Research Topics
Genomes and Genes
Species | Moises MalloSummaryCountry: Portugal Publications
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Detail Information
Publications
Hox genes and regional patterning of the vertebrate body planMoises Mallo
Instituto Gulbenkian de Ciencia, Oeiras, Portugal
Dev Biol 344:7-15. 2010..The control of these functions must have been intimately linked to the shaping of the body plan during evolution...
The road to the vertebral formulaMoises Mallo
Instituto Gulbenkian de Ciencia, Oeiras, Portugal
Int J Dev Biol 53:1469-81. 2009..The possible connections between Hox genes and all these signalling processes to generate a properly patterned axial skeleton are discussed in this review...
And the segmentation clock keeps tickingMoises Mallo
Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
Bioessays 29:412-5. 2007..have now shown that the segmentation clock is more complex than previously thought and includes oscillating expression of genes from at least three signaling pathways organized in coordinated networks...
A look at life from the homeodomain. Workshop on homeodomain proteins, hematopoietic development and leukemiasMoises Mallo
Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
EMBO Rep 7:976-80. 2006
Controlled gene activation and inactivation in the mouseMoises Mallo
Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
Front Biosci 11:313-27. 2006..The Cre/lox and FLP/FRT systems are the most popular of these. I will discuss how these recombination systems are used in the mouse with special focus on their use to achieve specific gene activation...
A novel possible mechanism for the genesis of genomic duplications and its experimental testMoises Mallo
Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780, Oeiras, Portugal
J Mol Evol 61:390-7. 2005..The model presented represents a novel mechanistic pathway that can explain a variety of rearrangements, including genomic tandem duplications and deletions...
Reversible gene inactivation in the mouseMoises Mallo
Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
Genomics 81:356-60. 2003..This procedure allows the production of gene inactivation that is complete, is reversible, and can be controlled at the spatial and temporal levels...
Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear developmentFilipa Moraes
Instituto Gulbenkian de Ciencia, UT, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
Mech Dev 122:199-212. 2005..The inability of the Tbx1(-/-) embryos to keep properly segregated functional domains in the otocyst is likely the cause of the strong inner ear phenotypes observed in these mutants...
Hox genes specify vertebral types in the presomitic mesodermMarta Carapuco
Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
Genes Dev 19:2116-21. 2005....
Hoxa2 downregulates Six2 in the neural crest-derived mesenchymeEva Kutejova
Department of Developmental Biology, Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
Development 132:469-78. 2005..Furthermore, we demonstrate that Hoxa2 regulation of Six2 is confined to a 0.9 kb fragment of the Six2 promoter and that Hoxa2 binds to this promoter region. These results strongly suggest that Six2 is a direct target of Hoxa2...
Evidence for a myotomal Hox/Myf cascade governing nonautonomous control of rib specification within global vertebral domainsTânia Vinagre
Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
Dev Cell 18:655-61. 2010..Our findings offer a new perspective of how Hox genes produce global patterns in the axial skeleton and support a redundant nonmyogenic role of Myf5 and Myf6 in rib formation...
Bmp2 is required for migration but not for induction of neural crest cells in the mouseAna Catarina Correia
Instituto Gulbenkian de Ciencia, Oeiras, Portugal
Dev Dyn 236:2493-501. 2007..Finally, our data suggest that the molecular cascade downstream of BMP signaling in early neural crest development may be different in mouse and avian embryos...
Aortic arch and pharyngeal phenotype in the absence of BMP-dependent neural crest in the mouseSabine Ohnemus
Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
Mech Dev 119:127-35. 2002....
Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1Nicoletta Bobola
Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
Development 130:3403-14. 2003....
Formation of the outer and middle ear, molecular mechanismsMoises Mallo
Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
Curr Top Dev Biol 57:85-113. 2003
Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasiaAlbert Gründer
Institut fur Biologie III, Albert Ludwigs Universitat, Freiburg, Germany
Mech Dev 112:69-77. 2002..Our study demonstrates that Nfib is essential for normal lung development, and suggests that it could be involved in the pathogenesis of respiratory distress syndromes in humans...
