Gianpaolo Suriano

Summary

Affiliation: Institute of Molecular Pathology and Immunology
Country: Portugal

Publications

  1. pmc Epidermal growth factor receptor structural alterations in gastric cancer
    Catia Moutinho
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto IPATIMUP, 4200 465 Porto, Portugal
    BMC Cancer 8:10. 2008
  2. ncbi request reprint A model to infer the pathogenic significance of CDH1 germline missense variants
    Gianpaolo Suriano
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, Rua Dr Roberto Frias S N 4200 465, Porto, Portugal
    J Mol Med (Berl) 84:1023-31. 2006
  3. ncbi request reprint Genetics of hereditary diffuse gastric cancer: progress and future challenges
    Gianpaolo Suriano
    Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias S N 4200 465, Porto, Portugal
    Future Oncol 2:363-70. 2006
  4. pmc The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC
    Joana Figueiredo
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Eur J Hum Genet 21:301-9. 2013
  5. doi request reprint De novo expression of CD44 variants in sporadic and hereditary gastric cancer
    Cristiana Branco da Cunha
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Lab Invest 90:1604-14. 2010
  6. pmc ADP-ribosylation factor 6 mediates E-cadherin recovery by chemical chaperones
    Joana Figueiredo
    Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    PLoS ONE 6:e23188. 2011
  7. doi request reprint E-cadherin impairment increases cell survival through Notch-dependent upregulation of Bcl-2
    António Carlos Ferreira
    IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Hum Mol Genet 21:334-43. 2012
  8. doi request reprint Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer
    Joana Simões-Correia
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Hum Mol Genet 17:3566-76. 2008
  9. pmc Genetic screening for familial gastric cancer
    Carla Oliveira
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto IPATIMUP, Porto, Portugal
    Hered Cancer Clin Pract 2:51-64. 2004
  10. ncbi request reprint In vitro demonstration of intra-locus compensation using the ornithine transcarbamylase protein as model
    Gianpaolo Suriano
    Institute of Molecular Pathology and Immunology, University of Porto, Portugal
    Hum Mol Genet 16:2209-14. 2007

