Margarida Lima

Summary

Country: Portugal

Publications

  1. ncbi request reprint Laboratory diagnosis of large granular lymphocytic leukemia
    Margarida Lima
    Service of Hematology, Hospital Geral de Santo Antonio, Porto Portugal
    Lab Hematol 10:148-9. 2004
  2. ncbi request reprint Guess what: Chronic 13q14.3+/CD5-/CD23+ lymphocytic leukemia in blood and t(11;14)(q13;q32)+/CD5+/CD23- mantle cell lymphoma in lymph nodes!
    Margarida Lima
    Service of Clinical Hematology, Hospital Geral de Santo Antonio, Porto, Portugal
    Cytometry B Clin Cytom 51:41-4. 2003
  3. ncbi request reprint Reactive phenotypes after acute and chronic NK-cell activation
    M Lima
    Service of Clinical Hematology, Laboratory of Cytometry, Hospital Geral de Santo Antonio, Porto, Portugal
    J Biol Regul Homeost Agents 18:331-4. 2004
  4. pmc Circulating endothelial cells in patients with venous thromboembolism and myeloproliferative neoplasms
    Claudia Torres
    Laboratório de Citometria, Serviço de Hematologia Clínica, Hospital de Santo António HSA, Centro Hospitalar do Porto CHP, Porto, Portugal Unidade Multidisciplinar de Investigação Biomédica UMIB, Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto ICBAS UP, Porto, Portugal
    PLoS ONE 8:e81574. 2013
  5. pmc Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis
    Margarida Lima
    Department of Hematology, Laboratory of Cytometry, Hospital de Santo Antonio, Centro Hospitalar do Porto, Rua D Manuel II, S N, 4099 001, Porto, Portugal
    Orphanet J Rare Dis 8:95. 2013
  6. pmc Immunophenotypic analysis of the TCR-Vbeta repertoire in 98 persistent expansions of CD3(+)/TCR-alphabeta(+) large granular lymphocytes: utility in assessing clonality and insights into the pathogenesis of the disease
    M Lima
    Serviço de Hematologia Clínica, Unidade de Citometria, Hospital Geral de Santo Antonio, Porto, Portugal
    Am J Pathol 159:1861-8. 2001
  7. pmc Clinicobiological, immunophenotypic, and molecular characteristics of monoclonal CD56-/+dim chronic natural killer cell large granular lymphocytosis
    Margarida Lima
    Servico de Hematologia, Unidade de Citometria, Hospital Geral de Santo Antonio, Rua D Manuel II, S N, 4099 001 Porto, Portugal
    Am J Pathol 165:1117-27. 2004
  8. ncbi request reprint Atopic dermatitis-like non-erythrodermic leukemic variant of CD3(-/+dim) CD4(+) cutaneous T-cell lymphoma preceded by cutaneous papular xanthomatosis
    Margarida Lima
    Service of Clinical Hematology, Hospital Geral de Santo Antonio, Porto, Portugal
    Leuk Lymphoma 45:597-603. 2004
  9. ncbi request reprint Utility of flow cytometry immunophenotyping and DNA ploidy studies for diagnosis and characterization of blood involvement in CD4+ Sézary's syndrome
    Margarida Lima
    Servico de Hematologia, Unidade de Citometria, Hospital Geral de Santo Antonio, Rua D Manuel II, S N, 4099 001 Porto, Portugal
    Haematologica 88:874-87. 2003
  10. ncbi request reprint Non-cytotoxic gamma-delta peripheral T-cell lymphoma affecting the mandibular and parotidal lymph nodes and the skin
    Margarida Lima
    Servico de Hematologia, Unidade de Citometria, Hospital Geral de Santo Antonio, Rua D Manuel II, s n 4099 001 Porto, Portugal
    Leuk Lymphoma 44:525-9. 2003

