Margarida Lima

Summary

Country: Portugal

Publications

  1. ncbi Laboratory diagnosis of large granular lymphocytic leukemia
    Margarida Lima
    Service of Hematology, , Porto Portugal
    Lab Hematol 10:148-9. 2004
  2. ncbi Reactive phenotypes after acute and chronic NK-cell activation
    M Lima
    Service of Clinical Hematology, Laboratory of Cytometry, Hospital Geral de Santo Antonio, Porto, Portugal
    J Biol Regul Homeost Agents 18:331-4. 2004
  3. ncbi Immunophenotypic analysis of the TCR-Vbeta repertoire in 98 persistent expansions of CD3(+)/TCR-alphabeta(+) large granular lymphocytes: utility in assessing clonality and insights into the pathogenesis of the disease
    M Lima
    Serviço de Hematologia Clínica, Unidade de Citometria, Hospital Geral de Santo Antonio, Porto, Portugal
    Am J Pathol 159:1861-8. 2001
  4. ncbi Clinicobiological, immunophenotypic, and molecular characteristics of monoclonal CD56-/+dim chronic natural killer cell large granular lymphocytosis
    Margarida Lima
    Servico de Hematologia, Unidade de Citometria, Hospital Geral de Santo Antonio, Rua D Manuel II, S N, 4099 001 Porto, Portugal
    Am J Pathol 165:1117-27. 2004
  5. ncbi Utility of flow cytometry immunophenotyping and DNA ploidy studies for diagnosis and characterization of blood involvement in CD4+ Sézary's syndrome
    Margarida Lima
    Servico de Hematologia, Unidade de Citometria, Hospital Geral de Santo Antonio, Rua D Manuel II, S N, 4099 001 Porto, Portugal
    Haematologica 88:874-87. 2003
  6. ncbi Non-cytotoxic gamma-delta peripheral T-cell lymphoma affecting the mandibular and parotidal lymph nodes and the skin
    Margarida Lima
    Servico de Hematologia, Unidade de Citometria, Hospital Geral de Santo Antonio, Rua D Manuel II, s n 4099 001 Porto, Portugal
    Leuk Lymphoma 44:525-9. 2003
  7. ncbi Immunophenotype and TCR-Vbeta repertoire of peripheral blood T-cells in acute infectious mononucleosis
    Margarida Lima
    Service of Clinical Haematology, Hospital Santo Antonio, Porto, Portugal
    Blood Cells Mol Dis 30:1-12. 2003
  8. ncbi Guess what: Chronic 13q14.3+/CD5-/CD23+ lymphocytic leukemia in blood and t(11;14)(q13;q32)+/CD5+/CD23- mantle cell lymphoma in lymph nodes!
    Margarida Lima
    Service of Clinical Hematology, Hospital Geral de Santo Antonio, Porto, Portugal
    Cytometry B Clin Cytom 51:41-4. 2003
  9. ncbi Atopic dermatitis-like non-erythrodermic leukemic variant of CD3(-/+dim) CD4(+) cutaneous T-cell lymphoma preceded by cutaneous papular xanthomatosis
    Margarida Lima
    Service of Clinical Hematology, Hospital Geral de Santo Antonio, Porto, Portugal
    Leuk Lymphoma 45:597-603. 2004
  10. ncbi Association of CD4+/CD56+/CD57+/CD8+(dim) large granular lymphocytic leukemia, splenic B-cell lymphoma with circulating villous lymphocytes, and idiopathic erythrocytosis
    M Lima
    Service of Clinical Hematology, Hospital Geral Santo Antonio, Porto, Portugal
    Ann Hematol 80:685-90. 2001

Collaborators

  • A Orfao
  • José Manuel Cabeda
  • Gustavo Rocha
  • Luisa Pinto
  • L Marques
  • M Gonzalez
  • Elisio Costa
  • João Moura
  • Karl Heinz Grzeschik
  • Cristina Dias
  • Estella Matutes
  • Manuel Campos
  • Luis Belo
  • A T Nurden
  • Anton W Langerak
  • M Teixeira
  • Ana Oliveira
  • Elisa Granjo
  • Pilar Garrido
  • Sofia Agueda
  • Manuela Selores
  • Rosario Alves
  • Rui Pereira
  • Jorge Candeias
  • Paloma Barcena
  • Francisco Ruiz-Cabello
  • Julia Canton
  • Julia Almeida
  • Yorick Sandberg
  • Alexandre Quintanilha
  • Ana Balanzategui
  • Loida Corbillon Garcia
  • Henrique Coelho
  • Luciana Xavier
  • Filipe Santos
  • Mónica Caetano
  • Fatima Ferreira
  • Bonito Vitor
  • Hercilia Guimaraes
  • Inês Lobo
  • Maria do Sameiro Faria
  • Vasco Miranda
  • Marta Goncalves
  • Alice Santos-Silva
  • Jose Maria Romero
  • Francisco Ruiz Cabello
  • Miguel Angel Lopez Nevot
  • Andres C Garcia Montero
  • Sara Morais
  • Maria dos Anjos Teixera
  • Benvindo Justica
  • Christelle Breillat
  • Manuel Cunha
  • Marisol Guerra
  • Jorge Coutinho
  • Aurea Canelhas
  • Carlos Resende
  • Conceição Magalhães
  • Irene Rebelo
  • Sandra Rocha
  • Ana Helena Santos
  • Nória Cunha
  • Maria Luís Queirós
  • Isabel Antunes
  • Ilidia Moreira
  • Alice Santos Silva
  • Jose Manuel Lopes
  • Maria Leticia Ribeiro
  • Manuela Fraga

