silico based structural analysis of some piperidine analogs as farnesyltransferase inhibitors
    Narayana Subbiah Hari Narayana Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, de Ciências, Universidade do Porto, 687, Rua do Campo Alegre, 4169 007 Porto, Portugal
    Med Chem 8:853-64. 2012
  9. ncbi request reprint Studies on α-glucosidase inhibitors development: magic molecules for the treatment of carbohydrate mediated diseases
    N S H N Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, 687, Rua do Campo Alegre, 4169 007 Porto, Portugal
    Mini Rev Med Chem 12:713-20. 2012
  10. doi request reprint Structural feature study of benzofuran derivatives as farnesyltransferase inhibitors
    N S Hari Narayana Moorthy
    REQUIMTE, Departamento de Quimica, Faculdade de Ciencias, Universidade do Porto, Porto, Portugal
    J Enzyme Inhib Med Chem 26:777-91. 2011

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Fused aryl-phenazines: scaffold for the development of bioactive molecules
    N S Hari Narayana Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, S N, Rua do Campo Alegre, 4169 007 Porto, Portugal
    Curr Drug Targets 15:681-8. 2014
    ..Recent patents on these scaffolds showed that the benzo[a]phenazine derivatives have inhibitory activity on topoisomerase enzymes (Topo I and II) and that act as anticancer agents. ..
  2. ncbi request reprint Development of ribonucleotide reductase inhibitors: a review on structure activity relationships
    Narayana S H N Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, S N, Rua do Campo Alegre, 4169 007 Porto, Portugal
    Mini Rev Med Chem 13:1862-72. 2013
    ..Further, the fragmental analysis of the RNR inhibitors on different toxicological and metabolic targets can provide significant novel molecules with acceptable pharmacokinetic properties. ..
  3. ncbi request reprint Aryl- and heteroaryl-thiosemicarbazone derivatives and their metal complexes: a pharmacological template
    Narayana S H N Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, S N, Rua do Campo Alegre, 4169 007 Porto, Portugal
    Recent Pat Anticancer Drug Discov 8:168-82. 2013
    ....
  4. ncbi request reprint Human ether-a-go-go-related gene channel blockers and its structural analysis for drug design
    Narayana S Hari Narayana Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, 687, Rua do Campo Alegre, 4169 007 Porto, Portugal
    Curr Drug Targets 14:102-13. 2013
    ..This review concluded that the consideration of physicochemical properties necessary for the hERG blocking activity will guide to develop novel drugs with less cardiotoxicity...
  5. doi request reprint Virtual screening and QSAR study of some pyrrolidine derivatives as α-mannosidase inhibitors for binding feature analysis
    N S H N Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto 687, Rua do Campo Alegre, 4169 007 Porto, Portugal
    Bioorg Med Chem 20:6945-59. 2012
    ..Our results suggest that the best compound to inhibit both classes of α-mannosidase is the compound 30, which may be used to design similar and better inhibitors to next generation drugs...
  6. ncbi request reprint Structural analysis of structurally diverse α-glucosidase inhibitors for active site feature analysis
    N S Hari Narayana Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, Rua do Campo Alegre, Porto, Portugal
    J Enzyme Inhib Med Chem 27:649-57. 2012
    ..These results reveal that the developed models are statistically significant and can be used with other molecular modelling works for designing novel α-glucosidase inhibitors with multiple activities (HIV, diabetics, cancer, etc)...
  7. doi request reprint Analysis of van der Waals surface area properties for human ether-a-go-go-related gene blocking activity: computational study on structurally diverse compounds
    N S H N Moorthy
    REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal
    SAR QSAR Environ Res 23:521-36. 2012
    ..These results can be used with other molecular modelling studies for the design of novel molecules that are free of cardiotoxicity...
  8. ncbi request reprint In silico based structural analysis of some piperidine analogs as farnesyltransferase inhibitors
    Narayana Subbiah Hari Narayana Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, de Ciências, Universidade do Porto, 687, Rua do Campo Alegre, 4169 007 Porto, Portugal
    Med Chem 8:853-64. 2012
    ..The pharmacophore analyses of the piperidine derivatives also show that the aromatic, acceptor and donor groups on the molecule favorable for the FTase inhibitory activity...