Collaborators

  • Alberto Orfao
  • Manuel Campos
  • José Manuel Cabeda
  • Catarina R Almeida
  • Alan T Nurden
  • Manuel Vilanova
  • Mario Dinis-Ribeiro
  • Luisa Pinto
  • L Marques
  • João Moura
  • Elisio Costa
  • M Gonzalez
  • Gustavo Rocha
  • Karl Heinz Grzeschik
  • Estella Matutes
  • Luis Belo
  • Cristina Dias
  • Anton W Langerak
  • M Teixeira
  • Ana Oliveira
  • Elisa Granjo
  • Pilar Garrido
  • Manuela Selores
  • Rosario Alves
  • Iolanda Conde Fernandes
  • Ana M Dias
  • Claudia Torres
  • Sofia Agueda
  • Rui Pereira
  • Sara Morais
  • Jorge Candeias
  • Yorick Sandberg
  • Julia Canton
  • Francisco Ruiz-Cabello
  • Paloma Barcena
  • Julia Almeida
  • Alexandre Quintanilha
  • Ana Balanzategui
  • Loida Corbillon Garcia
  • Henrique Coelho
  • Luciana Xavier
  • António Carlos Pinto Ribeiro
  • Jose Manuel Lopes
  • Sandra Carvalho
  • Joana Dourado
  • Ricardo Marcos-Pinto
  • Joana Cabral
  • Paulo Salgueiro
  • Filipe Santos
  • Celso A Reis
  • Salomé S Pinho
  • Paula Lago
  • Sonia Fonseca
  • Ines Freitas
  • Ana Mafalda Fonseca
  • Rui Matos
  • Magdalena Leander
  • Fatima Ferreira
  • Bonito Vitor
  • Hercilia Guimaraes
  • Mónica Caetano
  • Inês Lobo
  • Maria do Sameiro Faria
  • Alice Santos-Silva
  • Vasco Miranda
  • Marta Goncalves
  • Jose Maria Romero
  • Andres C Garcia-Montero
  • Miguel Angel Lopez-Nevot
  • Benvindo Justica
  • Christelle Breillat
  • Robert Combrie
  • Maria dos Anjos Teixera
  • Jorge Coutinho
  • Aurea Canelhas
  • Marisol Guerra
  • Manuel Cunha
  • Cristina Gonçalves
  • Irene Rebelo
  • Alice Santos Silva
  • Nória Cunha
  • Jose Carlos Fernandes
  • Isabel Antunes
  • Maria Leticia Ribeiro
  • Conceição Magalhães
  • Sandra Rocha
  • Ana Helena Santos
  • Maria Luís Queirós
  • Manuela Fraga
  • Carlos Resende