Detail Information

Publications31

  1. ncbi Laboratory diagnosis of large granular lymphocytic leukemia
    Margarida Lima
    Service of Hematology, , Porto Portugal
    Lab Hematol 10:148-9. 2004
  2. ncbi Reactive phenotypes after acute and chronic NK-cell activation
    M Lima
    Service of Clinical Hematology, Laboratory of Cytometry, Hospital Geral de Santo Antonio, Porto, Portugal
    J Biol Regul Homeost Agents 18:331-4. 2004
    ..Here, we review the reactive phenotypes observed in vivo after acute and chronic NK-cell activation...
  3. ncbi Immunophenotypic analysis of the TCR-Vbeta repertoire in 98 persistent expansions of CD3(+)/TCR-alphabeta(+) large granular lymphocytes: utility in assessing clonality and insights into the pathogenesis of the disease
    M Lima
    Serviço de Hematologia Clínica, Unidade de Citometria, Hospital Geral de Santo Antonio, Porto, Portugal
    Am J Pathol 159:1861-8. 2001
    ..In summary, our results suggest that flow cytometry immunophenotypic analysis of the TCR-Vbeta repertoire is a powerful screening tool for the assessment of T-cell clonality in persistent expansions of TCR-alphabeta(+) LGLs...
  4. ncbi Clinicobiological, immunophenotypic, and molecular characteristics of monoclonal CD56-/+dim chronic natural killer cell large granular lymphocytosis
    Margarida Lima
    Servico de Hematologia, Unidade de Citometria, Hospital Geral de Santo Antonio, Rua D Manuel II, S N, 4099 001 Porto, Portugal
    Am J Pathol 165:1117-27. 2004
    ....
  5. ncbi Utility of flow cytometry immunophenotyping and DNA ploidy studies for diagnosis and characterization of blood involvement in CD4+ Sézary's syndrome
    Margarida Lima
    Servico de Hematologia, Unidade de Citometria, Hospital Geral de Santo Antonio, Rua D Manuel II, S N, 4099 001 Porto, Portugal
    Haematologica 88:874-87. 2003
    ..The exact immunophenotypic criteria for the identification of Sézary cells in the blood are still poorly defined...
  6. ncbi Non-cytotoxic gamma-delta peripheral T-cell lymphoma affecting the mandibular and parotidal lymph nodes and the skin
    Margarida Lima
    Servico de Hematologia, Unidade de Citometria, Hospital Geral de Santo Antonio, Rua D Manuel II, s n 4099 001 Porto, Portugal
    Leuk Lymphoma 44:525-9. 2003
    ..The disease had an aggressive course and was resistant to chemotherapy and the patient died 4 months after diagnosis...
  7. ncbi Immunophenotype and TCR-Vbeta repertoire of peripheral blood T-cells in acute infectious mononucleosis
    Margarida Lima
    Service of Clinical Haematology, Hospital Santo Antonio, Porto, Portugal
    Blood Cells Mol Dis 30:1-12. 2003
    ..The results presented here provide evidence for an extensive T-cell activation during acute viral infection and establish the immunophenotype patterns associated with this condition...
  8. ncbi Guess what: Chronic 13q14.3+/CD5-/CD23+ lymphocytic leukemia in blood and t(11;14)(q13;q32)+/CD5+/CD23- mantle cell lymphoma in lymph nodes!
    Margarida Lima
    Service of Clinical Hematology, Hospital Geral de Santo Antonio, Porto, Portugal
    Cytometry B Clin Cytom 51:41-4. 2003
    ..The B-cell lymphocytic leukemia clone predominated in the blood and bone marrow, whereas the mantle cell clone predominated in lymph nodes...
  9. ncbi Atopic dermatitis-like non-erythrodermic leukemic variant of CD3(-/+dim) CD4(+) cutaneous T-cell lymphoma preceded by cutaneous papular xanthomatosis
    Margarida Lima
    Service of Clinical Hematology, Hospital Geral de Santo Antonio, Porto, Portugal
    Leuk Lymphoma 45:597-603. 2004
    ....
  10. ncbi Association of CD4+/CD56+/CD57+/CD8+(dim) large granular lymphocytic leukemia, splenic B-cell lymphoma with circulating villous lymphocytes, and idiopathic erythrocytosis
    M Lima
    Service of Clinical Hematology, Hospital Geral Santo Antonio, Porto, Portugal
    Ann Hematol 80:685-90. 2001
    ..We also discuss the possible reasons for this particular association...
