Affiliation: Institute of Molecular Pathology and Immunology
- Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutationSergia Velho
Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Dr, Roberto Frias, 4200 465 Porto, Portugal
BMC Cancer 14:182. 2014..Nevertheless, the molecular mechanism underlying the oncogenic activity of P252H mutant remained elusive...
- BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?Sergia Velho
Institute of Molecular Pathology and Immunology, University of Porto, Portugal
BMC Cancer 8:255. 2008..In the series of polyps CIMP, MLH1 methylation and MSI were also studied...
- A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activationAna Preto
Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias s n, 4200 465 Porto, Portugal
Virchows Arch 450:619-26. 2007..STI571/Gleevec increases apoptosis in CRC cell lines independently of its genetic profile, suggesting that STI571/Gleevec is likely to be an alternative drug for the clinical trials of CRC...
- Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation statusCarla Oliveira
Institute of Molecular Pathology and Immunology, The University of Porto, IPATIMUP, 4200 465 Porto, Portugal
Hum Mol Genet 13:2303-11. 2004....