Detail Information

Publications35

  1. ncbi request reprint Laboratory diagnosis of large granular lymphocytic leukemia
    Margarida Lima
    Service of Hematology, Hospital Geral de Santo Antonio, Porto Portugal
    Lab Hematol 10:148-9. 2004
  2. ncbi request reprint Guess what: Chronic 13q14.3+/CD5-/CD23+ lymphocytic leukemia in blood and t(11;14)(q13;q32)+/CD5+/CD23- mantle cell lymphoma in lymph nodes!
    Margarida Lima
    Service of Clinical Hematology, Hospital Geral de Santo Antonio, Porto, Portugal
    Cytometry B Clin Cytom 51:41-4. 2003
    ..The B-cell lymphocytic leukemia clone predominated in the blood and bone marrow, whereas the mantle cell clone predominated in lymph nodes...
  3. ncbi request reprint Reactive phenotypes after acute and chronic NK-cell activation
    M Lima
    Service of Clinical Hematology, Laboratory of Cytometry, Hospital Geral de Santo Antonio, Porto, Portugal
    J Biol Regul Homeost Agents 18:331-4. 2004
    ..Here, we review the reactive phenotypes observed in vivo after acute and chronic NK-cell activation...
  4. pmc Circulating endothelial cells in patients with venous thromboembolism and myeloproliferative neoplasms
    Claudia Torres
    Laboratório de Citometria, Serviço de Hematologia Clínica, Hospital de Santo António HSA, Centro Hospitalar do Porto CHP, Porto, Portugal Unidade Multidisciplinar de Investigação Biomédica UMIB, Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto ICBAS UP, Porto, Portugal
    PLoS ONE 8:e81574. 2013
    ..However, there is not a universally accepted standardized protocol to identify and quantify these cells and its clinical relevancy remains to be established...
  5. pmc Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis
    Margarida Lima
    Department of Hematology, Laboratory of Cytometry, Hospital de Santo Antonio, Centro Hospitalar do Porto, Rua D Manuel II, S N, 4099 001, Porto, Portugal
    Orphanet J Rare Dis 8:95. 2013
    ..The rarity of the NK-cell tumors limits our ability to standardize the procedures for the diagnosis and clinical management and efforts should be made to encourage multi-institutional registries...
  6. pmc Immunophenotypic analysis of the TCR-Vbeta repertoire in 98 persistent expansions of CD3(+)/TCR-alphabeta(+) large granular lymphocytes: utility in assessing clonality and insights into the pathogenesis of the disease
    M Lima
    Serviço de Hematologia Clínica, Unidade de Citometria, Hospital Geral de Santo Antonio, Porto, Portugal
    Am J Pathol 159:1861-8. 2001
    ..In summary, our results suggest that flow cytometry immunophenotypic analysis of the TCR-Vbeta repertoire is a powerful screening tool for the assessment of T-cell clonality in persistent expansions of TCR-alphabeta(+) LGLs...
  7. pmc Clinicobiological, immunophenotypic, and molecular characteristics of monoclonal CD56-/+dim chronic natural killer cell large granular lymphocytosis
    Margarida Lima
    Servico de Hematologia, Unidade de Citometria, Hospital Geral de Santo Antonio, Rua D Manuel II, S N, 4099 001 Porto, Portugal
    Am J Pathol 165:1117-27. 2004
    ....
  8. ncbi request reprint Atopic dermatitis-like non-erythrodermic leukemic variant of CD3(-/+dim) CD4(+) cutaneous T-cell lymphoma preceded by cutaneous papular xanthomatosis
    Margarida Lima
    Service of Clinical Hematology, Hospital Geral de Santo Antonio, Porto, Portugal
    Leuk Lymphoma 45:597-603. 2004
    ....
  9. ncbi request reprint Utility of flow cytometry immunophenotyping and DNA ploidy studies for diagnosis and characterization of blood involvement in CD4+ Sézary's syndrome
    Margarida Lima
    Servico de Hematologia, Unidade de Citometria, Hospital Geral de Santo Antonio, Rua D Manuel II, S N, 4099 001 Porto, Portugal
    Haematologica 88:874-87. 2003
    ..The exact immunophenotypic criteria for the identification of Sézary cells in the blood are still poorly defined...
  10. ncbi request reprint Non-cytotoxic gamma-delta peripheral T-cell lymphoma affecting the mandibular and parotidal lymph nodes and the skin
    Margarida Lima
    Servico de Hematologia, Unidade de Citometria, Hospital Geral de Santo Antonio, Rua D Manuel II, s n 4099 001 Porto, Portugal
    Leuk Lymphoma 44:525-9. 2003
    ..In situ" hybridization for Epstein-Barr virus-encoded RNA and latent membrane protein-1 gave negative results. The disease had an aggressive course and was resistant to chemotherapy and the patient died 4 months after diagnosis...
  11. ncbi request reprint Immunophenotype and TCR-Vbeta repertoire of peripheral blood T-cells in acute infectious mononucleosis
    Margarida Lima
    Service of Clinical Haematology, Hospital Santo Antonio, Porto, Portugal
    Blood Cells Mol Dis 30:1-12. 2003
    ..The results presented here provide evidence for an extensive T-cell activation during acute viral infection and establish the immunophenotype patterns associated with this condition...