  11. ncbi Immunophenotypic characterization of normal blood CD56+lo versus CD56+hi NK-cell subsets and its impact on the understanding of their tissue distribution and functional properties
    M Lima
    Service of Clinical Hematology, Unit of Cytometry, Hospital Geral de Santo Antonio, Porto, Portugal
    Blood Cells Mol Dis 27:731-43. 2001
    ....
  12. ncbi Philadelphia-positive T-cell acute lymphoblastic leukemia with polymyositis, migratory polyarthritis and hypercalcemia following a chronic myeloid leukemia
    M Lima
    Department of Clinical Hematology, Hospital Geral de Santo Antonio, Rua D Manuel II, S N, 4099 001 Porto, Portugal
    Ann Hematol 81:174-7. 2002
    ..Polymyositis and polyarthritis preceded by 4 months, and symptomatic hypercalcemia occurred just before blastic transformation, probably representing paraneoplastic manifestations of the disease...
  13. ncbi Aggressive natural-killer cell lymphoma presenting with skin lesions, breast nodule, suprarenal masses and life-threatening pericardial and pleural effusions
    M Lima
    Service of Clinical Hematology, Hospital Geral de Santo Antonio, Porto, Portugal
    Leuk Lymphoma 42:1385-91. 2001
    ..Death occurred 4 months after the first manifestations of the disease as a consequence of cardiac tamponade...
  14. ncbi The "ex vivo" patterns of CD2/CD7, CD57/CD11c, CD38/CD11b, CD45RA/CD45RO, and CD11a/HLA-DR expression identify acute/early and chronic/late NK-cell activation states
    Margarida Lima
    Service of Clinical Hematology, Hospital Geral de Santo Antonio, Porto, Portugal
    Blood Cells Mol Dis 28:181-90. 2002
    ....
  15. ncbi Intraclonal diversity in a Sezary syndrome with a differential response to 2-deoxycoformycin of the two lymphoma cell populations
    Elisa Granjo
    Department of Clinical Haematology, Hospital Geral de São João, Porto, Portugal
    Br J Haematol 119:629-33. 2002
    ....
  16. ncbi TCRalphabeta+/CD4+ large granular lymphocytosis: a new clonal T-cell lymphoproliferative disorder
    Margarida Lima
    , Unidade de Citometria, Hospital Geral de Santo Antonio, Porto, Portugal
    Am J Pathol 163:763-71. 2003
    ..Longer follow-up periods are necessary to determine the exact significance of this clonal disorder...
  17. ncbi Chemokine receptor repertoire reflects mature T-cell lymphoproliferative disorder clinical presentation
    João Moura
    Laboratório de Citometria, Serviço de Hematologia Clínica, Centro Hospitalar do Porto CHP, Hospital Geral de Santo António HGSA, Porto, Portugal
    Blood Cells Mol Dis 42:57-63. 2009
    ..In addition, in the case of CD8 T-cell leukemia patients, an inverse correlation with neutropenia was found. In lymphoma patients, higher CCR4 and CCR7 expression is accompanied by lower to absent CCR5 expression...
  18. ncbi Sezary syndrome presenting with leonine facies and treated with low-dose subcutaneous alemtuzumab
    Ana Oliveira
    Hospital de Santo Antonio, Centro Hospitalar do Porto, Porto, Portugal
    Dermatol Online J 17:6. 2011
    ..We present the case of a 54-year-old man with Sezary syndrome presenting with leonine facies, unresponsive to conventional therapies; he exhibited a promising response to subcutaneous low-dose alemtuzumab...
  19. ncbi Granulomatous slack skin
    Marta Teixeira
    Dept of Dermatology, Hospital Geral de Santo Antonio, Rua D Manuel II, Edificio ex Cicap, 4099 001 Porto, Portugal
    Eur J Dermatol 17:435-8. 2007
    ..Notwithstanding its indolent behavior, treatment is often disappointing. We describe an additional case of this rare disorder in a 44-year-old male patient...
  20. ncbi Hematological remission and long term hematological control of acute myeloblastic leukemia induced and maintained by granulocyte-colony stimulating factor (G-CSF) therapy
    Luciana Xavier
    Service of Clinical Hematology, Centro Hospitalar de Vila Nova de Gaia, Vila Nova de Gaia, Portugal
    Leuk Lymphoma 44:2137-42. 2003
    ....
  21. ncbi Mutations in the beta3 gene giving rise to type I Glanzmann thrombasthenia in two families in Portugal