  9. ncbi request reprint Studies on α-glucosidase inhibitors development: magic molecules for the treatment of carbohydrate mediated diseases
    N S H N Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, 687, Rua do Campo Alegre, 4169 007 Porto, Portugal
    Mini Rev Med Chem 12:713-20. 2012
    ..The structural analysis of these synthetic and natural derivatives guide for the development of novel semisynthetic/synthetic α-glucosidase inhibitors with free of toxicities...
  10. doi request reprint Structural feature study of benzofuran derivatives as farnesyltransferase inhibitors
    N S Hari Narayana Moorthy
    REQUIMTE, Departamento de Quimica, Faculdade de Ciencias, Universidade do Porto, Porto, Portugal
    J Enzyme Inhib Med Chem 26:777-91. 2011
    ..These results offer important clues for the development of novel FTase inhibitors...
  11. doi request reprint Topological, hydrophobicity, and other descriptors on α-glucosidase inhibition: a QSAR study on xanthone derivatives
    N S Hari Narayana Moorthy
    REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, Portugal
    J Enzyme Inhib Med Chem 26:755-66. 2011
    ..This study concluded that hydrophilic, polar and/or electron negative groups, which are responsible for hydrogen bonding and interaction with the enzyme for favourable activity...
  12. doi request reprint Comparative structural analysis of α-glucosidase inhibitors on difference species: a computational study
    N S Hari Narayana Moorthy
    REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Portugal
    Arch Pharm (Weinheim) 345:265-74. 2012
    ..Hence, these results will be useful for designing novel molecules with multiple activities...
  13. ncbi request reprint Structural analysis of 2-piperidin-4-yl-actamide derivatives for hERG blocking and MCH R1 antagonistic activities
    N S Hari Narayana Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Universidade do Porto, Porto, Portugal
    Curr Drug Discov Technol 9:25-38. 2012
    ....
  14. ncbi request reprint Analysis of the α-glucosidase inhibitory activity of chromenone derivatives based on their molecular features: a computational study
    N S Hari Narayana Moorthy
    REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 687, Rua do Campo Alegre, 4169 007, Porto, Portugal
    Med Chem 7:526-33. 2011
    ..The pharmacophore contours of the molecule also showed the importance of the polar surface property on the molecules. This computational analysis will help in the development of novel α-glucosidase inhibitors for various diseases...
  15. doi request reprint In silico-based structural analysis of arylthiophene derivatives for FTase inhibitory activity, hERG, and other toxic effects
    N S Hari Narayana Moorthy
    REQUIMTE, Departamento de Quimica, Faculdade de Ciencias, Universidade do Porto, Porto, Portugal
    J Biomol Screen 16:1037-46. 2011
    ..The pharmacophore analysis of the molecules demonstrated that the aromatic/hydrophobicity and polarizability features are important pharmacophore contours favorable for these activities...
  16. ncbi request reprint QSAR and pharmacophore analysis of a series of piperidinyl urea derivatives as HERG blockers and H3 antagonists
    N S Hari Narayana Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, 687, Rua do Campo Alegre, 4169 007 Porto, Portugal
    Curr Drug Discov Technol 10:47-58. 2013
    ..Hence, these results reveal the requirements on the structural properties and the distances between the pharmacophore contour sites of the molecules responsible for their hERG and H3 antagonistic activities...
  17. ncbi request reprint Predictive QSAR models development and validation for human ether-a-go-go related gene (hERG) blockers using newer tools
    N S Hari Narayana Moorthy
    REQUIMTE, Departamento de Quimica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, Porto, Portugal
    J Enzyme Inhib Med Chem 29:317-24. 2014
    ..The descriptors contributed in the models explain that the flexibility of the bonds connected to the aromatic rings or non-polar region of the molecules make π-π interaction with the aromatic residues of the protein...
  18. doi request reprint Prediction of the relationship between the structural features of andrographolide derivatives and α-glucosidase inhibitory activity: a quantitative structure-activity relationship (QSAR) study
    N S Hari Narayana Moorthy
    REQUIMTE, Department of Chemistry, Faculty of Sciences, University of Porto, Porto, Portugal
    J Enzyme Inhib Med Chem 26:78-87. 2011
    ....