  12. ncbi request reprint Association of CD4+/CD56+/CD57+/CD8+(dim) large granular lymphocytic leukemia, splenic B-cell lymphoma with circulating villous lymphocytes, and idiopathic erythrocytosis
    M Lima
    Service of Clinical Hematology, Hospital Geral Santo Antonio, Porto, Portugal
    Ann Hematol 80:685-90. 2001
    ..We also discuss the possible reasons for this particular association...
  13. ncbi request reprint Immunophenotypic characterization of normal blood CD56+lo versus CD56+hi NK-cell subsets and its impact on the understanding of their tissue distribution and functional properties
    M Lima
    Service of Clinical Hematology, Unit of Cytometry, Hospital Geral de Santo Antonio, Porto, Portugal
    Blood Cells Mol Dis 27:731-43. 2001
    ....
  14. ncbi request reprint The "ex vivo" patterns of CD2/CD7, CD57/CD11c, CD38/CD11b, CD45RA/CD45RO, and CD11a/HLA-DR expression identify acute/early and chronic/late NK-cell activation states
    Margarida Lima
    Service of Clinical Hematology, Hospital Geral de Santo Antonio, Porto, Portugal
    Blood Cells Mol Dis 28:181-90. 2002
    ....
  15. ncbi request reprint Philadelphia-positive T-cell acute lymphoblastic leukemia with polymyositis, migratory polyarthritis and hypercalcemia following a chronic myeloid leukemia
    M Lima
    Department of Clinical Hematology, Hospital Geral de Santo Antonio, Rua D Manuel II, S N, 4099 001 Porto, Portugal
    Ann Hematol 81:174-7. 2002
    ..Polymyositis and polyarthritis preceded by 4 months, and symptomatic hypercalcemia occurred just before blastic transformation, probably representing paraneoplastic manifestations of the disease...
  16. ncbi request reprint Aggressive natural-killer cell lymphoma presenting with skin lesions, breast nodule, suprarenal masses and life-threatening pericardial and pleural effusions
    M Lima
    Service of Clinical Hematology, Hospital Geral de Santo Antonio, Porto, Portugal
    Leuk Lymphoma 42:1385-91. 2001
    ..Death occurred 4 months after the first manifestations of the disease as a consequence of cardiac tamponade...
  17. pmc TCRalphabeta+/CD4+ large granular lymphocytosis: a new clonal T-cell lymphoproliferative disorder
    Margarida Lima
    Serviço de Hematologia Clínica, Unidade de Citometria, Hospital Geral de Santo Antonio, Porto, Portugal
    Am J Pathol 163:763-71. 2003
    ..Longer follow-up periods are necessary to determine the exact significance of this clonal disorder...
  18. ncbi request reprint Intraclonal diversity in a Sezary syndrome with a differential response to 2-deoxycoformycin of the two lymphoma cell populations
    Elisa Granjo
    Department of Clinical Haematology, Hospital Geral de São João, Porto, Portugal
    Br J Haematol 119:629-33. 2002
    ....
  19. doi request reprint Chemokine receptor repertoire reflects mature T-cell lymphoproliferative disorder clinical presentation
    João Moura
    Laboratório de Citometria, Serviço de Hematologia Clínica, Centro Hospitalar do Porto CHP, Hospital Geral de Santo António HGSA, Porto, Portugal
    Blood Cells Mol Dis 42:57-63. 2009
    ..In addition, in the case of CD8 T-cell leukemia patients, an inverse correlation with neutropenia was found. In lymphoma patients, higher CCR4 and CCR7 expression is accompanied by lower to absent CCR5 expression...
  20. ncbi request reprint Mutations in the beta3 gene giving rise to type I Glanzmann thrombasthenia in two families in Portugal
    Loida Corbillon Garcia
    Hospital de Santo Antonio, Serviço de Hematologia Clínica, Porto, Portugal
    Platelets 15:15-22. 2004
    ..For both patients a single mutated allele was inherited from each parent. Evidence is accumulating that nonsense mutations leading to a truncated beta3 may be a frequent cause of type I Glanzmann thrombasthenia in the Iberian peninsula...
  21. ncbi request reprint Hematological remission and long term hematological control of acute myeloblastic leukemia induced and maintained by granulocyte-colony stimulating factor (G-CSF) therapy
    Luciana Xavier
    Service of Clinical Hematology, Centro Hospitalar de Vila Nova de Gaia, Vila Nova de Gaia, Portugal
    Leuk Lymphoma 44:2137-42. 2003
    ....
  22. ncbi request reprint Sezary syndrome presenting with leonine facies and treated with low-dose subcutaneous alemtuzumab
    Ana Oliveira
    Hospital de Santo Antonio, Centro Hospitalar do Porto, Porto, Portugal
    Dermatol Online J 17:6. 2011
    ..We present the case of a 54-year-old man with Sezary syndrome presenting with leonine facies, unresponsive to conventional therapies; he exhibited a promising response to subcutaneous low-dose alemtuzumab...
  23. ncbi request reprint Granulomatous slack skin
    Marta Teixeira
    Dept of Dermatology, Hospital Geral de Santo Antonio, Rua D Manuel II, Edificio ex Cicap, 4099 001 Porto, Portugal
    Eur J Dermatol 17:435-8. 2007