    Loida Corbillon Garcia
    Hospital de Santo Antonio, , Porto, Portugal
    Platelets 15:15-22. 2004
    ..For both patients a single mutated allele was inherited from each parent. Evidence is accumulating that nonsense mutations leading to a truncated beta3 may be a frequent cause of type I Glanzmann thrombasthenia in the Iberian peninsula...
  22. ncbi Letter: Primary cutaneous marginal zone B cell lymphoma of the face: A challenging diagnosis
    Ana Oliveira
    Department of Dermatology, Centro Hospitalar do Porto Hospital de Santo António, Porto, Portugal
    Dermatol Online J 18:12. 2012
    ..We present a case report of a man, 80 years of age, with a primary cutaneous marginal B cell lymphoma of the chin, an atypical location...
  23. ncbi A nonsense porcn mutation in severe focal dermal hypoplasia with natal teeth
    Cristina Dias
    Centro de Genética Médica Dr Jacito Magalhaes INSA, Genetica Medica, Porto, Portugal
    Fetal Pediatr Pathol 29:305-13. 2010
    ..Mutation analysis of PORCN revealed a nonsense mutation-Y359X. She presented natal teeth, an unexpected feature considering the role of the Wnt pathway in tooth development...
  24. ncbi Abnormal NK cell lymphocytosis detected after splenectomy: association with repeated infections, relapsing neutropenia, and persistent polyclonal B-cell proliferation
    Elisa Granjo
    Department of Hematology, Hospital S Joao, Porto, Portugal
    Int J Hematol 75:484-8. 2002
    ....
  25. ncbi Neonatal alloimmune neutropenia: still a diagnostic and therapeutical challenge
    Sofia Agueda
    Neonatal Intensive Care Unit, Hospital Sao Joao, EPE, Alameda Prof Hernani Monteiro, Porto, Portugal
    J Pediatr Hematol Oncol 34:497-9. 2012
    ..To describe a case of neonatal alloimmune neutropenia (NAN), a very rare disease of the newborn and the first ever reported in our neonatal intensive care unit, with emphasis in its management and outcome...
  26. ncbi Neutrophil and monocyte activation in chronic kidney disease patients under hemodialysis and its relationship with resistance to recombinant human erythropoietin and to the hemodialysis procedure
    Rui Pereira
    Biochemistry Department, Faculty of Pharmacy, University of Porto, Porto, Portugal
    Hemodial Int 14:295-301. 2010
    ..Moreover, this activation is due, at least in part, to the HD procedure, although we should not exclude that it can also be due to the enhanced inflammatory process observed in nonresponder patients...
  27. ncbi Inflammation, T-cell phenotype, and inflammatory cytokines in chronic kidney disease patients under hemodialysis and its relationship to resistance to recombinant human erythropoietin therapy
    Elisio Costa
    Serviço de Bioquímica, Faculdade de Farmacia da Universidade do Porto, Rua Anibal Cunha, 164, 4099 030 Porto, Portugal
    J Clin Immunol 28:268-75. 2008
    ....
  28. ncbi Monoclonal TCR-Vbeta13.1+/CD4+/NKa+/CD8-/+dim T-LGL lymphocytosis: evidence for an antigen-driven chronic T-cell stimulation origin
    Pilar Garrido
    Servicio de Hematologia, Hospital Universitario Virgen de las Nieves, Granada, Spain
    Blood 109:4890-8. 2007
    ....
  29. ncbi Response to cyclosporine in a patient with disseminated granuloma annulare associated with CD4+/CD8+(dim)/CD56+ large granular lymphocytic leukemia
    Elisa Granjo
    Arch Dermatol 138:274-6. 2002
  30. ncbi Evaluation of functional single nucleotide polymorphisms of different genes coding for the immunoregulatory molecules in patients with monoclonal large granular lymphocyte lymphocytosis
    Pilar Garrido
    Servicio de Hematologia, Hospital Universitario Virgen de las Nieves, Granada, Spain
    Hum Immunol 69:101-7. 2008
    ..Our results suggest that the frequency of SNP of the genes coding for the studied immunoregulatory molecules are not associated with the development of CD4+/TCR alpha beta+ T-LGL...
  31. ncbi Bilateral orbital masses in a patient with B-cell chronic lymph
    Henrique Coelho
    Haematologica 88:ECR12. 2003