Collaborators

Detail Information

Publications32

  1. pmc Epidermal growth factor receptor structural alterations in gastric cancer
    Catia Moutinho
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto IPATIMUP, 4200 465 Porto, Portugal
    BMC Cancer 8:10. 2008
    ..Given its possible therapeutic relevance, we aimed to determine the frequency and type of structural alterations of the EGFR gene in a series of primary gastric carcinomas...
  2. ncbi request reprint A model to infer the pathogenic significance of CDH1 germline missense variants
    Gianpaolo Suriano
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, Rua Dr Roberto Frias S N 4200 465, Porto, Portugal
    J Mol Med (Berl) 84:1023-31. 2006
    ..The model described in this study provides an important tool that can ultimately improve the genetic counseling offered to the carriers of the germline CDH1 missense variants...
  3. ncbi request reprint Genetics of hereditary diffuse gastric cancer: progress and future challenges
    Gianpaolo Suriano
    Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias S N 4200 465, Porto, Portugal
    Future Oncol 2:363-70. 2006
    ..Since most of the HDGC families reported to date are negative for E-cadherin germline mutations, the identification of alternative genes underlying the tumorigenesis of diffuse gastric has become an important target for research...
  4. pmc The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC
    Joana Figueiredo
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Eur J Hum Genet 21:301-9. 2013
    ....
  5. doi request reprint De novo expression of CD44 variants in sporadic and hereditary gastric cancer
    Cristiana Branco da Cunha
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Lab Invest 90:1604-14. 2010
    ..Further, our results raise the hypothesis of using CD44v6 as a marker of early invasive intramucosal carcinoma in HDGC CDH1 mutation carriers that lack CDH1 expression in their tumors...
  6. pmc ADP-ribosylation factor 6 mediates E-cadherin recovery by chemical chaperones
    Joana Figueiredo
    Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    PLoS ONE 6:e23188. 2011
    ..We propose that this influence should be taken into account when exploring the therapeutic potential of this type of chemicals in genetic diseases associated to protein-misfolding...
  7. doi request reprint E-cadherin impairment increases cell survival through Notch-dependent upregulation of Bcl-2
    António Carlos Ferreira
    IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Hum Mol Genet 21:334-43. 2012
    ..These findings highlight the possibility of new targeted therapeutical strategies for the treatment of tumours associated with E-cadherin inactivation...
  8. doi request reprint Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer
    Joana Simões-Correia
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Hum Mol Genet 17:3566-76. 2008
    ..We show that ERQC plays a major role in E-cadherin regulation and propose that overcoming this regulation may represent an approach to rescue E-cadherin expression and functionality in cancer...
  9. pmc Genetic screening for familial gastric cancer
    Carla Oliveira
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto IPATIMUP, Porto, Portugal
    Hered Cancer Clin Pract 2:51-64. 2004
    ..This knowledge is a fundamental step towards accurate genetic counselling, in which a highly specialised pre-symptomatic therapeutic intervention should be offered...
  10. ncbi request reprint In vitro demonstration of intra-locus compensation using the ornithine transcarbamylase protein as model
    Gianpaolo Suriano
    Institute of Molecular Pathology and Immunology, University of Porto, Portugal
    Hum Mol Genet 16:2209-14. 2007
    ..We concluded that the presence of a threonine at position 135 in chimps rescues the deleterious effect of the methionine at position 125, in a mechanism of intra-locus compensation...
  11. ncbi request reprint The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population
    Paulo Canedo
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Eur J Cancer Prev 17:28-32. 2008
    ..In conclusion our results indicate that although the IL8-251 polymorphism might be a relevant host susceptibility factor for gastric carcinoma development, this association is likely to be ethnic-specific...
  12. doi request reprint E-cadherin mutations and cell motility: a genotype-phenotype correlation
    Ana Rita Mateus
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, 4200 465 Porto, Portugal
    Exp Cell Res 315:1393-402. 2009
    ..Our results allowed the identification of the E-cadherin domains pivotal for cell motility, further demonstrated a genotype-phenotype correlation, and defined a subset of HDGC cases which may benefit from EGFR inhibitors...
  13. ncbi request reprint Epistatic interactions: how strong in disease and evolution?
    Luisa Azevedo
    IPATIMUP, Rua Dr Roberto Frias s n, 4200 465 Porto, Portugal
    Trends Genet 22:581-5. 2006
    ..In this report we investigate the possible evolutionary histories by which substitution of alternative variants in these six genes either ameliorates or avoids pathological consequences...
  14. ncbi request reprint Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2
    Susana Seixas
    Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Mol Biol Evol 24:587-98. 2007
    ....
  15. ncbi request reprint Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner
    Maria J Oliveira
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, Portugal, and the Laboratory of Experimental Cancerology, Ghent University Hospital, Belgium
    J Biol Chem 281:34888-96. 2006
    ..Our findings demonstrate that H. pylori strains with a functional T4SS stimulate gastric epithelial cell invasion through a c-Met-dependent signaling pathway that comprises an increase in MMP-2 and MMP-9 activity...
  16. ncbi request reprint MBD4 mutations are rare in gastric carcinomas with microsatellite instability
    Mafalda Pinto
    IPATIMUP Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
    Cancer Genet Cytogenet 145:103-7. 2003
    ..We conclude that MBD4 mutations in the entire coding sequence, including the two poly(A) tracts, are rare in MSI gastric carcinomas. MBD4 is likely to be a bystander target gene in MSI-H tumors...
  17. ncbi request reprint Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred
    Carla Oliveira