    ..Notwithstanding its indolent behavior, treatment is often disappointing. We describe an additional case of this rare disorder in a 44-year-old male patient...
  24. doi request reprint Adult mastocytosis: a review of the Santo António Hospital 's experience and an evaluation of World Health Organization criteria for the diagnosis of systemic disease
    Iolanda Conde Fernandes
    Porto Hospital Center, Santo Antonio Hospital, Porto, Portugal, Professor of Medicine, MD Intern in the dermatoveneorology program at the Dermatovenereology Clinic of the Porto Hospital Center Santo António Hospital, EPE Santo António Hospital Porto, Portugal
    An Bras Dermatol 89:59-66. 2014
    ..Mastocytosis is a clonal disorder characterized by the accumulation of abnormal mast cells in the skin and/or in extracutaneous organs...
  25. ncbi request reprint Letter: Primary cutaneous marginal zone B cell lymphoma of the face: A challenging diagnosis
    Ana Oliveira
    Department of Dermatology, Centro Hospitalar do Porto Hospital de Santo António, Porto, Portugal
    Dermatol Online J 18:12. 2012
    ..We present a case report of a man, 80 years of age, with a primary cutaneous marginal B cell lymphoma of the chin, an atypical location...
  26. ncbi request reprint Abnormal NK cell lymphocytosis detected after splenectomy: association with repeated infections, relapsing neutropenia, and persistent polyclonal B-cell proliferation
    Elisa Granjo
    Department of Hematology, Hospital S Joao, Porto, Portugal
    Int J Hematol 75:484-8. 2002
    ....
  27. doi request reprint A nonsense porcn mutation in severe focal dermal hypoplasia with natal teeth
    Cristina Dias
    Centro de Genética Médica Dr Jacito Magalhaes INSA, Genetica Medica, Porto, Portugal
    Fetal Pediatr Pathol 29:305-13. 2010
    ..Mutation analysis of PORCN revealed a nonsense mutation-Y359X. She presented natal teeth, an unexpected feature considering the role of the Wnt pathway in tooth development...
  28. ncbi request reprint Neonatal alloimmune neutropenia: still a diagnostic and therapeutical challenge
    Sofia Agueda
    Neonatal Intensive Care Unit, Hospital Sao Joao, EPE, Alameda Prof Hernani Monteiro, Porto, Portugal
    J Pediatr Hematol Oncol 34:497-9. 2012
    ..To describe a case of neonatal alloimmune neutropenia (NAN), a very rare disease of the newborn and the first ever reported in our neonatal intensive care unit, with emphasis in its management and outcome...
  29. doi request reprint Neutrophil and monocyte activation in chronic kidney disease patients under hemodialysis and its relationship with resistance to recombinant human erythropoietin and to the hemodialysis procedure
    Rui Pereira
    Biochemistry Department, Faculty of Pharmacy, University of Porto, Porto, Portugal
    Hemodial Int 14:295-301. 2010
    ..Moreover, this activation is due, at least in part, to the HD procedure, although we should not exclude that it can also be due to the enhanced inflammatory process observed in nonresponder patients...
  30. doi request reprint Dysregulation of T cell receptor N-glycosylation: a molecular mechanism involved in ulcerative colitis
    Ana M Dias
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Porto, Portugal
    Hum Mol Genet 23:2416-27. 2014
    ....
  31. ncbi request reprint Response to cyclosporine in a patient with disseminated granuloma annulare associated with CD4+/CD8+(dim)/CD56+ large granular lymphocytic leukemia
    Elisa Granjo
    Arch Dermatol 138:274-6. 2002
  32. doi request reprint Evaluation of functional single nucleotide polymorphisms of different genes coding for the immunoregulatory molecules in patients with monoclonal large granular lymphocyte lymphocytosis
    Pilar Garrido
    Servicio de Hematologia, Hospital Universitario Virgen de las Nieves, Granada, Spain
    Hum Immunol 69:101-7. 2008
    ..Our results suggest that the frequency of SNP of the genes coding for the studied immunoregulatory molecules are not associated with the development of CD4+/TCR alpha beta+ T-LGL...
  33. doi request reprint Inflammation, T-cell phenotype, and inflammatory cytokines in chronic kidney disease patients under hemodialysis and its relationship to resistance to recombinant human erythropoietin therapy
    Elisio Costa
    Serviço de Bioquímica, Faculdade de Farmacia da Universidade do Porto, Rua Anibal Cunha, 164, 4099 030 Porto, Portugal
    J Clin Immunol 28:268-75. 2008
    ....
  34. ncbi request reprint Monoclonal TCR-Vbeta13.1+/CD4+/NKa+/CD8-/+dim T-LGL lymphocytosis: evidence for an antigen-driven chronic T-cell stimulation origin
    Pilar Garrido
    Servicio de Hematologia, Hospital Universitario Virgen de las Nieves, Granada, Spain
    Blood 109:4890-8. 2007
    ....
  35. ncbi request reprint Bilateral orbital masses in a patient with B-cell chronic lymph
    Henrique Coelho
    Haematologica 88:ECR12. 2003