    Cancer Genomics Program, Department of Oncology, University of Cambridge, Hutchison MRC Research Centre, Addenbrooke s Hospital, Cambridge, UK
    Hum Mutat 19:510-7. 2002
    ..These results add support to the evidence that only HDGC families harbor germline mutations in CDH1 and that genes other than CDH1 remain to be identified...
  18. ncbi request reprint Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands
    Gianpaolo Suriano
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto, 4200 Porto, Portugal
    Hum Mol Genet 12:575-82. 2003
    ....
  19. ncbi request reprint The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell-cell adhesion and to suppress invasion
    Gianpaolo Suriano
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto IPATIMUP, 4200 Porto, Portugal
    Oncogene 22:5716-9. 2003
    ....
  20. ncbi request reprint E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients
    Carla Oliveira
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Rua Roberto Frias, S N, 4200 465 Porto, Portugal
    Eur J Cancer 40:1897-903. 2004
    ..No evidence was found for a role of germline mutations in SMAD4 and Caspase-10 in families lacking CDH1 mutations...
  21. ncbi request reprint beta-catenin (CTNNB1) gene amplification: a new mechanism of protein overexpression in cancer
    Gianpaolo Suriano
    Genetic Pathology Evaluation Centre of the Department of Pathology and Prostate Centre at Vancouver General Hospital, Department of Pathology, British Columbia Cancer Agency and University of British Columbia, Vancouver, Canada
    Genes Chromosomes Cancer 42:238-46. 2005
    ..Our data suggest that gene amplification is a possible mechanism of beta-catenin overexpression in cancer...
  22. ncbi request reprint Gastric cancer: new genetic developments
    Henry T Lynch
    Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Surg Oncol 90:114-33; discussion 133. 2005
    ..This paper reviews the genetics of both intestinal and diffuse types of gastric carcinoma, their differential diagnosis, molecular genetics, pathology, and, when known, their mode of genetic transmission within families...
  23. doi request reprint High incidence of familial gastric cancer in Tuscany, a region in Italy
    Franco Roviello
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Oncology 72:243-7. 2007
    ..We studied a large cohort of gastric cancer patients from Tuscany, a region in Italy, to evaluate the presence of familial clustering of gastric cancer...
  24. ncbi request reprint Characterization of a recurrent germ line mutation of the E-cadherin gene: implications for genetic testing and clinical management
    Gianpaolo Suriano
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Clin Cancer Res 11:5401-9. 2005
    ..To identify germ line CDH1 mutations in hereditary diffuse gastric cancer (HDGC) families and develop guidelines for management of at risk individuals...
  25. ncbi request reprint Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer
    Pardeep Kaurah
    Hereditary Cancer Program, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    JAMA 297:2360-72. 2007
    ..Hereditary diffuse gastric cancer is caused by germline mutations in the epithelial cadherin (CDH1) gene and is characterized by an increased risk for diffuse gastric cancer and lobular breast cancer...
  26. ncbi request reprint EGFR regulates RhoA-GTP dependent cell motility in E-cadherin mutant cells
    Ana Rita Mateus
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto IPATIMUP, 4200 465 Porto, Portugal
    Hum Mol Genet 16:1639-47. 2007
    ..Furthermore, we demonstrate that E-cadherin-dependent EGFR activation contributes to enhanced cell motility, in a mechanism involving RhoA activation...
  27. ncbi request reprint Association between functional EGF+61 polymorphism and glioma risk
    Bruno Marques Costa
    Life and Health Sciences Research Institute ICVS, School of Health Sciences and Department of Production and Systems Engineering, University of Minho, Braga, Portugal
    Clin Cancer Res 13:2621-6. 2007
    ..A polymorphism in the EGF gene (EGF+61) may influence its expression and contribute to cancer predisposition and aggressiveness. In the present study, we aimed to elucidate the role of EGF+61 in glioma susceptibility and prognosis...
  28. ncbi request reprint E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia
    Paulo S Pereira
    Instituto de Biologia Molecular e Celular, IBMC, Universidade do Porto, Porto 4150 180, Portugal
    Hum Mol Genet 15:1704-12. 2006
    ..Therefore, the use of this simple in vivo system will contribute to characterize the effects that missense hEcad have on cell behavior in a tissue environment, and might help to understand their significance in gastric cancer onset...
  29. ncbi request reprint The prevalence of PIK3CA mutations in gastric and colon cancer
    Sergia Velho
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Portugal
    Eur J Cancer 41:1649-54. 2005
    ..016). In colorectal carcinoma, PIK3CA mutations occur preferentially together with activating KRAS-BRAF mutations (MSI and MSS) while in gastric carcinomas PIK3CA mutations tend to occur as isolated events (MSI)...
  30. ncbi request reprint E-cadherin germline missense mutations and cell phenotype: evidence for the independence of cell invasion on the motile capabilities of the cells
    Gianpaolo Suriano
    Instituto de Patologia e Immunologia Molecular da Universidade do Porto, Portugal
    Hum Mol Genet 12:3007-16. 2003
    ..Our data give new insights into the understanding of the mechanisms linking invasion and E-cadherin mutations in diffuse gastric cancer...
  31. ncbi request reprint Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro
    Paulo Ferreira
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto IPATIMUP, 4200 Porto, Portugal
    Exp Cell Res 310:99-104. 2005
    ..We found that in vitro functional E-cadherin renders cells more sensitive to the effect of taxol. Our results also indicate that this effect is associated to decreased level of the anti-apoptotic bcl-2 protein...
  32. pmc Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells
    Hafid Alazzouzi
    J Med Genet 44:75-80. 2007
    ..Mdm2 is a natural inhibitor of p53 function and its overexpression impairs p53 transcriptional activity. T-->G single-nucleotide polymorphism at position 309 (SNP309) of mdm2 induces overexpression of mdm2, but inhibits p53...